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Assessment of albendazole efficacy against Ascaris lumbricoides at three sites of Andhra Pradesh,Odisha,and Kerala in India

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Asian Pacific Journal of Tropical Medicine 2024年第7期17卷 310-316页

作者： Vinay Garg Ankur Garg Shubha Garg sudhir kumar Jain Tanzin Dikid Saurabh Jain Jitendra Manjhi Antonio Montresor Atul Goel Division of Parasitic Diseases National Centre for Disease ControlMinistry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India National Centre for Disease Control Ministry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India Epidemiology Division National Centre for Disease ControlMinistry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India Department of Control of Neglected Tropical Diseases(NTD) World Health Organization(WHO)Av Appia 20 CH-1211Geneva 27Switzerland Department of Community&Family Medicine AIIMS KalyaniIndia Community and Primary Care-based Intervention Department of Control of Neglected Tropical Diseases(NTD)World Health Organization(WHO)Av Appia 20 CH-1211Geneva 27Switzerland Director General of Health Sciences(DGHS)&Director National Centre for Disease ControlMinistry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India

Objective:To assess efficacy of albendazole against Ascaris(A.)lumbricoides among school-children at three sites of Rajahmundry,Sundergarh and ***:Sites were selected based on soil-transmitted helminths prevalence,different sociocultural-geographical characteristics and operational feasibility.9-12 Years old children from 14 schools were *** study was conducted in two rounds:baseline&follow up *** eligible children found positive for *** at baseline were administered supervised single tablet albendazole 400 mg under the National Deworming Day *** post-treatment follow-up survey,eligible children who provided second stool sample were included in the final *** samples were examined using WHO recommended Kato-Katz *** was estimated based on cure rate(CR)and Fecal Egg Count Reduction Rate(FECRR)among children found positive in baseline and follow-up ***:328 Out of 625(52.5%)were found positive for *** in the baseline survey and 85 out of 178 samples(47.8%)during post-treatment follow-up ***,the estimated CR was 52.2%.FECRR(95%CI)for albendazole was 72.6%(79.2%-66.0%).The FECRR was highest in East Godaveri[89.7%(96.8%-82.6%)],followed by Sundergarh[86.4%(95.3%-77.5%)]and Wayanad[69%(81.7%-56.4%)].Conclusions:Our study confirmed overall reduction in FEC although with varying albendazole efficacy for *** infection at three different locations in ***,these finding may be assessed in context of ongoing MDA under Filaria control program and further studies by in vivo as well as in vitro methods are required to reach to a conclusion on possible resistance if any.

关键词： Soil transmitted helminths Ascaris lumbricoides Albendazole Efficacy

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Comparative analysis of real-world data of frequent treatment sequences in metastatic prostate cancer

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Current Urology 2024年第2期18卷 104-109页

作者： Jiten Jaipuria Ishleen Kaur Mohammad Najmud Doja Tanvir Ahmad Amitabh Singh sudhir kumar Rawal Vineet Talwar Girish Sharma Uro-oncology division Rajiv Gandhi Cancer Institute and Research CentreNew DelhiIndia Amity Centre for Cancer Epidemiology and Cancer Research Amity Institute of BiotechnologyAmity UniversityNoidaIndia School of Engineering and Technology Vivekananda Institute of Professional Studies–Technical CampusNew DelhiIndia Department of Computer Engineering Jamia Millia IslamiaNew DelhiIndia Indian Institute of Information Technology SonepatIndia Department of MedicalOncology Rajiv Gandhi Cancer Institute and Research CentreNew DelhiIndia

Background:The incidence of prostate cancer is increasing worldwide.A significant proportion of patients developmetastatic disease and are initially prescribed androgen deprivation therapy(ADT).However,subsequent sequences of treatments in real-world settings that may improve overall survival remain an area of active *** and methods:Data were collected from 384 patients presenting with de novo metastatic prostate cancer from 2011 to 2015 at a tertiary cancer *** were categorized into surviving(n=232)and deceased(n=152)groups at the end of 3 *** sequence pattern mining techniques(Generalized Sequential Pattern Mining and Sequential Pattern Discovery using Equivalence Classes)were applied to determine the exact order of the most frequent sets of treatments in each ***:Degarelix,as the initial form of ADT,was uniquely in the surviving *** sequence of ADT followed by abiraterone and docetaxel was uniquely associated with a higher 3-year overall *** followed by fosfestrol was found to have a unique niche among surviving patients with a long duration of response to the initial *** who received chemotherapy followed by radiotherapy and those who received radiotherapy followed by chemotherapy were found more frequently in the deceased ***:We identified unique treatment sequences among surviving and deceased patients at the end of 3 *** should be the preferred formof *** who received ADT followed by abiraterone and chemotherapy showed better *** requiring palliative radiation and chemotherapy in any sequence were significantlymore frequent in the deceased group,identifying the need to offer such patients the most efficacious agents and to target them in clinical trial design.

