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Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-802 activation of AMPK-mediated modulation of hepatic lipid metabolism

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3949-3963页

作者： Li B. Xiao Q. Zhao h. Zhang J. Yang C. Zou Y. Zhang B. Liu J. sun h. Liu h. State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100193 China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Department of Pathophysiology Peking Union Medical College Beijing 100005 China

Non-alcoholic fatty liver disease (NAFLD), characterized by hepatic steatosis, is a common metabolic liver disease worldwide. Currently, satisfactory drugs for NAFLD treatment remain lacking. Obesity and diabetes are the leading causes of NAFLD, and compounds with anti-obesity and anti-diabetic activities are considered suitable candidates for treating NAFLD. In this study, biochemical and histological assays revealed that a natural lignan schisanhenol (SAL) effectively decreased lipid accumulation and improved hepatic steatosis in free fatty acid (FFA)-treated hepG2 cells and high-fat diet (hFD)-induced NAFLD mice. Further, molecular analyses, microRNA (miRNA)-seq, and bioinformatics analyses revealed that SAL may improve NAFLD by targeting the miR-802/adenosine monophosphate-activated protein kinase (AMPK) pathway. Liver-specific overexpression of miR-802 in NAFLD mice significantly impaired SAL-mediated liver protection and decreased the protein levels of phosphorylated (p)-AMPK and PRKAB1. Dual-luciferase assay analysis further confirmed that miR-802 inhibits hepatic AMPK expression by binding to the 3' untranslated region of mouse Prkab1 or human PRKAA1. Additionally, genetic silencing of PRKAA1 blocked SAL-induced AMPK pathway activation in FFA-treated hepG2 cells. The results demonstrate that SAL is an effective drug candidate for treating NAFLD through regulating miR-802/AMPK-mediated lipid metabolism. © 2024 The Authors

关键词： AMPK hepatic steatosis Lipid metabolism miR-802 Non-alcoholic fatty liver disease PPARα Schisanhenol SREBP-1c

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Composition and size dependent torsion fracture of metallic glasses

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Journal of Materials Science & Technology 2021年第23期82卷 153-160页

作者： J.Dong J.Shen Y.h.sun h.B.Ke B.A.sun W.h.Wang h.Y.Bai Institute of Physics Chinese Academy of SciencesBeijing100190PR China College of Materials Science and Opto Electronic Technology University of Chinese Academy of SciencesBeijing100049PR China Songshan Lake Materials Laboratory DongguanGuangdong523808PR China

The fracture of metallic glasses(MGs)of different compositions and sizes down to micrometers under torsion loading were systematically *** to the flat shear fracture along the circumferential plane as commonly supposed under torsion,we find that the torsion fracture of metallic glasses can deviate from flat shear plane,and the fracture angle is closely dependent on the composition and the size of MG *** a conversion method,we show that the torsion fracture of both millimeterand micrometer-sized MGs can be described by the ellipse fracture criterion as originally proposed for the tension *** deviation from the circumferential shear plane under torsion is further shown to intrinsically relate to the fracture toughness of *** tougher MG tends to have a smaller fracture angle with respect to the maximum shear plane,and vice versa,indicating a correlation between the fracture toughness and pressure/normal stress sensitivity in *** results provide new insights on the fracture mechanism and are helpful to design and control the deformation and fracture behavior of MGs under torsion loading.

关键词： Metallic glasses Torsion fracture Pressure sensitivity Fracture toughness

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Interface effect on the giant magnetoresistance for different magnetic multilayers systems

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Chinese Science Bulletin 1997年第9期42卷 729-733页

作者： Zhang, LY sun, h Li, BZ Pu, FK Institute of Physics Chinese Academy of Sciences Beijing China State Key Laboratory of Molecular Reaction Dynamics Institute of Chemistry Chinese Academy of Sciences Beijing China

ThE giant magnetoresistance(GMR)effect in magnetic multilayer has been the subject of in-tense investigation since its *** theories,including semiclassical theoryand quantum theory,have been developed to deal with the... 详细信息

关键词： magnetic multilayer interface effect giant magnetoresistance Anderson model.

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Microstructure change in Fe-based metallic glass and nanocrystalline alloy induced by liquid nitrogen treatment

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Journal of Materials Science & Technology 2021年第10期69卷 1-6页

作者： M.C.Ri D.W.Ding Y.h.sun W.h.Wang Institute of Physics Chinese Academy of SciencesBeijing100190China Songshan Lake Materials Laboratory Dongguan523808China

The effects of acyclic liquid nitrogen(LN)treatment in a temperature range of-196℃to 50℃on the thermal and magnetic stability of Fe78Si9B13 and Fe73.5Si13.5B9Nb3Cu1 glassy ribbons have been *** intrinsic heterogeneities of the metallic glasses can be activated through cryogenic thermal cycling,making irreversible structural changes after the treatment and inducing rejuvenation to the *** microstructural changes of both Fe-based metallic glass(MG)and nanocrystalline alloy induced by LN treatment were *** experimental results show that the LN treatment could effectively rejuvenate the Fe-Si-B MGs and change their thermomechanical and magnetic *** on the partially-crystallinity and well-known magnetic constants,the increase of the energy at the order of 10m J/g and magnetic domain wall movement and rotation at the order of 5-6μm and 0.5°-0.8°are found for FINEMET-type amorphous alloy after LN *** is also found that LN treatment can contribute a little stored energy to the magnetic domain wall movement and magnetic domain rotation.

