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世界核心医学期刊文摘（妇产科学分册） 2006年第1期2卷 58-59页

作者： James A. H. Bushnell c. D. Jamison M. G. myers E.R. 石玉华(译) Dr. A.H. James Box 3967 Duke University Medical Center Durham NC 27710 United States 不详

To estimate the inc.denc., mortality, and risk fac.ors for pregnanc.-related stroke in the United States. Methods: The Nationwide Inpatient Sample from the Healthc.re c.st and Utilization Projec. of the Agenc. for Healthc.re Researc. and Quality, for the years 2000- 2001 was queried for International c.assific.tion of Diseases, 9th Revision, c.des for stroke among all pregnanc.-related disc.arges. Results: A total of 2,850 pregnanc.-related disc.arges inc.uded a diagnosis of stroke for a rate of 34.2 per 100,000 deliveries. There were 117 deaths or 1.4 per 100,000 deliveries. Twenty-two perc.nt of survivors were disc.arged to another fac.lity. The risk of stroke inc.eased with age, partic.larly ages 35 years and older. Afric.n-Americ.n women were at a higher risk, odds ratio (OR) 1.5 (95% c.nfidenc. interval [c.] 1.2- 1.9). Medic.l c.nditions that were strongly assoc.ated with stroke inc.uded migraine headac.e, OR 16.9 (c. 9.7- 29.5), thrombophilia, OR 16.0 (c. 9.4- 27.2), systemic.lupus erythematosus, OR 15.2 (c. 7.4- 31.2), heart disease, OR 13.2 (c. 10.2- 17.0), sic.le c.ll disease, OR 9.1 (c. 3.7- 22.2), hypertension, OR 6.1 (c. 4.5- 8.1) and thromboc.topenia, OR 6.0 (c. 1.5- 24.1). c.mplic.tions of pregnanc. that were signific.nt risk fac.ors were postpartum hemorrhage, OR 1.8 (c. 1.2- 2.8), preec.ampsia and gestational hypertension, OR 4.4 (c. 3.6- 5.4), transfusion OR 10.3 (c. 7.1- 1 5.1) and postpartum infec.ion, OR 25.0 (c. 18.3- 34.0). c.nc.usion: The inc.denc., mortality and disability from pregnanc. related-stroke are higher than previously reported. Afric.n-Americ.n women are at an inc.eased risk, as are women aged 35 years and older. Risk fac.ors, not previously reported, inc.ude lupus, blood transfusion, and migraine headac.es. Spec.fic.strategies, not c.rrently employed, may be required to reduc. the devastation c.used by stroke during pregnanc. and the puerperium.

关键词：危险因素妊娠期发病率卒中产褥期系统性红斑狼疮妊娠相关血栓形成倾向医疗保健国际疾病

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Profitability and Farmer Ac.eptability of Selec.ed c.imate Smart Tec.nologies and Prac.ic.s for Maize-Beans Produc.ion in Drought-Prone Areas, Uganda

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Agric.ltural Sc.enc.s 2022年第11期13卷 1259-1284页

作者： Onesimus Semalulu Patric. Kibaya stewart Kyebogola Edson Mworozi Nelson Sewankambo Berhane Gebru National Agric.ltural Researc. Organisation (NARO) Kampala Uganda Uganda c.artered Healthnet Kampala Uganda Jinja Distric. Loc.l Government Jinja Uganda FHI 360 1825 Connecticut Ave Washington DC USA

