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Resolving impact volatilization and condensation from target rock mixing and hydrothermal overprinting within the Chicxulub impact structure

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Geoscience Frontiers 2022年第5期13卷 16-31页

作者： Thomas Déhais Stepan M.Chernonozhkin Pim Kaskes Sietze j.de Graaff Vinciane Debaille Frank Vanhaecke Philippe Claeys steven Goderis Analytical Environmental and Geo-ChemistryVrije Universiteit BrusselBrusselsBelgium Laboratoire G-Time UniversitécLibre de BruxellesBrusselsBelgium Department of Chemistry Atomic&Mass SpectrometryGhent UniversityGhentBelgium

This work presents isotopic data for the non-traditional isotope systems Fe,Cu,and Zn on a set of Chicxulub impactites and target lithologies with the aim of better documenting the dynamic processes taking place during hypervelocity impact events,as well as those affecting impact structures during the post-impact *** focus lies on material from the recent IODP-ICDP Expedition 364 Hole M0077A drill core obtained from the offshore Chicxulub peak *** ejecta blanket samples from the UNAM 5 and 7 cores were used to compare the crater lithologies with those outside of the impact *** datasets of bulk Fe,Cu,and Zn isotope ratios are coupled with petrographic observations and bulk major and trace element compositions to disentangle equilibrium isotope fractionation effects from kinetic *** observed Fe and Cu isotopic signatures,with δ^(56/54)Fe ranging from0.95‰to 0.58‰and δ^(65/63)Cu from0.73‰to 0.14‰,mostly reflect felsic,mafic,and carbonate target lithology mixing and secondary sulfide mineral formation,the latter associated to the extensive and long-lived(>105 years)hydrothermal system within Chicxulub *** the other hand,the stable Zn isotope ratios provide evidence for volatility-governed isotopic *** heavier Zn isotopic compositions observed for the uppermost part of the impactite sequence and a metamorphic clast(δ^(66/64)Zn of up to 0.80‰and 0.87‰,respectively)relative to most basement lithologies and impact melt rock units indicate partial vaporization of Zn,comparable to what has been observed for Cretaceous-Paleogene boundary layer sediments around the world,as well as for tektites from various strewn *** contrast to previous work,our data indicate that an isotopically light Zn reservoir(δ^(66/64)Zn down to0.49‰),of which the existence has previously been suggested based on mass balance considerations,may reside within the upper impact melt rock(UIM)*** observation is restricted to a few UIM sampl

关键词： Chicxulub impact structure Non-traditional stable isotopes Impact volatilization Impact condensation Hydrothermal alteration Target lithology mixing

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What is the purpose of launching the World journal of Otorhinolaryngology？

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World journal of Otorhinolaryngology 2011年第1期1卷 1-3页

作者： steven j Wang Department of Otolaryngology-Head and Neck Surgery University of California San Francisco CA 94115 United StatesAuthor contributions: Wang SJ solely contributed to this paper.Correspondence to: Steven J Wang MD FACS Associate Professor Department of Otolaryngology-Head and Neck Sur-gery University of California 2233 Post St PO Box 1225 San Francisco CA 94115 United States. swang@ohns.ucsf.edu

We are pleased to announce the launching of the World journal of Otorhinolaryngology （WjO） as a new mem-ber of the World Series journal family. The WjO is a peer-reviewed open-access journal dedicated to pub-lishing original research articles, review articles, clinical studies, and case reports in all areas of otorhinolaryn-gology. Please consider submitting your research fnd-ings in otorhinolaryngology to the WjO.

关键词： Otorhinolaryngology Biomedical sciences Peer-reviewed Open-access journal

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miR398b negatively regulates cotton immune responses to Verticillium dahliae via multiple targets

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The Crop journal 2022年第4期10卷 1026-1036页

作者： Yuhuan Miao Kun Chen jinwu Deng Lin Zhang Weiran Wang jie Kong steven j.Klosterman Xianlong Zhang Alifu Aierxi Longfu Zhu National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070HubeiChina Hubei University of Chinese Medicine Wuhan 430065HubeiChina Oil Crops Research Institute Chinese Academy of Agricultural SciencesWuhan 430062HubeiChina Institute of Economic Crops Xinjiang Academy of Agricultural SciencesUrumchi 842000XinjiangChina United States Department of Agriculture Agricultural Research ServiceSalinasCA 93905USA

MicroRNAs(miRNAs)play essential roles in plant defense responses,although such roles have not been identified in cotton in response to the plant pathogenic fungus Verticillium *** this study,the functions of miR398b and its target genes in *** interaction were *** transcript levels of miR398b were down-regulated by *** infection and miR398b overexpression in cotton made the plants more susceptible to *** results suggest that miR398b negatively regulates cotton resistance to *** may occur by miR398b repression of some CC-NBS-LRR genes via translational inhibition,interfering with defense responses and leading to cotton susceptibility to ***,miR398b may guide the cleavage of the mRNAs of GhCSD1,GhCSD2 and GhCCS,each of which functions in reactive oxygen species(ROS)regulation and homeostasis,thereby causing excessive ROS accumulation in miR398b-overexpressing plants in response to *** *** study suggests conserved and novel roles of miR398b in the cotton–*** *** discoveries may be coupled with new strategies in cotton breeding programs to improve resistance to ***.

