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Frontiers of Materials Science 2024年第2期18卷 129-137页

作者： Huaying Hao lihong sun Jiaxuan Chen Jun Liang State Key Laboratory of Food Nutrition and Safety Tianjin University of Science&TechnologyTianjin 300457China College of Light Industry Science and Engineering Tianjin University of Science&TechnologyTianjin 300457China College of Food Science and Engineering Tianjin University of Science&TechnologyTianjin 300457China

The in vitro expansion of stem cells is important for their application in different life science fields such as cellular tissue and organ *** objective of this paper was to achieve static cell culture in vitro through peptide hydrogel-supported microspheres(MSs).The peptides,with their gel-forming properties,microstructures,and mechanical strengths characterized,were found to have good support for the MSs and to be *** internal structures of poly(L-lactic acid)microspheres(PLLA-MSs)and polystyrene microspheres(PS-MSs)made in thelaboratory were observed and statistically analyzed in terms of particle size and pore size,following which the co-cultured MSs with cells were found to have good cell *** addition,three-dimensional(3D)culturing of cells was performed on the peptide and microcarrier composite scaffolds to measure cell viability and cell *** results showed that the peptides could be stimulated by the culture medium to self-assembly form a 3D fiber network *** the peptide-Ms composite scaffold-based cell culture system,further enhancement of the cell culture effect was *** peptide-Ms composite scaffolds have great potential for the application in 3D cell culture and in vitro cellexpansion.

关键词： microcarrier microsphere peptide hydrogel cell scaffold three-dimensional culture cell expansion

Effect of Pb Content on Phase Composition and Property of Bi-Pb-Sr-Ca-Cu-O System Superconductors

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Rare Metals 1990年第1期10卷 24-29页

作者： Ren, Hongtao Xiao, Ling Wang, Xiaoping Wang, Ruikun Zhao, Bolang sun, lihong General Research Inst for Non-ferrous Metals China

The addition of Pb in the superconductors of BiSrCaCuO system is very helpful for growth of the high-Tc phase (Tc 110K). We prepared a series of samples with nominal composition of Bi2-xPbxSr2Ca2Cu3Oy (0.1&lex&le2). The zero resistance transition temperature Tc of 106K and the critical transport current density Jc of 1 × 103A/cm2 at 77K have been obtained for the samples of Bi2-xPbxSr2Ca2Cu3Oy (x=0.2 and 0.3). The X-ray diffraction analysis and measurement of AC magnetic susceptibility confirmed that the material is comprised of single high-Tc phase. We also report the magnetic properties of this material as well as the results of TEM observation.

关键词： Bismuth Compounds Magnetic Properties Ceramic Materials Superconducting Lead Compounds Effects Microscopic Examination Transmission Electron Microscopy Oxides Phase Transitions

Indocyanine Green-Conjugated Magnetic Prussian Blue Nanoparticles for Synchronous Photothermal/Photodynamic Tumor Therapy

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Nano-Micro Letters 2018年第4期10卷 324-338页

作者： Peng Xue Ruihao Yang lihong sun Qian Li Lei Zhang Zhigang Xu Yuejun Kang Faculty of Materials and Energy Institute for Clean Energy and Advanced Materials Southwest University Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices State Key Laboratory of Silkworm Genome Biology Southwest University

Indocyanine green(ICG) is capable of inducing a photothermal effect and the production of cytotoxic reactive oxygen species for cancer therapy. However, the major challenge in applying ICG molecules for antitumor therapy is associated with their instability in aqueous conditions and rapid clearance from blood circulation,which causes insufficient bioavailability at the tumor ***, we conjugated ICG molecules with Prussian blue nanoparticles enclosing a Fe_3O_4 nanocore, which was facilitated by cationic polyethyleneimine via electrostatic adsorption. The nanocarrier-loaded ICG formed stable aggregates that enhanced cellular uptake and prevented fluorescence quenching. Moreover, the strong superparamagnetism of the Fe_3O_4 core in the obtained nanocomposites further improved cellular internalization of the drugs guided by a localized magnetic field. The therapeutic efficacy of this nanoplatform was evaluated using tumor models established in nude mice, which demonstrated remarkable tumor ablation in vivo due to strong photothermal/photodynamic effects. This study provides promising evidence that this multifunctional nanoagent might function as an efficient mediator for combining photothermal and photodynamic cancer therapy.

