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Psychiatric disorders and caregiver burden in children with transfusion dependentβ-thalassaemia and their caregivers

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World Journal of Clinical Pediatrics 2023年第3期12卷 125-132页

作者： Samiksha Sahu Amit Agrawal Jyotsna Shrivastava sudhir tonk Department of Psychiatry Gandhi Medical CollegeBhopal 462030Madhya PradeshIndia Department of Pediatrics Gandhi Medical CollegeBhopal 462030Madhya PradeshIndia

BACKGROUND Children with thalassemia need care from the first years of life owing to the physical and psychological effects of their *** is a concern not only for the children’s physical health but also the mental health of themselves and their *** To screen the psychosocial problems and assessment of psychiatric morbidities among thalassaemic children and their caretakers,along with an assessment of caregiver burden in *** In this observational cross-sectional study,children with transfusion-dependent thalassemia,were included and were assessed for psychiatric morbidity and global *** parents were assessed for psychiatric morbidity and the caregiver burden they *** the parents completed two different questionnaires to assess their knowledge about the psycho-social functioning[using Pediatric Symptom Checklist-35(PSC-35)]of their children and the level of the burden faced by them by Caregiver Burden Scale(CBS).RESULTS A total of 46 children(28 boys and 18 girls)with transfusion-dependent thalassemia with a mean age of 8.83±2.70 years and 46 parents(12 fathers and 34 mothers)were included in this *** than 32 children had some psychosocial problems on screening by *** assessment by CBS moderate caregiver burden was perceived in domains of general strain,isolation,disappointment,emotional involvement,and environment.A total of 65.3%of children and 62.7%of parents were diagnosed with psychiatric *** Thalassemia affects not only the persons with the disorder but also their caregivers in several aspects,including their psychosocial *** study emphasizes the role of a supportive group in the psychological well-being of caregivers,which could be used to prevent the pathological effects of caregiver burden and enhance their psychological well-being through counselling.

关键词： Thalassemia Children Caregiver burden scale Psychiatric morbidity

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Assessment of albendazole efficacy against Ascaris lumbricoides at three sites of Andhra Pradesh,Odisha,and Kerala in India

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Asian Pacific Journal of Tropical Medicine 2024年第7期17卷 310-316页

作者： Vinay Garg Ankur Garg Shubha Garg sudhir Kumar Jain Tanzin Dikid Saurabh Jain Jitendra Manjhi Antonio Montresor Atul Goel Division of Parasitic Diseases National Centre for Disease ControlMinistry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India National Centre for Disease Control Ministry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India Epidemiology Division National Centre for Disease ControlMinistry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India Department of Control of Neglected Tropical Diseases(NTD) World Health Organization(WHO)Av Appia 20 CH-1211Geneva 27Switzerland Department of Community&Family Medicine AIIMS KalyaniIndia Community and Primary Care-based Intervention Department of Control of Neglected Tropical Diseases(NTD)World Health Organization(WHO)Av Appia 20 CH-1211Geneva 27Switzerland Director General of Health Sciences(DGHS)&Director National Centre for Disease ControlMinistry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India

Objective:To assess efficacy of albendazole against Ascaris(A.)lumbricoides among school-children at three sites of Rajahmundry,Sundergarh and ***:Sites were selected based on soil-transmitted helminths prevalence,different sociocultural-geographical characteristics and operational feasibility.9-12 Years old children from 14 schools were *** study was conducted in two rounds:baseline&follow up *** eligible children found positive for *** at baseline were administered supervised single tablet albendazole 400 mg under the National Deworming Day *** post-treatment follow-up survey,eligible children who provided second stool sample were included in the final *** samples were examined using WHO recommended Kato-Katz *** was estimated based on cure rate(CR)and Fecal Egg Count Reduction Rate(FECRR)among children found positive in baseline and follow-up ***:328 Out of 625(52.5%)were found positive for *** in the baseline survey and 85 out of 178 samples(47.8%)during post-treatment follow-up ***,the estimated CR was 52.2%.FECRR(95%CI)for albendazole was 72.6%(79.2%-66.0%).The FECRR was highest in East Godaveri[89.7%(96.8%-82.6%)],followed by Sundergarh[86.4%(95.3%-77.5%)]and Wayanad[69%(81.7%-56.4%)].Conclusions:Our study confirmed overall reduction in FEC although with varying albendazole efficacy for *** infection at three different locations in ***,these finding may be assessed in context of ongoing MDA under Filaria control program and further studies by in vivo as well as in vitro methods are required to reach to a conclusion on possible resistance if any.

