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Differential Splicing of Skipped Exons Predicts Drug Response in Cancer Cell Lines

Genomics, Proteomics & Bioinformatics 2021年第6期19卷 901-912页

作者： Edward Simpson steven chen Jill L.Reiter Yunlong Liu Center for Computational Biology and Bioinformatics Indiana University School of MedicineIndianapolisIN 46202USA Department of BioHealth Informatics School of Informatics and ComputingIndiana University-Purdue University IndianapolisIndianapolisIN 46202USA Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202USA

Alternative splicing of pre-mRNA transcripts is an important regulatory mechanism that increases the diversity of gene products in *** studies have linked specific transcript isoforms to altered drug response in cancer;however,few algorithms have incorporated splicing information into drug response *** this study,we evaluated whether basal-level splicing information could be used to predict drug sensitivity by constructing doxorubicin-sensitivity classification models with splicing and expression *** detailed splicing differences between sensitive and resistant cell lines by implementing quasi-binomial generalized linear modeling(QBGLM)and found altered inclusion of 277 skipped *** additionally conducted RNA-binding protein(RBP)binding motif enrichment and differential ex-pression analysis to characterize cis-and trans-acting elements that potentially influence doxorubicin response-mediating splicing *** results showed that a classification model built with skipped exon data exhibited strong predictive *** discovered an association between differentially spliced events and epithelial-mesenchymal transition(EMT)and observed motif enrichment,as well as differential expression of RBFOX and ELAVL RBP family *** work demonstrates the potential of incorporating splicing data into drug response algorithms and the utility of a QBGLM approach for fast,scalable identification of relevant splicing differences between large groups of samples.

关键词： Alternative splicing Transcript isoform Splicing regulation Drug sensitivity Precision medicine

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Preparation and Surfactant Properties of Amino Acid-based Surfactants

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Chinese Chemical Letters 1999年第9期10卷 789-792页

作者： Qian chen steven F. chen Zu Yi LI(1 Shanghai Institute of Organic Chemistry. Chinese Academy of Sciences. 354 Fenglin Lu.Shanghai 2000322 Depaftment of Botany. The University of Hong Kong) Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Department of Botany The University of Hong Kong

1-O-aminoacyl-3-O-alkyl acyl glycerols were synthesized by lipases in good yields and their surfactant properties were explored.

关键词： Amino Acids lipase fatty acids glycerol esters

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Recent advances in photochemistry for positron emission tomography imaging

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Chinese Chemical Letters 2024年第8期35卷 149-162页

作者： Jing-Jing Zhang Lujun Lou Rui Lv Jiahui chen Yinlong Li Guangwei Wu Lingchao Cai steven H.Liang Zhen chen Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest BiomassJiangsu Key Lab of Biomass-Based Green Fuels and ChemicalsInternational Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China Department of Radiology and Imaging Sciences Emory UniversityAtlantaGA 30322United States

As a powerful noninvasive imaging technology,positron emission tomography(PET)has been playing an important role in disease theranostics and drug *** successful application of PET relies on not only the biological properties of PET tracers but also the availability of facile and efficient radiochemical reactions to enable practical production and widespread use of PET *** recently,photochemistry is emerging as a novel,mild and efficient approach to generating PET *** this review,we focus on the recent advances in newly developed photocatalytic radiochemical reactions,innovation on automated photochemical radiosynthesis modules,as well as implementation in late-stage radiolabeling and radio-pharmaceutical synthesis for PET *** believe that this review will inspire the development of more promising radiolabeling protocols for the preparation of clinically useful PET agents.

关键词： Positron emission tomography(PET) Fluorine-18 Carbon-11 Photocatalysis Automation Late-stage functionalization

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A glycine-rich nuclear effector VdCE51 of Verticillium dahliae suppresses plant immune responses by inhibiting the accumulation of GhTRXH2

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The Crop Journal 2024年第4期12卷 1137-1149页

作者： Chi Li Yingqi Huang Wenjing Shang Jieyin chen steven J.Klosterman Krishna V.Subbarao Jun Qin Xiaoping Hu State Key Laboratory of Crop Stress Resistance and High-Efficiency Production Key Laboratory of Plant Protection Resources and Pest Management of Ministry of EducationKey Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture and Rural AffairsCollege of Plant ProtectionNorthwest A&F UniversityYangling 712100ShaanxiChina State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Western Agricultural Research Center Chinese Academy of Agricultural SciencesChangji 831100XinjiangChina Agricultural Research Service United States Department of AgricultureSalinasCA 93905USA Department of Plant Pathology University of CaliforniaDavisc/o United States Agricultural Research StationSalinasCA 93905USA

Verticillium dahliae is an important soil-borne fungal pathogen that causes great yield losses in many cash *** of this fungus are known to regulate plant immunity but the mechanism much remains unclear.A glycine-rich nuclear effector,VdCE51,was able to suppress immune responses in tobacco against Botrytis cinerea and Sclerotinia *** effector was a required factor for full virulence of ***,and its nuclear localization was a requisite for suppressing plant *** thioredoxin GhTRXH2,identified as a positive regulator of plant immunity,was a host target of *** findings show a virulence regulating mechanism whereby the secreted nuclear effector VdCE51 interferes with the transcription of PR genes,and the SA signaling pathway by inhibiting the accumulation of GhTRXH2,thus suppressing plant immunity.