关键词： Combination therapy Prussian blue nanoparticles Photothermal therapy Photodynamic therapy Indocyanine green

Ultrasound-induced biophysical effects in controlled drug delivery

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Science China(Life Sciences) 2022年第5期65卷 896-908页

作者： Lulu Zhang Zhuohua Lin Lan Zeng Fan Zhang lihong sun Suhui sun Ping Wang Menghong Xu Jinxia Zhang Xiaolong Liang Huiyu Ge Department of Ultrasound Peking University Third HospitalBeijing 100191China

Ultrasound is widely used in biomedical engineering and has applications in conventional diagnosis and drug *** advances in ultrasound-induced drug delivery have been summarized previously in several reviews that have primarily focused on the fabrication of drug delivery *** review discusses the mechanisms underlying ultrasound-induced drug delivery and factors affecting delivery efficiency,including the characteristics of drug delivery carriers and ultrasound ***,biophysical effects induced by ultrasound,namely thermal effects,cavitation effects,and acoustic radiation forces,are ***,the use of these biophysical effects to enhance drug delivery by affecting drug carriers and corresponding tissues is clarified in ***,recent advances in ultrasound-triggered drug delivery are *** issues and optimization strategies to improve therapeutic outcomes and reduce side effects are ***,current progress and future directions are discussed.

关键词： ultrasound biophysical effects drug delivery systems ultrasound parameters ultrasound-triggered drug delivery

Targeted drug delivery strategies for the treatment of rheumatoid arthritis

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Science China(Life Sciences) 2021年第7期64卷 1187-1189页

作者： Jinxia Zhang Ling Jiang lihong sun Ping Wang Suhui sun Menghong Xu Lulu zhang Shumin Wang Xiaolong Liang Ligang Cui Department of Ultrasound Peking University Third HospitalBeijing 100191China

A chronic autoimmune disease named rheumatoid arthritis(RA)is characterized mainly by synovitis,which has high morbidity,disability and mortality *** addition,the aetiology and pathogenesis of RA have not been fully *** is usually accompanied by persistent arthritic pain,swelling,stiffness,and functional disorders;in severe cases,it may result in cardiovascular,pulmonary,psychological and skeletal diseases(Scott et al.,2010).

关键词： mortality cardiovascular diseases

SEM ANALYSIS FOR EFFECT OF ADDING RARE EARTH ELEMENTS IN CEMENTED CARBIDE YG8

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电子显微学报 1991年第2期 217-218页

作者： sun lihong, He Congxun, Lin Chenguang and Wang YoumingGeneral Research Institute For Non-ferrous Metals, Beijing

It is well known that rare earths can improve strength,hardness,high temperature antioxidization and wear resistance ofcemented carbides. Since computer technique was applied to SEM, thevideo image was acquired and sizes of irregular shape or overlappedparticles can be measured besides the qualitative and quantitativeanalyses by *** samples of YG8 and YG8Re were ground and polished (the contentof the rare earth elements is less than 0.10 wt%). The properties ofthe cemented carbides are as follows.

关键词： SEM ANALYSIS FOR EFFECT OF ADDING RARE EARTH ELEMENTS IN CEMENTED CARBIDE YG8 Co EDS

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大型超高分子量聚乙烯制件的注射成型研究

工程塑料应用 2005年第5期33卷 34-36页

作者：孙立鸿山东华宏化工有限公司德州253421

介绍超高分子量聚乙烯(UHMWPE)的特性及熔体流动特点,分析了大型UHMWPE注塑机的构造原理及应用。阐述了大型UHMWPE制件的注射成型工艺,以及大型UHMWPE注塑机在生产效率和原料利用率上的优势。其生产效率可比传统加工方法提高6～7倍,原... 详细信息

介绍超高分子量聚乙烯(UHMWPE)的特性及熔体流动特点,分析了大型UHMWPE注塑机的构造原理及应用。阐述了大型UHMWPE制件的注射成型工艺,以及大型UHMWPE注塑机在生产效率和原料利用率上的优势。其生产效率可比传统加工方法提高6～7倍,原料利用率由原来的55%左右提高到80%～90%。

关键词：超高分子量聚乙烯制件 UHMWPE 原料利用率注射成型工艺传统加工方法生产效率流动特点构造原理注塑机熔体

Origin of CO_2 in natural gas from the Triassic Feixianguan Formation of Northeast Sichuan Basin

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Science China Earth Sciences 2010年第5期53卷 642-648页

作者： HUANG SiJing, HUANG KeKe, TONG HongPeng, LIU lihong, sun Wei & ZHONG QianQian State Key Lab of Oil and Gas Reservoir Geology and Exploitation, Institute of Sedimentary Geology, Chengdu University of Technology, Chengdu 610059, China 1. State Key Lab of Oil and Gas Reservoir Geology and Exploitation Institute of Sedimentary Geology Chengdu University of Technology Chengdu 610059 China

