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Dragging 3D printing technique controls pore sizes of tissue engineered blood vessels to induce spontaneous cellular assembly

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Bioactive Materials 2024年第1期31卷 590-602页

作者： hun-Jin Jeong Hyoryung Nam Jae-Seok Kim sungkeon cho Hyun-Ha Park Young-Sam cho Hyungkook Jeon Jinah Jang Seung-Jae Lee Department of Mechanical Engineering Wonkwang University54538IksanRepublic of Korea Department of Convergence IT Engineering Pohang University of Science and Technology37673PohangGyeongbukRepublic of Korea Department of Mechanical and Design Engineering Wonkwang University54538IksanRepublic of Korea Department of Mechanical Engineering Pohang University of Science and Technology37673PohangGyeongbukRepublic of Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and Technology37673PohangGyeongbukRepublic of Korea Institute of Convergence Science Yonsei University03722SeoulRepublic of Korea Regenerative Engineering Laboratory Columbia University630W 168th STNew York10032USA Department of Manufacturing Systems and Design Engineering Seoul National University of Science and Technology01811SeoulRepublic of Korea

To date,several off-the-shelf products such as artificial blood vessel grafts have been reported and clinically tested for small diameter vessel(SDV)***,conventional artificial blood vessel grafts lack endothelium and,thus,are not ideal for SDV transplantation as they can cause *** addition,a suc-cessful artificial blood vessel graft for SDV must have sufficient mechanical properties to withstand various external ***,we developed a spontaneous cellular assembly SDV(S-SDV)that develops without additional *** improving the dragging 3D printing technique,SDV constructs with free-form,multilayers and controllable pore size can be fabricated at ***,The S-SDV filled in the natural poly-mer bioink containing human umbilical vein endothelial cells(HUVECs)and human aorta smooth muscle cells(HAoSMCs).The endothelium can be induced by migration and self-assembly of endothelial cells through pores of the SDV *** antiplatelet adhesion of the formed endothelium on the luminal surface was also *** addition,this S-SDV had sufficient mechanical properties(burst pressure,suture retention,leakage test)for *** believe that the S-SDV could address the challenges of conventional SDVs:notably,endothelial formation and mechanical *** particular,the S-SDV can be designed simply as a free-form structure with a desired pore *** endothelial formation through the pore is easy even in free-form con-structs,it is expected to be useful for endothelial formation in vascular structures with branch or curve shapes,and in other tubular tissues such as the esophagus.

关键词： Small diameter vessel Dragging 3D printing Pore control Spontaneous cellular assembly

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Wrinkle-free graphene with spatially uniform electrical properties grown on hot-pressed copper

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Nano Research 2015年第4期8卷 1075-1080页

作者： Jeong hun Mun Joong Gun Oh Jae Hoon Bong Hai Xu Kian Ping Loh Byung Jin cho Departmen t of Electrical Engineering KAIST Daejeon 305-701 Republic of Korea Department of Chemistry National University of Singapore Singapore 117543 Singapore

The chemical vapor deposition （CVD） of graphene on Cu substrates enables the fabrication of large-area monolayer graphene on desired substrates. However, during the transfer of the synthesized graphene, topographic defects are unavoidably formed along the Cu grain boundaries, degrading the electrical properties of graphene and increasing the device-to-device variability. Here, we introduce a method of hot-pressing as a surface pre-treatment to improve the thermal stability of Cu thin film for the suppression of grain boundary grooving. The flattened Cu thin film maintains its smooth surface even after the subsequent high temperature CVD process necessary for graphene growth, and the formation of graphene without wrinkles is realized. Graphene field effect transistors （FETs） fabricated using the graphene synthesized on hot-pressed Cu thin film exhibit superior field effect mobility and significantly reduced device-to-device variation.

关键词： CVD graphene graphene synthesis graphene wrinkle graphene field effecttransistor

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Simultaneous determination of fourteen components of Gumiganghwal-tang tablet in human plasma by UPLC-ESI-MS/MS and its application to pharmacokinetic study

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Journal of Pharmaceutical Analysis 2021年第4期11卷 444-457页

作者： Seung-Hyun Jeong Ji-hun Jang Guk-Yeo Lee Seung-Jung Yang Hea-Young cho Yong-Bok Lee College of Pharmacy Chonnam National University77 Yongbong-roBuk-guGwangju61186Republic of Korea National Development Institute of Korean Medicine 288 Udeuraendeu-gilAnyang-myeonJangheung-gunJeollanam-do59338Republic of Korea Department of Oriental Rehabilitation Medicine Dongshin University Gwangju Korean Medicine Hospital141 Wolsan-roNam-guGwangju61619Republic of Korea College of Pharmacy CHA University335 Pangyo-roBundang-guSeongnam-siGyeonggi-do13488Republic of Korea

