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Journal of Geriatric Cardiology 2024年第1期21卷 90-103页

作者： Cheng-Yan HU Yan-ling WANG Zhen-Xing FAN Xi-Peng sun Shuai WANG Zhi LIU Department of Geriatrics Fu Xing HospitalCapital Medical UniversityBeijingChina Department of Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina Emergency Department of Xuanwu Hospital Capital Medical UniversityBeijingChina

Objective To investigate the impact of CYP2C19 gene polymorphism on clopidogrel reactivity and its association with longterm clinical outcome in patients with coronary heart disease(CHD)undergoing percutaneous coronary intervention(PCI).Methods In total,675 patients were *** on the platelet inhibition rate,patients were categorized into two groups:clopidogrel low responsiveness(CLR)and normal clopidogrel responsiveness(NCR).The CLR group was divided into ticagrelor and clopidogrel group based on the antiplatelet drugs used in the follow-up *** were classified into three groups(normal metabolizer,intermediate metabolizer,and poor metabolizer)based on the CYP2C19 *** aimed to evaluate the impact of CYP2C19 gene polymorphism on clopidogrel *** cumulative rates of 12-month all-cause deaths,major adverse cardiovascular events(MACCEs),and bleeding events were *** CLR was observed in 44.4%of the overall *** differences were observed in the platelet inhibition rate of clopidogrel among the three metabolic genotypes(P0.05).Conclusions Low response to clopidogrel in CHD patients is correlated with CYP2C19 gene ***2C19 genotyping combined with platelet reactivity is an independent predictor of 12-months MACCEs in patients with clopidogrel treatment after PCI,which is better than either test alone.

关键词： CYP2C19 drugs PCI

X-ray excited Mn^(2+)-doped persistent luminescence materials with biological window emission for in vivo bioimaging

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Journal of Rare Earths 2024年第1期42卷 28-35,I0001页

作者： Hanrun Zheng Lin Liu Yi’ang Li Rui Rong Liang Song Junpeng Shi Jing Teng Xia sun yun Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002China University of the Chinese Academy of Sciences Beijing100049China Xiamen Hospital of Traditional Chinese Medicine Xiamen361015China Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108China

In recent years,persistent luminescence materials(PLMs)excited by X-rays and emitting in biological windows have received extensive attention in the field of high-sensitivity *** metal Mn^(2+)is an ideal emission center,but few studies focus on Mn^(2+)-doped PLMs with X-ray excitation and biological window ***,we report a Mn^(2+)-doped PLM,LiYGeO_(4):Mn^(2+)(LYGM),with excellent biological window persistent luminescence *** excitation by UV,LYGM produces a durable biological window of persistent luminescence emission at 660 nm for up to 20 *** *** can be repeatedly excited by X-rays,resulting in long-term biological window persistent luminescence *** addition,we obtain LYGM around 200 nm in diameter by ball milling and centrifugation and improve its biocompatibility by surface modification to apply it to in vivo imaging in *** LYGM are injected into mice through the tail vein,in situ excitation of X-rays can be *** the persistent luminescence decays,LYGM can be re-excited for repeated ***,LYGM shows potential prospects for in vivo deep tissue and long-term bioimaging.

关键词： Persistent luminescence X-ray Biological window In vivo imaging Rare earths

Visible-light-driven photocatalysis degradation of antibiotic pollutants by La-doped CeO_(2) nanorods:synergy of La doping and oxygen vacancy

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Rare Metals 2024年第7期43卷 3134-3145页

作者： Shi-Hai Cao Jing-Ru Qu Yu-Qi Zhao yun-Tong sun Wen-Tong Gao Bing Han Yao Lu College of Environmental Engineering Nanjing Institute of TechnologyNanjing 211167China School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing 211167China School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingapore 637459Singapore Institute of Environmental Health and Ecological Security School of Environment and Safety EngineeringJiangsu UniversityZhenjiang 212013China Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment Suzhou University of Science and TechnologySuzhou215009China

Elemental doping is an effective strategy to enhance photocatalytic activity and extend the light absorption range of single-component *** this work,a series of La-doped CeO_(2) nanorods(La-CeO_(2)-x) with La content of 1 wt%-15 wt% are synthesized by a simple hydrothermal method and further used as photocatalyst for sulfamerazine(SMR) *** prepared La-CeO_(2)-x nanorods exhibit a great improvement in electron-hole pair migration and visible-light response due to the synergistic effect of abundant oxygen vacancies and heterogeneous elements(La).Consequently,La-CeO_(2)-x exhibited excellent visible-light photocatalytic performances and chemical stability for SMR degradation,the La-CeO_(2)-5 sample achieved the highest SMR degradation rate of 81%,which was 3.4 times higher than that of the original CeO_(2).Furthermore,three possible degradation pathways of SMR in La-CeO_(2) photocatalytic reactions were proposed by liquid chromatography-mass spectrometry ***,density functional theory calculations were carried out to provide an in-depth understanding of the structure-performance *** its excellent properties and better photocatalytic performance,this study demonstrates that La doping in CeO_(2) is an effective way to increase oxygen vacancy and improve the photochemical properties of photocatalysts.

