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Effects of advanced glycosylation end products and rosiglitazone on the expression and secretion of galectin-3 in human renal mesangial cells

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Chinese Medical Journal 2009年第9期122卷 1067-1071页

作者： sun zi-lin MA Chan-juan JIN Hui YUAN Yang LIU Nai-feng Department of Endocrinology Zhongda Hospital Southeast University Nanjing Jiangsu 210009China Department of Cardiology Zhongda Hospital SoutheastUniversity Nanjing Jiangsu 210009 China

Background Galectin-3 is the most recently identified advanced glycosylation end products （AGEs） binding protein. This study aimed to investigate the effects of AGEs and rosiglitazone on the expression and secretion of galectin-3 in cultured human renal mesangial cells （HRMCs）. Methods HRMCs were incubated with different concentrations of AGE-bovine serum albumin （BSA）（0, 50, 100, 200, and 400 mg/L） for different time （0, 24, 36, 48, and 72 hours）, and exposed to AGE-BSA in the presence of different concentrations of rosiglitazone （1, 10, and 100 μmol/L）. The mRNA and protein expression of galectin-3 in HRMCs were analyzed by reverse transcription polymerase chain reaction （RT-PCR） and Western blotting. The culture medium of HRMCs was collected and concentrated, and the content of galectin-3 in the medium was detected by Western blotting. Results Both RT-PCR and Western blotting revealed that AGE-BSA up-regulated the expression of galectin-3 in HRMCs in a concentration- （P 〈0.05） and time-dependent （P 〈0.05） manner compared with the control. Compared with the control, AGE-BSA elevated the content of galectin-3 in the culture medium of HRMCs time- and concentrationdependently （P 〈0.05, respectively）. Both protein and mRNA expression of galectin-3, and its content in the medium of HRMCs exposed to different concentrations of rosiglitazone in the presence of AGE-BSA were increased compared with those of cells exposed to AGE-BSA alone （P 〈0.05）. Rosiglitazone increased the expression and secretion of galectin-3 in a dose-dependent manner （P 〈0.05）. Conclusions AGEs up-regulates the expression and secretion of galectin-3 in HRMCs. Rosiglitazone further enhances the upregulation of galectin-3 in HRMCs induced by AGEs, which suggests that rosiglitazone may play a role of reno-protection via up-regulation of galectin-3.

关键词： glycosylation end products, advanced galectin 3 diabetic nephropathies rosiglitazone mesangial cells

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Lipohypertrophy:prevalence,clinical consequence,and pathogenesis

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Chinese Medical Journal 2021年第1期134卷 47-49页

作者： Xiao-Han Xu Vladmir Carvalho Xiao-Hang Wang Shan-Hu Qiu zi-lin sun Department of Endocrinology Zhongda HospitalInstitute of DiabetesSchool of MedicineSoutheast UniversityNanjingJiangsu 210009China.

Insulin treatment has many cutaneous alterations and skin-related adverse effect,lipohypertrophy(LH)is the commonest among them.[1]LH has the definition with a tumor-like lump,visible and touchable,adipose tissue at the site of insulin injection.[2]It might result from the lipogenic effect of repeated insulin exposure.[3,4]Injecting insulin into the tissue with LH weakens insulin physiological function,and leads to a resulting excess glucose exposure,glycemic modifiability,and an increased risk of hypoglycemia.[5]Unfortunately,there is limited information about the pathophysiology of LH in insulin *** a result,reports of prevalence,clinical consequence,and pathogenesis are needed.

关键词： prevalence pathogenesis hypertrophy

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Dyslipidaemia among diabetic patients with ischemic stroke in a Chinese hospital

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Chinese Medical Journal 2009年第21期122卷 2567-2572页

作者： WANG Shao-hua sun zi-lin RUAN Xiong-zhong GUO Yi-jing WANG Yao JIN Hui YUAN Yang WEI Qiong Department of Endocrinology Affiliated Zhongda Hospital of Southeast University Nanjing Jiangsu 210009 China Department of Neurology Affiliated Zhongda Hospital of Southeast University Nanjing Jiangsu 210009 China Centre for Nephrology Royal Free and University College Medical School University College London Royal Free Campus London UK