Gumiganghwal-tang is a traditional herbal medicine widely used for its anti-inflammatory,analgesic,and antipyretic ***,the safety and efficacy of its active ingredients based on an in vivo pharmacokinetic(PK)study have yet been *** have established a sensitive and accurate UPLC-ESI-MS/MS method and conducted a PK study on 14 constituents of Gumiganghwal-tang through human plasma *** conditions were optimized according to the physicochemical properties of the 14 compounds to facilitate efficient separation and eliminate overlap or interference between ***-C18 and Inertsil-C8 columns were used as UPLC stationary phases,and acetonitrile and aqueous formic acid were used as mobile *** the analytes were quantified with a triple quadrupole mass spectrometer using electrospray ionization in multiple reaction monitoring *** chromatograms of 14 bioactive compounds showed excellent elution and sensitivity,and each peak was selectively separated and quantified without interference with each other or *** established analytical method was based on international guidelines and was successfully used to perform PK studies of 14 herbal ingredients in humans after oral administration with Gumiganghwal-tang *** oral absorption of most active components of Gumiganghwal-tang was relatively rapid and remained considerably long in the body to be quantified in plasma up to 48 h after administration.

关键词： Gumiganghwal-tang Fourteen bioactive ingredients Simultaneous analysis UPLC-ESI-MS/MS Pharmacokinetics Clinical study

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Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients

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World Journal of Gastroenterology 2015年第5期21卷 1457-1467页

作者： Jeong Mo Bae Tae hun Lee Nam-Yun cho Tae-You Kim Gyeong Hoon Kang Laboratory of Epigenetics Cancer Research InstituteSeoul National University College of MedicineSeoul 110-799South Korea Department of Pathology Seoul National University College of MedicineSeoul 110-799South Korea Department of Internal Medicine Seoul National University College of MedicineSeoul 110-799South Korea

AIM:To investigate the clinicopathologic characteristics and prognostic implications associated with loss of CDX2 expression in colorectal cancers(CRCs).METHODS:We immunohistochemically evaluated CDX2 expression in 713 CRCs and paired our findings to clinicopathologic and molecular characteristics of each *** included cytokeratin 7 and CK20 expression,microsatellite instability,Cp G island methylator phenotype,and KRAS and BRAF mutation *** and multivariate survival analysis was performed to reveal the prognostic value of CDX2 ***:CDX2 expression was lost in 42(5.9%) ***,loss of CDX2 expression was associated with proximal location,infiltrative growth,advanced T,N,M and overall *** microscopic examination,loss of CDX2 expression was associated with poor differentiation,increased number of tumor-infiltrating lymphocytes,luminal serration and mucin *** of CDX2 expression was also associated with increased CK7 expression,decreased CK20 expression,Cp G island methylator phenotype,microsatellite instability and BRAF *** a univariate survival analysis,patients with loss of CDX2 expression showed worse overall survival(P < 0.001) and progression-free survival(P < 0.001).In a multivariate survival analysis,loss of CDX2 expression was an independent poor prognostic factor of overall survival [hazard ratio(HR) = 1.72,95%CI:1.04-2.85,P = 0.034] and progression-free survival(HR = 1.94,95%CI:1.22-3.07,P = 0.005).CONCLUSION:Loss of CDX2 expression is associated with aggressive clinical behavior and can be used as a prognostic marker in CRCs.

关键词： CDX2 CpG island methylator phenotype Microsatellit

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Ultrafast photonic PCR

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Light(Science & Applications) 2015年第1期4卷 267-273页

作者： Jun Ho Son Byungrae cho SoonGweon Hong Sang hun Lee Ori Hoxha Amanda J Haack Luke P Lee Department of Bioengineering University of CaliforniaBerkeleyCA 94720USA Berkeley Sensor and Actuator Center University of CaliforniaBerkeleyCA 94720USA Department of Electrical Engineering and Computer Sciences University of CaliforniaBerkeleyCA 94720USA Biophysics Graduate Program University of CaliforniaBerkeleyCA 94720USA

