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Genome-wide gene expression analysis for target genes to differentiate patients with intestinal tuberculosis and Crohn’s disease and discriminative value of FOXP3 mRNA expression

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Gastroenterology Report 2016年第1期4卷 59-67,I0003页

作者： Vineet Ahuja Swati subodh Amit Tuteja Veena Mishra Sushil Kumar Garg Neha Gupta Govind Makharia SK Acharya Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew DelhiIndia The Centre for Genomic Application(An IGIB–IMM collaboration) New DelhiIndia

Background and aims:Crohn’s disease(CD)and intestinal tuberculosis(ITB)are both chronic granulomatous conditions with similar phenotypic ***,there is need for a biomarker to differentiate between both these two *** study aimed at genome-wide gene expression analysis of colonic biopsies from confirmed cases of ITB and CD in comparison with *** evaluate the role of T regulatory cells,forkhead box P3(FOXP3)mRNA expression was quantified in serum as well as in colonic biopsies from patients with ITB and with the ***:Paired samples,including serum and colonic biopsies,were taken from 33 study subjects(CD,ITB and controls),and total RNA was *** whole genome gene expression microarray analysis was performed using the Illumina HumanWG-6 BeadChip Kit with six total RNA samples of the three groups in ***-time PCR for FOXP3 mRNA expression was analyzed in serum samples and colonic biopsy samples(4-CD,5-ITB,4-controls).Results:In CD and ITB there was 1.5-fold upregulation of 92 and 382 genes and 1.5-fold downregulation of 91 and 256 genes,*** proliferators via the PPARc pathway were most significantly downregulated(P2-fold *** ITB,the complement activation pathway,specifically the classical pathway,was the most significantly ***3 mRNA expression was significantly elevated in colonic biopsies obtained from ITB patients as compared with CD cases(4.7062.21 vs 1.4860.31,P=0.016).Conclusions:FOXP3 mRNA expression in colonic mucosa could be a discriminatory marker between ITB and *** of the complement activation pathway in ITB suggests that pathogenetic mechanisms for ITB are similar to those of pulmonary *** CD,downregulation of PPARc was seen in colonic tissue,suggesting that restoratio

关键词： Crohn’s disease intestinal tuberculosis microarray gene expression profiling signaling pathway FOXP3 mRNA

Evolutional Characteristics of Debris Flow in the Siwalik Hills of Nepal

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International Journal of Geosciences 2019年第12期10卷 1049-1067页

作者： Bharat Prasad Bhandari subodh Dhakal Central Department of Environment Science Tribhuvan University Kirtipur Nepal Department of Geology Tri-Chandra Multiple Campus Tribhuvan University Kathmandu Nepal

As a youngest Mountain of the world, Siwalik region of Nepal is facing several mass movements like landslide and debris flow in monsoon period every year. Debris flow is very common in the steep slope of weak and fragile sedimentary rocks. This paper used remote sensing data and GIS to evaluate evolutional characteristics of debris flow hazard in the Siwalik hill of Babai watershed based on the geological, topographical and hydrological factors. All together 101 debris flow polygons were made by using Google Earth and by field verification. Digital Elevation Model (DEM) was used to analyze debris flow distribution and topographical features. Lithostratigraphy was studied to evaluate geological characters and rainfall data was used to evaluate hydrological character. Average slope for debris flow evolution in Lower, Middle and Upper Siwalik is 34°, 50° and 30° respectively. The average 24 hours rainfall to occur debris flow is found 160.67 mm. The area and length of debris flow channel are significantly different in three geological formations. The temporal distribution of debris flow from 2001 to 2018 shows that the trend of debris flow generation is higher in Middle Siwalik rocks with slope greater than 30°. Three major sources of debris flows were evaluated namely slide induced debris flow, fall induced debris flow and erosion induced debris flow where the slide induced debris flow is predominant. This study can be better source to understand the general mechanism of debris flow generation to the policy makers for reducing the future impact of debris flow in the overall Siwalik zone of Nepal.

