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Fusobacterium 's link to colorectal neoplasia sequenced: A systematic review and future insights

World Journal of Gastroenterology 2017年第48期23卷 8626-8650页

作者： Hisham Hussan steven k clinton kristen Roberts Michael T Bailey Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineThe Ohio State University Wexner Medical Center Comprehensive Cancer Center The Ohio State University Division of Medical Oncology Department of Internal MedicineThe Ohio State University Wexner Medical Center Department of Pediatrics OSU College of Medicine And Center for Microbial PathogenesisThe Research Institute at Nationwide Children’s Hospital

AIM To critically evaluate previous scientific evidence on Fusobacterium's role in colorectal neoplasia *** Two independent investigators systematically reviewed all original scientific articles published between January,2000,and July,2017,using Pub Med,EMBASE,and MEDLINE. A total of 355 articles were screened at the abstract level. Of these,only original scientific human,animal,and in vitro studies investigating Fusobacterium and its relationship with colorectal cancer(CRC) were included in the analysis. Abstracts,review articles,studies investigating other colonic diseases,and studies written in other languages than English were excluded from our analysis. Ninety articles were included after removing duplicates,resolving disagreements between the two reviewers,and applying the above *** Studies have consistently identified positive associations between Fusobacterium,especially Fusobacterium nucleatum(F. nucleatum),and CRC. Stronger associations were seen in CRCs proximal to the splenic flexure and Cp G island methylator phenotype(CIMP)-high CRCs. There was evidence of temporality and a biological gradient,with increased F. nucleatum DNA detection and quantity along the traditional adenoma-carcinoma sequence and in CIMP-high CRC precursors. Diet may have a differential impact on colonic F. nucleatum enrichment;evidence suggests that high fiber diet may reduce the risk of a subset of CRCs that are F. nucleatum DNA-positive. Data also suggest shorter CRC and disease-specific survival with increased amount of F. nucleatum DNA in CRC tissue. The pathophysiology of enrichment of F. nucleatum and other Fusobacterium species in colonic tissue is unclear;however,the virulence factors and changes to the local colonic environment with disruption of the protective mucus layer may contribute. The presence of a host lectin(Gal-Gal NAc) in the colonic epithelium may also mediate F. nucleatum attachment to CRC and precursors through interaction with a

关键词： Colon microbiota Fusobacterium Systematic review Fusobacterium nucleatum Colorectal cancer Colorectal polyps Carcinogenesis

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The potential role of DEk over-expression in the radiation response of head and neck cancer

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Radiation Medicine and Protection 2021年第1期2卷 28-32页

作者： Hui Xiao Bismarck Odei steven k.clinton Darrion L.Mitchell Department of Radiation Oncology The Ohio State UniversityOH43210USA The Ohio State University Comprehensive Cancer Center The Ohio State UniversityOH43210USA Division of Medical Oncology Department of Internal MedicineThe Ohio State UniversityOH43221USA

Objective:To determine if DEk over-expression is associated with radiation resistance in HPV positive head and neck cancer ***:Control and DEk over-expressing keratinocytes and an HPV positive head and neck cancer cell line respectively were irradiated with 2–10 Gy and the impact on cell survival,γ-H2AX(a marker of DNA damage)and RAD51(homologous recombination)were analyzed via clonogenic assays,and immunofluorescence measurements ***:Upon exposure to increasing doses of radiation,DEk over-expression in keratinocytes at 2,4(Pk cancer cell line at 2,4,8,and 10 Gy(PkS,and at 0,6,24,48 h post-irradiation(Pk over-expressing cell lines relative to their respective control cells at all times points(Pk over-expression contributes to radio-resistance in HPV positive head and neck cancer cells,potentially by improving repair of DNA double strand breaks through homologous *** molecular mechanisms and relevance to in vivo responses needs further investigation.

关键词： HPV Oropharynx Radiation DEk

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