关键词： CeO_(2)nanorod La-doped Photocatalysis Oxygen vacancy Sulfamerazine

Hedgehog信号通路与淋巴细胞及干细胞分化

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国际免疫学杂志 2011年第3期34卷 227-229,226页

作者：刘蕾孙凌云南京大学医学院鼓楼医院风湿免疫科 210008

Hedgehog（Hh）蛋白是一种广泛分布的分泌蛋白，在机体的分化发育成熟中起着非常重要的作用。Hh蛋白通过与其膜受体结合从而激活胞内一系列的信号因子，包括第二信使Ser—Thr蛋白激酶Fu、Fu抑制剂Su（Fu）、激酶样蛋白Cos-2和核转录因... 详细信息

Hedgehog（Hh）蛋白是一种广泛分布的分泌蛋白，在机体的分化发育成熟中起着非常重要的作用。Hh蛋白通过与其膜受体结合从而激活胞内一系列的信号因子，包括第二信使Ser—Thr蛋白激酶Fu、Fu抑制剂Su（Fu）、激酶样蛋白Cos-2和核转录因子Ci。Hh通路在淋巴细胞的发生发展过程中占重要地位，主要在T、B淋巴细胞分化的早期阶段起作用。另外，Hh通路对间充质干细胞及造血干细胞的增殖和分化也有非常重要的调节作用。

关键词： Hedgehog 淋巴细胞干细胞

Icariin plus curcumol enhances autophagy through the mTOR pathway and promotes cathepsin B-mediated pyroptosis of prostate cancer cells

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 55-64页

作者： Xu-yun Wang Wen-Jing Xu Bo-Nan Li Tian-Song sun Wen Sheng Department of Andrology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China Department of Dermatology The First Affiliated Hospital of Hunan University of Chinese MedicineChangsha410021China School of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha410208China Andrology Laboratory Hunan University of Chinese MedicineChangsha410208China School of Rehabilitation Medicine and Health Care Hunan University of MedicineHuaihua418000China School of Traditional Chinese Medicine Hunan University of MedicineHuaihua418000China

Objective:To examine the effect of icariin plus curcumol on prostate cancer cells PC3 and elucidate the underlying ***:We employed the Cell Counting Kit 8 assay and colony formation assay to assess cell viability and *** expression was analyzed using monodansylcadaverine *** and Western blot analyses were used to evaluate protein expressions related to autophagy,pyroptosis,and the mTOR *** damage was examined using the lactate dehydrogenase ***,cathepsin B and NLRP3 were detected by ***:Icariin plus curcumol led to a decrease in PC3 cell proliferation and an enhancement of *** levels of LC3-Ⅱ/LC3-Ⅰand beclin-1 were increased,while the levels of p62 and mTOR were decreased after treatment with icariin plus *** changes were reversed upon overexpression of ***,3-methyladenine resulted in a decrease in inflammatory cytokines,pyroptosis-related protein levels,and lactate dehydrogenase concentration,compared to the icariin plus curcumol *** cathepsin B reversed the regulatory effects of icariin plus ***:Icariin plus curcumol demonstrates great potential as a therapeutic agent for castration-resistant prostate cancer by enhancing autophagy via the mTOR pathway and promoting pyroptosis mediated by cathepsin *** findings provide valuable insights into the molecular mechanisms underlying the therapeutic potential of icariin and curcumol for prostate cancer treatment.