关键词： Cotton miR398b NBS-LRR ROS homeostasis Verticillium dahliae

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The US ESRD program-can we get the genie back in the bottle?

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中国血液净化 2014年第12期13卷 851-853页

作者： steven j.Rosansky Dorn Research Institute William Jennings Bryan Dorn VA Medical Center

1972年美国社会保险立法修订案决定为终末期肾病(ESRD)治疗提供基金,并开始对其发病和患病情况进行监测。1988年美国建立了肾脏病数据系统(USRDS),使监测数据更为准确。美国大学的Rosansky教授着眼于ESRD开始透析时机,对美国ESRD管理系... 详细信息

1972年美国社会保险立法修订案决定为终末期肾病(ESRD)治疗提供基金,并开始对其发病和患病情况进行监测。1988年美国建立了肾脏病数据系统(USRDS),使监测数据更为准确。美国大学的Rosansky教授着眼于ESRD开始透析时机,对美国ESRD管理系统进行了回顾,并对美国未来几十年ESRD的发病和患病趋势进行了预测。慢性肾脏病(CKD)时患者肾功能逐渐下降,达到什么程度就能被叫做ESRD?在美国初始覆盖肾脏替代治疗(RRT)时,残余肾功能(RRF)下降到原始值的5%时,患者被称为ESRD,可以接受RRT。之后用作ESRD定义的RRF值逐渐提升到原始值的10%、15%。从1996年到2009年,RRF还剩超过10%的患者即开始RRT的患者占全部开始RRT治疗患者比例从19%上升到54%。但是,最新发表的一系列观察性研究均表明了早开始透析对患者的长期存活是有害的。也许是由于这些研究结果的发布,美国ESRD发病率自2010年后呈下降趋势,同时没有观察到RRT患者死亡率的增加,提示了避免过早透析的安全性和益处。美国ESRD治疗在1981年耗资仅16亿,而2011年高达近340亿元,花费骤增的原因与治疗人数的增加不无关系。较早开始RRT是ESRD发病率和患病率升高的一个重要原因,或许延迟透析会降低RRT发病和患病率,从而降低ESRD治疗成本。据USRDS统计,75岁以上ESRD患者多较早开始透析治疗,预计至2030年该人群患者人数将翻倍。相应的,美国ESRD报销计划纳入了排除RRT的保守治疗方案,这有利于十分危重的老年患者选择保守治疗,而减少RRT的使用。

关键词：肾病 ESRD 老年患者保守治疗

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Functional brain imaging of gastrointestinal sensation in health and disease

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World journal of Gastroenterology 2007年第25期13卷 3438-3445页

作者： Lukas Van Oudenhove steven j Coen Qasim Aziz Department of Neurosciences Division of Psychiatry & Department of Pathophysiology Gastroenterology Section University Hospital Gasthuisberg University of Leuven Belgium Centre for Neuroimaging Sciences Institute of Psychiatry London United Kingdom Division of Neuroscience & Medicine Department of GI Sciences Hope Hospital University of Manchester United Kingdom

It has since long been known, from everyday experience as well as from animal and human studies, that psychological processes-both affective and cognitive- exert an influence on gastrointestinal sensorimotor function. More specifically, a link between psychological factors and visceral hypersensitivity has been suggested, mainly based on research in functional gastrointestinal disorder patients. However, until recently, the exact nature of this putative relationship remained unclear, mainly due to a lack of non-invasive methods to study the （neurobiological） mechanisms underlying this relationship in non-sleeping humans. As functional brain imaging, introduced in visceral sensory neuroscience some 10 years ago, does provide a method for in vivo study of brain-gut interactions, insight into the neurobiological mechanisms underlying visceral sensation in general and the influence of psychological factors more particularly, has rapidly grown. In this article, an overview of brain imaging evidence on gastrointestinal sensation will be given, with special emphasis on the brain mechanisms underlying the interaction between affective ＆ cognitive processes and visceral sensation. First, the reciprocal neural pathways between the brain and the gut （brain- gut axis） will be briefly outlined, including brain imaging evidence in healthy volunteers. Second, functional brain imaging studies assessing the influence of psychological factors on brain processing of visceral sensation in healthy humans will be discussed in more detail. Finally, brain imaging work investigating differences in brain responses to visceral distension between healthy volunteers and functional gastrointestinal disorder patients will be highlighted.

