Engineered nucleus-free mesenchymal stem cells (MSCs) for the targeted delivery of therapeutics to disease site
作者机构：School of Biomedical EngineeringVanderbilt UniversityNashvilleTN 37235USA Molecular Oncology LaboratoryDepartment of Orthopedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Departments of Orthopaedic Surgery and UrologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Clinical Laboratory MedicineShanghai Jiaotong University School of MedicineShanghai 200000China Laboratory of Craniofacial Suture Biology and DevelopmentDepartment of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2023年第10卷第2期
页 面：310-312,I0001页
核心收录：
学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学]
基 金：supported in part by research grants from the National Institutes of Health(No.CA226303 to TCH and No.DE030480 to RRR) supported in part by The University of Chicago Cancer Center Support Grant(No.P30CA014599) the National Center for Advancing Translational Sciences(NCATS)of the National Institutes of Health(No.5UL1TR002389) TCH was also supported by the Mabel Green Myers Research Endowment Fund and The University of Chicago Orthopaedics Alumni Fund.Funding sources were not involved in the study design
摘 要：Specialized therapeutic delivery, or use of pharmaceuticals and other biomaterials to target specific parts of the body or diseased tissue, has long been sought as an ideal way of treating human diseases. A recent article published in Nature Biomedical Engineering revealed an innovative strategy to engineer nucleus-free human mesenchymal stem cells (MSCs) for targeted delivery of therapeutics to disease site.1 MSCs have emerged as promising vehicles of therapeutic delivery.2,3 MSCs are undifferentiated pluripotent stem cells derived from areas such as bone marrow and adipose tissue.4,5 MSCs are sought after for their chemotaxis, or ability to home towards a chemical stimulus, and capacity for modification with elements such as chemoattractant receptors and adhesion molecules.1 These properties allow for site-specific and minimally-invasive therapeutic administration and treatment.
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