关键词： Soil transmitted helminths Ascaris lumbricoides Albendazole Efficacy

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The Determination of Heritability in palatal Rugae Pattern among Parents and their Off-Springs in Western India-A Cross-sectional Study

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Journal of Forensic Science and Medicine 2024年第1期10卷 42-46页

作者： Aishwarya Bhatnagar Sugandha Arya Jyothi S Kumar Aishwarya Arya Kailash Chandra Morya sudhir Baroopal Department of Oral Medicine and Radiology Vyas Dental College and HospitalJodhpurRajasthanIndia Department of Conservative and Endodontics Vyas Dental College and HospitalJodhpurRajasthanIndia

Background:Palatal rugae are asymmetrical elevations present on hard palate and are significant due to their uniqueness,stability and thus,aid in forensic ***:The objective is to determine palatal rugae morphology between parents and their offsprings and to determine their genetic *** and Methods:This randomized controlled cross-sectional single-blinded study was conducted on 50 families(randomly selected)who visited Vyas Dental College and Hospital.A total of 150 maxillary study models were examined and rugae were delineated and shape,size,and pattern of rugae were ***:Weak but significant correlation was seen in the nonspecific and angular type of palatal rugae between child and mother and child and father as P<*** with either or both of their parent was seen for curved,wavy,divergent,straight,horseshoe,angular,and nonspecific type of rugae with the higher%of wavy pattern matching(52%with mother and 54%with father).A considerable number of samples showed high heritability of primary and secondary rugae from both parents,but more predominantly to their mothers(branched,nonspecific,and straight).Conclusion:Both environmental and genetic factors can influence the rugae ***,studies should be conducted on a larger sample size to get more significant results.

关键词： Forensic identification heredity palatal rugae uniqueness

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Comparative analysis of real-world data of frequent treatment sequences in metastatic prostate cancer

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Current Urology 2024年第2期18卷 104-109页

作者： Jiten Jaipuria Ishleen Kaur Mohammad Najmud Doja Tanvir Ahmad Amitabh Singh sudhir Kumar Rawal Vineet Talwar Girish Sharma Uro-oncology division Rajiv Gandhi Cancer Institute and Research CentreNew DelhiIndia Amity Centre for Cancer Epidemiology and Cancer Research Amity Institute of BiotechnologyAmity UniversityNoidaIndia School of Engineering and Technology Vivekananda Institute of Professional Studies–Technical CampusNew DelhiIndia Department of Computer Engineering Jamia Millia IslamiaNew DelhiIndia Indian Institute of Information Technology SonepatIndia Department of MedicalOncology Rajiv Gandhi Cancer Institute and Research CentreNew DelhiIndia

Background:The incidence of prostate cancer is increasing worldwide.A significant proportion of patients developmetastatic disease and are initially prescribed androgen deprivation therapy(ADT).However,subsequent sequences of treatments in real-world settings that may improve overall survival remain an area of active *** and methods:Data were collected from 384 patients presenting with de novo metastatic prostate cancer from 2011 to 2015 at a tertiary cancer *** were categorized into surviving(n=232)and deceased(n=152)groups at the end of 3 *** sequence pattern mining techniques(Generalized Sequential Pattern Mining and Sequential Pattern Discovery using Equivalence Classes)were applied to determine the exact order of the most frequent sets of treatments in each ***:Degarelix,as the initial form of ADT,was uniquely in the surviving *** sequence of ADT followed by abiraterone and docetaxel was uniquely associated with a higher 3-year overall *** followed by fosfestrol was found to have a unique niche among surviving patients with a long duration of response to the initial *** who received chemotherapy followed by radiotherapy and those who received radiotherapy followed by chemotherapy were found more frequently in the deceased ***:We identified unique treatment sequences among surviving and deceased patients at the end of 3 *** should be the preferred formof *** who received ADT followed by abiraterone and chemotherapy showed better *** requiring palliative radiation and chemotherapy in any sequence were significantlymore frequent in the deceased group,identifying the need to offer such patients the most efficacious agents and to target them in clinical trial design.