关键词： Hormone therapy Metastatic prostate cancer Sequence mining Survival

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Renal resistive index measurements by ultrasound in patients with liver cirrhosis:Magnitude and associations with renal dysfunction

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World Journal of Radiology 2024年第6期16卷 221-231页

作者： Himanshu Surya Ramesh kumar Rajeev Nayan Priyadarshi Sabbu Surya Prakash sudhir kumar Department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Department of Radiodiagnosis All India Institute of Medical SciencesPatna 801507India

BACKGROUND The hemodynamic alterations seen in liver cirrhosis lead to renal vasoconstriction,ultimately causing acute kidney injury(AKI).The renal resistive index(RRI)is the most common Doppler ultrasound variable for measuring intrarenal vascular *** To evaluate the association of the RRI with AKI in patients with liver cirrhosis and to identify risk factors for high *** This was a prospective observational study,where RRI was measured using Doppler ultrasound in 200 consecutive hospitalized patients with *** association of RRI with AKI was *** receiver operating characteristic(ROC)curve analysis was utilized to determine discriminatory cut-offs of RRI for various AKI *** analysis was conducted to determine the predictors of high *** The mean patient age was 49.08±11.68 years,with the majority(79.5%)being male;the predominant etiology of cirrhosis was alcohol(39%).The mean RRI for the study cohort was 0.68±0.09,showing a progressive increase with higher Child-Pugh class of ***,AKI was present in 129(64.5%)*** mean RRI was significantly higher in patients with AKI compared to those without it(0.72±0.06 vs 0.60±0.08;P<0.001).A total of 82 patients(41%)had hepatorenal syndrome(HRS)-AKI,29(22.4%)had prerenal AKI(PRA),and 18(13.9%)had acute tubular necrosis(ATN)-*** mean RRI was significantly higher in the ATN-AKI(0.80±0.02)and HRS-AKI(0.73±0.03)groups than in the PRA(0.63±0.07)and non-AKI(0.60±0.07)*** demonstrated excellent discriminatory ability in distinguishing ATN-AKI from non-ATN-AKI(area under ROC curve:93.9%).AKI emerged as an independent predictor of high RRI(adjusted odds ratio[OR]:11.52),and high RRI independently predicted mortality among AKI patients(adjusted OR:3.18).CONCLUSION In cirrhosis patients,RRI exhibited a significant association with AKI,effectively differentiated between AKI phenotypes,and predicted AKI mortality.

关键词： Renal resistive index Cirrhosis Acute kidney injury Hepatorenal syndrome Renal Doppler

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Lighting up aggregate emission of perylene diimide by leveraging polymerization-mediated through-space charge transfer and π-π stacking

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Science China Chemistry 2024年

作者： Suiying Ye Désirée Füglistaller Tian Tian Anjay Manian sudhir kumar Celine Nardo Andrew J.Christofferson Salvy P.Russo Chih-Jen Shih Jean-Christophe Leroux Yinyin Bao Institute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH Zurich Vladimir-Prelog-Weg 3 Institute for Chemical and Bioengineering Department of Chemistry and Applied Biosciences ETH Zurich Vladimir-Prelog-Weg 1-5 ARC Centre of Excellence in Exciton Science School of Science RMIT University School of Science STEM College RMIT University

The molecular engineering of fluorescent organic/polymeric materials, specifically those emitting in the deep red to near-infrared spectrum, is vital for advancements in optoelectronics and biomedicine. Perylene diimide(PDI), a well-known fluorescent scaffold, offers high thermal and photophysical stability but suffers from fluorescence quenching in solid or aggregate states due to intense π-π interactions. To mitigate this, simple and versatile methods for strong PDI aggregate emission without extensive synthetic demands are highly desirable but still lacking. Here, we report a straightforward strategy to enhance the solid-state emission of PDI by introducing certain degree of through-space charge transfer(TSCT) via controlled radical polymerization,which can efficiently distort the typical face-to-face PDI stacking, enabling greatly enhanced deep red emission. This is achieved by growing electron-donating star-shape styrenic(co)polymers from a multidirectional electron-accepting PDI initiator. The incorporation of polycyclic aromatic monomers further shifted the emission into the near-infrared region, albeit with a reduced intensity. Overall, the emission of the PDI-based TSCT polymers can be systematically manipulated by leveraging the balance between PDI stacking and the TSCT degree, as confirmed by both experimental study and theoretical calculations. Our approach circumvents complex synthetic procedures, offering highly emissive materials with large Stokes shifts and showing broad potential for optoelectronic technology.