关键词： Functional brain imaging Functionalgastro-intestinal disorders Visceral hypersensitivity Gastrointestinal sensation Psychological factors

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Proteasome inhibition-induces endoplasmic reticulum dysfunction and cell death of human cholangiocarcinoma cells

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World journal of Gastroenterology 2007年第6期13卷 851-857页

作者： Yucel Ustundag steven F Bronk Gregory j Gores Mayo Clinic College of Medicine Rochester MN 55905 United States

AIM: To determine if proteasome inhibition induces apoptosis in human cholangiocarcinoma cells, and if so, to elucidate the cellular mechanisms. METHODS: Studies were performed in the human KMCH, KMBC, and Mz-ChA-1 cholangiocarcinoma, and normal rat cell lines. MG132, a peptide aldehyde, which inhibits the chymotrypsin-like activity of the proteaosome was employed for this study. Apoptosis was assessed morphologically by 4'-6-Diamidino-2-phenylindole (DAPI) nuclear staining and fluorescence microscopy. Mitochondrial membrane potential was examined using a fluorescent unquenching assay. Ultrastructural changes during cell death were examined using transmission electron microscopy (TEM). Caspase 3/7 activity was assessed using an enzymatic-based fluorescent assay. Cytosolic-free calcium concentrations were measured using Fura-2 and digitized fluorescent microscopy. RESULTS: MG132, a proteasome inhibitor, induced apoptosis in all the cholangiocarcinoma cell lines examined. In contrast, minimal cytotoxicity was observed in normal rat cholangiocytes. Apoptosis was time-and -concentration-dependent. There was no change in the mitochondrial membrane potential between treated and untreated cells. Ultrastructural examination by transmission electron microscopy displayed the classic features of apoptosis, but in addition, there was also dramatic vacuolization of the endoplasmic reticulum (ER). Unexpectedly, no increase in caspase 3/7 activity was observed in MG132 treated cells, nor did the pancaspase inhibitor, Q-VD-OPh prevent cell death. The protein synthesis inhibitor, cycloheximide, blocked apoptosis induced by proteosome inhibitor indicating that ER dysfunction was dependent upon the formation of new proteins. CONCLUSION: Proteosome inhibition induces ERdysfunction and caspase-independent cell death selectively in human cholangiocarcinoma cells. Proteasome inhibitors warrant evaluation as anticancer agents for the treatment of human cholangiocarcinoma.

关键词： MG132 Cholangiocarcinoma Proteosome Apoptosis Calcium

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Entropy and enthalpy for triggering cutaneous erythema

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journal of Innovative Optical Health Sciences 2015年第4期8卷 54-57页

作者： steven L.jacques joseph T.Walsh Wellman Laboratories Massachusetts General Hospital BostonMAUSA Harvard Medical School-M.I.T. CambridgeMAUSA Oregon Health&Science University 3303 SW Bond Ave.PortlandORUSA 97239

The molar entropy(OS)and molar enthalpy(△H)for the denaturation event that triggers cutaneous erythema was determined to be △S=190j/(mole K)and△H=146.9×10^(3) j/*** experiment involved placing heated water against the skin of the forearm,for a range of termperatures and exposure *** the skin to 45℃ for 22 s was at the threshold for producing erythema,which was similar to the threshold for a slight degree of pain.

关键词： Skin erythema thermal entropy enthalpy

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Cost-effectiveness of Crohn's disease post-operative care

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World journal of Gastroenterology 2016年第14期22卷 3860-3868页

作者： Emily K Wright Michael A Kamm Peter Dr Cruz Amy L Hamilton Kathryn j Ritchie Sally j Bell steven j Brown William R Connell Paul V Desmond Danny Liew Department of Gastroenterology St Vincent's Hospital University of Melbourne Fitzroy VIC 3065 Melbourne Australia Imperial College London SW7 2AZ United Kingdom Melbourne EpiCentre University of Melbourne and Melbourne Health Parkville VIC 3010 Melbourne Australia

AIM: To define the cost-effectiveness of strategies, including endoscopy and immunosuppression, to prevent endoscopic recurrence of Crohn’s disease following intestinal ***: In the “POCER” study patients undergoing intestinal resection were treated with post-operative drug therapy. Two thirds were randomized to active care (6 mo colonoscopy and drug intensification for endoscopic recurrence) and one third to drug therapy without early endoscopy. Colonoscopy at 18 mo and faecal calprotectin (FC) measurement were used to assess disease recurrence. Administrative data, chart review and patient questionnaires were collected prospectively over 18 ***: Sixty patients (active care n = 43, standard care n = 17) were included from one health service. Median total health care cost was $6440 per patient. Active care cost $4824 more than standard care over 18 mo. Medication accounted for 78% of total cost, of which 90% was for adalimumab. Median health care cost was higher for those with endoscopic recurrence compared to those in remission [$26347 (IQR 25045-27485) vs $2729 (IQR 1182-5215), P < 0.001]. FC to select patients for colonoscopy could reduce cost by $1010 per patient over 18 mo. Active care was associated with 18% decreased endoscopic recurrence, costing $861 for each recurrence ***: Post-operative management strategies are associated with high cost, primarily medication related. Calprotectin use reduces costs. The long term cost-benefit of these strategies remains to be evaluated.

