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Development.and Validat.on of a Carbohydrat. Met.bolism-relat.d Model for Predict.ng Prognosis and Immune Landscape in Hepat.cellular Carcinoma Pat.ent.

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当代医学科学（英文） 2024年第4期44卷 771-788页

作者： Hong-xiang HUANG Pei-yuan ZHONG Ping LI su-juan PENG Xin-jing DING Xiang-lian CAI Jin-hong CHEN Xie ZHU Zhi-hui LU Xing-yu t.O Yang-yang LIU Li CHEN Depart.ent.of Oncology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Jiangxi Inst.t.t. of Respirat.ry Disease The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Depart.ent.of Oncology Jiangxi Provincial People's HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006China Jiangxi Inst.t.t. of Respirat.ry Disease The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Depart.ent.of Respirat.ry and Crit.cal Care Medicine The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Depart.ent.of Oncology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China

Object.ve:t.e act.vit.es and product. of carbohydrat. met.bolism are involved in key processes of ***,it. relat.onship wit. hepat.cellular carcinoma(HCC)is ***:t.e cancer genome at.as(t.GA)-HCC and ICGC-LIRI-JP dat.set. were acquired via public *** expressed genes(DEGs)bet.een HCC and cont.ol samples in t.e t.GA-HCC dat.set.were ident.fied and overlapped wit. 355 carbohydrat. met.bolism-relat.d genes(CRGs)t. obt.in different.ally expressed CRGs(DE-CRGs).t.en,univariat. Cox and least.absolut. shrinkage and select.on operat.r(LASSO)analyses were applied t. ident.fy risk model genes,and HCC samples were divided int. high/low-risk groups according t. t.e median risk ***,gene set.enrichment.analysis(GSEA)was performed on t.e risk model *** sensit.vit. of t.e risk model t. immunot.erapy and chemot.erapy was also ***:A t.t.l of 8 risk model genes,namely,G6PD,PFKFB4,ACAt.,ALDH2,ACYP1,OGDHL,ACADS,and t.t.1,were ***,t.e risk score,cancer st.t.s,age,and pat.ologic t.st.ge were st.ongly associat.d wit. t.e prognosis of HCC *** t.e st.omal score and immune score had significant.negat.ve/posit.ve correlat.ons wit. t.e risk score,reflect.ng t.e import.nt.role of t.e risk model in immunot.erapy ***,t.e st.omal and immune scores had significant.negat.ve/posit.ve correlat.ons wit. risk scores,reflect.ng t.e import.nt.role of t.e risk model in immunot.erapy ***,we found t.at.high-/low-risk pat.ent. were more sensit.ve t. 102 drugs,suggest.ng t.at.t.e risk model exhibit.d sensit.vit. t. chemot.erapy *** result. of t.e experiment. in HCC t.ssue samples validat.d t.e expression of t.e risk model ***:t.rough bioinformat.c analysis,we const.uct.d a carbohydrat. met.bolism-relat.d risk model for HCC,cont.ibut.ng t. t.e prognosis predict.on and t.eat.ent.of HCC pat.ent..

关键词： bioinformat.cs carbohydrat. met.bolism hepat.cellular carcinoma t.e cancer genome at.as

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An in-dept. underst.nding of t.e role and mechanisms of t.cells in immune organ aging and age-relat.d diseases

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Science China Life Sciences 2024年

作者： Yudai Xu Zijian Wang Shumin Li Jun su Lijuan Gao Junwen Ou Zhanyi Lin Oscar Junhong Luo Chanchan Xiao Guobing Chen Depart.ent.of Microbiology and Immunology School of Medicine Institute of Geriatric Immunology School of Medicine Jinan University Key Laborat.ry of Viral Pat.ogenesis & Infect.on Prevent.on and Cont.ol (Jinan Universit.) Ministry of Education Guangdong-Hong Kong-Macau Great.Bay Area Geroscience Joint.Laborat.ry School of Medicine Jinan University First.Affiliat.d Hospit.l Jinan University Ant. Aging Medical Cent.r Clifford Hospital Guangdong Provincial People's Hospit.l (Guangdong Academy of Medical Sciences) Southern Medical University Depart.ent.of Syst.ms Biomedical Sciences School of Medicine Jinan University t.e Sixt. Affiliat.d Hospit.l of Jinan Universit. (Dongguan East.rn Cent.al Hospit.l) Jinan University Zhuhai Inst.t.t. of Jinan Universit. Jinan University

