检索结果-南通市图书馆

How old is too old? In vivo engraftment of human peripheral blood stem cells cryopreserved for up to 18 years-implications for clinical transplantation and stability programs

引用

World Journal of Stem Cells 2020年第5期12卷 359-367页

作者： John Underwood mahvish Rahim Carijo West Rebecca Britton Elaine Skipworth Vicki Graves Steven sexton Hillary Harris Dave Schwering Anthony Sinn Karen E Pollok Kent A Robertson W Scott Goebel Kerry m Hege Departments of Internal medicine and Pediatrics Indiana University School of MedicineIndianapolisIN 46202United States Department of Pediatrics Division of Pediatric Hematology/OncologyIndiana University School of MedicineIndianapolisIN 46202United States Cellular Therapy Laboratory Indiana University HealthIndianapolisIN 46202United States Department of Pediatrics Herman B Wells Center for Pediatric ResearchIn Vivo Therapeutics Core and Angio Biocore Shared Resource Facilities for the Indiana University Simon Cancer CenterIndiana University School of MedicineIndianapolisIN 46202United States

BACKGROUND Peripheral blood stem cells(PBSC)are commonly cryopreserved awaiting clinical use for hematopoietic stem cell *** term cryopreservation is commonly defined as five years or longer,and limited data exists regarding how long PBSC can be cryopreserved and retain the ability to successfully *** programs,stem cell banks,and regulatory and accrediting agencies interested in product stability would benefit from such ***,we assessed recovery and colony forming ability of PBSC following long-term cryopreservation as well as their ability to engraft in NOD/SCID/IL-2 Rγnull(NSG)*** To investigate the in vivo engraftment potential of long-term cryopreserved PBSC *** PBSC units which were collected and frozen using validated clinical protocols were obtained for research use from the Cellular Therapy Laboratory at Indiana University *** units were thawed in the Cellular Therapy Laboratory using clinical standards of practice,and the pre-freeze and post-thaw characteristics of the units were *** function was assessed using standard colony-forming ***34-selected cells were transplanted into immunodeficient mice to assess stem cell *** Ten PBSC units with mean of 17 years in cryopreservation(range 13.6-18.3 years)demonstrated a mean total cell recovery of 88%±12%(range 68%-110%)and post-thaw viability of 69%±17%(range 34%-86%).BFU-E growth was shown in 9 of 10 units and CFU-Gm growth in 7 of 10 units *** mice were transplanted with CD34-selected cells from four randomly chosen PBSC *** mice demonstrated long-term engraftment at 12 wk with mean34%±24%human CD45+cells,and differentiation with presence of human CD19+,CD3+and CD33+*** bone marrow from all mice demonstrated growth of erythroid and myeloid *** We demonstrated engraftment of clinically-collected and thawed PBSC following cryopreservation up to 18 years in NSG mice,sign

关键词： Colony-forming units assay Cryopreservation Hematopoietic stem cells Hematopoietic stem cell transplantation In vitro techniques Peripheral blood stem cell Viability Transplant Long-term storage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

汽轮发电机绝缘概念、要求和趋向

引用

绝缘材料通讯 1973年第5期 51-54页

作者： R.m.sexton

在近十年中,大概没有那一种电机象汽轮发电机单机尺寸和容量那样发生这样引人注目的变化,现在制造的许多电机的单机容量,往往超过四十年代末和五十年代初整个动力系统的容量。一种新的发电机出现就会有新的绝缘要求和产生新的概念,其中... 详细信息

在近十年中,大概没有那一种电机象汽轮发电机单机尺寸和容量那样发生这样引人注目的变化,现在制造的许多电机的单机容量,往往超过四十年代末和五十年代初整个动力系统的容量。一种新的发电机出现就会有新的绝缘要求和产生新的概念,其中一些改革已用于实践,还有些尚需进一步发展以满足将来更高容量的要求。定子绕组绝缘和评定

关键词：汽轮发电机同步发电机绕组铜导体绝缘系统冷却方式电压等级概念思维形式

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Traffic Impacts on Fine Particulate matter Air Pollution at the Urban Project Scale: A Quantitative Assessment

引用

Journal of Environmental Protection 2013年第12期4卷 49-62页

作者： Chidsanuphong Chart-asa Kenneth G. sexton Jacqueline macDonald Gibson University of North Carolina at Chapel Hill Chapel Hill USA.

