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Helicobacter pylori infection is not associated with nonalcoholic fatty liver disease

World Journal of Gastroenterology 2016年第8期22卷 2592-2600页

作者： Myong Ki Baeg Seung Kew Yoon sun-hye ko Yong-sun Noh In-Seok Lee Myung-Gyu Choi Department of Internal Medicine The Catholic University of Korea College of Medicine

AIM: To determine whether Helicobacter pylori (H. pylori) infection confers a higher risk of Nonalcoholic fatty liver disease (NAFLD).METHODS: Healthy people who underwent health screening were analyzed retrospectively. Inclusion criteria were age ≥ 20 years, history of H. pylori infection, and recorded insulin level. Participants were classified as H. pylori positive or negative according to 13C urea breath tests. NAFLD was defined using the hepatic steatosis index (HSI) and NAFLD liver fat score (NAFLD-LFS). Those with an HSI > 36 or NAFLD-LFS > -0.640 were considered to have NAFLD. Multivariable logistic regression was performed to identify risk factors for ***: Three thousand six hundred and sixty-three people were analyzed and 1636 (44.7%) were H. pylori positive. H. pylori infection was associated with older age, male gender, hypertension, higher body mass index, and a dyslipidemic profile. HSI differed significantly between H. pylori positive and negative subjects (median 33.2, interquartile range (IQR) 30.0-36.2 for H. pylori-positive vs median 32.6, IQR 29.8-36.0 for negative participants, P = 0.005), but NAFLD-LSF did not [median -1.7, IQR -2.4 - -0.7 vs median -1.8, IQR -2.4-(-0.7), respectively, P = 0.122]. The percentage of people with NAFLD did not differ between infected and uninfected groups: HIS, 26.9% vs 27.1%, P = 0.173; NAFLD-LFS, 23.5% vs 23.1%, P = 0.778. H. pylori infection was not a risk factor, but C-reactive protein concentration and smoking were significant risk factors for ***: H. pylori infection is not a risk factor for NAFLD as indicated by HSI or NAFLD-LFS. Prospective, large-scale studies involving liver biopsies should be considered.

关键词： Helicobacter pylori Nonalcoholic fatty liver disease Hepatic steatosis index Nonalcoholic fatty liver disease liver fat score Urea breath test

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Case of inappropriate ADH syndrome:Hyponatremia due to polyethylene glycol bowel preparation

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World Journal of Gastroenterology 2014年第34期20卷 12350-12354页

作者： sun-hye ko Chul-Hyun Lim Jae-Young Kim Seung Hun Kang Myong Ki Baeg Hyun Jin Oh Division of Endocrinology and Metabolism Department of Internal MedicineCollege of MedicineThe Catholic UniversitySeoul 137-701South Korea Division of Gastroenterology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 137-701South Korea

Colonoscopic screening has been reported to reduce deaths from colorectal *** bowel preparation is essential for this and safety is an important issue in choosing the *** glycol(PEG)is regarded as a safe method for cleansing,especially compared with oral sodium ***,we present a case of hyponatremia caused by the syndrome of inappropriate antidiuretic hormone(ADH)syndrome after PEG precolonoscopic cleansing resulting in generalized tonic-clonic seizures.A 62-year-old women had ingested PEG for precolonoscopic bowel *** waiting for the colonoscopy,she developed a stuporous mentality and generalized tonic-clonic seizures,which did not correlate with brain magnetic resonance *** serum sodium level was 113 mEq per liter and laboratory analyses were consistent with inappropriate ADH *** thyroid and adrenal functions were *** were no malignancies,infections,respiratory disorders or central nervous disorders and she had no history of taking either diuretics or other medications,which might have caused inappropriate ADH *** was treated with 3%hypertonic saline and showed a complete neurological recovery as her sodium levels ***-up visits showed the patient to have a normal sodium level without neurologic *** case shows that inappropriate ADH syndrome can be caused by PEG preparation,which implies that physicians have to be aware of the possible side effects of this colonic cleansing approach and mindful of the possible ensuing symptoms.