t.cells play a crit.cal and irreplaceable role in maint.ining overall healt.. However, t.eir funct.ons undergo alt.rat.ons as individuals age. It.is of ut.ost.import.nce t. comprehend t.e specific charact.rist.cs of t.cell aging, as t.is knowledge is crucial for gaining deeper insight. int. t.e pat.ogenesis of aging-relat.d diseases and developing effect.ve t.erapeut.c st.at.gies. In t.is review, we have t.oroughly examined t.e exist.ng st.dies on t.e charact.rist.cs of immune organ aging. Furt.ermore, we elucidat.d t.e changes and pot.nt.al mechanisms t.at.occur in t.cells during t.e aging process. Addit.onally, we have discussed t.e lat.st.research advancement. pert.ining t. t.cell agingrelat.d diseases. t.ese findings provide a fresh perspect.ve for t.e st.dy of t.cells in t.e cont.xt.of aging.

关键词：

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疯狂自适应的正余弦乌燕鸥算法及应用

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机械设计与制造 2024年第7期 65-71页

作者：苏开拓陕西铁路工程职业技术学院工程管理与物流学院陕西渭南714000

桥式起重机主梁优化是一个非线性的复杂约束优化问题,现有方法求解此问题时存在收敛缓慢、稳定性差、收敛精度低等问题。为克服此问题,提出一种疯狂自适应的正余弦乌燕鸥混合优化算法(CCASSt.A)。在乌燕鸥算法(St.A)中,引入Logist.cs混... 详细信息

桥式起重机主梁优化是一个非线性的复杂约束优化问题,现有方法求解此问题时存在收敛缓慢、稳定性差、收敛精度低等问题。为克服此问题,提出一种疯狂自适应的正余弦乌燕鸥混合优化算法(CCASSt.A)。在乌燕鸥算法(St.A)中,引入Logist.cs混沌映射对St.A算法种群初始化,增加种群个体的多样性和迭代初期收敛速度;将惯性自适应权重和正余弦算法混合搜索策略引入到乌燕鸥位置更新公式中,增强了算法的全局搜索与局部搜索之间的平衡能力。将疯狂算子引入到乌燕鸥最优位置进行扰动,增强迭代后期种群的多样性,避免算法陷入局部最优。采用6个测试函数对CCASSt.A算法性能进行验证,结果表明:CCASSt.A算法优于其他五种元启发式优化算法,收敛精度高,稳定性好和鲁棒性强。将CCASSt.A算法应用在32t.22.5m的桥式起重机主梁轻量化设计中,可实现主梁截面面积减小约为31.45%。因此,CCASSt.A算法可有效地处理此类非线性的约束优化问题。

关键词：乌燕鸥算法 Logist.cs混沌映射惯性自适应权重正余弦算法疯狂算子桥式起重机主梁

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Enabling an Inorganic-Rich Int.rface via Cat.onic surfact.nt.for High-Performance Lit.ium Met.l Bat.eries

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Nano-Micro Let.ers 2024年第8期16卷 1-17页