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Study of synthetic aperture radar and automatic identification system for ship target detection

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Journal of Ocean Engineering and Science 2019年第2期4卷 173-182页

作者： sudhir kumar Chaturvedi Department of Aerospace Engineering University of Petroleum&Energy StudiesDehradun 248007India

In the past,the main goals of Synthetic Aperture Radar(SAR)systems were the study of the interaction of electromagnetic waves with the earth ***,the development of multi-channel SAR systems has enabled the development of more sophisticated techniques for the surveillance *** is the most efficient instrument,which provides high-resolution data for wide ocean area surveillance under all weather *** intrinsic capability of this instrument is to provide a quick view of the oceanic surface features such as vessels,waves and currents,oil spills,laver facilities and wind *** ship detection or recognition is achieved in two steps:the first step is to identify the target in SAR images of a busy traffic,which corresponds to Automatic Identification System(AIS)signals by the“dead-reckoning(DR)position”,and the second step is to estimate the position,size and speed of the ship from SAR images and compare these results with the AIS“true”*** paper presents the fundamentals of SAR and its integration with the AIS data for the ship target detection.

关键词： SAR AIS Dead reckoning Target detection.

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A case study of tsunami detection system and ocean wave imaging mechanism using radar

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Journal of Ocean Engineering and Science 2019年第3期4卷 203-210页

作者： sudhir kumar Chaturvedi Faculty Department of Aerospace EngineeringUniversity of Petroleum and Energy StudiesDehradun 248007India

Tsunamis are the seismic generated waves,which causes the huge displacement of water volume in ocean from deep water to the coastal *** detection and investigation of its early warning is the very important issue nowadays,which supports our existing system more *** paper proposes a case study of the mathematical models of the ocean wave imaging schemes and the Tsunami detection system model for the Japan’s region where Tsunamis hits on March 11,*** detection function(q-factor)was developed which is well known as q-factor estimates.q-factor works on the principle of selected radar band *** tsunami reaches around an hour afterward the earthquake,as specified through the relationship in the velocities in altered *** effects in a high-pitched upsurge in the q-factor,descriptive the tsunami *** radar functions for only 40 min in the hour,causing in the 20 min gaps noticeable in *** entrance of the tsunami is specified by relationship between velocities in altered bands early about 2.5 h afterward the volcanic activity.q-factor demonstrates a sudden conversion in magnitude about 8 min afterward the start of the velocity *** this point,the velocity is declining,representing that the tsunami is stirring offshore,subsequent in the negative *** future improvements in integrated tsunami detection systems can also be easily incorporated in this technique in order to obtain better detection capabilities.

关键词： Tsunami detection RADAR Waves modulations

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Selective Mapping Scheme for Universal Filtered Multicarrier

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Intelligent Automation & Soft Computing 2023年第5期36卷 1273-1282页

作者： Akku Madhusudhan sudhir kumar Sharma Jaipur National University JagatpuraJaipur302017RajasthanIndia

The next step in mobile communication technology,known as 5G,is set to go live in a number of countries in the near *** wireless applica-tions have high data rates and mobility requirements,which have posed a chal-lenge to mobile communication technology researchers and designers.5G systems could beneﬁt from the Universal Filtered Multicarrier(UFMC).UFMC is an alternate waveform to orthogonal frequency-division multiplexing(OFDM),inﬁltering process is performed for a sub-band of subcarriers rather than the entire band of subcarriers Inter Carrier Interference(ICI)between neighbouring users is reduced via the sub-bandﬁltering process,which reduces out-of-band ***,the UFMC system has a high Peak-to-Average Power Ratio(PAPR),which limits its *** optimization based Selective mapping(SLM)is used in this paper to optimise the *** on the cognitive behaviour of crows,the research study suggests an innovative metaheuristic opti-mization known as Crow Search Algorithm(CSA)for SLM ***-pared to the standard UFMC,SLM-UFMC system,and SLM-UFMC with conventional metaheuristic optimization techniques,the suggested technique sig-niﬁcantly reduces *** the UFMC system,the suggested approach has a very low Bit Error Rate(BER).