Background Dyslipidaemia is a potential independent The aim of this study was to investigate dyslipidaemia, with ischemic stroke in a Chinese hospital. risk factor for cerebrovascular disease in patients with diabetes. treatment and control of dyslipidaemia among diabetic patients Methods A total of 1046 type 2 diabetic patients were assigned to diabetes with （n=-522） and diabetes without stroke groups. The two groups were matched by gender, age and diabetes duration. Lipid and lipoprotein profile were measured. Serum level and control of lipids were assessed and classified according to American Diabetes Association （ADA） guidelines and an intensified low density lipoprotein-cholesterol （LDL-C） target recommended in Chinese dyslipidaemia control criteria. Results Diabetic patients suffering stroke displayed not only poorly-controlled lipid and lipoprotein profiles, including the significantly lower proportion of patients achieving intensified LDL-C target of 〈2.07 mmol/L （80 mg/dl）, and high density lipoprotein-cholesterol （HDL-C） target （14.4% vs 21.0%, P=0.005; 45.8% vs 51.9%, P=0.048 respectively）, but also less adherence to therapy prescribed for dyslipidaemia （30.8% vs 41.0%, P=0.001）, when compared with diabetic patients without stroke. For the diabetic women with stroke, situation of dyslipidaemia was worse, with significantly lower serum level of HDL-C and apoA1, higher LDL-C level and higher ratio of apoB/apoA1 when compared with diabetic counterparts without stroke. Conclusions Many diabetic patients with ischemic stroke remain uncontrolled for dyslipidaemia. Intensified LDL-C and overall lipid lowering clinical goals are potential precautions taken against ischemic stroke among diabetic patients in China.

关键词： stroke, ischemic diabetes dyslipidaemia low density lipoprotein-cholesterol high density lipoprotein-cholesterol triglyceride

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A nationwide survey of diabetes education, self-management and glycemic control in patients with type 2 diabetes in China

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Chinese Medical Journal 2012年第23期125卷 4175-4180页

作者： GUO Xiao-hui YUAN Li LOU Qing-qing SHEN Li sun zi-lin ZHAO Fang DAI Xia HUANG Jin YANG Hui-ying Department of Endocrinology Peking University First HospitalBeijing 100034 China Department of Endocrinology West China Medical School WestChina Hospital Sichuan University Chengdu 610041 China Department of Endocrinology Sir Run Run Shaw HospitalHangzhou Zhejiang 310016 China Institute of Diabetes Zhongda Hospital Medical School SoutheastUniversity Nanjing Jiangsu 210009 China Department of Endocrinology China-Japan Friendship HospitalBeijing 100029 China Department of Endocrinology First Affiliated Hospital GuangxiMedical University Nanning Guangxi 530021 China Nursing Department Second Xiangya Hospital of Central SouthUniversity Changsha Hunan 410011 China Department of Endocrinology and Metabolism First AffiliatedHospital of Kunming Medical College Kunming Yunnan 650032China

Background Diabetes management could be improved by diabetes education, through influencing attitudes towards diabetes, knowledge and behaviors of patients. The purpose of this study was to characterize the impact of diabetes education on glycemic control, and to assess the attitude, knowledge and self-care behavior in patients with type 2 diabetes in China. Methods This questionnaire-based survey was conducted in 50 medical centers across China from April to July of 2010. The patients with type 2 diabetes were eligible for the study. The information of glycemic control and diabetes education was collected. The diabetes attitude scale-3 formulae, a questionnaire of diabetes knowledge and Summary of Diabetes Self-care Activities scale were used to assess attitude, knowledge and the self-care of patients, respectively. Results Among the 5961 eligible respondents （3233 males; mean age （59.50＋12.48） years; mean hemoglobin Alc （HbAlc）（8.27＋2.23）%）, most patients （79.8%） considered themselves educated on diabetes. Compared with patients without diabetes education, their educated counterparts showed significant lower value of HbAlc, after controlling for age, gender, body mass index and duration of diabetes （P 〈0.01）. The patients who received diabetes education also performed significant higher scores on attitude, knowledge and self-care than their uneducated counterparts. Patients with lower income or education level tended to have higher glucose levels, and showed lower percentage of patients received diabetic education. Conclusions Chinese patients with diabetes education achieved better glycemic control than un-educated patients. Our study indicates effort is required to provide professional education to patients, with emphasis on lower income and lower education level populations.

