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Journal of Integrative Nursing 2021年第3期3卷 128-134页

作者： subhash kumar saini Vandna PANDEY Ashok kumar Abhay ELHENCE AIIMS Jodhpur2Department of College of NursingAIIMSJodhpur3Department of OrthopaedicsAIIMSJodhpurIndia

Objective:The objective of the study was to identify musculoskeletal problems(MSPs)among nursing *** and Methods:A nonexperimental research design was *** hundred and seventy nursing officers were selected by purposive sampling *** standardized Nordic questionnaire was used to assess the MSPs and self-structured three-point rating scale was used to assess expressed practice of body mechanics of nursing ***:The study findings revealed that 64.4% of nursing officers suffered from MSP such as ache,pain,and discomfort during the past 12 months and 43.7% during the past 7 *** problem in the low back and the neck were highest 45.1% and 22.2%,*** was followed by MSP of the upper back(14.0%),ankles(13.7%),knees(10.7%),shoulder(10.3%),hip/thighs(5.9%),wrists(4.4%),and elbows(3.3%).Around 49.2%complained that MSPs limit their *** was significant association of MSP with selected personal variables like body mass index(P=0.001)and family history(P=0.02).There were also significant association of expressed practices of body mechanics with gender(P=0.01),area of current work(P=0.00),professional experience(P=0.03)and physical activity(P=0.00).Conclusion:The study indicates the large number of nursing officers had MSPs with the two most common sites being the lower back and the *** creates a need for prompt hospital education programs aimed to create awareness among nursing officers on the prevalence of MSPs.

关键词： Expressed practice musculoskeletal problems nursing officers

Improved Energy Management Strategy for Prosumer Buildings with Renewable Energy Sources and Battery Energy Storage Systems

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 381-392页

作者： Pavitra Sharma Krishna kumar saini Hitesh Datt Mathur Puneet Mishra Department of Electrical&Electronics Engineering Birla Institute of Technology&SciencePilaniIndia IEEE

The concept of utilizing microgrids(MGs)to convert buildings into prosumers is gaining massive popularity because of its economic and environmental *** pro-sumer buildings consist of renewable energy sources and usually install battery energy storage systems(BESSs)to deal with the uncertain nature of renewable energy ***,because of the high capital investment of BESS and the limitation of available energy,there is a need for an effective energy management strategy for prosumer buildings that maximizes the profit of building owner and increases the operating life span of *** this regard,this paper proposes an improved energy management strategy(IEMS)for the prosumer building to minimize the operating cost of MG and degradation factor of ***,to estimate the practical operating life span of BESS,this paper utilizes a non-linear battery degradation *** addition,a flexible load shifting(FLS)scheme is also developed and integrated into the proposed strategy to further improve its *** proposed strategy is tested for the real-time annual data of a grid-tied solar photovoltaic(PV)and BESS-powered AC-DC hybrid MG installed at a commercial ***,the scenario reduction technique is used to handle the uncertainty associated with generation and load *** validate the performance of the proposed strategy,the results of IEMS are compared with the well-established energy management *** simulation results verify that the proposed strategy substantially increases the profit of the building owner and operating life span of ***,FLS enhances the performance of IEMS by further improving the financial profit of MG owner and the life span of BESS,thus making the operation of prosumer building more economical and efficient.

关键词： Prosumer building battery energy storage system(BESS) battery degradation factor demand response energy management microgrid solar photovoltaic(PV)system

Transcriptomic and pathological profiling of a new congenic mouse model with Lepr mutation:Evaluating susceptibility to the development of obesity and NAFLD

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Genes & Diseases 2024年第3期11卷 34-38页

作者： MJ Mahesh kumar Shailendra Arindkar Masum saini Perumal Nagarajan National Institute of Immunology New Delhi 100067India Center for Cellular and Molecular Biology Hyderabad 500007India Regional Center for Biotechnology Faridabad 121001India

Non-alcoholic fatty liver disease(NAFLD)and type 2 diabetes mellitus(T2DM)are two disease conditions for which obesity is a risk factor.^(1)Due to the close relationship between the three pathologies,researchers frequently use the same mouse models to identify the underlying processes of obesity,NAFLD,and *** instance,leptin(Lep)-null(ob/ob)and leptin receptor(Lepr)-deficient(db/db)mice spontaneously develop NAFLD and show different phenotypes of extreme obesity and diabetes,respectively.