关键词： -Universalﬁltered multicarrier(UFMC) selective mapping(SLM) metaheuristic optimization crow search algorithm(CSA) bit error rate(BER)

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Comprehensive isotopic characterization of the hydrological processes of the Indus river basin(IRB):A comparison between Upper Indus Basin(UIB)and Lower Indus Basin(LIB)

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Journal of Mountain Science 2023年第3期20卷 705-723页

作者： Akhtar JAHAN Tanveer DAR sudhir kumar Nachiketa RAI Department of Earth Sciences Indian Institute of TechnologyRoorkee 247667India National Institute of Hydrology Roorkee 247667India

The Indus river basin(IRB)is one of the most depleted water basins globally,having significant challenges for its water *** of stable isotope composition(δ^(18)O and δ^(2)H)across IRB is a critical aspect that can provide deeper insights for investigating complex hydrological *** work analyses the spatial pattern of the isotopic signature using a comprehensive compilation of available datasets of the Global Network of Isotopes in River(GNIR)and Global Network of Isotopes in Precipitation(GNIP),along with the previously published isotopic studies in the Indus ***,this work provides a detailed comparison of the isotopic signature of the Upper Indus Basin(UIB),and Lower Indus Basin(LIB).The IRBs waterline was found to beδ^(2)H=7.89×δ^(18)O+13.51,which shows a close similarity with the Global Meteoric Water Line(GMWL),indicating the meteoric origin of the water with insignificant secondary evaporation prevailing across the *** Main Indus Channel(MIC)river water line(δ^(2)H=8.88×δ^(18)O+26.05)indicates a major contribution from the meteoric origin(precipitation/rain)of water with minimal effect of evaporation *** water line for UIB samples,(δ^(2)H=7.88×δ^(18)O+11.94)was found to be moderately higher in slope than LIB samples(δ^(2)H=7.17×δ^(18)O+7.16).However,the slopes of both UIB and LIB river water lines closely approached the slope of GMWL and were consistent with the slope of IRB water line,which indicates similarity in contribution of water *** higher slope and intercept in UIB suggest that meteoric water sources contributed to streamflow *** snow/glacier with insignificant evapotranspiration,which is also validated by the scarce vegetation cover in the ***,the lower slope and intercept in LIB suggest stream water contribution from significantly evaporated groundwater and precipitation with a complete homogenization of discharge coming from the *** substantiate that distinct isotopi

关键词： Isotopes Spatial variability Indian summer monsoon Western Disturbance Indus river Water

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Measurement and validation of tsunami Eigen values for the various water wave conditions

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Journal of Ocean Engineering and Science 2020年第1期5卷 41-54页

作者： sudhir kumar Chaturvedi Ugur Guven Pankaj kumar Srivastava Department of Aerospace Engineering University of Petroleum and Energy StudiesDehradun 248007India Department of International Affairs University of Petroleum and Energy StudiesDehradun 248007India Department of Petroleum Engineering&Earth Sciences University of Petroleum and Energy StudiesDehradun 248007India

This paper proposes the mathematical model to investigate how to compute and analyze the tsunami wave parameters and the retrieval of its early warning using remote sensing technique to improve the detection *** different methods available for the evaluation of the tsunami detection systems are also *** research work is to compute and analyze the tsunami wave parameters such as Eigen functions in deep,intermediate and shallow water *** computational and algorithmic analysis of tsunami wave parameters are achieved in three steps:the first step is to calculate the earthquake fault parameters such as length,width,area and displacement from the epicenter,which corresponds to the effect of its variation with respect to the earthquake *** variation of each fault parameters have been measured and recorded out over the certain moment of magnitudes(M).This shows smaller values as compared to the earthquake magnitude M 9.5 at which all the parameters shows very large *** second step involves the measurements of water wave angular frequency in deep,intermediate and shallower region of *** values of angular frequencies in deep water shows the lesser response as compared to other two water conditions because,in deep water the angular velocity of water particles travels with the lesser speed as compared to the shallower region as per Airy’s wave *** simulation results show the angular velocity in Deep Ocean is very less,moderate in the intermediate water and very high on the coastal *** indicates the higher impact on coastal *** third step involves the simulation study of measurement of tsunami Eigen functions such as orbital velocity,acceleration,wave potential in deep,intermediate and shallower water *** simulation result shows the resultant orbital velocity and accelerations in deep,intermediate and shallow water regions provides the similar response as angular velocity due to same proportion of the

关键词： Tsunami Eigen functions Monitoring Detection.

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A brief review on tsunami early warning detection using BPR approach and post analysis by SAR satellite dataset

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Journal of Ocean Engineering and Science 2017年第2期2卷 83-89页

作者： sudhir kumar Chaturvedi Pankaj kumar Srivastava Ugur Guven Department of Aerospace Engineering University of Petroleum&Energy StudiesDehradun 248007India Department of Petroleum Engineering&Earth Sciences University of Petroleum&Energy StudiesDehradun 248007India

Tsunami early warning systems have provided to be the extreme importance after the tsunami that hit Japan in March *** research article presents a case study based on the tsunami detection using Bottom Pressure Rate(BPR)measurement and the post the analysis using the SAR datasets.A final decision based system using BPR has been studied to carry out the measurements of tsunami wave *** based study has also been carried out for the post tsunami *** filters are utilized to remove the speckle noise presents in *** scope of this work has also been proposed.

关键词： Remote sensing Tsunami damage detection Epicenter BPR

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