关键词： diabetes education self-management glycemic control

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Identification of Newly Diagnosed Diabetes and Prediabetes Using Fasting Plasma Glucose and Urinary Glucose in a Chinese Population： A Multicenter Cross-Sectional Study

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Chinese Medical Journal 2018年第14期131卷 1652-1657页

作者： Juan Chen Hai Jian Guo Shan-Hu Qiu Wei Li Xiao-Hang Wang Min Cai Bei Wang Xiao-Ning Li zi-lin sun Department of Endocrinology Zhongda Hospital Institute of Diabetes Medical School Southeast University Nanjing Jiangsu 210009 China Integrated Business Management Office Jiangsu Provincial Center for Disease Control and Prevention Nanjing Jiangsu 210009 China Department of Epidemiology and Statistics School of Public Health Southeast University Nanjing Jiangsu 210009 China Institute of Health Education Jiangsu Provincial Center for Disease Control and Prevention Nanjing Jiangsu 210009 China

Background： Although fasting plasma glucose （FPG） has been highly recommended as the sole test for diabetes screening, the efficacy of FPG alone for diabetes screening is potentially limited due to its low sensitivity. The aim of this study was to improve the efficacy of FPG for diabetes screening using urinary glucose （UG）. Methods： This study was initiated on November 12, 2015, and ended on June 28, 2016. A representative sample of individuals aged between 18 and 65 years, with no history of diabetes, from 6 cities in Jiangsu Province participated in this study. A 75-g oral glucose tolerance test was used to diagnose diabetes. All urine samples were collected within 2 h of oral glucose loading to measure UG. Partial correlation analyses were used to evaluate the associations between UG and other glycemic variables, including FPG, 2-h plasma glucose （2h-PG）, and glycated hemoglobin A 1 c, after adjustment for age. Tile perfbnnance of UG was evaluated using a receiver operating characteristic （ROC） curve analysis. Results： Of the 7485 individuals included, 8% were newly diagnosed with diabetes and 48.7% had prediabetes. The areas under the ROC curves for UG were 0.75 for estimation of 2h-PG ≥7.8 mmol/L and 0,90 for 2h-PG ≥11.1 mmol/L, respectively. The sensitivity and specificity of UG were 52.3% and 87.8%, respectively, for 2h-PG ≥7.8 mmol/L （cutoff point ≥130 mg）, and 83.5% and 87.5%, respectively, for 2h-PG ≥11.1 mmol/L （cutoff point ≥ 178.5 mg）. The combination of FPG and UG demonstrated a significantly higher sensitivity than that of FPG alone for the identification of diabetes （[483/597] 80.9% vs. [335/597] 56.1%, x2 = 85.0, P 〈 0.001） and glucose abnormalities （[2643/4242] 62.3% vs. [2365/4242] 55.8%, x2 = 37.7 P 〈 0.001）. Conclusions： The combination of UG and FPG substantially improves the efficacy of using FPG alone for diabetes screening; this combination might be a practical screening tool and is worth being recommended in the future.

关键词： Diabetes Mellitus Screening Urinary glucose

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糖尿病药物治疗新进展——来自2005年欧洲糖尿病年会的最新信息

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中国药科大学学报 2006年第2期37卷 105-110页

作者：王祥香孙子林东南大学附属中大医院内分泌科南京210009

结合2005年欧洲糖尿病年会的最新信息,对近年来已上市和正在试验及研发阶段的新型降糖药物,如非噻唑烷二酮类胰岛素增敏剂、肠促胰岛素、DPP-Ⅳ抑制剂、新型胰岛素类似物等进行综述。

关键词：噻唑烷二酮肠促胰岛素 DPIP-Ⅳ抑制剂胰岛素类似物吸入胰岛素口服胰岛素

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基于图像灰度的大范围辐射温度反演

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激光与红外 2023年第12期53卷 1866-1870页

作者：孙子林李科天津津航技术物理研究所天津300300

为解决高温辐射源和环境温度对红外测温的影响,提高极端工况下红外热像仪的测温精度,以红外辐射理论以及红外热像仪测温原理为基础,提出了一种将红外图像灰度与目标温度、环境温度和积分时间相结合的综合辐射温度反演方法,该方法实现了... 详细信息