关键词： obesity NAFLD Lep

Morphological and molecular description of a new species of sandfly,Sergentomyia(Neophlebotomus)ashwanii ***.(Diptera:Psychodidae)from Western Ghats,India

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Asian Pacific Journal of Tropical Medicine 2024年第5期17卷 226-234页

作者： Prasanta saini Harish kumar Shah Mathew Jessu Sonia T Tom Anns KP Amju ICMR-Vector Control Research Centre(Field Station) KottayamKeralaIndia

Objective:To report a new species of sandfly,Sergentomyia(Neophlebotomus)ashwanii ***.(Diptera:Psychodidae)from Western Ghats,***:A systematic sandfly survey was conducted in the Thrissur and Kollam districts of Kerala,India using mechanical aspirators,light and sticky traps,both indoor and outdoor habitats,for a period of one *** acid barcoding of samples was performed targeting mitochondrial cytochrome oxidase I(COI)gene and sequence generated was subjected to phylogenetic ***:Sergentomyia(Neophlebotomus)ashwanii,a new sandfly species is recorded and described in this communication.A single row of 10-12 pointed teeth in the cibarium with 4-6 small denticles or fore-teeth are the key characteristics that is distinctive from other members of the subgenus *** COI barcode followed by phylogenetic analysis of the nucleotide sequence confirms that specimens of the species belong to the same taxonomic group while the genetic distance(14.2%)with the congeners established it to be a different ***:The Western Ghats'being an important biodiversity hotspot and has dearth of systematic entomological surveys on *** current study tried to fill the void and also report a new sandfly species.

关键词： Sergentomyia(Neophlebotomus)ashwanii COI barcode Western Ghats Phlebotomine sandflies

Advancing orthopaedic trauma care through WhatsApp:An analysis of clinical and non-clinical applications,challenges,and future directions

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World Journal of Orthopedics 2024年第6期15卷 529-538页

作者： Ravi saini Madhan Jeyaraman Naveen Jeyaraman Vijay kumar Jain Swaminathan Ramasubramanian Karthikeyan P Iyengar Department of Orthopaedics Atal Bihari Vajpayee Institute of Medical SciencesDr Ram Manohar Lohia HospitalNew Delhi 110001India Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia Department of Trauma and Orthopaedics Southport and Ormskirk HospitalsMersey and West Lancashire Teaching NHS TrustSouthport PR86PNUnited Kingdom

The integration of WhatsApp,a widely-used instant messaging application(IMA),into the realm of orthopaedics and trauma surgery has emerged as a significant development in recent *** paper explores the multifaceted role of WhatsApp in orthopaedics,focusing on its clinical and non-clinical applications,advantages,disadvantages,and future *** study synthesizes findings from various research papers,emphasizing the growing reliance on mobile technology in ***’s role in orthopaedics is notable for its ease of use,real-time communication,and ***,it facilitates triage,teleconsultation,diagnosis,treatment,patient advice,and post-operative ***-clinically,it supports telemedicine,teleradiology,virtual frac-ture clinics,research,and education in orthopaedic *** application has proven beneficial in enhancing communication among healthcare teams,providing quick responses,and motivating junior *** use in educational settings has been shown to improve learner’s understanding and patient ***,the use of WhatsApp in orthopaedics is not without *** include the potential spread of misleading information,privacy concerns,and issues with image quality affecting diagnosis and treatment *** paper acknowledges the importance of maintaining professional boundaries and the need for oversight measures to ensure content *** forward,the potential of WhatsApp and similar IMAs in orthopaedics lies in their ability to streamline data collection and retrieval,improve doctor-patient communication,and address challenges like bureaucratic red tape and limited *** paper suggests that future orthopaedic practice,particularly in emergency departments,will increasingly rely on such technologies for efficient patient *** shift,however,must be approached with an understanding of the ethical,legal,and practical implications of integrating social media and mobile