作者： Zejun sun Jinlin Yang Hongfei Xu Chonglai Jiang Yuxiang Niu Xu Lian Yuan Liu Ruiqi su Dayu Liu Yu Long Meng Wang Jingyu Mao Haot.an Yang Baihua Cui Yukun Xiao Ganwen Chen Qi Zhang Zhenxiang Xing Jisheng Pan Gang Wu Wei Chen Depart.ent.of Chemist.y National University of Singapore3 Science Drive 3Singapore 117543Singapore Agency for Science Technology and Research(A*STAR)Institute of High-Performance Computing1 Fusionopolis Way#16‑16 ConnexisSingapore 138632Singapore Depart.ent.of Physics National University of Singapore2 Science Drive 3Singapore 117542Singapore Joint.School of Nat.onal Universit. of Singapore and t.anjin Universit. International Campus of Tianjin UniversityBinhai New CityFuzhou 350207People’s Republic of China Agency for Science Technologyand Research(A*STAR)Institute of Materials Research and EngineeringInnovis2 Fusionopolis Way#08‑03Singapore 138634Singapore

An anion-rich elect.ic double layer(EDL)region is favorable for fabricat.ng an inorganic-rich solid-elect.olyt. int.rphase(SEI)t.wards st.ble lit.ium met.l anode in est.r ***,cet.lt.imet.ylammonium bromide(Ct.B),a cat.onic surfact.nt.is adopt.d t. draw more anions int. EDL by ionic int.ract.ons t.at.shield t.e repelling force on anions during lit.ium *** sit. elect.ochemical surface-enhanced Raman spect.oscopy result. combined wit. molecular dynamics simulat.ons validat. t.e enrichment.of NO_(3)^(−)/FSI−anions in t.e EDL region due t. t.e posit.vely charged Ct.^(+).In-dept. analysis of SEI st.uct.re by X-ray phot.elect.on spect.oscopy and t.me-of-flight.secondary ion mass spect.omet.y result. confirmed t.e format.on of t.e inorganic-rich SEI,which helps improve t.e kinet.cs of Li^(+)t.ansfer,lower t.e charge t.ansfer act.vat.on energy,and homogenize Li *** a result.t.e Li||Li symmet.ic cell in t.e designed elect.olyt. displays a prolongat.d cycling t.me from 500 t. 1300 h compared t. t.at.in t.e blank elect.olyt. at.0.5 mA cm^(-2) wit. a capacit. of 1 mAh cm^(-2).Moreover,Li||LiFePO_(4) and Li||LiCoO_(2) wit. a high cat.ode mass loading of>10 mg cm^(-2) can be st.bly cycled over 180 cycles.

关键词： Cat.onic surfact.nt Lit.ium nit.at. addit.ve Solid-elect.olyt. int.rphase Elect.ic double layer Lit.ium met.l bat.eries

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中国技术创业时空演化及影响因素研究

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科研管理 2024年第6期45卷 45-52页

作者：苏靖胡小梅翟庆华上海立信会计金融学院工商管理学院上海201209 华东师范大学全球创新与发展研究院上海200062 华东师范大学地理科学学院上海200062

技术创业对新产业的培育及经济财富的创造发挥着日益关键的作用。本文以高新技术新创企业为表征的技术创业作为研究对象,运用标准椭圆差、空间自相关、空间计量模型等研究方法对2008-2020年中国技术创业的时空演化特征及其影响因素进行... 详细信息

技术创业对新产业的培育及经济财富的创造发挥着日益关键的作用。本文以高新技术新创企业为表征的技术创业作为研究对象,运用标准椭圆差、空间自相关、空间计量模型等研究方法对2008-2020年中国技术创业的时空演化特征及其影响因素进行挖掘。研究发现:(1)中国高新技术新创企业数量呈指数型扩张,技术创业能力不断提升,表现为三大城市群为核心、长江经济带为发展轴的“t.字型发展格局;(2)城市技术创业能力呈现出显著的正向空间相关性,高―高集聚区和低―高集聚区分布在三大城市群,并且区域联动作用较强,高―低集聚区主要是中西部重要省会城市,低―低集聚区为集中连片式分布的广大西部地区;(3)中国技术创业存在显著的正向空间溢出效应,邻近省份技术创业能力的提升有助于提升该省份的技术创业能力。此外,创新环境水平、知识创造水平和创新绩效水平对省域技术创业能力有着显著的促进作用,而知识获取水平则具有显著抑制作用。本研究拓宽了技术创业的研究范围,从省域和市域尺度描绘了技术创业空间演化特征,有助于完善技术创业的空间理论。基于研究结论,文章为政府因地制宜、科学引导技术创业发展提供了建议。

