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Current Phthalate Exposure Risks of Rural Population in the Northwest China: Evidence from an Internal Exposure Study

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Environment & Health 2024年第8期2卷 586-595页

作者： Yawen Zheng Liting Hua Zining Zhang Lin Zhu Hongkai Zhu hongwen sun Hongzhi Zhao Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China School of Urban and Environmental Sciences Key Laboratory of the Ministry of Education for Earth Surface ProcessesPeking UniversityBeijing 100871China State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong KongChina

Phthalates(PAEs)are synthetic chemicals widely used in industrial and personal consumer products as adhesives or *** have been demonstrated to have toxic effects on the human ***,biological monitoring data for the internal PAE exposure levels of Chinese rural residents are still *** present study investigated the exposure levels of ten phthalate metabolites(mPAEs)of rural residents in Northwest *** results showed that mPAEs were wildly prevalent in urine and the geometric mean concentration ofΣ10mPAEs was 957.02 ng mL^(–1)(adjusted by specific gravity).Mono-n-butyl phthalate(MBP)and metabolites of di(2-ethylhexyl)-phthalate(DEHP)were the most dominant mPAEs in urine,with specific gravity adjusted median concentrations of 174.67 and 156.30 ng mL^(–1),*** concentrations of mPAEs were significantly associated with age,body mass index and economic level(p<0.05).By calculating the percentage and relative conversion rate of DEHP metabolites,it was found that the degree of oxidative metabolism of DEHP in children was significantly higher than that in adults(p<0.05),indicating that the pathway and degree of DEHP oxidation were *** risk assessment showed that 59.12%of rural residents may have a noncancer risk from PAE *** study provides important basis for assessing the occurrence and exposure of urinary phthalate metabolites among rural residents in China.

关键词： Phthalate Metabolites Human Biomonitoring Health Risk Assessment Rural Residents

Unexpected Exposure Risks to Emerging Aromatic Amine Antioxidants and p‑Phenylenediamine Quinones to Residents:Evidence from External and Internal Exposure as Well as Hepatotoxicity Evaluation

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Environment & Health 2024年第5期2卷 278-289页

作者： Zijin Guo Zhipeng Cheng Shaohan Zhang Hongkai Zhu Leicheng Zhao Mujtaba Baqar Lei Wang hongwen sun MOE Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China School of Environment Key Laboratory for Yellow River and Huai River Water Environment and Pollution ControlMinistry of EducationHenan Normal UniversityXinxiang 453007China Sustainable Development Study Centre Government College UniversityLahore 54000Pakistan

Aromatic amine antioxidants(AAs),extensively used in rubber products,and their ozone-photolyzed product pphenylenediamine quinones(PPD-Qs)were found to be pervasive in various environments and with potential ecological and health *** relationship between external and internal exposure to these contaminants and their exposure risks to the general population remain poorly ***,dust−handwipe−urine samples(n=97 pairs)from families in Tianjin,China was collected for analyzing 20 AAs and 6 PPD-Qs(including self-synthesized emerging PPD-Qs).The median concentration ofΣ_(20)AAs(1310 ng/g,354 ng/m^(2),and 18.5 ng/mL,respectively)andΣ_(6)PPD-Qs(1645 ng/g,3913 ng/m^(2)and 3.76 ng/mL,respectively)in dust,handwipe,and urine samples indicated a non-negligible contamination of AAs and PPD-Qs in indoor ***,emerging DPPD-Q and DNPD-Q(oxidation products of DPPD and DNPD,respectively)were prominent,accounting for>90%of *** correlation analysis and estimated daily intake(EDI)assessments indicated that neither dust ingestion nor dermal exposure may be the primary source of internal exposure to AAs and PPD-Qs in the general population,and other exposure pathways(e.g.,diet and inhalation)may *** vitro HepG2 cell experiments demonstrated that both PPD-Qs and PPDs may have potential exposure risk of hepatotoxicity.

关键词： Aromatic amine antioxidants p-phenylenediamine human exposure risk assessment cytotoxicity

Do wearing masks and preservatives have a combined effect on skin health?