关键词： Debris Flow GIS Siwaliks Topography

The main protease of SARS-CoV-2 downregulates innate immunity via a translational repression

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2054-2057页

作者： Weifeng Liang Ming Gu Lingxiang Zhu Ziqi Yan Dominik Schenten Shelby Herrick Hongmin Li subodh Kumar Samrat Jiapeng Zhu Yin Chen School of Medicine&Holistic Integrative Medicine Nanjing University of Chinese MedicineNanjingJiangsu210023China Department of Pharmacology and Toxicology School of PharmacyThe University of ArizonaTucsonAZ85721USA Department of Immunology School of MedicineThe University of ArizonaTucsonAZ85724USA Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of PharmacyNanjing University of Chinese MedicineNanjingJiangsu210023China Jiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative Medicine Nanjing University of Chinese MedicineNanjingJiangsu210023China

Dear Editor,SARS-CoV-2 is the etiological cause of ***-I-like receptor(RLR)signaling pathway appeared to be responsible for SARS-CoV-2 induced IFN,1 a major antiviral *** deficiency2,3 was identified to be a significant risk factor of severe COVID-19,highlighting an important role of IFN in the defense against SARS-CoV-2 and in the pathogenesis of severe COVID-19.

关键词： immunity pathogenesis translational

Synthesis of Porous NiO Nanocrystals with Controllable Surface Area and Their Application as Supercapacitor Electrodes

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Nano Research 2010年第9期3卷 643-652页

作者： Xiaojun Zhang Wenhui Shi Jixin Zhu Weiyun Zhao Jan Ma subodh Mhaisalkar Tuti Lim Maria Yanhui Yang Hua Zhang Huey Hoon Hng Qingyu Yan School of Materials Science and Engineering Nanyang Technological University639798Singapore College of Chemistry and Materials Science Anhui Normal UniversityWuhu 241000China Energy Research Institute Nanyang Technological University637459Singapore School of Civil and Environmental Engineering Nanyang Technological University639798Singapore School of Life Sciences and Chemical Technology Ngee Ann Polytechnic535 Clementi RoadSingapore School of Chemical and Biomolecular Engineering Nanyang Technological University637459Singapore

We report a facile way to grow various porous NiO nanostructures including nanoslices,nanoplates,and nanocolumns,which show a structure-dependence in their specific charge *** formation of controllable porosity is due to the dehydration and re-crystallization of β-Ni(OH)_(2) nanoplates synthesized by a hydrothermal *** analysis shows that the decomposition temperature of the β-Ni(OH)_(2) nanostructures is related to their *** electrochemical tests,the porous NiO nanostructures show stable cycling performance with retention of specific capacitance over 1000 ***,the formation of nanocolumns by the stacking of β-Ni(OH)_(2) nanoslices/plates favors the creation of small pores in the NiO nanocrystals obtained after annealing,and the surface area is over five times larger than that of NiO nanoslices and ***,the specific capacitance of the porous NiO nanocolumns(390 F/g)is significantly higher than that of the nanoslices(176 F/g)or nanoplates(285 F/g)at a discharge current of 5 A/*** approach provides a clear illustration of the process-structure-property relationship in nanocrystal synthesis and potentially offers strategies to enhance the performance of supercapacitor electrodes.

关键词： Ni(OH)_(2) NiO porous nanocrystals supercapacitor

RAPD-PCR Based Marker Approach for the Genetic Differentiation of Two Species of Cockroach （Order-Dictyoptera）

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Journal of Life Sciences 2012年第12期6卷 1328-1333页

作者： Bharat Neekhra Divya Pandey subodh Kumar Jain Molecular Biology Laboratory Department of Biotechnology Dr. Hari Singh Gour Universi~ Sagar 470003 India