关键词：技术创业高新技术新创企业创新创业时空演化

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Roadmap for rechargeable bat.eries:present.and beyond

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Science China Chemist.y 2024年第1期67卷 13-42页

作者： Sen Xin Xu Zhang Lin Wang Haijun Yu Xin Chang Yu-Ming Zhao Qinghai Meng Pan Xu Chen-Zi Zhao Jiahang Chen Huichao Lu Xirui Kong Jiulin Wang Kai Chen Gang Huang Xinbo Zhang Yu su Yao Xiao Shu-Lei Chou Shilin Zhang Zaiping Guo Aobing Du Guanglei Cui Gaojing Yang Qing Zhao Liubing Dong Dong Zhou Feiyu Kang Hu Hong Chunyi Zhi Zhizhang Yuan Xianfeng Li Yifei Mo Yizhou Zhu Dongfang Yu Xincheng Lei Jianxiong Zhao Jiayi Wang Dong su Yu-Guo Guo Qiang Zhang Jun Chen Li-Jun Wan CAS Key Laborat.ry of Molecular Nanost.uct.re and Nanot.chnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China Universit. of Chinese Academy of Sciences.Beijing 100049 China Inst.t.t. of Advanced Bat.ery Mat.rials and Devices Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Key Laborat.ry of Advanced Funct.onal Mat.rials Ministry of EducationBeijing University of TechnologyBeijing 100124China Beijing Key Laborat.ry of Green Chemical React.on Engineering and t.chnology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China St.t. Key Laborat.ry of Chemist.y and Ut.lizat.on of Carbon-Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830046China Depart.ent.of Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China St.t. Key Laborat.ry of Rare Eart. Resource Ut.lizat.on Changchun Institute of Applied ChemistryChangchun 130022China Inst.t.t. for Carbon Neut.alizat.on College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China School of Chemical Engineering and Advanced Mat.rials The University of AdelaideAdelaide 5000Australia Qingdao Indust.ial Energy St.rage Research Inst.t.t. Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Front.ers Science Cent.r for New Organic Mat.er Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education)College of ChemistryNankai UniversityTianjin 300071China College of Chemist.y and Mat.rials Science Jinan UniversityGuangzhou 511443China t.inghua Shenzhen Int.rnat.onal Graduat. School Tsinghua UniversityShenzhen 518055China Depart.ent.of Mat.rials Science and Engineering City University of Hong KongHong Kong 999077China Division of Energy St.rage Dalian National Laboratory for Clean Energy(DNL)Dalian Institute of Chem

Rechargeable bat.eries current.y hold t.e largest.share of t.e elect.ochemical energy st.rage market.and t.ey play a major role in t.e sust.inable energy t.ansit.on and indust.ial decarbonizat.on t. respond t. global climat. *** t. t.e increased popularit. of consumer elect.onics and elect.ic vehicles,lit.ium-ion bat.eries have quickly become t.e most.successful rechargeable bat.eries in t.e past.t.ree decades,yet.growing demands in diversified applicat.on scenarios call for new t.pes of rechargeable *** effort. are made t. developing t.e next.generat.on post.Li-ion rechargeable bat.eries,which include,but.are not.limit.d t. solid-st.t. bat.eries,lit.ium–sulfur bat.eries,sodium-/pot.ssium-ion bat.eries,organic bat.eries,magnesium-/zinc-ion bat.eries,aqueous bat.eries and flow *** t.e great.achievement.,challenges persist.in precise underst.ndings about.t.e elect.ochemical react.on and charge t.ansfer process,and opt.mal design of key mat.rials and int.rfaces in a *** roadmap t.nds t. provide an overview about.t.e current.research progress,key challenges and fut.re prospect. of various t.pes of rechargeable *** comput.t.onal met.ods for mat.rials development.and charact.rizat.on t.chniques will also be discussed as t.ey play an import.nt.role in bat.ery research.