关键词： Crohn’ s disease Post-operative Health economics Health care cost Biologics

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Diabetes pathogenesis and management:the endothelium comes of age

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journal of Molecular Cell Biology 2021年第7期13卷 500-512页

作者： Kaitlin M.Love Eugene j.Barrett steven K.Malin jane E.B.Reusch judith G.Regensteiner Zhenqi Liu Division of Endocrinology and Metabolism Department of MedicineUniversity of Virginia Health SystemCharlottesvilleVA 22908USA Department of Kinesiology and Health Rutgers UniversityNew BrunswickNJUSA Division of Endocrinology Metabolism and NutritionRutgers UniversityNew BrunswickNJUSA New jersey Institute for Food Nutrition and HealthRutgers UniversityNew BrunswickNJUSA Institute of Translational Medicine and Research Rutgers UniversityNew BrunswickNJUSA Center for Women’s Health Research University of Colorado School of MedicineAuroraCOUSA Department of Medicine University of ColoradoAnschutz Medical CampusAuroraCOUSA Rocky Mountain Regional Veterans Affairs Medical Center AuroraCOUSA

Endothelium,acting as a barrier,protects tissues against factors that provoke insulin resistance and type 2 diabetes and itself responds to the insult of insulin resistance inducers with altered *** insulin resistance and vascular dysfunction occur early in the evolution of insulin resistance-related disease,can co-exist with and even contribute to the development of metabolic insulin resistance,and promote vascular complications in those *** impact of endothelial insulin resistance and vascular dysfunction varies depending on the blood vessel size and location,resulting in decreased arterial plasticity,increased atherosclerosis and vascular resistance,and decreased tissue *** with insulin resistance and diabetes are disproportionately impacted by cardiovascular disease,likely related to differential sex-hormone endothelium ***,reducing endothelial insulin resistance and improving endothelial function in the conduit arteries may reduce atherosclerotic complications,in the resistance arteries lead to better blood pressure control,and in the microvasculature lead to less microvascular complications and more effective tissue *** diabetes therapeutic modalities,including medications and exercise training,improve endothelial insulin action and vascular *** action may delay the onset of type 2 diabetes and/or its complications,making the vascular endothelium an attractive therapeutic target for type 2 diabetes and potentially type 1 diabetes.

关键词： diabetes insulin resistance endothelium vascular function

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e-VLBI observations of GRB 080409 afterglow with an Australasian radio telescope network

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Research in Astronomy and Astrophysics 2016年第11期16卷 1-6页

作者： Aquib Moin Philip G. Edwards steven j. Tingay Chris j. Phillips Anastasios K. Tzioumis Shaun W. Amy Tao An Mamoru Sekido Zhong-Xiang Wang Physics Department United Arab Emirates University RO. Box 15551 A1-Ain United Arab Emirates Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China International Centre for Radio Astronomy Research Curtin University Bentley WA Australia CSIRO Astronomy and Space Science P.O. Box 76 Epping NSW 2121 Australia Kashima Space Research Center National Institute of Information and Communications Technology (NICT) 893-1 Hirai Kashima 314-0014 Ibaraki Japan Key Laboratory of Radio Astronomy Chinese Academy of Sciences Nanjing 210008 China Osservatorio di Radio Astronomia Istituto Nazionale di Astrofisica Italy

Transcontinental e-VLBI observations were conducted in june 2008 with telescopes in Australia, China and japan. Detections were made of the radio-loud quasar PKS B0727-115, which shows superlu- minal motion, and the intra-day variable quasar PKS B0524＋034. The latter source was used as a phase reference calibrator for observations at the position of the gamma-ray burst GRB 080409, for which an upper limit to the radio emission is set. Australia Telescope Compact Array data were also used to derive a limit on the radio flux density of the GRB afterglow. These observations demonstrate the capability to form a large Australasian radio telescope network for e-VLBI, with data transported and processed in realtime over high capacity networks. This campaign represents the first step towards more regular e-VLBI observations in this region.

关键词： techniques: interferometric -- galaxies: active -- gamma rays: bursts

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