Current Phthalate Exposure Risks of Rural Population in the Northwest China: Evidence from an Internal Exposure Study
作者机构：Ministry of Education Key Laboratory of Pollution Processes and Environmental CriteriaCollege of Environmental Science and EngineeringNankai UniversityTianjin 300350China School of Urban and Environmental SciencesKey Laboratory of the Ministry of Education for Earth Surface ProcessesPeking UniversityBeijing 100871China State Key Laboratory of Environmental and Biological AnalysisDepartment of ChemistryHong Kong Baptist UniversityHong KongChina
出 版 物：《Environment & Health》 (环境与健康（英文）)
年 卷 期：2024年第2卷第8期
页 面：586-595页
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100402[医学-劳动卫生与环境卫生学] 10[医学]
基 金：The authors gratefully acknowledge financial support from the National Natural Science Foundation of China(42177412) Ministry of Education of China(B17025)
主 题：Phthalate Metabolites Human Biomonitoring Health Risk Assessment Rural Residents
摘 要：Phthalates(PAEs)are synthetic chemicals widely used in industrial and personal consumer products as adhesives or *** have been demonstrated to have toxic effects on the human ***,biological monitoring data for the internal PAE exposure levels of Chinese rural residents are still *** present study investigated the exposure levels of ten phthalate metabolites(mPAEs)of rural residents in Northwest *** results showed that mPAEs were wildly prevalent in urine and the geometric mean concentration ofΣ10mPAEs was 957.02 ng mL^(–1)(adjusted by specific gravity).Mono-n-butyl phthalate(MBP)and metabolites of di(2-ethylhexyl)-phthalate(DEHP)were the most dominant mPAEs in urine,with specific gravity adjusted median concentrations of 174.67 and 156.30 ng mL^(–1),*** concentrations of mPAEs were significantly associated with age,body mass index and economic level(p0.05).By calculating the percentage and relative conversion rate of DEHP metabolites,it was found that the degree of oxidative metabolism of DEHP in children was significantly higher than that in adults(p0.05),indicating that the pathway and degree of DEHP oxidation were *** risk assessment showed that 59.12%of rural residents may have a noncancer risk from PAE *** study provides important basis for assessing the occurrence and exposure of urinary phthalate metabolites among rural residents in China.
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