关键词： Hormone therapy Metastatic prostate cancer Sequence mining Survival

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Renal resistive index measurements by ultrasound in patients with liver cirrhosis:Magnitude and associations with renal dysfunction

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World Journal of Radiology 2024年第6期16卷 221-231页

作者： Himanshu Surya Ramesh Kumar Rajeev Nayan Priyadarshi Sabbu Surya Prakash sudhir Kumar Department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Department of Radiodiagnosis All India Institute of Medical SciencesPatna 801507India

BACKGROUND The hemodynamic alterations seen in liver cirrhosis lead to renal vasoconstriction,ultimately causing acute kidney injury(AKI).The renal resistive index(RRI)is the most common Doppler ultrasound variable for measuring intrarenal vascular *** To evaluate the association of the RRI with AKI in patients with liver cirrhosis and to identify risk factors for high *** This was a prospective observational study,where RRI was measured using Doppler ultrasound in 200 consecutive hospitalized patients with *** association of RRI with AKI was *** receiver operating characteristic(ROC)curve analysis was utilized to determine discriminatory cut-offs of RRI for various AKI *** analysis was conducted to determine the predictors of high *** The mean patient age was 49.08±11.68 years,with the majority(79.5%)being male;the predominant etiology of cirrhosis was alcohol(39%).The mean RRI for the study cohort was 0.68±0.09,showing a progressive increase with higher Child-Pugh class of ***,AKI was present in 129(64.5%)*** mean RRI was significantly higher in patients with AKI compared to those without it(0.72±0.06 vs 0.60±0.08;P<0.001).A total of 82 patients(41%)had hepatorenal syndrome(HRS)-AKI,29(22.4%)had prerenal AKI(PRA),and 18(13.9%)had acute tubular necrosis(ATN)-*** mean RRI was significantly higher in the ATN-AKI(0.80±0.02)and HRS-AKI(0.73±0.03)groups than in the PRA(0.63±0.07)and non-AKI(0.60±0.07)*** demonstrated excellent discriminatory ability in distinguishing ATN-AKI from non-ATN-AKI(area under ROC curve:93.9%).AKI emerged as an independent predictor of high RRI(adjusted odds ratio[OR]:11.52),and high RRI independently predicted mortality among AKI patients(adjusted OR:3.18).CONCLUSION In cirrhosis patients,RRI exhibited a significant association with AKI,effectively differentiated between AKI phenotypes,and predicted AKI mortality.

关键词： Renal resistive index Cirrhosis Acute kidney injury Hepatorenal syndrome Renal Doppler

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Cluster sampling methodology to evaluate immunization coverage

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World Journal of Methodology 2024年第3期14卷 78-89页

作者： Aishwarya Sharma RB Jain Jitesh Satija Aditi Sharma Avani Sharma sudhir Shekhawat Department of Community Medicine School of Medical Sciences&ResearchSharda UniversityGreater Noida 201306UPIndia Department of Community Medicine World College of Medical Sciences&ResearchJhajjar 124103HaryanaIndia Department of Community Medicine ESIC Medical College&HospitalFaridabad 121012HaryanaIndia Department of Community Medicine Hamdard Institute of Medical Sciences&ResearchNew Delhi 110062India Department of Community Medicine Pt.B.D.Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia Independent Biostatistician Ghaziabad 201014UPIndia