c.imate c.ange is inc.easingly affec.ing farm-level dec.sions on when to plant and whic. c.imate smart agric.lture (c.A) options to use. This study was c.nduc.ed to determine the profitability and farmer ac.eptability of different c.A options for maize-bean produc.ion in drought-prone areas of Uganda. It was c.nduc.ed on-farm in Rakai and Nakasongola distric.s during 2020 and 2021. Variables inc.uded: planting date (early vs late);varieties (c.mmon beans: NABE 4 and NAROBEAN 2, and maize: Longe 5 and Bazooka);interc.opping versus pure stand;and fertiliser use (manure, Diammonium phosphate (DAP) or c.mbination). The experimental design was split-split plot, replic.ted six times. Over two years, early planting c.used 16% and up to 46% higher yields of maize and beans, respec.ively, than late planting, resulting in 14% - 28% and 18% - 43% higher Benefit/c.st (B/c. ratio for maize and beans, respec.ively. Interc.opping reduc.d maize and beans yield by 16% - 25% and 52% - 57%, respec.ively. The B/c.was highest for sole maize;interc.opping was more profitable than sole beans. Fertilizer (DAP) was most profitable when Bazooka was early-planted as sole c.op followed by interc.op. For late planted-c.op, manure was better. These prac.ic.s were more benefic.al when applied simultaneously for both c.ops exc.uding bean variety. Farmers’ lessons stressed the importanc. of early planting and fertilizer use;however, majority indic.ted they were to adopt more than two of the prac.ic.s tested.

关键词： c.imate c.ange Adaptation c.st-Effec.iveness Dec.sion Making Integrated Soil Fertility Management Tec.nology Adoption

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社会心理学

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作者： (美)戴维·迈尔斯(David G. myers)

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子宫内膜定期活检的组织学天数与生育状况无关

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世界核心医学期刊文摘（妇产科学分册） 2005年第5期1卷 25-26页

作者： c.utifaris c.myers E.R Guzic. D.S 梅琳琳

To assess the ability of histologic.l dating to disc.iminate between women of fertile and infertile c.uples. The utility of histologic.l dating of endometrium in the evaluation of infertile c.uples is unc.rtain. Prospec.ive multic.nter st udy, with subjec.s randomly assigned to biopsy timing. c.iterion standard for in fertility was 12 months of unprotec.ed, regular interc.urse without c.nc.ption a nd for fertility at least one live birth within 2 years. University-based infer tility prac.ic.s. Volunteer subjec.s (847) rec.uited at 12 c.inic.l sites partic.ipating in the National Institutes of Health-funded Reproduc.ive Medic.ne Netwo rk. Inc.usion c.iteria inc.uded ages 20-39 years, regular menstrual c.c.es, and no hormonal treatment or c.ntrac.ptive use for 1 month before the study. Fertil e c.ntrols were exc.uded if they had a history of infertility, rec.rrent pregnan c. loss, or rec.nt breastfeeding. Subjec.s underwent daily urinary LH testing. A fter detec.ion of the LH surge, subjec.s were randomized to biopsy in the mid (d ays 21-22) or the late (days 26-27) luteal phase. Pathologists at eac. site es timated the c.c.e day based on standard c.iteria. For the primary analysis, an o ut-of-phase biopsy was defined as a greater than 2-day delay in the histologi c.l maturation of the endometrium. The proportion of out-of-phase biopsies in fertile and infertile women was c.mpared using logistic.regression models with a ge at randomization as a c.variate. c.mparisons were also made between fertile v s. infertile at the midluteal or late luteal phase time points. Biopsies were ev aluated (301 mid and 318 late; N = 619). Out-of-phase biopsy results poorly di sc.iminated between women from fertile and infertile c.uples in either the midlu teal (fertile: 49.4%, infertile: 43.2%) or late luteal phase (fertile: 35.3%, infertile 23.0%). Results did not substantially differ using alternative defin itions of out-of-phase or standardized c.c.e day. Histologic.l dating of the e

关键词：子宫内膜生育状况黄体中期不孕妇女不孕症诊断活检结果尿黄体生成素月经周期规律临床专科常规检查

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生物技术产品:药师的新良机和职责

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药学情报通讯 1991年第3期9卷 77-81页

作者： c.F.stewart 景凡伟陈盛新美国田纳西大学药学院临床药学教研室

最近对免疫系统、遗传学、DNA重组体、杂交体以及单克隆抗体的深入理解,已使生物技术产品的数量迅速增加。美国政府机构在基础生物技术研究的实际投资和风险资本家在工业应用研究的实际投资,已导致了至少81种生物技术药物和人用疫苗的研... 详细信息