关键词： Icariin Curcumol Autophagy mTOR Cathepsin B Pyroptosis Prostate cancer

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脱氢表雄酮在体外对胸腺细胞的调节机制研究

中华风湿病学杂志 2009年第8期13卷 547-549页

作者：梁军孙凌云南京大学医学院附属鼓楼医院风湿免疫科 210008

目的通过观察脱氢表雄酮（DHEA）对胸腺细胞凋亡及CD95／CD95配体（Fas／FasL）表达的影响，探讨在免疫系统中的作用。方法四甲基偶氮唑盐比色分析法（MTT法）观察细胞的活力，用梯度状凝胶电泳观察细胞凋亡，反转录-聚合酶链反应（RT—... 详细信息

目的通过观察脱氢表雄酮（DHEA）对胸腺细胞凋亡及CD95／CD95配体（Fas／FasL）表达的影响，探讨在免疫系统中的作用。方法四甲基偶氮唑盐比色分析法（MTT法）观察细胞的活力，用梯度状凝胶电泳观察细胞凋亡，反转录-聚合酶链反应（RT—PCR）法检测Fas与Fas—L的表达。结果DHEA在体外降低胸腺细胞活力，促进细胞的凋亡，上调Fas／Fas—L mRNA的表达。结论DHEA能通过Fas／FasL途径诱导胸腺细胞凋亡，提示DHEA可能在一些凋亡失调相关的自身免疫性疾病的发生发展中起作用。

关键词：去氢表雄酮胸腺细胞凋亡抗原,CD95

国内20年原发性胆汁性肝硬化临床研究回顾与相关因素Meta分析

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中华风湿病学杂志 2010年第8期14卷 526-529页

作者：朱赟王晶孙凌云南京大学医学院附属鼓楼医院风湿免疫科 210008 南京大学医学院附属鼓楼医院血液科 210008

目的综合分析国内对原发性胆汁性肝硬化（PBC）的临床研究情况，了解我国PBC患者的临床特点。方法计算机检索已发表的国内PBC患者相关临床文献，汇总临床及预后资料，采用Re，Man4．2软件对相关病例对照研究进行Meta分析。结果①纳入91... 详细信息

目的综合分析国内对原发性胆汁性肝硬化（PBC）的临床研究情况，了解我国PBC患者的临床特点。方法计算机检索已发表的国内PBC患者相关临床文献，汇总临床及预后资料，采用Re，Man4．2软件对相关病例对照研究进行Meta分析。结果①纳入91篇文献，观察2315例PBC患者。②临床症状以乏力多见（54．54％）；抗线粒体抗体（AMA）阳性率范围74．1％～100％，其中AMA—M2阳性率范围45％～83％；抗核抗体（ANA）阳性率范围20％～83．78％，核膜型多见38．65％；免疫球蛋白以IgM[（2．8±0．7）～（7．3±5．1）g／L]、IgG[（16．5±4．9）～（20．5±5．9）g／L]升高为主；病理分期以Ⅱ期常见（149例，占36．61％）；干燥综合征（ss）为最常见合并症（范围1．96％～34．61％）；至随访期（5．96个月）结束，3．80％（52／1370）患者死亡。③Meta分析结果显示：AMA阳性与阴性组患者碱性磷酸酶（ALP）、丙氨酸转移酶（ALT）、天冬氨酸转氨酶（AST）、总胆红素（TBil）、谷氨酰转肽酶（GGT）、IgG指标及性别比较差异无统计学意义，IgM值在阴性组更低；熊去氧胆酸治疗后患者ALP水平下降；老年患者ALP、TBil水平偏低，但病死率高。结论国内PBC患者大部分临床特点与国外报道相似，病例对照研究样本量较少、缺乏高质量的双盲、随机、对照研究是国内临床研究的缺陷。

关键词：肝硬化胆汁性 Meta分析熊去氧胆酸

Validity of fatty liver prediction scores for diagnosis of fatty liver by Fibroscan

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 353-360页

作者： Seogsong Jeong sun Jae Park Seong Kyun Na Sang Min Park Byung-Cheol Song yun Hwan Oh Department of Biomedical Sciences Seoul National University Graduate SchoolSeoul 03080Korea Department of Biomedical Informatics CHA University School of MedicineCHA UniversitySeongnam 13488Korea Department of Internal Medicine Inje University College of MedicineSeoul 50834Korea Department of Family Medicine Seoul National University HospitalSeoul National University College of MedicineSeoul 03080Korea Department of Internal Medicine Jeju National University HospitalJeju National University College of MedicineJeju 63241Korea Department of Family Medicine Jeju National University HospitalJeju National University College of MedicineJeju 63241Korea Department of Family Medicine Chung-Ang University Gwangmyeong HospitalChung-Ang University College of MedicineGwangmyeong 14353Korea