关键词： Inappropriate antidiuretic hormone syndrome Colonoscopy Polyethyelene glycol Hyponatremia Seizure

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Increased liver markers are associated with higher risk of type 2 diabetes

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World Journal of Gastroenterology 2015年第24期21卷 7478-7487页

作者： sun-hye ko Myong Ki Baeg Kyung-Do Han Seung-Hyun ko Yu-Bae Ahn Division of Endocrinology and Metabolism Department of Internal Medicine College of Medicine The Catholic University of Korea Division of Gastroenterology Department of Internal Medicine College of Medicine The Catholic University of Korea Department of Biostatistics College of Medicine The Catholic University of Korea

AIM: To investigate the association between liver markers and the risk of type 2 diabetes(T2DM) and impaired fasting glucose(IFG).METHODS: A total of 8863 participants(3408 men and 5455 women) over 30 years of age were analyzed from the fifth korean National Health and Nutrition Examination Survey(2010-2011). The associations of serum liver markers such as aspartate aminotransferase(AST), alanine aminotransferase(ALT), AST/ALT, and gamma-glutamyltransferase(GGT) with T2 DM and IFG were analyzed using logistic regression models. Participants were divided into sex-specific quartiles on the basis of liver ***: The prevalence of T2 DM and IFG were 11.3% and 18.3%. Increasing quartiles of ALT and GGT were positively and AST/ALT were negatively correlated with T2 DM and IFG. Analysis of the liver marker combinations showed that if any two or more markers were in the highest risk quartile, the risks of both T2 DM and IFG increased significantly. The risk was greatest when the highest ALT and GGT and lowest AST/ALT quartile were combined, with the riskof T2 DM at 3.21(95%CI: 1.829-5.622, P < 0.001) in men and 4.60(95%CI: 3.217-6.582, P < 0.001) in women. Men and women with the highest AST and ALT and lowest AST/ALT quartile had a 1.99 and 2.40 times increased risk of ***: Higher levels of GGT and ALT and lower AST/ALT within the physiological range are independent, additive risk factors of T2 DM and IFG.

关键词： Type 2 diabetes mellitus Liver markers Impaired fasting glucose Gamma-glutamyl transferase Aspartate aminotransferase Alanine aminotransferase

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A case of a duodenal duplication cyst presenting as melena

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World Journal of Gastroenterology 2013年第38期19卷 6490-6493页

作者： Seung Yeon ko sun hye ko sungeun Ha Mi sung Kim Hyang Mi Shin Myong Ki Baeg Department of General Surgery College of MedicineThe Catholic University of Korea Department of Internal Medicine College of MedicineThe Catholic University of Korea Department of Pathology College of MedicineThe Catholic University of Korea

Duodenal duplication cysts are benign rare congenital anomalies reported mainly in the pediatric population,but seldom in *** depend on the type and location and can present as abdominal pain,distension,dysphagia or *** have been reported to be responsible for duodenal obstruction,pancreatitis and,in rare cases,gastrointestinal *** present a case of a duodenal duplication cyst in a 43-year-old man presenting as *** gastroduodenoscopy and colonoscopy did not reveal any bleeding ***,the patient began passing melena after 3 d,with an acute decrease in hemoglobin *** studies revealed a duplication cyst in the second portion of the duodenum which was surgically *** revealed a duodenal duplication cyst consisting of intestinal *** was no further bleeding and the patient recovered *** rare cases,duodenal duplication cysts might cause gastrointestinal bleeding and should be included in the differential diagnosis.

关键词： Gastrointestinal hemorrhage Duodenum Duplication

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ELK3-ID4 axis governs the metastatic features of triple negative breast cancer

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Oncology Research 2024年第1期32卷 127-138页

作者： JIN-HO CHOI JOO DONG PARK SEUNG HEE CHOI EUN-SU ko hye JUNG JANG KYUNG-SOON PARK Department of Biomedical Science CHA UniversitySeongnamKorea

Purpose:Cancer cell metastasis is a multistep process,and the mechanism underlying extravasation remains ***3 is a transcription factor that plays a crucial role in regulating various cellular processes,including cancer *** on the finding that ELK3 promotes the metastasis of triple-negative breast cancer(TNBC),we investigated whether ELK3 regulates the extravasation of TNBC by forming the ELK3-ID4 ***4 functions as a transcriptional regulator that interacts with other transcription factors,inhibiting their activity and subsequently influencing various biological processes associated with cell differentiation,survival,growth,and ***:We assessed the correlation between the expression of ELK3 and that of ID4 in TNBCs using bioinformatics analyses,QRT-PCR,western blot analysis,luciferase reporter assays,and chromatin ***,adhesion,invasion,and lung metastasis assays were employed to determine whether the ELK3-ID4 axis regulates the metastatic features of ***:We found that ELK3 binds directly to a binding motif close to the ID4 promoter to repress promoter *** expression of E-cadherin in TNBC was regulated by the ELK3-ID4 *** vitro and in vivo analyses showed that inhibiting ID4 expression in ELK3-knockdown MDA-MB-231(ELK3KD)cells restored the ability to extravasate and ***:The results indicate that the ELK3 regulates ID4 promoter activity,and that the ELK3-ID4 axis regulates the metastatic characteristics of TNBC ***,the data suggest that the ELK3-ID4 axis regulates metastasis of TNBCs by modulating expression of E-cadherin.