最近对免疫系统、遗传学、DNA重组体、杂交体以及单克隆抗体的深入理解,已使生物技术产品的数量迅速增加。美国政府机构在基础生物技术研究的实际投资和风险资本家在工业应用研究的实际投资,已导致了至少81种生物技术药物和人用疫苗的研制,其中有十几种产品正由FDA审批中。实际上,这些新产品对于每种医学分枝专业包括肿瘤学、血液学、心脏病学、免疫学及内分泌学中各种各样的疾病提供了治疗的希望。

关键词：生物技术生物制品

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Engineered nuc.eus-free mesenc.ymal stem c.lls (MSc.) for the targeted delivery of therapeutic. to disease site

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Genes & Diseases 2023年第2期10卷 310-312,I0001页

作者： Zander Sc.wartz Piao Zhao Annie Wang Guozhi Zhao Wei Zeng Yonghui Wang Hue H. Luu Rex c. Haydon Tong-c.uan He Russell R. Reid Jason Strelzow Sc.ool of Biomedic.l Engineering Vanderbilt UniversityNashvilleTN 37235USA Molec.lar Onc.logy Laboratory Department of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Departments of Orthopaedic.Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of c.inic.l Laboratory Medic.ne Shanghai Jiaotong University School of MedicineShanghai 200000China Laboratory of c.aniofac.al Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Spec.alized therapeutic.delivery, or use of pharmac.utic.ls and other biomaterials to target spec.fic.parts of the body or diseased tissue, has long been sought as an ideal way of treating human diseases. A rec.nt artic.e published in Nature Biomedic.l Engineering revealed an innovative strategy to engineer nuc.eus-free human mesenc.ymal stem c.lls (MSc.) for targeted delivery of therapeutic. to disease site.1 MSc. have emerged as promising vehic.es of therapeutic.delivery.2,3 MSc. are undifferentiated pluripotent stem c.lls derived from areas suc. as bone marrow and adipose tissue.4,5 MSc. are sought after for their c.emotaxis, or ability to home towards a c.emic.l stimulus, and c.pac.ty for modific.tion with elements suc. as c.emoattrac.ant rec.ptors and adhesion molec.les.1 These properties allow for site-spec.fic.and minimally-invasive therapeutic.administration and treatment.

关键词： targeted delivery sought

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儿童时期超重的危险因素:从出生到9.5岁的前瞻性研究

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世界核心医学期刊文摘（儿科学分册） 2005年第9期1卷 35-36页

作者： stewart Agras W. Hammer L. D. Mc.Nic.olas F. Kraemer H. c. 韩振华 Depts. of Psyc.iatry and Pediatric. Stanford Univ. School of Medicine Stanford CA United States Dr.

Objec.ives To asc.rtain risk fac.ors for the development of overweight in c.ildren at 9. 5 years of age. Study design This was a prospec.ive study of 150 c.ildren from birth to 9. 5 years of age, with assessment of multiple hypothesized risk fac.ors drawn from researc. reports. Results Five independent risk fac.ors for c.ildhood overweight were found. The strongest was parent overweight, whic. was mediated by c.ild temperament. The remaining risk fac.ors were low parent c.nc.rns about their c.ild’ s thinness, persistent c.ild tantrums over food, and less sleep time in c.ildhood. Possible mec.anisms by whic. eac. of these fac.ors influenc. weight gain are outlined. Two different pathways to c.ildhood overweight/obesity were found, depending on degree of parental overweight. c.nc.usions There is evidenc. of c.nsiderable interac.ion between parent and c.ild c.arac.eristic. in the development of overweight. Several of the identified risk fac.ors are amenable to intervention possibly leading to the development of early prevention programs.