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Eco-Environment & Health 2024年第1期3卷 107-115页

作者： Yu Liu Leijian Chen Shuyi Zhang Xiaoxiao Wang Yuanyuan Song hongwen sun Zongwei Cai Lei Wang MOE Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong Kong 999077China

Chemical exposure and local hypoxia caused by mask-wearing may result in skin physiology *** effects of methylparaben(MeP),a commonly used preservative in personal care products,and hypoxia on skin health were investigated by HaCaT cell and ICR mouse *** exposure resulted in lipid peroxidation and interfered with cellular glutathione metabolism,while hypoxia treatment disturbed phenylalanine,tyrosine,and tryptophan biosynthesis pathways and energy metabolism to respond to oxidative stress.A hypoxic environment increased the perturbation of MeP on the purine metabolism in HaCaT cells,resulting in increased expression of proinflammatory *** synergistic effects were further validated in a mouse model with MeP dermal exposure and“mask-wearing”***,PPARG,and MMP2 were identified as possible key gene targets associated with skin health risks posed by MeP and *** toxicity analysis suggested a synergistic effect,indicating the risk of skin inflammation and skin barrier aging.

关键词： MeP Hypoxia Synergistic effect Skin metabolomics Network toxicology

Thyroid Hormone Biomonitoring:A Review on Their Metabolism and Machine-Learning Based Analysis on Effects of Endocrine Disrupting Chemicals

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Environment & Health 2024年第6期2卷 350-372页

作者： Shijie Chen Mengjie Yu Yiming Yao Yongcheng Li Ana He Zijun Zhou Liyang Pan Nan Xiao Haining Luo hongwen sun MOE Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300071China Tianjin Tianshi College Tianjin 301700China Dalian Center for Disease Control and Prevention DalianLiaoning Province 116000China Department of Center for Reproductive Medicine Tianjin Central Hospital Of Gynecology Obstetrics/Tianjin Key Laboratory Of Human Development And Reproductive RegulationTianjin 300052China

The thyroid is an essential endocrine organ in human body,and thyroid hormones(THs)are pivotal signaling molecules and mediators in various physiological ***,particularly in their free form,play a critical role in regulating body temperature and in the metabolism of lipid and glucose,making the maintenance of TH levels crucial for human *** undergo a series of metabolic processes,producing TH metabolites(THMs).THMs are significant in endocrine regulation,such as 3,5-diiothyronine(3,5-T2)and 3-iodothyronamine(3-T1AM),which exhibit activities akin to *** production and distribution of THMs are intricately linked to the function of specific organs and tissues,highlighting the need for advanced research into the determination and mechanisms of THMs in *** to endocrine disrupting chemicals(EDCs)can significantly affect the levels of thyroid stimulating hormone(TSH)and *** review utilizes machine learning to analyze epidemiological data,identifying potential EDCs that pose risks of hyperthyroidism and ***,it delves into the toxicological mechanisms of these EDCs,examining their effects on TH production,binding processes,related proteins,and metabolic *** approach effectively bridges the gap between epidemiological studies and toxicological researches,laying the groundwork for future research *** integrating epidemiological studies with machine learning,this review offers insightful perspectives on the potential risks associated with chemical exposure and underscores the necessity for further research in understanding the impact of EDCs on TH metabolism and TH-related health effects.

关键词： Thyroid stimulating hormone Emerging contaminants Data mining Thyroxine 3,3′,5-Triiodothyronine Homeostasis

Regulatory effects of the p38 mitogen-activated protein kinase-myosin light chain kinase pathway on the intestinal epithelial mechanical barrier and the mechanism of modified Pulsatilla decoction(加味白头翁汤)in the treatment of ulcerative colitis

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Journal of Traditional Chinese Medicine 2024年第5期44卷 885-895页

作者： WU Tingting YANG Xin ZHU Huiping GUO Jinwei ZHU Hui ZHANG Peipei WANG Meng LIANG Guoqiang sun hongwen Department of Internal Medicine Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine Department of Internal Medicine The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University Suzhou Academy of Wumen Chinese Medicine Suzhou Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine

OBJECTIVE: To investigate the mechanism of the protective effect of modified Pulsatilla decoction(加味白头翁汤, MPD) on the mechanical barrier of the ulcerative colitis(UC) intestinal epithelium in vitro and in vivo. METHODS: We established an intestinal epithelial crypt cell line-6 cell barrier injury model by using lipopolysaccharide(LPS). The model was then treated with p38 mitogen-activated protein kinase-myosin light chain kinase(p38MAPK-MLCK) pathway inhibitors, p38MAPK-MLCK pathway silencing genes(si-p38MAPK, si-NF-κB, and si-MLCK), and MPD respectively. Transepithelial electronic resistance(TEER) measurements and permeability assays were performed to assess barrier function. Immunofluorescence staining of tight junctions(TJ) was performed. In in vivo experiment, dextran sodium sulfate-induced colitis rat model was conducted to evaluate the effect of MPD and mesalazine on UC. The rats were scored using the disease activity index based on their clinical symptoms. Transmission electron microscopy and hematoxylineosin staining were used to examine morphological changes in UC rats. Western blotting and real-time quantitative polymerase chain reaction were performed to examine the gene and protein expression of significant differential molecules. RESULTS: In in vitro study, LPS-induced intestinal barrier dysfunction was inhibited by p38MAPK-MLCK pathway inhibitors and p38MAPK-MLCK pathway gene silencing. Silencing of p38MAPK-MLCK pathway genes decreased TJ expression. MPD treatment partly restored the LPSinduced decreased in TEER and increase in permeability. MPD increased the gene and protein expression of TJ, while down-regulated the LPS-induced high expression of p-p38MAPK and p-MLC. In UC model rats, MPD could ameliorate body weight loss and disease activity index, relieve colonic pathology, up-regulate TJ expression as well as decrease the expression of p-p38MAPK and pMLC in UC rat colonic mucosal tissue. CONCLUSIONS: The p38MAPK-MLCK signaling pathway can affect m

关键词： colitis, ulcerative experimental verification intestinal epithelial mechanical barrier mitogen-activated protein kinase 14 modified pulsatilla decoction myosin-light-chain kinase

阴离子交换树脂对典型及新型全氟/多氟烷基酸的吸附去除

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科学通报 2024年第14期69卷 1934-1944页

作者：李霞曹溢方博张连营陈浩孙红文天津理工大学环境科学与安全工程学院天津300384 南开大学环境科学与工程学院教育部环境污染过程与基准重点实验室天津300350

全氟/多氟烷基酸类物质(PFAAs)作为一类优良的表面活性剂被广泛应用于纺织、半导体和航天等多种商业和工业领域,造成了水体中PFAAs的严重污染.常规饮用水处理工艺如絮凝、高级氧化等不能有效去除PFAAs,而离子交换树脂仅能去除传统的长链... 详细信息

全氟/多氟烷基酸类物质(PFAAs)作为一类优良的表面活性剂被广泛应用于纺织、半导体和航天等多种商业和工业领域,造成了水体中PFAAs的严重污染.常规饮用水处理工艺如絮凝、高级氧化等不能有效去除PFAAs,而离子交换树脂仅能去除传统的长链PFAAs,对于短链替代物C4 PFAAs和全/多氟醚羧酸的去除效果仍然未知.因此,本研究选取不同链长和官能团的PFAAs,探究不同结构PFAAs的吸附动力学特征,以及树脂性质和水化学条件(溶液pH、共存污染物、无机盐离子)对阴离子交换树脂(AERs)吸附去除不同结构PFAAs的影响特征及关键控制因素.结果表明, PFAAs在大孔AERs(A860)上的吸附速率更快,而凝胶型高憎水性的聚苯乙烯基树脂(A600)对PFAAs的吸附容量和去除率更高. PFAAs链长及官能团的电负性对其吸附速率和去除率均有较大影响:相同碳链长度下,全氟磺酸(PFSAs)>全氟羧酸(PFCAs).对于含有相同官能团的PFAAs,短链PFAAs的吸附速率高于长链PFAAs.溶液pH对PFAAs在树脂上的吸附影响较小.短链PFAAs在AERs上的吸附主要受离子交换作用控制,易受无机盐离子干扰.憎水性较强的PFAAs在树脂上的吸附除静电作用外,主要受憎水性分配的控制.常规的AERs难以有效去除水体中亲水性较强的短链PFCAs(C<4)和全氟醚羧酸(如GenX),因此这些新型PFAAs替代物给未来的水处理工作带来了极大挑战.