关键词： E-cadherin Extravasation Colonization

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Enhancing the Performance of Perovskite Light-Emitting Diodes via Synergistic Effect of Defect Passivation and Dielectric Screening

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Nano-Micro Letters 2024年第10期16卷 244-256页

作者： Xuanchi Yu Jia Guo Yulin Mao Chengwei Shan Fengshou Tian Bingheng Meng Zhaojin Wang Tianqi Zhang Aung ko ko Kyaw Shuming Chen Xiaowei sun Kai Wang Rui Chen Guichuan Xing Institute of Applied Physics and Materials Engineering University of MacaoAvenida da UniversidadeTaipaMacao 999078People's Republic of China Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen 518055People's Republic of China

Metal halide perovskites,particularly the quasi-two-dimensional perovskite subclass,have exhibited considerable potential for next-generation electroluminescent materials for lighting and ***,the presence of defects within these perovskites has a substantial influence on the emission efficiency and durability of the *** this study,we revealed a synergistic passivation mechanism on perovskite films by using a dual-functional compound of potassium *** dual functional potassium bromide on the one hand can passivate the defects of halide vacancies with bromine anions and,on the other hand,can screen the charged defects at the grain boundaries with potassium *** approach effectively reduces the probability of carriers quenching resulting from charged defects capture and consequently enhances the radiative recombination efficiency of perovskite thin films,leading to a significant enhancement of photoluminescence quantum yield to near-unity values(95%).Meanwhile,the potassium bromide treatment promoted the growth of homogeneous and smooth film,facilitating the charge carrier injection in the ***,the perovskite light-emitting diodes based on this strategy achieve a maximum external quantum efficiency of~21%and maximum luminance of~60,000 cd m^(-2).This work provides a deeper insight into the passivation mechanism of ionic compound additives in perovskite with the solution method.

关键词： Synergistic passivation strategy Defects passivation Dielectric screening Perovskite light-emitting diodes

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Factors determining changes in the network of marked hiking trails in the Sudetes

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Journal of Mountain Science 2024年第4期21卷 1075-1099页

作者： Krzysztof koŁODZIEJCZYK Department of Regional Geography and Tourism Institute of Geography and Regional DevelopmentFaculty of Earth Sciences and Environmental ManagementUniversity of WroclawNo.1Uniwersytecki Square50-137 WroclawPoland

Hiking trails are a basic type of tourist infrastructure,which,on the one hand,make areas available for tourist traffic,and on the other hand,can contribute to the protection of the natural environment(if they are well designed and maintained).Owing to the variety of performed functions,their designation is determined by several factors:natural,technical,economic,*** of trails change *** aim of this article is to determine exactly what factors influence transformations within the hiking trail networks and what is their *** this end,three study areas in the Sudetes were analysed:one on the Polish side of the Sudetes-the Table(Stołowe)Mountains,and two on the Czech side-the rock town near the village of Sloup vČechách and the central part of Zlatohorská*** analysis of changes in the shape of the networks over time was carried out,as well as surveys of institutions that were responsible for or influenced these *** areas are characterised by a significant level of changes in the trail *** the factors influencing these changes,the tourist attractiveness of the area,the resilience of the environment,the intensity of tourism traffic,the environmental transformations associated with it,the history of tourism development and land ownership changes should be considered the most *** each stage of forming networks,the key factor should be tourists’needs,including the desire to escape the urbanised *** this reason,trails should avoid roads with artificial(hard)surfaces and heavy automobile traffic.

关键词： Hiking trails Trail networks Graphs Tourist traffic Sudetes

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Dragonfly Interaction Algorithm for Optimization of Queuing Delay in Industrial Wireless Networks

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Journal of Bionic Engineering 2024年第1期21卷 447-485页

作者： Sanjay Bhardwaj Da-hye Kim Dong-Seong Kim Department of IT Convergence Engineering ICT Convergence Research CenterKumoh National Institute of TechnologyGumiSouth Korea