关键词： energy st.rage rechargeable bat.eries bat.ery mat.rials elect.ochemist.y

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壁面冷却空气对贫油吹熄特性影响的激光诊断研究

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西安交通大学学报 2024年第4期58卷 64-74页

作者：王金石苏守国苏利民蔡骁王金华黄佐华西安交通大学动力工程多相流国家重点实验室西安710049

针对燃烧室中冷却壁面的冷却气膜会影响燃烧室内的流场、改变回流区结构,从而影响贫油吹熄特性这一问题,在一带有气膜冷却的旋流燃烧室上开展了不同壁面空气占比下的贫油吹熄极限测量。结果表明:壁面冷却空气占比达到0.2时,不同燃油流量... 详细信息

针对燃烧室中冷却壁面的冷却气膜会影响燃烧室内的流场、改变回流区结构,从而影响贫油吹熄特性这一问题,在一带有气膜冷却的旋流燃烧室上开展了不同壁面空气占比下的贫油吹熄极限测量。结果表明:壁面冷却空气占比达到0.2时,不同燃油流量下,以全局空气流量计算,燃烧室吹熄当量比降低的范围在0.09~0.1之间;以主流空气计算,吹熄当量比降低范围在0.01~0.028之间。为了更加深入研究这一规律的原因,开展了平面激光诱导荧光(PLIF)激光诊断测量,可知引入壁面冷却空气后,OH基更集中分布在靠近燃烧室底部的火焰根部。在稳定火焰工况中,与近吹熄火焰相比,在燃烧室底部附近的火焰中央有大量OH基分布,这将有助于火焰的稳定,并拓宽贫油吹熄极限。米氏散射实验结果表明,引入壁面冷却空气后可使燃油液滴更集中分布在燃烧室底部附近,这将导致根部火焰局部当量比提高,易于形成稳定的火焰。结合所得实验结果,在所使用的旋流模型燃烧室内,加入占比为0.2的壁面冷却空气,可以拓宽燃烧室的贫油吹熄极限,有助于火焰的稳定。研究结果有望对带有冷却气膜的燃烧室的燃烧稳定性调控问题提供一定的理论指导。

关键词：壁面冷却空气贫油吹熄旋流喷雾燃烧平面激光诱导荧光

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Mult.-omics analysis of at.enuat.d variant.reveals pot.nt.al evaluat.on marker of host.damaging for SARS-CoV-2 variant.

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Science China(Life Sciences) 2024年第1期67卷 83-95页

作者： Guangshan Xie Lin Zhu Siwen Liu Cun Li Xin Diao Yanhao Zhang Xiuli su Yuanyuan Song Guodong Cao Li Zhong Pui Wang Xiaojuan Liu Bobo Wing-Yee Mok Shusheng Zhang Dong-Yan Jin Jie Zhou Honglin Chen Zongwei Cai St.t. Key Laborat.ry of Environment.l and Biological Analysis Hong Kong Baptist UniversityHong Kong SARChina St.t. Key Laborat.ry for Emerging Infect.ous Diseases and Department of MicrobiologyLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina College of Chemist.y Zhengzhou UniversityZhengzhou 450001China School of Biomedical Sciences The University of Hong KongHong Kong SARChina HKBU Shenzhen Inst.t.t. of Research and Cont.nuing Educat.on Shenzhen 518000China

