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Endometrial response to conceptus-derived estrogen and interleukin-1β at the time of implantation in pigs

Journal of Animal Science and Biotechnology 2018年第3期9卷 531-547页

作者： Hakhyun Ka Heewon Seo Yohan Choi Inkyu yoo Jisoo Han Department of Biological Science and Technology Yonsei University Department of Veterinary Integrated Biosciences Texas A&M University College Station Department of Obstetrics and Gynecology University of Kentucky College of Medicine

The establishment of pregnancy is a complex process that requires a well-coordinated interaction between the implanting conceptus and the maternal uterus. In pigs, the conceptus undergoes dramatic morphological and functional changes at the time of implantation and introduces various factors, including estrogens and cytokines,interleukin-1β2(IL1 B2), interferon-γ(IFNG), and IFN-δ(IFND), into the uterine lumen. In response to ovarian steroid hormones and conceptus-derived factors, the uterine endometrium becomes receptive to the implanting conceptus by changing its expression of cell adhesion molecules, secretory activity, and immune response. Conceptus-derived estrogens act as a signal for maternal recognition of pregnancy by changing the direction of prostaglandin(PG) F2αfrom the uterine vasculature to the uterine lumen. Estrogens also induce the expression of many endometrial genes,including genes related to growth factors, the synthesis and transport of PGs, and immunity. IL1 B2, a pro-inflammatory cytokine, is produced by the elongating conceptus. The direct effect of IL1 B2 on endometrial function is not fully understood. IL1 B activates the expression of endometrial genes, including the genes involved in IL1 B signaling and PG synthesis and transport. In addition, estrogen or IL1 B stimulates endometrial expression of IFN signaling molecules,suggesting that estrogen and IL1 B act cooperatively in priming the endometrial function of conceptus-produced IFNG and IFND that, in turn, modulate endometrial immune response during early pregnancy. This review addresses information about maternal-conceptus interactions with respect to endometrial gene expression in response to conceptus-derived factors, focusing on the roles of estrogen and IL1 B during early pregnancy in pigs.

关键词： Conceptus Endometrium Estrogen Interleukin-1β Pig Uterus

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Antioxidant effect of indirect moxibustion on healthy subjects:a pilot study

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Journal of Traditional Chinese Medicine 2012年第4期32卷 590-595页

作者： Hyejung Park Hyeunggeug Kim Sara yoo Namhun Lee Changgue Son Liver and Immunology Research Center Daejeon Oriental Hospital of Oriental Medical College of Daejeon University22-5 Daehung-dongJung-guDaejeon 301-724Republic of Korea

OBJECTIVE:Moxibustion has long been thought to promote vital energy or immunity through clinical *** study aimed to investigate the clinical effects of indirect moxibustion on antioxidant and immunomodulation in a normal ***:Twenty-five healthy volunteers with no objective or subjective disorders were *** participants were treated with indirect moxibustion on acupoints Guanyuan(CV 4) and Shenque(CV 8) three times per week for 4 *** serum levels of reactive oxygen species(ROS) and malondialdehyde(MDA),the total antioxidant capacity(TAC),the activities of catalase and superoxide dismutase(SOD),and the total glutathione content were determined before and after the 12th *** subpopulations and 42 cytokines in the peripheral blood were analyzed using flow cytometry and antibody array,***:Compared with the initial time point,the serum levels of ROS and MDA were significantly lowered by moxibustion,while TAC was increased(P<0.01 for all).A significant increase was observed in catalase activity(P<0.05),but not in SOD or total *** were no significant changes in lymphocyte subpopulations or cytokines in the peripheral *** of 25 participants reported at least one symptom in which they felt subjective improvement after ***:Indirect moxibustion on acupoints CV 4 and CV 8 improved the antioxidant defense system,which may be a mechanism explaining the clinical effects of moxibustion.

关键词： Moxibustion Point CV 4 (Guanyuan) Point CV 8 (Shenque) Antioxidants Pilot projects

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LongLine:Visual Analytics System for Large-scale Audit Logs

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Visual Informatics 2018年第1期2卷 82-97页

作者： Seunghoon yoo Jaemin Jo Bohyoung Kim Jinwook Seo Seoul National University Korea Hankuk University of Foreign Studies Korea

Audit logs are different from other software logs in that they record the most primitive events(i.e.,system calls)in modem operating *** logs contain a detailed trace of an operating system,and thus have received great attention from security experts and system ***,the complexity and size of audit logs,which increase in real time,have hindered analysts from understanding and analyzing *** this paper,we present a novel visual analytics system,LongLine,which enables interactive visual analyses of large-scale audit *** lowers the interpretation barrier of audit logs by employing human-understandable representations(e.g.,file paths and commands)instead of abstract indicators of operating systems(e.g.,file descriptors)as well as revealing the temporal patterns of the logs in a multi-scale fashion with meaningful granularity of time in mind(e.g.,hourly,daily,and weekly).LongLine also streamlines comparative analysis between interesting subsets of logs,which is essential in detecting anomalous behaviors of *** addition,LongLine allows analysts to monitor the system state in a streaming fashion,keeping the latency between log creation and visualization less than one ***,we evaluate our system through a case study and a scenario analysis with security experts.