关键词： Metallic glasses Cryogenic thermal treatment Soft magnetic materials Rejuvenation Stored energy Domain wall

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A continuum traffic flow model with the consideration of coupling effect for two-lane freeways

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Acta Mechanica Sinica 2011年第2期27卷 228-236页

作者： D.-h. sun G.-h. Peng L.-P. Fu h.-P. he College of Automation Chongqing University400030 Chongqing China Department of Civil & Environmental Engineering University of Waterloo Waterloo Ontario N2L 3G 1 Canada College of Automation Chongqing University 400030 Chongqing China

A new higher-order continuum model is proposed by considering the coupling and lane changing effects of the vehicles on two adjacent lanes. A stability analysis of the proposed model provides the conditions that ensure its linear stability. Issues related to lane changing, shock waves and rarefaction waves, local clustering and phase transition are also investigated with numerical experiments. The simulation results show that the proposed model is capable of providing explanations to some particular traffic phenomena commonly observable in real traffic flows.

关键词： Two-lane traffic Two delay time scales model Numerical simulation Coupling effect Phase transition

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Fluid/melt in continental deep subduction zones: Compositions and related geochemical fractionations

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Science China Earth Sciences 2015年第8期58卷 1457-1476页

作者： XIAO YiLin sun he GU haiOu hUANG Jian LI WangYe LIU Lei CAS Key Laboratory of Crust-Mantle Materials and Environments School of Earth and Space Sciences University of Science and Technology of China

Plate subduction is the most magnificent process in the Earth. Subduction zones are important sites for proceeding matter- and energy- transports between the Earth's surface and the interior, continental crust growth, and crust-mantle interactions. Besides, a number of geological processes in subduction zones are closely related to human beings' daily life, such as volcanic eruptions and earthquakes, formation of mineral deposits. Subduction process thus has long been the centric topic of Earth sciences. The finding in 1980 s that continental crust could be subducted to mantle depths is a revolutionary progress in plate tectonic theory. Compared to oceanic crust, continental crust is colder, drier, lighter, and much more geochemically/isotopically heterogeneous. hence, continental subduction process would affect the structure, compositions and evolutions of the overlying mantle wedge even more. During continental subduction and subsequent exhumation, fluids and melts can be generated in the(de)hydration process and partial melting process, respectively. These melts/fluids play important roles in crust-mantle interactions, elemental migrations, isotopic fractionations, and mantle metasomatism. By summarizing recent research works on subduction zones in this paper, we present a review on the types, physicochemical conditions and compositions of fluids/melts, as well as the migration behaviors of fluid-related characteristic elements(Nb-Ta-V) and the fractionation behaviors of non-traditional stable isotopes(Li-Mg) in subduction zones. The aim of this paper is to provide the readers an update comprehensive overview of the melt/fluid activities in subduction zones and of Li-Mg isotope systematics in subduction-related rocks and minerals.

关键词： subduction process melt/fluid composition crust-mantle interaction elemental mobility isotopic fractionation

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Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban h.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann h.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.h.Chen Chao Chen G.Chen h.S.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui h.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.h.Feng Y.T.Feng K.Fischer M.Fritsch C.D.Fu J.L.Fu Y.W.Fu h.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du Z.h.Duan P.Egorov Y.h.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.h.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.han T.T.han X.Q.hao F.A.harris K.K.he K.L.he F.h.heinsius C.h.heinz Y.K.heng C.herold T.holtmann P.C.hong G.Y.hou X.T.hou Y.R.hou Z.L.hou B.Y.hu h.M.hu J.F.hu T.hu Y.hu G.S.huang K.X.huang L.Q.huang X.T.huang Y.P.huang T.hussain F.h\"olzken N.h\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.h.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang h.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.h.Lei h.Leithoff M.Lellmann T.Lenz C.Li C.Li C.h.Li Cheng Li D.M.Li F.Li G.Li h.Li h.B.Li h.J.Li h.N.Li hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li M.h.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.h.Li X.L.Li X.Y.Li Y Institute of high Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI helmholtzcentre for heavy Ion Research Gmbh D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China hangzhou Normal University Hangzhou 310036China hebei University Baoding 071002China helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China henan University of Science and Technology Luoyang 471003China henan University of Technology Zhengzhou 450001China huangshan College Huangshan 245000China hunan Normal University Changsha 410081China hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