关键词： Social media WhatsApp Orthopaedics Trauma Research

Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： saini Setua Shabia Shabir Poornima Shaji Ana Martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh K.Mittal Nirakar Sahoo Tripti saini Francesco Giorgianni Mohammad Sikander Andrew E.Massey Bilal B.Hafeez Manish K.Tripathi Vincent P.Diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema Khan subhash C.Chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of Excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAC tumors,thus imply feasibility of developing a novel personalized medicine for PDAC patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

Management of proximal tibial stress fracture associated with advanced knee osteoarthritis:A systematic review

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Chinese Journal of Traumatology 2024年第3期27卷 147-152页

作者： Mukesh kumar saini Mahendra Singh Devendra Singh Prem Manohar Seervi Pera Jayavardhan Reddy Neelam Ramana Reddy Department of Orthopaedics Dr SN Medical CollegeJodhpur342011India Department of Orthopaedics Star HospitalsB Block Banjara HillsHyderabad500034India

Purpose:Tibial stress fracture associated with knee osteoarthritis is an unusual and difficult clinical *** is no clear existing treatment guideline for this uncommon clinical *** aim of this study is to review the impact of various treatment options for patients with advanced knee osteoarthritis associated with proximal tibial stress ***:The study was performed using the databases of PubMed and *** index for non-randomized studies score was used to evaluate the included studies’*** concluded data included the treatment approach,reported outcome measure,and time to fracture *** literature search was started in December 2021 and accomplished in January 2022.A narrative description of the different methods and comparison of their results were ***:Out of total assessed 69 studies,9 studies were included in our *** commonest treatment approach used was total knee arthroplasty by long tibial stem *** mean preoperative knee society score and knee functional score were 30.62 and 23.17,*** mean postoperative knee society knee score was 86.87,while the functional score was *** average reported time to achieve fracture union was 4 months(a range of 2.07-5.50 months).Conclusion:The optimal clinical outcome for treating either acute or mobile tibial stress fracture in patients with advanced knee osteoarthritis can be achieved with long stem total knee ***,due to heterogeneity of data,comparison of different treatment options for chronic proximal tibial stress fracture mal-union/non-union coexisting with knee osteoarthritic and such inferences need to be judged cautiously.

关键词： Tibial stress fracture Knee osteoarthritis Total knee arthroplasty

Metformin reduces testosterone level in type 2 diabetes mellitus patients and its therapy by traditional medicine

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Clinical Traditional Medicine and Pharmacology 2024年第4期5卷 19-26页

作者： Gorika Tomar Mitushi Singh Isha Sharma Anuj Nautiyal Saurabh Aggarwal subhash Chandra Havagiray R.Chitme Cassio Rocha Medeiros Micheline de Azevedo Lima Lucia Raquel de Lima Henrique Douglas Melo Coutinho Bhavna kumar Department of Pharmacy Practice School of Pharmaceutical SciencesSGRR UniversityPatel NagarDehradun 248001UttarakhandIndia Department of Medicine Shri MahantIndiresh HospitalSGRR UniversityPatel NagarDehradun 248001UttarakhandIndia Department of Pharmaceutical Chemistry School of Pharmaceutical SciencesSGRR UniversityPatel NagarDehradun 248001UttarakhandIndia Department of Pharmacology and Toxicology Amity Institute of PharmacyAmity UniversitySector-125Noida 201313 UPGwaliorIndia CECAPE College Av.Padre Cícero3917-São JoséJuazeiro do Norte 63024-015CEBrazil Department of Molecular Biology Federal University of Paraiba-UFPBJoao Pessoa 58051-900ParaibaBrazil Department of Biological Chemistry Regional University of Cariri-URCACrato 63105-000CEBrazil Department of Pharmaceutics DIT UniversityDehradun 248009UttarakhandIndia

