Lipohypertrophy:prevalence,clinical consequence,and pathogenesis

作     者：Xiao-Han Xu Vladmir Carvalho Xiao-Hang Wang Shan-Hu Qiu Zi-Lin Sun 

作者机构：Department of EndocrinologyZhongda HospitalInstitute of DiabetesSchool of MedicineSoutheast UniversityNanjingJiangsu 210009China. 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2021年第134卷第1期

页      面：47-49页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：prevalence pathogenesis hypertrophy 

摘      要：Insulin treatment has many cutaneous alterations and skin-related adverse effect,lipohypertrophy(LH)is the commonest among them.[1]LH has the definition with a tumor-like lump,visible and touchable,adipose tissue at the site of insulin injection.[2]It might result from the lipogenic effect of repeated insulin exposure.[3,4]Injecting insulin into the tissue with LH weakens insulin physiological function,and leads to a resulting excess glucose exposure,glycemic modifiability,and an increased risk of hypoglycemia.[5]Unfortunately,there is limited information about the pathophysiology of LH in insulin *** a result,reports of prevalence,clinical consequence,and pathogenesis are needed.