Formal health impact assessment (HIA), currently underused in the United States, is a relatively new process for assisting decision-makers in non-health sectors by estimating the expected public health impacts of policy and planning decisions. In this paper we quantify the expected air quality impacts of increased traffic due to a proposed new university campus extension in Chapel Hill, North Carolina. In so doing, we build the evidence base for quantitative HIA in the United States and develop an improved approach for forecasting traffic effects on exposure to ambient fine particulate matter (Pm2.5) in air. Very few previous US HIAs have quantified health impacts and instead have relied on stakeholder intuition to decide whether effects will be positive, negative, or neutral. Our method uses an air dispersion model known as CAL3QHCR to predict changes in exposure to airborne, traffic-related Pm2.5 that could occur due to the proposed new campus development. We employ CAL3QHCR in a new way to better represent variability in road grade, vehicle driving patterns (speed, acceleration, deceleration, and idling), and meteorology. In a comparison of model predictions to measured Pm2.5 concentrations, we found that the model estimated Pm2.5 dispersion to within a factor of two for 75% of data points, which is within the typical benchmark used for model performance evaluation. Applying the model to present-day conditions in the study area, we found that current traffic contributes a relatively small amount to ambient Pm2.5 concentrations: about 0.14 μg/m3 in the most exposed neighborhood—relatively low in comparison to the current US National Ambient Air Quality Standard of 12 μg/m3. Notably, even though the new campus is expected to bring an additional 40,000 daily trips to the study community by the year 2025, vehicle-related Pm2.5 emissions are expected to decrease compared to current conditions due to anticipated improvements in vehicle technologies and cleaner fuels.

关键词： Pm2.5 Traffic Health Impact Assessment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于表观扩散系数鉴别颈部淋巴瘤和鳞状细胞癌结节的局灶性缺损的诊断重要性

引用

国际医学放射学杂志 2009年第3期 309-310页

作者： m.sumi T.Nakamura 马聪 Department of Radiology and Cancer Biology Nagasaki University School of DentistryNagasakiJapan

研究基于表观扩散系数(ADC)区分颈部淋巴瘤和鳞状细胞癌(SCC)结节的局灶性缺损的诊断重要性。分析26例淋巴瘤病人的79个结节和45例鳞状细胞癌病人的88个结节的ADC值。没有局灶性缺损的淋巴瘤结节的ADC值[(0.449±0.096)×10-3mm2/s]显... 详细信息

研究基于表观扩散系数(ADC)区分颈部淋巴瘤和鳞状细胞癌(SCC)结节的局灶性缺损的诊断重要性。分析26例淋巴瘤病人的79个结节和45例鳞状细胞癌病人的88个结节的ADC值。没有局灶性缺损的淋巴瘤结节的ADC值[(0.449±0.096)×10-3mm2/s]显著低于没有局灶性缺损的SCC结节的[(0.960±0.310)×10-3mm2/s]。

关键词：淋巴瘤转移淋巴结颈部 mRI 扩散加权成像局灶性缺损

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Effects of oral contrast on dose in abdominopelvic computed tomography with pure iterative reconstruction

引用

World Journal of Radiology 2016年第9期8卷 809-815页

作者： Kevin P murphy Liam J Healy Lee Crush maria Twomey Fiachra moloney Sylvia sexton Owen J O'Connor michael m maher Department of Radiology Cork University Hospital

AIm To assess the effect of neutral(NC) and positive(PC) oral contrast use on patient dose in low-dose abdominal computed tomography(CT).mETHODS Low-dose clinically indicated CTs were performed on 79 Crohn's patients(35 = PC, 1 L 2% gastrografin; 44 = NC, 1.5 L polyethylene glycol). Scanner settings for both acquisitions were identical apart from 25 s difference in intravenous contrast timing. Body mass index(BmI), scan-ranges, dose-length product and size-specific dose estimated were recorded. Data was reconstructed with pure model-based iterative reconstruction. Image quality was objectively and subjectively analysed. Data analysis was performed with Statistical Package for Social *** Higher doses were seen in neutral contrast CTs(107.60 ± 78.7 m ***, 2.47 ± 1.21 m Gy vs 85.65 ± 58.2 m ***, 2.18 ± 0.96 m Gy). The differencehad both NC and PC investigations. Image-quality assessment yielded 6952 datapoints. NC image quality was significantly superior(P minal CT imaging. This is possibly related to the osmotic effect of the agent resulting in larger intraluminal fluid volumes and resultant increased overall beam attenuation.

关键词： Radiation dose Low dose computed tomography Abdominal imaging Oral contrast Computed tomography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

联合应用mRI体素内非相干性运动和时间-信号曲线鉴别不同组织类型的头颈部肿瘤

引用

国际医学放射学杂志 2014年第2期 190-191页

作者： m.sumi T.Nakamura 朱晓明 Department of Radiology and Cancer Biology Nagasaki University School of Dentistry1 -7 -1 Sakamoto Nagasaki 852 -8588Japan