为解决高温辐射源和环境温度对红外测温的影响,提高极端工况下红外热像仪的测温精度,以红外辐射理论以及红外热像仪测温原理为基础,提出了一种将红外图像灰度与目标温度、环境温度和积分时间相结合的综合辐射温度反演方法,该方法实现了环境(镜头)温度与场景温度参量解耦,可以独立预估各参量变化所产生的探测器响应变化。首先对红外热像仪进行数据标定,标定时一般采用高精度面源黑体,之后通过计算面源黑体辐射亮度,利用黑体辐亮度和黑体灰度的线性关系,对黑体温度与黑体图像灰度值两组数据之间关系进行拟合,建立全环境温度和全积分时间的大范围温度反演匹配模型。最后在实验室环境下,分别用热像仪和基于灰度的温度反演模型对探测目标进行测温。经过实验验证,该反演模型在实验室环境下取得了较为良好的效果。

关键词：红外测温图像灰度黑体温度反演

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叉头转录因子与糖尿病及其并发症的相关研究进展

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中国糖尿病杂志 2015年第10期23卷 946-948页

作者：陈娟李伟孙子林东南大学医学院南京210009 东南大学附属中大医院内分泌科

临床研究发现叉头转录因子(FoxO)在糖尿病、卒中和衰老中发挥着不可忽视的作用。FoxO3属于叉头转录因子O亚群,广泛表达于机体组织,维持内环境稳态,调节多种病理生理过程,与寿命及年龄相关性疾病如肿瘤、糖尿病等密切相关。本文就FoxO3... 详细信息

临床研究发现叉头转录因子(FoxO)在糖尿病、卒中和衰老中发挥着不可忽视的作用。FoxO3属于叉头转录因子O亚群,广泛表达于机体组织,维持内环境稳态,调节多种病理生理过程,与寿命及年龄相关性疾病如肿瘤、糖尿病等密切相关。本文就FoxO3与糖尿病及并发症的关系做一综述。

关键词：叉头转录因子糖尿病糖尿病并发症

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促进理解的视频学习资源表征策略——基于皮尔斯符号学视角

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现代教育技术 2019年第12期29卷 28-34页

作者：孙田琳子沈书生南京邮电大学教育科学与技术学院江苏南京210023 南京师范大学教育科学学院江苏南京210097

视频学习资源是在线课程的主要呈现形式,其表征形式将直接影响学习者的理解效果,建构促进理解的视频学习资源表征策略是资源设计者需要直面的新问题。文章从皮尔斯的符号学理论出发,分析符号的"三元结构"和"三分法",探寻促进理解的表征... 详细信息

视频学习资源是在线课程的主要呈现形式,其表征形式将直接影响学习者的理解效果,建构促进理解的视频学习资源表征策略是资源设计者需要直面的新问题。文章从皮尔斯的符号学理论出发,分析符号的"三元结构"和"三分法",探寻促进理解的表征设计原理,并以此指导视频学习资源的表征设计,形成从结构到方法、从在线到临场、从感知到认知、从表达到解释等促进理解的资源表征策略,为在线课程资源建设提供参考。

关键词：理解视频学习资源表征策略符号学在线课程

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智能媒体“青少年模式”应用的评价研究--基于32个样本APP“青少年模式”应用的调查与评价

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现代教育技术 2023年第11期33卷 79-90页

作者：孙田琳子周奕南京邮电大学教育科学与技术学院江苏南京210023 南京师范大学教育科学学院江苏南京210097

网络平台的“青少年模式”虽已从鼓励支持上升为法律的强制性要求,但各平台“青少年模式”应用差异较大。为调查并评价“青少年模式”的应用情况,文章采用内容分析法和德尔菲法,设计了包含6个一级指标、19个二级指标、67个三级指标的智... 详细信息

网络平台的“青少年模式”虽已从鼓励支持上升为法律的强制性要求,但各平台“青少年模式”应用差异较大。为调查并评价“青少年模式”的应用情况,文章采用内容分析法和德尔菲法,设计了包含6个一级指标、19个二级指标、67个三级指标的智能媒体“青少年模式”应用评价指标体系。之后,文章依托此指标体系,对四种类型、32个样本APP的“青少年模式”应用进行了调查与评价,结果显示:“青少年模式”应用评分排序为移动游戏类APP>视频媒体类APP>社交媒体类APP>教育学习类APP。基于此,文章探讨了智能媒体“青少年模式”应用存在的产品内容供给未分层、家长监护功能欠缺、认证精准识别技术待完善、沉迷防护机制单一等问题,并有针对性地提出治理对策,以科学规范青少年的智能媒体使用行为,推动负责任的技术创新。

关键词：智能媒体 “青少年模式” 技术道德化网络保护 APP

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