Background:The Korea National Health and Nutrition Examination Survey nonalcoholic fatty liver disease(K-NAFLD)score was recently developed with the intent to operationally define nonalcoholic fatty liver disease(NAFLD).However,there remained an external validation that confirmed its diagnostic performance,especially in patients with alcohol consumption or hepatitis virus ***:Diagnostic accuracy of the K-NAFLD score was evaluated in a hospital-based cohort consisting of 1388 participants who received Fibroscan®.Multivariate-adjusted logistic regression models and the contrast estimation of receiver operating characteristic curves were used for validation of the K-NAFLD score,fatty liver index(FLI),and hepatic steatosis index(HSI).Results:K-NAFLD-moderate[adjusted odds ratio(aOR)=2.53,95%confidence interval(CI):1.13-5.65]and K-NAFLD-high(aOR=4.14,95%CI:1.69-10.13)groups showed higher risks of fatty liver compared to the K-NAFLD-low group after adjustments for demographic and clinical characteristics,and FLI-moderate and FLI-high groups revealed aORs of 2.05(95%CI:1.22-3.43)and 1.51(95%CI:0.78-2.90),*** addition,the HSI was less predictive for Fibroscan®-defined fatty *** K-NAFLD and FLI also demonstrated high accuracy in the prediction of fatty liver in patients with alcohol consumption and chronic hepatitis virus infection,and the adjusted area under curve values were comparable between K-NAFLD and ***:Externally validation of the K-NAFLD and FLI showed that these scores may be a useful,noninvasive,and non-imaging modality for the identification of fatty *** addition,these scores also predicted fatty liver in patients with alcohol consumption and chronic hepatitis virus infection.

关键词： Nonalcoholic fatty liver disease Fatty liver index Hepatic steatosis index

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生物制剂对风湿免疫病的目标治疗

中华医学杂志 2011年第11期91卷 730-732页

作者：冯学兵孙凌云南京大学医学院附属鼓楼医院风湿免疫科 210008

生物制剂（biologics）是指应用微生物、微生物代谢产物、寄生虫和动物的毒素、人或动物的血液或组织等,直接制成或用现代生物技术、化学方法制成,用于人类疾病预防、治疗和诊断的药品.

关键词：目标治疗生物制剂风湿免疫病微生物代谢产物现代生物技术疾病预防寄生虫动物

Meta-analysis of transarterial chemoembolization combined with cryoablation vs transarterial chemoembolization alone for≥5 cm hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2793-2803页

作者： Jie-Fei Cheng Qiu-Lian sun ling Tang Xin-Jian Xu Xiang-Zhong Huang Department of Radiology The Fifth People’s Hospital of TaizhouTaizhou 225300Jiangsu ProvinceChina Department of Radiology The Fifth People’s Hospital of SuzhouSuzhou 215100Jiangsu ProvinceChina Department of Radiology The Fourth People’s Hospital of TaizhouTaizhou 225300Jiangsu ProvinceChina Department of Interventional Radiology Jiangyin People HospitalJiangyin 214400Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)ranks sixth globally in cancer incidence and third in mortality ***,over 70% of HCC patients forego the opportunity for curative surgery or liver transplantation due to inadequate physical examinations,poor physical condition,and limited organ availability upon *** guidelines endorse transarterial chemoembolization(TACE)as the frontline treatment for intermediate to advanced-stage ***(CRA)is an emerging local ablative therapy increasingly used in HCC *** studies suggest that combining CRA with TACE offers complementary and synergistic effects,potentially improving long-term survival ***,the superiority of combined TACE+CRA therapy over TACE alone for HCC lesions equal to or exceeding 5 cm requires further *** To compare the efficacy and safety of TACE combined with CRA vs TACE alone in the treatment of HCC with a diameter of≥5 *** PubMed,EMBASE,Cochrane Library,CNKI,Wanfang,and VIP databases were searched to retrieve all relevant studies on TACE and CRA up to July ***-analysis was performed using RevMan 5.3 *** After screening according to the inclusion and exclusion criteria,6 articles were included,including 2 randomized controlled trials and 4 nonrandomized controlled trials,with a total of 575 patients included in the *** results showed that the objective response rate[odds ratio(OR)=2.56,95%confidence interval(CI):1.66-3.96,P<0.0001],disease control rate(OR=3.03,95%CI:1.88-4.89,P<0.00001),1-year survival rate(OR=3.79,95%CI:2.50-5.76,P<0.00001),2-year survival rate(OR=2.34,95%CI:1.43-3.85,P=0.0008),and 3-year survival rate(OR=3.34,95%CI:1.61-6.94,P=0.001)were all superior to those of the control group;the postoperative decrease in alpha-fetoprotein value(OR=295.53,95%CI:250.22-340.85,P<0.0001),the postoperative increase in CD4 value(OR=10.59,95%CI:8.78-12.40,P<0.00001),and the postoperative decrease in

关键词： Hepatic cancer Cryoablation Chemoembolization Transarterial chemoembolization Meta analysis