Nucleic acid amplification and quantification via polymerase chain reaction(PCR)is one of the most sensitive and powerful tools for clinical laboratories,precision medicine,personalized medicine,agricultural science,forensic science and environmental *** multiplex PCR,characterized by low power consumption,compact size and simple operation,is ideal for timely diagnosis at the point-of-care(POC).Although several fast/ultrafast PCR methods have been proposed,the use of a simple and robust PCR thermal cycler remains challenging for POC ***,we present an ultrafast photonic PCR method using plasmonic photothermal light-to-heat conversion via photon–electron–phonon *** demonstrate an efficient photonic heat converter using a thin gold(Au)film due to its plasmon-assisted high optical absorption(approximately 65%at 450 nm,the peak wavelength of heat source light-emitting diodes(LEDs)).The plasmon-excited Au film is capable of rapidly heating the surrounding solution to over 150℃ within 3 *** this method,ultrafast thermal cycling(30 cycles;heating and cooling rate of 12.7960.93℃ s^(-1) and 6.660.29℃ s^(-1),respectively)from 55℃(temperature of annealing)to 95℃(temperature of denaturation)is accomplished within 5 *** photonic PCR thermal cycles,we demonstrate here successful nucleic acid(λ-DNA)*** simple,robust and low cost approach to ultrafast PCR using an efficient photonic-based heating procedure could be generally integrated into a variety of devices or procedures,including on-chip thermal lysis and heating for isothermal amplifications.

关键词： genomics light-emitting diodes(LEDs) molecular diagnostics personalized medicine plasmonics point-of-care(POC)diagnostics polymerase chain reaction(PCR)

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Optimization of rotor shape for constant torque improvement and radial magnetic force minimization

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Journal of Central South University 2012年第2期19卷 357-364页

作者： cho Gyu-won WOO Seok-hyun JI Seung-hun PARK Kyoung-won JANG Ki-bong KIM Gyu-tak School of Mechatronics Changwon National University

The design of notch and barrier was optimized in order to improve the characteristics of constant torque while minimizing the cogging torque that occurs as a result of teeth and slot structure. The barrier was installed in order to minimize the cogging torque and torque ripple by finite element method (FEM) with a reduced barrier width toward the center of magnetic pole. The position and width of notch, which can offset cogging torque, can be calculated with energy distribution of air-gap using Fourier series. The optimized model demonstrates a 60% decrease in the cogging torque, a 75.3% decrease in the torque ripple and a 3% increase in the operating torque when compared with the basic model.

关键词： permanent magnet synchronous motor barrier notch radial magnetic force cogging torque

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Development of a skill assessment tool for the Korea operational oceanographic system

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Acta Oceanologica Sinica 2013年第9期32卷 74-81页

作者： cho Kyoung-Ho choI Jin-Yong JEONG Sang-hun choI Jung-Woon KWON Jae-Il PARK Kwang-Soon Coastal Disaster Research Center Korea Institute of Ocean Science and Technology

A standard skill assessment （SA） tool was developed and implemented to evaluate the performance of op- erational forecast models in the Korea operational oceanographic system. The SA tool provided a robust way to assess model skill in the system by comparing predictions and observations, and involved the com- putation of multiple skill metrics including correlation and error skills. User- and system-based acceptance criteria of skill metrics were applied to determine whether predictions were acceptable for the system. To achieve this, the tool produced a time series comparison plot, a skill score table, and an advanced sum- marized diagram to effectively demonstrate the multiple skill scores. Moreover, the SA was conducted to evaluate both atmospheric and hydrodynamic forecast variables. For the atmospheric variables, acceptable error criteria were preferable to acceptable correlation criteria over short timescales, since the mean square error overwhelmed the observation variance. Conversely, for the hydrodynamic variables, acceptable root mean square percentage error （e.g., perms） criteria were preferable to acceptable error （e.g., erms） criteria owing to the spatially variable tidal intensity around the Korean Peninsula. Furthermore, the SA indicated that predetermined acceptance error criteria were appropriate to satisfy a target central frequency （fc） for which errors fell within the specified limits （i.e., the .fc equals 70%）.