BACKGROUND Immunization is a key component of primary health care and an indisputable human *** are critical to the prevention and control of infectious disease *** coronavirus disease 2019(COVID-19)pandemic and associated disruptions over the past two years have strained the health systems,with many children missing out on essential childhood *** To evaluate the immunization coverage among 12-23-month-old children in the rural areas of Community Health Centre(CHC)Dighal and to determine the factors influencing the existing immunization *** A coverage evaluation survey was conducted according to the 30-cluster sampling technique,which is the standard methodology for such surveys devised by World Health Organization.A total of 300 children aged 12-23 months were included,whose immunization details were noted from their immunization *** Full immunization rate was noted in 86.7%of the children,with partial and non-immunized children accounting for 9%and 4.3%*** full immunization dropout rate was 4.2%.The common reasons for partial or non-immunization were family problem including illness of mother,vaccine not being available and child being *** of birth(P=0.014)and availability of immunization card(P<0.001)were significant predictors of the immunization *** the study was conducted in 2020/2021,health services were disrupted due to the COVID-19 *** Due to the coverage being higher than the national average,it was concluded that the immunization coverage was optimal and not affected by the COVID-19 pandemic.

关键词： Immunization coverage Children COVID 19 pandemic Vaccines Family health Routine immunization

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Lighting up aggregate emission of perylene diimide by leveraging polymerization-mediated through-space charge transfer and π-π stacking

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Science China Chemistry 2024年

作者： Suiying Ye Désirée Füglistaller Tian Tian Anjay Manian sudhir Kumar Celine Nardo Andrew J.Christofferson Salvy P.Russo Chih-Jen Shih Jean-Christophe Leroux Yinyin Bao Institute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH Zurich Vladimir-Prelog-Weg 3 Institute for Chemical and Bioengineering Department of Chemistry and Applied Biosciences ETH Zurich Vladimir-Prelog-Weg 1-5 ARC Centre of Excellence in Exciton Science School of Science RMIT University School of Science STEM College RMIT University

The molecular engineering of fluorescent organic/polymeric materials, specifically those emitting in the deep red to near-infrared spectrum, is vital for advancements in optoelectronics and biomedicine. Perylene diimide(PDI), a well-known fluorescent scaffold, offers high thermal and photophysical stability but suffers from fluorescence quenching in solid or aggregate states due to intense π-π interactions. To mitigate this, simple and versatile methods for strong PDI aggregate emission without extensive synthetic demands are highly desirable but still lacking. Here, we report a straightforward strategy to enhance the solid-state emission of PDI by introducing certain degree of through-space charge transfer(TSCT) via controlled radical polymerization,which can efficiently distort the typical face-to-face PDI stacking, enabling greatly enhanced deep red emission. This is achieved by growing electron-donating star-shape styrenic(co)polymers from a multidirectional electron-accepting PDI initiator. The incorporation of polycyclic aromatic monomers further shifted the emission into the near-infrared region, albeit with a reduced intensity. Overall, the emission of the PDI-based TSCT polymers can be systematically manipulated by leveraging the balance between PDI stacking and the TSCT degree, as confirmed by both experimental study and theoretical calculations. Our approach circumvents complex synthetic procedures, offering highly emissive materials with large Stokes shifts and showing broad potential for optoelectronic technology.

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Synthesis and Characterization of ZnO Nanowires and ZnO–CuO Nanoflakes from Sputter-Deposited Brass(Cu_(0.65)–Zn_(0.35)) Film and Their Application in Gas Sensing

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Journal of Materials Science & Technology 2015年第11期31卷 1069-1078页

作者： Bhagaban Behera sudhir Chandra Centre for Applied Research in Electronics Indian Institute of Technology Delhi