Background:Type 2 Diabetes Mellitus(T2DM)is a chronic metabolic disorder characterized by insulin resistance and ***,a commonly prescribed treatment for T2DM,is known for its effectiveness in improving glycemic *** studies suggest that metformin may also influence testosterone levels in male patients,a hormone crucial for male reproductive health,muscle mass maintenance,and overall quality of *** plants were traditionally used for influencing the testosterone level in the body which may be given as a therapy for the side–effects of metformin ***:To assess the impact of metformin treatment on testosterone levels in male patients with T2DM compared to non-diabetic males,and to evaluate the potential implications of traditional medical treatments in managing the consequences of reduced testosterone ***:This study is a prospective observational investigation conducted among a total of 60 patients,divided into two groups:30 males taking metformin as a hyperglycaemic agent with T2DM and 30 males without any diabetic *** study was be carried out in different outpatient department of Shri Mahant Indiresh Hospital,Patel Nagar,Dehradun to assess the level of testosterone in male patients with T2DM taking metformin and in non-Diabetic *** on these findings,potential traditional medicines methods for reducing testosterone levels were ***:It was demonstrated that male patients with T2DM undergoing metformin treatment exhibited significant reduction in testosterone serum levels compared to non-diabetic *** plants were examinedand,and clinical studies were conducted on *** was discovered that these plants have been effective in increasingtestosterone level,suggesting their potential use as therapy for ***:This study shows reduction in the testosterone levels,which may lead to low sex drives and induction of low testosterone induced erectile dy

关键词： Type 2 diabetes mellitus Testosterone Metformin Erectile dysfunction Hyperglycaemia

Mitigation of the impacts of electric vehicle charging on energy-star ratings for residential buildings in India

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Clean Energy 2023年第5期7卷 981-993页

作者： Rakesh Dalal Devender kumar saini Electrical Cluster School of EngineeringUniversity of Petroleum and Energy Studies(UPES)DehradunIndia

The star-labelling programme for residential buildings was introduced by India in 2020 and applies to all residential buildings with no lower limit on the built-up area or electrical *** energy-star label for a residential building is awarded against the notified standard by the regulatory body and electric vehicles(EVs)have not been accommodated as a load for residential *** en-ergy consumption of an existing residential building is taken from a study already carried out and compared with the requirement of the Indian residential star-labelling programme with an EV as a plugged-in *** annual energy gap of 6060 kWh for the existing residential buildings considered in this study for five-star building energy labels increases to 7784 kWh if the EV load is added to the building *** residential building will lose two energy stars if it caters to the EV load and,to bridge this energy gap,the replace-ment of existing electrical appliances with five-star-rated energy appliances,employing grid-connected rooftop solar photovoltaics(PV)and retrofit of the building envelope are *** techno-economic potential of rooftop solar PV and building envelope retrofitting for existing residential buildings is explored using RETScreen®and eQUEST software,*** study establishes that the installation of rooftop solar PV can accommodate the additional load of EVs and can bridge half and three-quarters of the energy gap to achieve five energy stars for an existing building with and without EVs,*** is the most economical option among the options explored in this *** target Energy Performance Index is achievable by high-end energy consumers(12000 kWh/year)by additional measures,the replacement of inefficient electrical appliances and building envelope retrofitting in addition to the installation of rooftop solar PV.

关键词： energy conservation building code energy-star building envelope retrofit EV load

Quantization error in stereo imaging system with noise distributions

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International Journal of Modeling, Simulation, and Scientific Computing 2020年第5期11卷 86-117页

作者： Deepika saini Sanjeev kumar Department of Mathematics Graphic Era Deemed to be University Dehradun Uttarakhand 248002India Department of Mathematics Indian Institute of Technology Roorkee Roorkee 247667India

The problem of estimating quantization error in 2D images is an inherent problem in computer *** outcome of this problem is directly related to the error in reconstructed 3D position coordinates of an *** estimation of quantization error has its own importance in stereo *** the quantization error cannot be controlled fully,still statistical error analysis helps us to measure the performance of stereo systems that relies on the imaging ***,it is assumed that the quantization error in 2D images is distributed uniformly that need not to be true from a practical *** this paper,we have incorporated noise distributions(Triangular and Trapezoidal)for the stochastic error analysis of the quantization error in stereo imaging *** the validation of the theoretical analysis,the detailed simulation study is carried out by considering different cases.

关键词： Quantization error stereo images noise distributions range estimation error range error magnitude relative range error