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Rotational and translational domains of beta precipitate in aged binary Mg-Ce alloys

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Journal of Magnesium and Alloys 2021年第3期9卷 1039-1056页

作者： B.Z.sun h.X.Zhang Y.Dong J.X.Ren Y.Tian G.M.Xie J.Tan Y.h.sun Na Xiao School of Materials Science and Engineering Northeastern UniversityShenyang 110819China State Key Lab Rolling&Automat Northeastern UniversityShenyang 110819China Key Laboratory for Anisotropy and Texture of Materials Ministry of EducationNortheastern UniversityShenyang 110819China Analytical and Testing Center Northeastern UniversityShenyang 110819China

The structural evolution fromβ_(1)(Mg_(3)Ce)toβ(Mg_(12)Ce)precipitates,which takes place at the over-aged stage of binary Mg-Ce alloys,are investigated by high-angle annular dark-field scanning transmission electron *** structural transformation mainly occurs in the{111}_(β1)crystallographic planes,where the newly formedβlattices exhibit two categories of domain structures,namely rotational and translational *** rotational domain is composed of threeβdomains(β_(RA),β_(RB)andβ_(RC)),which are related by a 120°rotation with respect to each other around the 111_(β1)axis of theirβ_(1)parent ***{111}_(β1)crystallographic planes can provide four sets of sublattices with the same orientation for an initial nucleation ofβ*** leads to the formation of four translationalβdomains(β_(TA),β_(TB),β_(TC)andβ_(TD)),among which any two differ by a vector of 1/6112_(β1).We deduce theoretically that there exist twenty-fourβdomains during this ***,considering the interfacial misfit,only one-third of domains can grow up and eventually formsβ***,a majority ofβribbons overlap partiallyβ_(1)plate,which is beneficial to relax interfacial strain amongβ,β_(1)andα-Mg matrix(α/β/β_(1)).The configuration of multipleβdomains can effectively regulate interfacial misfit ofα/βandβ/β_(1),which are responsible for enhancing the hardness and strength of Mg-Ce ***,this study aims to provide some clues to improve the over-aged performance of magnesium alloys by constructingβdomains and optimizing theα/β/β_(1)interface.

关键词： Magnesium alloys hAADF-STEM Rotational domain Translational domain Phase transition Interfacial misfit

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Local Convective heat Transfer from Small heaters to Impinging Submerged Axisymmetric Jets of Seven Coolants with Prandtl Number Ranging from 0.7 to 348

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Journal of Thermal Science 1997年第4期6卷 286-297页

作者： h.sun C.F.Ma 等 DepartmentofThermalScience＆Engineering BeijingPolytechnicUniversityBeijing100022China DepartmentofT

Using seven working fluids, a systematic experimental study was performed to investigate the local convective heat transfer from vertical heaters to impinging circular submerged jets in the range of Reynolds number between 1.17 ×102 and 3.69 × 104 with the emphasis placed on the examination of Prandtl number dependence. heat transfer coefficiellts at the stagnation point were collected and correlated with the plate held within and beyond the potential core. Radial distribution of the local heat transfer coefficient was measured with five test liquids. Based on the measured profiles of the local heat transfer, a correlation was developed to cover the entire range of the radial distance. Besides the presellt data, the correlations developed in this work were also compared with a large quantity of available data of circular air jets. General agreement was observed between the air data and the correlat ions.

关键词： forced convection jets Prandtl number

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Improvement of Coercivity and Corrosion Resistance of Nd-Fe-B Sintered Magnets with Cu Nano-particles Doping

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Journal of Materials Science & Technology 2012年第10期28卷 927-930页

作者： C.sun W.Q.Liu h.sun M.Yue X.F.Yi J.W.Chen College of Materials Science and Engineering Beijing University of TechnologyBeijing 100124China Earth-panda Advance Magnetic Material Co. Ltd.Anhui 231500China

Nd-Fe-B permanent magnets with a small amount of Cu nano-particles doping have been prepared by con-ventional sintered method. Effects of Cu content on magnetic properties, corrosion resistance, and oxidation properties of the magnets have been studied. It shows that the coercivity rises gradually, while the remanence decreases simultaneously with increasing Cu doping amount. Microstructure observation reveals that Cu ele- ment enriches mainly the Nd-rich phase. Autoclave test results show that the corrosion rate of the magnets decreases with increasing Cu content. After oxidation, the maximum energy product loss of the magnets with 0 and 0.2 wt% Cu nano-particles doping are 6.13% and 0.g9%, respectively. Therefore, it is concluded that Cu nano-particles doping is a promising way to enhance the coercivity and corrosion resistance of sintered Nd-Fe-B magnets.

关键词： Nd-Fe-B Cu nano-particles Coercivity Corrosion resistance Oxidation

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