关键词： Verticillium dahliae Plant immunity Effector Thioredoxin

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Simultaneous genetic transformation and genome editing of mixed lines in soybean(Glycine max)and maize(Zea mays)

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aBIOTECH 2024年第2期5卷 169-183页

作者： Michelle Valentine David Butruille Frederic Achard steven Beach Brent Brower-Toland Edward Cargill Megan Hassebrock Jennifer Rinehart Thomas Ream Yurong chen Bayer Crop Science 700 Chesterfield Parkway WChesterfieldMO 63017USA

Robust genome editing technologies are becoming part of the crop breeding ***,genome editing is usually conducted either at a single locus,or multiple loci,in a variety at one *** parallel genomics platforms,multifaceted genome editing capabilities,and flexible transformation systems enable targeted variation at nearly any locus,across the spectrum of genotypes within a *** demonstrate here the simultaneous transformation and editing of many genotypes,by targeting mixed seed embryo explants with genome editing machinery,followed by re-identification through genotyping after plant *** and Editing of Mixed Lines(TREDMIL)produced transformed individuals representing 101 of 104(97%)mixed elite genotypes in soybean;and 22 of 40(55%)and 9 of 36(25%)mixed maize female and male elite inbred genotypes,*** of edited genotypes for the regenerated individuals identified over 800 distinct edits at the Determinate1(Dt1)locus in samples from 101 soybean genotypes and 95 distinct Brown midrib3(Bm3)edits in samples from 17 maize *** results illustrate how TREDMIL can help accelerate the development and deployment of customized crop varieties for future precision breeding.

关键词： Maize Soybean Seed embryo explants TREDMIL Genetic transformation Genome editing

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NMR Spectral Analysis and Hydrolysis Studies of Rebaudioside N, a Minor Steviol Glycoside of <i>Stevia rebaudiana</i>Bertoni

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Food and Nutrition Sciences 2013年第10期4卷 1004-1008页

作者： Venkata Sai Prakash Chaturvedula steven chen Oliver Yu Guohong Mao Natural Ingredient Development Blue California Rancho Santa Margarita USA Natural Ingredient Development Blue California Rancho Santa Margarita USA.

The complete proton and carbon NMR spectral assignments of a diterpene glycoside isolated from the commercial extract of the leaves of Stevia rebaudiana Bertoni, 13-[(2-O-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy] entkaur-16-en-19-oic acid-[(2-O-α-L-rhamnopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl) ester] (1);also known as rebaudioside N, was achieved by the extensive 1D and 2D NMR (1H and 13C, COSY, HMQC, HMBC) as well as mass spectral data. Further, hydrolysis studies were performed on rebaudioside N using acid and enzymatic studies to identify aglycone and sugar residues in its structure.

关键词： Stevia rebaudiana Diterpene Glycoside Isolation Structure Elucidation Spectral Data Hydrolysis Studies

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Cantonese porcelain classification and image synthesis by ensemble learning and generative adversarial network

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Frontiers of Information Technology & Electronic Engineering 2019年第12期20卷 1632-1643页

作者： steven Szu-Chi chen Hui CUI Ming-han DU Tie-ming FU Xiao-hong SUN Yi JI Heniy DUH Department of Computer Science and Information Technology La Trobe UniversityMelbourne 3086Australia School of Art and Design Guangdong University of TechnologyGuangzhou 510006China

Accurate recognition of modern and traditional porcelain styles is a challenging issue in Cantonese porcelain management due to the large variety and complex elements and patterns. We propose a hybrid system with porcelain style identification and image recreation modules. In the identification module, prediction of an unknown porcelain sample is obtained by logistic regression of ensembled neural networks of top-ranked design signatures, which are obtained by discriminative analysis and transformed features in principal components. The synthesis module is developed based on a conditional generative adversarial network, which enables users to provide a designed mask with porcelain elements to generate synthesized images of Cantonese porcelain. Experimental results of 603 Cantonese porcelain images demonstrate that the proposed model outperforms other methods relative to precision, recall, area under curve of receiver operating characteristic, and confusion matrix. Case studies on image creation indicate that the proposed system has the potential to engage the community in understanding Cantonese porcelain and promote this intangible cultural heritage.