关键词：全氟/多氟烷基酸短链全氟烷基酸离子交换树脂竞争吸附

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数字经济时代休闲时空行为研究现状与展望

四川师范大学学报（自然科学版） 2024年第4期47卷 469-480页

作者：刘雪蕊孙红雯东南大学人文学院旅游学系江苏南京211189

中国已迈入数字经济时代.居民的休闲行为成为现代城市生活必不可少的组成部分.基于时空行为研究范式来创新现有的休闲理论体系,结合中国实际总结休闲时空行为,是数字经济时代中国人本城镇建设面临的迫切现实需求.围绕休闲时空行为研究... 详细信息

中国已迈入数字经济时代.居民的休闲行为成为现代城市生活必不可少的组成部分.基于时空行为研究范式来创新现有的休闲理论体系,结合中国实际总结休闲时空行为,是数字经济时代中国人本城镇建设面临的迫切现实需求.围绕休闲时空行为研究的最新发展与创新以及前沿问题展开系统梳理,面向数字经济时代居民休闲时空行为的变化,提出休闲时空行为研究的若干前沿命题,为中国休闲时空行为研究提供理论支撑和实践思路.数字经济时代下休闲时空行为研究的核心依旧是研究主题的确立,尤其是理论层面的问题.通过多学科的协同、不同类型数据的融合,实现理论和方法突破,为中国数字化发展与智慧城市建设奠定基础.

关键词：数字经济时空行为休闲行为信息和通信技术

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Effects of natural organic matter on cadmium mobility in paddy soil: A review

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Journal of Environmental Sciences 2021年第6期33卷 204-215页

作者： Chaolei Yuan Qi Li Zhaoyang sun hongwen sun Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria Tianjin Key Laboratory of Environmental Remediation and Pollution ControlCollege of Environmental Science and EngineeringNankai UniversityTianjin 300350China

Cadmium(Cd) contamination in paddy soil has caused public concern. The uptake of Cd by rice plants depends on soil Cd mobility, which is in turn substantially influenced by organic matter(OM). In this review, we first summarize the fate of Cd in soil and the role of OM. We then focus on the effects of OM on Cd mobility in paddy soil and the factors influencing the remedial effectiveness of OM amendments. We further discuss the performance of straw incorporation in the remediation of Cd-contaminated paddy soils reported in laboratory and field studies. Considering the huge production of organic materials(such as straw) in agriculture, the use of natural OM for soil remediation has obvious appeal due to the environmental benefits and low cost. Although there have been successful application cases, the properties of OM amendments and soil can significantly affect the remedial performance of the OM amendments. Importantly, straw incorporation alone does not often decrease the mobility of Cd in soil or the Cd content in rice grains. Careful evaluation is required when considering natural OM amendments, and the factors and mechanisms that influence their remedial effectiveness need further investigation in paddy soil with realistic Cd concentrations.

关键词： Cadmium Mobility Organic matter Paddy soil Remediation

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Hierarchically porous Fe_2O_3 /CuO composite monoliths:Synthesis and characterization

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Journal of Natural Gas Chemistry 2010年第6期19卷 589-592页

作者： Xiaodong Ma hongwen sun Quan sun hongwen Guo Bo Fan Shuo Zhao Tianjin Key Laboratory of Environmental Remediation and Pollution Control Key Laboratory of Environmental Pollution Process and Standard Ministry of Education College of Environmental Science and Engineering Nankai University lianjin 300071 China

In this paper,hierarchically porous Fe2O3 /CuO composite monoliths were first successfully synthesized by a mild method using silica monoliths as *** structure of composite monoliths was characterized by X-ray diffraction,scanning electron microscopy,nitrogen *** results indicated that the molar ratio of Fe to Cu had a great influence on the crystal phase of Fe2O3,pore size and the structure of the macroporous *** Fe2O3 /CuO composite monoliths consist of hierarchically macroporous and mesoporous structure,while the sample with the Fe/Cu molar ratio of 2：1 possesses tighter wall structure than other *** is expected that asprepared Fe2O3/CuO composite monoliths have potential applications in several fields as catalysts,catalyst supports,chemical sensors and high-performance liquid chromatography （HPLC）.

关键词： hierarchically porous Fe2O3/CuO composite monolith synthesis characterization

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