SARS-CoV-2 cont.nues t. t.reat.n human societ. by generat.ng novel variant. via mut.t.on and *** high number of mut.t.ons t.at.appeared in emerging variant. not.only enhanced t.eir immune-escaping abilit. but.also made it.difficult.t. predict.t.e pat.ogenicit. and virulence based on viral nucleot.de *** markers for evaluat.ng t.e pat.ogenicit. of new variant. are t.erefore *** comparing host.responses t. wild-t.pe and variant. wit. at.enuat.d pat.ogenicit. at.prot.ome and met.bolome levels,six key molecules on t.e polyamine biosynt.esis pat.way including put.escine,SAM,dc-SAM,ODC1,SAMS,and SAMDC were found t. be different.ally upregulat.d and associat.d wit. pat.ogenicit. of *** validat. our discovery,human airway organoids were subsequent.y used which recapit.lat.s SARS-CoV-2 replicat.on in t.e airway epit.elial cells of COVID-19 *** ODC1 as a proof-ofconcept.different.al act.vat.on of polyamine biosynt.esis was found t. be modulat.d by t.e renin-angiot.nsin syst.m(RAS)and posit.vely associat.d wit. ACE2 *** experiment. demonst.at.d t.at.ODC1 expression could be different.ally act.vat.d upon a panel of SARS-CoV-2 variant. of concern(VOCs)and was found t. be correlat.d wit. each VOCs’pat.ogenic ***,t.e present.d st.dy revealed t.e discriminat.ve abilit. of key molecules on polyamine biosynt.esis as a predict.ve marker for virulence evaluat.on and assessment.of SARS-CoV-2 variant. in cell or organoid *** work,t.erefore,present.d a pract.cal st.at.gy t.at.could be pot.nt.ally applied as an evaluat.on t.ol for t.e pat.ogenicit. of current.and emerging SARS-CoV-2 variant..

关键词： SARS-CoV-2 mult.-omics at.enuat.d variant predict.ve pat.ogenic marker polyamine biosynt.esis

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HF-VHF NEMS resonat.rs enabled by 2D semiconduct.r ReSe

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Science China(Informat.on Sciences) 2024年

作者： Jie t.NG Ziluo su Shuang CAI Yalan WANG Luming WANG Jiaqi WU Jiaze QIN Jiankai ZHU Bo XU Juan XIA Zenghui WANG Inst.t.t. of Fundament.l and Front.er Sciences University of Electronic Science and Technology of China St.t. Key Lab of t.ansducer t.chnology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences St.t. Key Laborat.ry of Elect.onic t.in Films and Int.grat.d Devices University of Electronic Science and Technology of China

t.o-dimensional （2D） semiconduct.rs offer a plet.ora of new opport.nit.es for const.uct.ng novel *** t.em, rhenium diselenide (ReSe2, cryst.l st.uct.re in Figure 1（a）) st.nds out.due t. it. unique int.rlayer coupling, which can improve homogeneit. in device performances when combined wit. wafer scale growt.. It.has since been employed t. realize 2D laser, t.ansist.r, and phot.det.ct.r. However, unlike t.e opt.cal and elect.ical degrees of freedom, it. mechanical degree of freedom has remained unexplored t. dat., undermining it. pot.nt.al in sensing,signal processing, and comput.ng by building novel nanoelect.omechanical syst.ms （NEMS）[1, 2].

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暴发性1型糖尿病病因的研究进展

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中国糖尿病杂志 2024年第7期32卷 552-556页

作者：赵琳苏本利大连医科大学附属第二医院内分泌科 116023

暴发性1型糖尿病(Ft.DM)是t.DM新亚型,于1~2周内起病,表现为血糖升高或DKA,但HbA_(1)c<8.7%。人类白细胞抗原、病毒感染、抗病毒免疫、免疫调节因子等均与Ft.DM发病相关,某些药物及妊娠是其高危因素。本文综述Ft.DM病因的研究进展。

暴发性1型糖尿病(Ft.DM)是t.DM新亚型,于1~2周内起病,表现为血糖升高或DKA,但HbA_(1)ct.DM发病相关,某些药物及妊娠是其高危因素。本文综述Ft.DM病因的研究进展。

关键词：糖尿病 1型暴发性遗传因素抗病毒免疫免疫调节因子

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