Random amplified polymorphic DNA （RAPD） analysis was conducted for the differentiation of two most commonly occurring insect species Periplaneta americana and Blatella germanicana. This technique is proved to be a quick and effective to establish genetic markers to differentiate morphologically similar populations. During the study cockroach species Periplanata americana and Blatella germanicana were considered. Ten random primers were used for polymerase chain reaction （PCR）. Many of such bands obtained, which differentiate between the two species. On the basis of interpretability, simplicity and reproducibility, six primers P1 （GATGACCGCC）, P3 （GGCACGTAAC）, P6 （GGTGCGCCTT）, P7 （GTCAGAGTCG）, P8 （GTCGCCGTCT） and PI0 （GTGCCCGATG） were considered positive for genetic differentiation and analysis. A series of bands ranging from -300 bp to -1,000 bp obtained indicates that these two species are related, however they exhibit some variations. It has also been observed that the same primers also amplified some DNA fragments of the same size in both the species, which indicates the presence of conserved regions, sharing ancestral relationship. Some of the fragments were unique in both the species which may be used for diagnostic purposes. The study concludes that the RAPD-PCR technique is useful for the study of molecular taxonomy in insects.

关键词： RAPD PCR cockroach random primers genetic differentiation.

The Impact of Precipitation on Drinking Water Resources in the Sagarmatha National Park (Mt. Everest Region), Nepal

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Journal of Water Resource and Protection 2019年第11期11卷 1351-1368页

作者： Kirsten Ngaire Nicholsona Klaus Neumann subodh Sharma Department of Environment Geology and Natural Resources Ball State University Muncie IN USA School of Science Kathmandu University Kathmandu Nepal

This study focuses on the link between precipitation, the bacteriological characteristics, and the physical parameters of drinking water sources from 2016 to 2018 in the Sagarmatha National Park (Mt. Everest region), Nepal. Surface water shows a positive correlation between bacteria content, altitude and corresponding temperature, whereas water from springs shows no correlation between bacteria content and altitude and corresponding temperature. Correlation between precipitation data and both pH and conductivity suggests a link between drinking water quality and precipitation whereby high precipitation rates result in increased contamination of both surface water and springs used for drinking water. This data also indicates that during periods of low precipitation, water handling is likely to contribute to water contamination. These results highlight vulnerability to climate change as melting glacial ice and changing precipitation patterns are key factors for safe drinking water.

关键词： Himalaya Mountains Drinking Water Precipitation Fecal Contamination Climate Change

Ureteric Stone Containing Gas: First Case Report with Review of Cases of Urolithiasis with Gas within the Stone and Its Clinical Implications

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Open Journal of Urology 2022年第4期12卷 203-208页

作者： Rohan Valsangkar Sameer Jog Jaydeep Date subodh Shivde Deenanath Mangeshkar Hospital and Research Center Pune India

We report the first case of a ureteric stone containing gas. This rare stone with gas within it was found during the management of a diabetic patient with urosepsis as the initial presentation. Literature review of cases of renal stone containing gas, mechanisms of gas within the stone, and clinical implications of stone containing gas are discussed. Also, a new terminology is proposed to describe this phenomenon.

关键词： Urolithiasis Containing Gas Pyelonephritis Pneumourolithiasis

An overview of pancreatic trauma

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Journal of Pancreatology 2020年第3期3卷 139-146页

作者： Harshit Agarwal Amit Gupta subodh Kumar Division of Trauma Surgery&Critical Care JPN Apex Trauma CenterAll India institute of Medical SciencesNew DelhiIndia

Pancreatic trauma remains a challenge to a trauma surgeon even with extensive advancement in *** mortality and morbidity associated with this injury remain high.A high index of suspicion,mechanism of injury,and early identification hold key in the final *** management of pancreatic injury should involve a multidisciplinary team comprising of trauma surgeons,radiologists,and *** review highlights the burden of the pancreatic injury and its management.

关键词： Distal pancreatectomy ERCP Pancreatic trauma

Obesity Management-Bariatric Surgery vs Lifestyle Modification

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Open Journal of Endocrine and Metabolic Diseases 2013年第1期3卷 69-74页

作者： Poondy G. R. Raman subodh Banzal MGM Medical College Indore India Shri Aurobindo Institute of Medical Sciences Indore India

Role of Bariatric surgery for obesity is briefly outlined. Selection criteria, contraindications, evaluations of patients before surgery, types of bariatric surgery with their merits and demerits are discussed. Result... 详细信息

关键词： Types of Bariatric Surgery Selection Criteria Contraindication Merits and Demerits Lifestyle Modification