关键词： skill assessment tool operational forecast system Korea operational oceanographic system

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Syndrome Pattern and Its Application in Parallel Randomized Controlled Trials

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Chinese Journal of Integrative Medicine 2013年第3期19卷 163-171页

作者： Byung-Cheul Shin Sina Kim Young-hun cho Division of Clinical Medicine School of Korean MedicinePusan National University Department of Korean Medicine School of Korean MedicinePusan National University Department of Korean Medical Science School of Korean MedicinePusan National University

Syndrome pattern （SP） is a core concept of Chinese medicine （CM） and is used to diagnose and treat patients based on an overall analysis of symptoms and signs. This study aimed to systematically review randomized controlled trials （RCTs） using the SP concept and to demonstrate how the SP concept could be applied to the study design of parallel RCTs, considering a gold standard of clinical research. After conducting a brief systematic review by way of a PubMed search, we analyzed how the SP concept was applied to the design of RCT in a CM herbal medicine trial. We then formulated possible research questions, applied the SP concept to answer the research questions, and suggested possible RCT designs to be used for conducting future trials. Fourteen RCTs were included in our systematic review, and three key points of the SP concept were formulated for the design of parallel RCTs： the time point of SP diagnosis between before and after randomization; the relationship between the international classification of diseases （ICD） and SP for the inclusion of target population; and the proper diagnostic method of SP. In this study, we formulated three possible research questions and then suggested perspectives for five possible RCT models arrived at using SP concepts. Future trials applying SP concept to RCTs should overcome the shortcomings of past SP trials, moving CM forward from experience-based to evidence-based medicine.

关键词： syndrome pattern randomized controlled trial traditional Chinese medicine evidence-basedmedicine integrative medicine

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Intraoperative sudden arrhythmias in cervical spine surgery adjacent to the stellate ganglion:A case report

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World Journal of Clinical Cases 2023年第24期11卷 5789-5796页

作者： Jong-hun Seo Su-Yeon cho Ji-Hwan Park Jin-Young Seo Hyun-Young Lee Dong-Joon Kim Department of Neurosurgery Chosun University HospitalGwangju 61453South Korea Department of Anesthesiology and Pain Medicine Chosun University HospitalGwangju 61453South Korea Department of Anesthesiology and Pain Medicine College of MedicineChosun UniversityGwangju 61453South Korea

BACKGROUND Atrial arrhythmias such as paroxysmal supraventricular tachycardia(PSVT)and atrial flutter(AF)are common in the perioperative *** commonly resolve ***,occasionally,they may continually progress to fatal arrhythmias or cause ***,prompt and appropriate management is *** SUMMARY A 46-year-old female patient diagnosed with cervical C6-7 radiculopathy characterized by decreased sensation in the right third,fourth and fifth fingers underwent C6-7 anterior cervical disc fusion *** showed PSVT and ventricular tachycardia during C6-7 disc ***,the patient remained *** treatment with esmolol and lidocaine for ventricular tachycardia was *** massage and Valsalva maneuver were attempted but PSVT did not *** surgery was paused,and the patient’s fraction of inspired oxygen was set to 100%.Adenosine was administered for pharmacological management of *** arrhythmia temporarily ***,it then transformed into *** was administered,which briefly decreased blood pressure,which immediately *** resumed while the patient was in normal sinus *** was discharged safely on postoperative day 6 without complications or ***,she is living a healthy life without arrhythmia *** Ganglia associated with cardiac arrhythmias in the surgical site should be identified during cervical spine surgery.

关键词： Supraventricular tachycardia Atrial flutter Stellate ganglion Adenosine Diltiazem Case Report

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Treatment with Modified Bazhen Decoction(八珍汤)for A Patient with Autoimmune Hemolytic Anemia: A Case Report of A Ten-Month Period

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Chinese Journal of Integrative Medicine 2014年第4期20卷 296-299页

作者： Nam-hun Lee Jung-Hyo cho Chang-Gue Son Department of Oriental Internal Medicine Cheonan Oriental HospitalOriental Medical CollegeDaejeon University Liver and Immunology Research Center Daejeon Oriental HospitalOriental Medical College

Autoimmune hemolytic anemia（AIHA）is uncommon but prospective fatal condition with an incidence rate of 1-3 per 100,000 persons.;（1,2）]AIHA is characterized by autoantibodies with specificity against red blood cell（RBC）antigens leading to an increased removal of red cells from blood circulation.;（1,3）]AIHA responds well to steroids,but most patients remain steroid-dependent,and many cases require secondline ***,splenectomy can be regarded as the most effective and best-evaluated second-line therapy,but there are still only limited data on longterm efficacy and adverse *** monoclonal anti-CD20 antibody rituximab,another second-line

关键词：八珍汤氮/代谢钙调蛋白结合蛋白质类红细胞磷蛋白磷酸酶类敏感性与特异性脾切除术贫血溶血性自身免疫性

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