A novel method was presented for synthesis of ZnO and ZnO-CuO composites in the form of nanowires, nanorods and nanoflakes on oxidized silicon substrates. Further, the use of the synthesized nanostructures for gas sensing was demonstrated. Pure brass （Cu0.65-Zn0.35） films were deposited on oxidized Si substrate by radio frequency （RF） diode sputtering. Subsequently, these films having thickness in the range of 100-200 nm were oxidized in different oxidizing ambient in the temperature range of 300-550 ℃. The effect of temperature, time and oxidizing ambient on the growth of nanostructures was investigated by scanning electron microscopy （SEM）, transmission electron microscopy （TEM）, X-ray diffraction （XRD） and photoluminescence （PL） techniques. The nanostructures surface was analyzed by X-ray photoelectron spectroscopy （XPS）. The synthesized nanowires had diameter in the range of 60-100 nm and length up to 50 μm. Based on these observations, the growth mechanism has been suggested. For the nanorods, the diameter was observed to be -150 nm. Samples having dense nanowires, nanorods and nanoflakes were used as a gas sensing material. The performance Of the sensor was investigated for different nanostructured materials for various volatile organic compounds （VOCs）, It was observed that ZnO- CuO nanoflakes were more sensitive to VOC sensing compared to ZnO nanowires and nanorods.

关键词： Brass Thermal oxidation Nanostructures ZnO CuO sensor Sensor Volatile organic compounds (VOCs)

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Strategies to modulate the intestinal microbiota and their effects on nutrient utilization, performance, and health of poultry

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Journal of Animal Science and Biotechnology 2019年第3期10卷 529-539页

作者： sudhir Yadav Rajesh Jha Department of Human Nutrition Food and Animal Sciences College of Tropical Agriculture and Human Resources University of Hawaii at Manoa

Poultry is widely produced and consumed meat *** demand is expected to continue increasing to meet the animal protein requirement for ever-increasing human ***,the challenge that poultry scientists and industry face are to produce sufficient amount of poultry meat in the most efficient *** the past,using antibiotics to promote the growth of poultry and manage gut microbiota was a ***,due to concerns over potential fatalistic impacts on food animals and indirectly to humans,their use as feed additives are banned or regulated in several *** this changed context,several alternative strategies have been proposed with some success that mimics the functions of antibiotics as growth promoters and modulate gut microbiota for their beneficial *** include the use of probiotics,prebiotics,organic acids,and exogenous enzyme,among *** microbiota and their metabolic products improve nutrient digestion,absorption,metabolism,and overall health and growth performance of *** paper reviews the available information on the effect of feed additives used to modulate intestinal microbiota of poultry and their effects on overall health and growth *** these functions and interactions will help to develop new dietary and managerial strategies that will ultimately lead to enhanced feed utilization and improved growth performance of *** review will help future researchers and industry to identify alternative feed ingredients having properties like prebiotics,probiotics,organic acids,and exogenous enzymes.

关键词： Enzymes Microbiota Organic acids Poultry Prebiotics Probiotics

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Dragonfly Inspired Nanocomposite Flapping Wing for Micro Air Vehicles

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Journal of Bionic Engineering 2019年第5期16卷 894-903页

作者： David Kumar Preetamkumar Marutrao Mohite sudhir Kamle Department of Aerospace Engineering Indian Institute of Technology KanpurKanpur 208016India

The current research is aimed towards the development of dragonfly inspired nanocomposite flapping wing for micro air vehicles(MAVs).The wing is designed by taking inspiration from the hind wing of dragonfly(Anax Parthenope Julius).Carbon nanotubes(CNTs)/polypropylene nanocomposite and low-density polyethylene are used as the wing *** nanocomposites are developed with varying CNTs'weight percentage(0%-1%)and characterized for dynamic mechanical properties,which revealed that the 0.1 weight percentage case produces highest storage modulus values throughout the frequency range(1 Hz一90 Hz).It is also observed that the storage modulus values are in the range ofYoung^modulus of veins and membrane of natural insect *** is useful to achieve true *** manufacturing technique such as photolithography is used for wing *** length,weight and average thickness of the fabricated wing are^44 mm,26.22 mg and 187 pm,*** structural dynamic properties of the fa bricated wing are obtained experimentally and computationally using DIC and ANSYS,*** developed dragonfly inspired wing showed a natural frequency of 29.4 Hz with a bending mode shape which is close to the characteristic frequency of its natural counterpart.

关键词： flapping wings biomimicking nanocomposites MAVs

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