目的评估联合应用体素内非相干性运动(IVIm)和时间-信号曲线(TIC)对头颈部肿瘤的诊断效果。方法本研究对92例不同组织学类型的肿瘤通过IVIm和TIC测定

关键词： mR扩散加权成像体素内非相干性运动原理 mR增强扫描头颈部肿瘤鉴别诊断

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

岛轩怡然——韩国Island住宅

引用

中国建筑装饰装修 2011年第5期 56-61页

作者： sumi Jung Jungmin Oh ARum Kim SunHee Kim JongOh Ki

这个依山面江而建被唤作Island House的大房子,每一间都有如画的风景取悦你的全身心和视线。它建在韩国江原道的汉江河域,面积达约700m^2,像一只巨大的玻璃钢架船,以不凡的姿态伫立在在波光粼粼的汉江之畔。

关键词：韩国住宅 House 汉江房子视线

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Purification and Crystallization of Nattokinase from Bacillus subtilis natto

Purification and Crystallization of Nattokinase from Bacillu...

引用

作者： Y.Yanagisawa T.Chatake T.Ishikawa Y.morimoto I.Yasuda T.Ohsugi H.sumi Faculty of Pharmaceutical Sciences Chiba Institute of Sciences Research Reactor Institute Kyoto University Department of Life Science Kurashiki University of Science and the Arts

INTRODUCTION:Nattokinase(NK) is abundantly contained in Japanese traditional food *** is a 275 ***(m.W.=27,724),which is produced by Bacillus subtilis *** previously reported that it would be a kind of serine proteases and has thrombolytic *** would be one of candidates for neutron protein crystallography,because a large amount of native NK can be easily obtained from Bacillus subtilis natto and a clinical application would be *** the present study,we purified NK and crystallized it for dif-

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Increasing loss of mature boreal forests around protected areas with red-listed forest species

引用

Ecological Processes 2022年第1期11卷 319-331页

作者： Aino‑maija määttänen Raimo Virkkala Niko Leikola Risto K.Heikkinen Biodiversity Centre Finnish Environment InstituteLatokartanonkaari 1100790 HelsinkiFinland

Background:Protected areas(PA)are central to biodiversity,but their efficiency is challenged by human‑induced habitat loss and *** the Fennoscandian boreal region,forestry with clearcutting is a threat to biodiversity causing the loss of mature forest elements and deterioration of ecological processes in forest landscapes,ultimately affecting PAs via declined structural *** paper aims to(1)determine PAs with high,red‑listed species concentrations;(2)estimate the change in forest habitat around these PAs on different spatial scales;and(3)determine if forest management intensity is higher around biologically most valuable *** of red‑listed forest‑dwelling species in Finland were used to identify PAs harbouring these species and to produce site‑specific importance *** landcover data was used as a baseline for the distribution of forests to assess the cover of clear‑cuttings from 2001 to 2019 with the Global Forest Change(GFC)data set in three buffer areas around the PAs with occurrences of red‑listed ***:The largest proportion of clear‑cuts occurred in 1 km and 10 km buffers around the PAs in the southern and middle boreal zones,being ca.20%.This indicates that the forest habitat is degrading fast at regional and landscape *** the positive side,the change in forest cover was lower around the biologically most important PAs compared to other PAs with red‑listed ***:Open and free satellite‑data based assessments of the cover and change of forests provide reliable estimates about the rates at which mature and old‑growth forests are being converted into young managed ones in Finland mainly via clear‑cuts on different scales around *** rate of clear‑cuts was lowest in adjacent buffer areas next to the most species‑rich PAs,which provides opportunities for biodiversity conservation efforts to be targeted to the remaining mature and old‑growth forests found in the vicinity of these areas.

关键词： Biodiversity conservation Boreal forest Change detection Global Forest Watch Habitat loss Structural connectivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

体素内无序运动mRI评价扩散与灌注鉴别诊断良性与恶性唾液腺肿瘤

引用

国际医学放射学杂志 2012年第4期 385-385页

作者： m. sumi m.V. Cauteren T. sumi m. Obara Y. Ichikawa T. Nakamura 唐光健 Radiology and Cancer Biology Nagasaki University School of Dentistry1-7-1 Sakamoto Nagasaki 852-8588 Japan

摘要目的前瞻性评价体素内无序运动(IVIm)参数(微血管内容量分数f;纯扩散系数D;与灌注相关无序微循环D*)对良性与恶性唾液腺肿瘤的鉴别。材料与方法此项前瞻性研究由学院审查委员会批准,向所有参与者提供书面知情同意通知。以IVIm理论... 详细信息

摘要目的前瞻性评价体素内无序运动(IVIm)参数(微血管内容量分数f;纯扩散系数D;与灌注相关无序微循环D*)对良性与恶性唾液腺肿瘤的鉴别。材料与方法此项前瞻性研究由学院审查委员会批准,向所有参与者提供书面知情同意通知。以IVIm理论为基础评价20例(65%)良性(12例多形性腺

关键词：唾液腺肿瘤体素无序运动 mRI

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：