The natural gas from the Triassic Feixianguan Formation of Northeast Sichuan Basin contains high H2S whereas relatively low CO2 concentrations and the CO2 display high δ13C values (ranging from -5.81‰ to 3.3‰ (PDB)). This seems to contradict the conventional wisdom that TSR should be a primary source of CO2 in natural gas from the Feixianguan Formation. In contrast, many authigenic calcite samples from these sites display very low δ13C values (ranging from -18.4‰ to -10.3‰ (PDB)). This suggests that the carbon from TSR source dominated the formation of calcite whereas the carbon from inorganic source came into CO2 in natural gas. In order to assess the origin of CO2 from these H2S-rich sites, we have calculated the relative contributions of organic and inorganic carbon sources to the CO2 and authigenic calcite. The organic carbon source possibly originated from TSR, whereas the inorganic one might be generated from marine carbonates dissolution. This calculation is based on the carbon isotopic compositions of CO2 and authigenic calcite as well as an isotopic mass balance. The results show that the contribution of organic carbon source to the CO2 is only 2%, whereas that to authigenic calcite is as high as 43% on average. Such results combined with thermodynamic evidence indicate that the isotopically light CO2 produced by TSR process may contribute to authigenic calcite precipitation during burial diagenesis. Distinguishable from Ordovician reservoir of Tarim Basin, Feixianguan reservoir of Northeast Sichuan Basin experienced rapid tectonic uplift due to Yanshanian movement after TSR occurred. Such tectonic event could induce temperature decrease and further promote carbonates dissolution. During these processes, secondary porosity has developed in Feixianguan carbonate reservoirs. Therefore, much attention should be paid to the structural highs in search of high quality carbonate reservoirs.

关键词： northeastern Sichuan Feixianguan Formation origin of CO2 TSR tectonic uplift carbonates precipitation and dissolution

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生命选择案件中的康德悖论及其解决思路

中外法学 2019年第2期31卷 404-432页

作者：孙立红华东师范大学法学院

康德提出以自由的普遍法则作为法权的基础,影响了现代刑法体系的构建。然而根据康德的理性原则却无法证明紧急避险这一刑法正当事由的合法性,导致刑法体系的分裂。以功利主义法哲学为基础的利益衡量理论,试图取代康德原则为紧急避险提... 详细信息

康德提出以自由的普遍法则作为法权的基础,影响了现代刑法体系的构建。然而根据康德的理性原则却无法证明紧急避险这一刑法正当事由的合法性,导致刑法体系的分裂。以功利主义法哲学为基础的利益衡量理论,试图取代康德原则为紧急避险提供合法根据,但最终这一标准不得不受到康德原则的修正和限制,因此无法得以贯彻。黑格尔法哲学超越了抽象法权的范畴,对紧急避险中个人福祉的追求提供了合理根据,但在生命选择困境面前,这一观念再次遭遇康德原则的阻碍。根据黑格尔法哲学观念,可以从更高的伦理层次去理解个人福祉与自由的普遍性关系,并从公民义务的层面,为极端紧急状况下公民的牺牲提供了合法根据。这为国家在遭受恐怖袭击中击落被作为犯罪工具的满载乘客的飞机提供了理由,同时这一理由能够处于防御性紧急避险的法教义中,在不违反宪法原则的前提下被置于法秩序框架之内。

关键词：康德原则功利主义原则伦理原则生命选择避险

基于乘法群Zp^＊的ELGamal公钥密码系统

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辽宁工程技术大学学报（自然科学版） 2011年第3期30卷 464-467页

作者：孙立宏阜新高等专科学校师范部辽宁阜新123000

为了解决发送方与接收方不能识别对方身份的问题,在研究ElGamal密码体制的基础上,给出了一种基于乘法群Zp*的ELGamal公钥密码体制。结果表明:该算法可以实现通信双方的双向身份认证,有效地防止了攻击者冒充发送方伪造要发送的消息。同... 详细信息

为了解决发送方与接收方不能识别对方身份的问题,在研究ElGamal密码体制的基础上,给出了一种基于乘法群Zp*的ELGamal公钥密码体制。结果表明:该算法可以实现通信双方的双向身份认证,有效地防止了攻击者冒充发送方伪造要发送的消息。同时该算法在通信过程中加入了可以追踪消息来源的信息,使得接收者可以对消息的真实性进行有效的验证。通过对消息的双重保护,该体制实现了在公开信道上的安全通信。

关键词：乘法群 ELGamal 有限循环群 Pohlig-Hellman算法公钥密码系统