关键词： Visual Analytics Log Visualization Multidimensional Data

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Regulation of epithelial function, differentiation, and remodeling in the epididymis

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Asian Journal of Andrology 2016年第1期18卷 3-9页

作者： Sylvie Breton Ye Chun Ruan yoo-Jin Park Bongki Kim Center for Systems Biology Program in Membrane Biology/Nephrology Division Massachusetts General Hospital Boston MA 02114 and Harvard Medical School Boston MA 02115 USA Epithelial Cell Biology Research Centre School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Hong Kong China

The epididymis is a single convoluted tubule lined by a pseudostratified epithelium. Specialized epididymal epithelial cells, the so-called principal, basal, narrow, and clear cells, establish a unique luminal environment for the maturation and storage of spermatozoa. The epididymis is functionally and structurally divided into several segments and sub-segments that create regionally distinct luminal environments. This organ is immature at birth, and epithelial cells acquire their fully differentiated phenotype during an extended postnatal period, but the factors involved in this complex process remain incompletely characterized. In the adult epididymis, the establishment of an acidic luminal pH and low bicarbonate concentration in the epididymis contributes to preventing premature activation of spermatozoa during their maturation and storage. Clear cells are proton-secreting cells throughout the epididymis, but principal cells have distinct acid/base transport properties, depending on their localization within the epididymis. Basal cells are located in all epididymal segments, but they have a distinct morphology depending on the segment and species examined. How this structural plasticity of basal cells is regulated is discussed here. Also, the role of luminal factors and androgens in the regulation of epithelial cells is reviewed in relation to their respective localization in the proximal versus distal regions of the epididymis. Finally, we describe a novel role for CFTR in tubulogenesis and epithelial cell differentiation.

关键词： basal cells clear cells principal cells pseudostratified epithelia transepithelial transport

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Ultralong persistent luminescence from carbon dots

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Light(Science & Applications) 2022年第6期11卷 1019-1020页

作者： Seunghyup yoo Youngjin Song Sangin Hahn School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea

Hour-level persistent luminescence is realized with carbon dots embedded in cyanuric acid,the composition of which is easily obtained by the microwave-assisted heating of carbon dots and *** forming donor-acceptor blends,the proposed composition yields intermediate states with long lifetimes,providing a rare-earth-metal-free route to ultralong persistent luminescence.

关键词： luminescence donor microwave

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Verification of Beam Models for Ionic Polymer-Metal Composite Actuator

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Journal of Bionic Engineering 2009年第3期6卷 232-238页

作者： Hoon Cheol Park Quoc Viet Nguyen Jang Woo Lee Young Tai yoo Artificial Muscle Research Center Konkuk University Department of Advanced Technology Fusion Konkuk University Department of Materials Chemistry and Engineering Konkuk University

Ionic Polymer-Metal Composite (IPMC) can work as an actuator by applying a few voltages.A thick IPMC actuator,where Nafion-117 membrane was synthesized with polypyrrole/alumina composite filler,was analyzed to verify the equivalent beam and equivalent bimorph beam *** blocking force and tip displacement of the IPMC actuator were measured with a DC power supply and Young's modulus of the IPMC strip was measured by bending and tensile tests *** calculated maximum tip displacement and the Young's modulus by the equivalent beam model were almost identical to the corresponding measured *** element analysis with thermal analogy technique was utilized in the equivalent bimorph beam model to numerically reproduce the force-displacement relationship of the IPMC *** results by the equivalent bimorph beam model agreed well with the force-displacement relationship acquired by the measured *** is confirmed that the equivalent beam and equivalent bimorph beam models are practically and effectively suitable for predicting the tip displacement,blocking force and Young's modulus of IPMC actuators with different thickness and different composite of ionic polymer membrane.