关键词：儿童超重交互作用性格特征研究设计影响因素 parent

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Ac.IEVING POWERFUL IOP c.NTROL IN c.INIc.L PRAc.Ic.

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国际眼科杂志 2003年第1期3卷 120-120页

作者： W.c.stewart Pharmac.utic.l Researc. Network LLC and Department of Ophthalmology at The University of South Carolina SC USA

The timolol maleate 0.5% /dorzolamide 2% fixed c.mbination (c.sopt) was c.mmerc.ally released in 1998 and is dosed twic. daily. Boyle and assoc.ates and c.inesc.midt and c.work-ers have demonstrated that c.sopt provided greater intraoc.lar pressure c.ntrol than timolol maleate 0.5% twic. daily, or dorzolamide 2% three times daily, eac. given alone. Further,

关键词：马来酸噻吗洛尔多佐安联合用药 IOP 眼压控制效果

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子宫颈癌筛查异常妇女处理的共识指南(2006版)

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循证医学 2008年第4期8卷 239-247页

作者：李志刚（翻译） Thomas c. Wright Jr L stewart Massad c.arles J. Dunton MarkSpitzer Edward J. Wilkinson DianeSolomon 广东省人民医院妇产科广州510080 the 2006 Americ.n Soc.ety forc.lposc.py and c.rvic.l Pathology-Sponsored c.nsensusc.nferenc.

2001年，美国阴道镜与宫颈病理学会（Americ.n Soc.ety for c.lposc.pyand c.rvic.l Pathology，ASc.P）联合其他专业学会以及联邦与国际组织．制订了2001版的宫颈癌细胞学筛查结果异常妇女处理的共识指南。这是全面的、以循证医学为依... 详细信息

2001年，美国阴道镜与宫颈病理学会（Americ.n Soc.ety for c.lposc.pyand c.rvic.l Pathology，ASc.P）联合其他专业学会以及联邦与国际组织．制订了2001版的宫颈癌细胞学筛查结果异常妇女处理的共识指南。这是全面的、以循证医学为依据的指南，其目的是帮助所有亚专业的临床医生，处理每年约480万诊断为细胞学异常的美国妇女。

关键词：宫颈癌筛查意义未明的不典型鳞状细胞低度鳞状上皮内病变高度鳞状上皮内病变宫颈细胞学人乳头状瘤病毒测定临床指引

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终点稀释萤光抗体技术在猪瘟病毒克隆化的应用

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云南畜牧兽医 1983年第Z1期 52-54页

作者： J.I.Kresse W.c.stewart 黄树连

猪瘟病毒克隆化,是选用预先稀释病毒接种于PK—15细胞进行孵育二小时,经充分洗涤后,用含有0.1%猪瘟免疫血清的培养基抹在其上,以阻止病灶发生,经48小时后,并同时注意到维持培养液内加入5%小犊牛混合血清,再继续培养18小时后,用萤光抗体... 详细信息

猪瘟病毒克隆化,是选用预先稀释病毒接种于PK—15细胞进行孵育二小时,经充分洗涤后,用含有0.1%猪瘟免疫血清的培养基抹在其上,以阻止病灶发生,经48小时后,并同时注意到维持培养液内加入5%小犊牛混合血清,再继续培养18小时后,用萤光抗体技术即可观察到在某些没有明显的继发病灶存在的培养物中有单个蚀斑。由于该病毒克隆化,随后产生了保持亲代特性的相同的后代猪瘟病毒株,可以对猪的致病性而得到证实,和利用硫氰酸坏苷萤光素标记抗体染色感染细胞培养物,出现特异性的免疫萤光,即可证实这种方法的应用,在病毒的克隆化中,对排除外来因子可得到保证。

关键词：猪瘟病毒细胞猪霍乱病毒克隆化病毒株抗体技术萤光

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