Assessment of albendazole efficacy against Ascaris lumbricoides at three sites of Andhra Pradesh,Odisha,and Kerala in India

作     者：Vinay Garg Ankur Garg Shubha Garg Sudhir Kumar Jain Tanzin Dikid Saurabh Jain Jitendra Manjhi Antonio Montresor Atul Goel Vinay Garg;Ankur Garg;Shubha Garg;Sudhir Kumar Jain;Tanzin Dikid;Saurabh Jain;Jitendra Manjhi;Antonio Montresor;Atul Goel

作者机构：Division of Parasitic DiseasesNational Centre for Disease ControlMinistry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India National Centre for Disease ControlMinistry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India Epidemiology DivisionNational Centre for Disease ControlMinistry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India Department of Control of Neglected Tropical Diseases(NTD)World Health Organization(WHO)Av Appia 20 CH-1211Geneva 27Switzerland Department of Community&Family MedicineAIIMS KalyaniIndia Community and Primary Care-based InterventionDepartment of Control of Neglected Tropical Diseases(NTD)World Health Organization(WHO)Av Appia 20 CH-1211Geneva 27Switzerland Director General of Health Sciences(DGHS)&DirectorNational Centre for Disease ControlMinistry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2024年第17卷第7期

页      面：310-316页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Soil transmitted helminths Ascaris lumbricoides Albendazole Efficacy 

摘      要：Objective:To assess efficacy of albendazole against Ascaris(A.)lumbricoides among school-children at three sites of Rajahmundry,Sundergarh and ***:Sites were selected based on soil-transmitted helminths prevalence,different sociocultural-geographical characteristics and operational feasibility.9-12 Years old children from 14 schools were *** study was conducted in two rounds:baseline&follow up *** eligible children found positive for *** at baseline were administered supervised single tablet albendazole 400 mg under the National Deworming Day *** post-treatment follow-up survey,eligible children who provided second stool sample were included in the final *** samples were examined using WHO recommended Kato-Katz *** was estimated based on cure rate(CR)and Fecal Egg Count Reduction Rate(FECRR)among children found positive in baseline and follow-up ***:328 Out of 625(52.5%)were found positive for *** in the baseline survey and 85 out of 178 samples(47.8%)during post-treatment follow-up ***,the estimated CR was 52.2%.FECRR(95%CI)for albendazole was 72.6%(79.2%-66.0%).The FECRR was highest in East Godaveri[89.7%(96.8%-82.6%)],followed by Sundergarh[86.4%(95.3%-77.5%)]and Wayanad[69%(81.7%-56.4%)].Conclusions:Our study confirmed overall reduction in FEC although with varying albendazole efficacy for *** infection at three different locations in ***,these finding may be assessed in context of ongoing MDA under Filaria control program and further studies by in vivo as well as in vitro methods are required to reach to a conclusion on possible resistance if any.