关键词： jonic polymer-metal composite beam model displacement force

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Flow Visualization and Performance Measurements of a Flagellar Propeller

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Journal of Bionic Engineering 2012年第3期9卷 322-329页

作者： Hyejin Jeon yoon-Cheol Kim Dongwook Yim Jung Yui yoo Songwan Jin School of Mechanical and Aerospace Engineering Seoul National University Seoul 151-744 Korea Department of Mechanical Engineering Korea Polytechnic University Siheung-si Gyeonggi-do 429-793 Korea

A new type of propeller that is optimized for low Reynolds numbers is required to propel a small object in a medium where the flow is dominated by viscous rather than inertial forces. A propeller in the shape of a bacterial flagellum seems an appro- priate choice for driving a small object. Accordingly, in this study, we visualized the velocity field induced by a spring-like propeller inspired by the Escherichia coli flagellum, using a macroscopic model and applying stereoscopic particle image velocimetry. We also experimentally evaluated the effect of pitch and rotational speed on the performance of this flagellar propeller. Silicone oil, which has a kinematic viscosity 100,000 times that of water, was used as the working fluid to generate a low Reynolds number for the macroscopic model. Thrust, torque, and velocity were measured as functions of pitch and rota- tional speed, and the efficiency of the propeller was calculated from the measured results. We found that the flagellar propeller reached a max!mum efficiency when the pitch angle was approximately 53°. Compared to pitch, rotational speed had a relatively small effect on the efficiency, and the pitch altered the flow pattern behind the rotating propeller.

关键词： flagellar propeller stereoscopic PIV bacterial flagellum small swimming object

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旋转热管砂轮冷凝端单翅片对流换热仿真研究

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机械制造 2024年第5期62卷 15-19页

作者：何永节杜宝瑞姚俊袁达忠沈阳航空航天大学机电工程学院沈阳110136 中国科学院工程热物理研究所北京100190 中国科学院大学北京100049

为优化旋转热管砂轮冷凝端结构,在冷凝端添加翅片,增大散热面积,实现有效散热,从而提高换热能力。应用FLUENT软件对旋转热管砂轮冷凝端单翅片进行对流换热仿真研究,通过建模分析翅片高度、翅片厚度、冷风条件、转速对冷凝端换热性能的... 详细信息

为优化旋转热管砂轮冷凝端结构,在冷凝端添加翅片,增大散热面积,实现有效散热,从而提高换热能力。应用FLUENT软件对旋转热管砂轮冷凝端单翅片进行对流换热仿真研究,通过建模分析翅片高度、翅片厚度、冷风条件、转速对冷凝端换热性能的影响。研究表明,当翅片高度为6 mm,翅片厚度为1 mm时,冷凝端外壁面的平均对流换热系数最大,平均温度最低。当冷风压力为0.6MPa时,冷凝端换热性能较好。随着旋转速度的加快,冷凝端外壁面平均对流换热系数增大,表明换热能力不断提高。仿真研究结果为旋转热管砂轮冷凝端结构优化及后续磨削试验提供了参考,具有较高的实际工程应用价值。

关键词：旋转热管砂轮翅片对流换热研究

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Application of Integrated Database to the Casting Design

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Journal of Materials Science & Technology 2008年第3期24卷 351-355页

作者： In-Sung Cho Seung-Mok yoo Chae-Ho Lim Jeong-Kil Choi KITECH 7-47 Songdo-dongYeonsu-gu

Construction of integrated database including casting shapes with their casting design, technical knowledge, and thermophysical properties of the casting alloys were introduced in the present study. Recognition tech- nique for casting design by industrial computer tomography was used for the construction of shape database. Technical knowledge of the casting processes such as ferrous and non-ferrous alloys and their manufacturing process of the castings were accumulated and the search engine for the knowledge was developed. Database of thermophysical properties of the casting alloys were obtained via the experimental study, and the properties were used for the in-house computer simulation of casting process. The databases were linked with intelligent casting expert system developed in center for e-design, KITECH. It is expected that the databases can help non casting experts to devise the casting and its process. Various examples of the application by using the databases were shown in the present study.

关键词： Integrated database Casting design Shape recognition

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Polaron Effect of a Two Electron Parabolic Quantum Dot

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Communications in Theoretical Physics 2013年第6期59卷 763-768页

作者： S.Saravana Kumar A.John Peter Chang Kyoo yoo Department of Physics Nadar Saraswathi College of Engineering and Tecchnology Vadapudupatti Department of Physics Government Arts College Center for Environmental Studies/Green Energy Center Department of Environmental Science and Engineering Collegeof Engineering Kyung Hee University

Polaron induced double electron in a quantum dot is investigated using the exact diagonalization techniques and the compact density-matrix approach. The dependence of nonlinear optical processes on the incident photon energies and the polaronic effect are brought out. The linear, third order non-linear optical absorption coefficients and the refractive index changes of singlet and triplet states as a function of photon energy are obtained with and without the inclusion of polaronic effect. It is found that the geometrical confinement and the effect of polaron have great influence on the optical properties of dots.

关键词： parabolic quantum dot correlation energy semiconductor

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