In industrial wireless networks,data transmitted from source to destination are highly *** often leads to the queuing of the data,and poor management of the queued data results in excessive delays,increased energy consumption,and packet ***,a nature-inspired-based Dragonfly Interaction Optimization Algorithm(DMOA)is proposed for optimization of the queue delay in industrial wireless *** term“interaction”herein used is the characterization of the“flying movement”of the dragonfly towards damselflies(female dragonflies)for *** a result,interaction is represented as the flow of transmitted data packets,or traffic,from the source to the base *** includes each and every feature of dragonfly movement as well as awareness of the rival dragonflies,predators,and damselflies for the desired optimization of the queue *** features are juxtaposed as noise and interference,which are further used in the calculation of industrial wireless metrics:latency,error rate(reliability),throughput,energy efficiency,and fairness for the optimization of the queue *** analysis,convergence analysis,the Wilcoxon test,the Friedman test,and the classical as well as the 2014 IEEE Congress of Evolutionary Computation(CEC)on the benchmark functions are also used for the evaluation of DMOA in terms of its robustness and *** results demonstrate the robustness of the proposed algorithm for both classical and benchmarking functions of the IEEE CEC ***,the accuracy and efficacy of DMOA were demonstrated by means of the convergence rate,Wilcoxon testing,and ***,fairness using Jain’s index in queue delay optimization in terms of throughput and latency,along with computational complexity,is also evaluated and compared with other *** results show that DMOA exceeds other bio-inspired optimization algorithms in terms of fairness in queue delay management and average packet *** proposed a

关键词： Dragonfly Damselfly Interaction Queuing delay Optimization Industrial wireless networks

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Electrochemical biosensors for point-of-care testing

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Bio-Design and Manufacturing 2024年第4期7卷 548-565页

作者： Jinsol Kim Juho Jeong Seung Hwan ko Department of Mechanical Engineering Seoul National UniversitySeoul 08826Republic of Korea Institute of Advanced Machinery and Design(SNU-IAMD) Seoul National UniversitySeoul 08826Republic of Korea

Point-of-care testing(POCT)is the practice of diagnosing and monitoring diseases where the patient is located,as opposed to traditional treatment conducted solely in a medical laboratory or other clinical *** has been less common in the recent past due to a lack of portable medical devices capable of facilitating effective medical ***,recent growth has occurred in this field due to advances in diagnostic technologies,device miniaturization,and progress in wearable *** these developments,electrochemical sensors have attracted interest in the POCT field due to their high sensitivity,compact size,and *** are used in various applications,from disease diagnosis to health status *** this paper we explore recent advancements in electrochemical sensors,the methods of fabricating them,and the various types of sensing mechanisms that can be ***,we delve into methods for immobilizing specific biorecognition elements,including enzymes,antibodies,and aptamers,onto electrode surfaces and how these sensors are used in real-world POCT settings.

关键词： Point-of-care testing(POCT) Electrochemical sensor Enzyme Antibody Health care

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Divergent responses of runoff to climate change in the upper basins of the Third Pole dominated by westerlies and monsoon

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Science China Earth Sciences 2024年第8期67卷 2592-2614页

作者： Qikai sun Fengge SU He sun State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China

The diverse climates,distribution of snow and glaciers,and geographic locations directly affect the runoff response to climate change in the upper basins of the Third *** present,a comprehensive analysis of runoff variations and their distinct responses to climate change in the westerlies-and monsoon-dominated upper basins is still *** study comprehensively analyzed annual runoff variations in westerlies-dominated basins(the upper basins of the Aksu(UAKS),Syr Darya(USRD),Yarkant(UYK),Hotan(UHT),Amu Darya(UAMD),and Indus(UI))and monsoon-dominated basins(the upper basins of the Yangtze(UYA),Yellow(UYE),Lancang(ULC),Nujiang(UNJ),and Yarlung Zangbo(UYZ))of the Third Pole from 1961 *** multi-source meteorological data and large-scale circulation factors,this study investigated the divergent responses of runoff in the upper basins to climate change,and explored the large-scale circulation mechanisms underlying runoff variations in these upper *** results showed that:(1)The annual runoff in the majority of upper basins(except for the UYE and UYZ)exhibited an increasing trend,and the annual runoff in the UAKS,UYK,and UI showed a significant increasing trend from1961 to *** annual runoff in the upper basins of the Third Pole changed abruptly from decreasing to increasing between the 1980s and 2000s,with the exception of the UYE.(2)The runoff in the monsoon-dominated upper basins has been controlled primarily by changes in precipitation over the past 55 *** contrast,the runoff in the westerlies-dominated upper basins exhibited three distinct long-term responses to climate change:temperature-dominated(UYK and UHT),precipitation-dominated(USRD and UAMD),and the combined influence of precipitation and temperature(UAKS and UI).Since the 1960s,the sensitivity of runoff to warm season temperature changes in the most westerlies-dominated upper basins has decreased,while the response of runoff to precipitation changes has intensified.(3)The stud

关键词： Upper basins of the Third Pole Climate change Westerlies and monsoon Runoff variations Large-scale circulation factors

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