关键词： Cantonese porcelain Classification Generative adversarial network Creative arts

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Growth of nitrate contribution to aerosol pollution during wintertime in Xi'an,northwest China:Formation mechanism and effects of NH_(3)

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Particuology 2024年第4期87卷 303-315页

作者： Hui Su Ting Zhang Suixin Liu Yao Qu Huan Li Jiamao Zhou Zhuzi Zhao Qiyuan Wang Lu Li Minxia Shen Shuoyuan chen steven Sai Hang Ho Junji Cao State Key Laboratory of Loess and Quaternary Geology.Key Laboratory ofAerosol Chemistry and Plhysics Institute of Earth EnvironmentChinese Acadery of SciencesXi'an 710061China Xi'an Institute for Innovative Earth Environment Research Xi'an 710061China National pbservation and Research Station of Regional Ecological Environment Change and Cornprehensive Management in the Guanzhong Plain Xi'an 710061China Shaanxi Key Laboratory of Atmospheric and Haze fog Pollution Prevention Institute of Earth EnvironmentChinese Academy of SciencesXi'an 710061China University of Chinese Academy of Sciences Beijing 100049China School of Chemical and Environmental Engineering Jiangsu University of TechnologyChangzhou 213001China Division of Atmospheric Sciences Desert Research InstituteReno NV89512United States Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China

With the strengthened controls on SO2 emissions and extensive increases in motor vehicles'exhaust,aerosol pollution shifts from sulfate-rich to nitrate-rich in recent years in Xi'an,*** further gain insights into the factors on nitrate formation and efficiently mitigate air pollution,highly time-resolved observations of water-soluble inorganic ions(WSIIs)in PM_(2.5) were measured in a suburban area of Xi'an,China during *** concentration of total WSIIs is 39.8μg m-3 on average,accounting for 50.3%of PM_(2.5) *** contrast to a slight decrease in the mass fraction of SO_(4)^(2-),NO_(3)-shows a sig-nificant increase of the PM_(2.5) contribution with the aggravation of aerosol *** suggests the importance of NO_(3)-formation to haze ***,homogeneous reactions govern the formation of NO_(3)-,while alkali metals such as calcium and sodium play an additional role in retaining NO_(3)-in PM_(2.5) during clean ***,the heterogeneous hydrolysis reaction contributed more to NO_(3)-formation during the pollution periods under high relative *** investigation reveals that temperature,relative humidity,oxidant,and ammonia emissions facilitate rapid NO_(3)-*** the random forest(RF)model,NO_(3)-concentrations were successfully simulated with measured variables for the training and testing datasets(R2>0.95).Among these variables,CO,NH_(3),and NO_(2) were found to be the main factors affecting the NO_(3)-*** with the period without vehicle re-striction,the contributions of NO_(3)-and NH4+to PM_(2.5) mass decreased by 5.3%and 3.4%in traffic re-striction periods,*** vehicle restriction leads to the decreases of precursor gases of NO_(2),SO_(2),and NH_(3) by 12.8%,5.9%,and 27.6%,*** results demonstrate collaborative emission reduction of NO_(x) and NH_(3) by vehicle restrictions,and using new energy vehicles(or electric vehicles)can effectively alleviate particul

关键词： PM_(2.5) Water-soluble inorganic ions Nitrate formation Excess ammonium Vehicle restrictions

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Discovery and evaluation of a novel 18F-labeled vasopressin 1a receptor PET ligand with peripheral binding specificity

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4014-4027页

作者： Junqi Hu Yinlong Li chenchen Dong Huiyi Wei Kai Liao Junjie Wei Chunyu Zhao Ahmad Chaudhary Jiahui chen Hao Xu Ke Zhong steven HLiang Lu Wang Weijian Ye Center of Cyclotron and PET Radiopharmaceuticals Department of Nuclear Medicine&Key Laboratory of Basic and Translational Research on Radiopharmaceuticalsthe First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Department of Radiology and Imaging Sciences Emory UniversityAtlant1GA 30322USA Department of Pharmacy Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

The arginine-vasopressin(AVP)hormone plays a pivotal role in regulating various physiological processes,such as hormone secretion,cardiovascular modulation,and social *** studies have highlighted the V1a receptor as a promising therapeutic ***-depth insights into V1a receptor-related pathologies,attained through in vivo imaging and quantification in both peripheral organs and the central nervous system(CNS),could significantly advance the development of effective V1a *** address this need,we develop a novel V1a-targeted positron emission tomography(PET)ligand,[18F]V1A-2303([18F]8),which demonstrates favorable in vitro binding affinity and selectivity for the V1a *** tracer binding in peripheral tissues was also confirmed through rigorous cell uptake studies,autoradiography,biodistribution ***,[18F]8 was employed in PET imaging and arterial blood sampling studies in healthy rhesus monkeys to assess its brain permeability and specificity,whole-body distribution,and kinetic *** research indicated[18F]8 as a valuable tool for noninvasively studying V1a receptors in peripheral organs,and as a foundational element for the development of next-generation,brain-penetrant ligands specifically designed for the CNS.

关键词： Vasopressin Autism V1a receptor Positron emission tomography PET imaging Radiolabeling Fluorine 18 Kinetic modeling

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USB 3.0为移动设备带来超快的连接速度

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电子设计技术 EDN CHINA 2012年第8期19卷 37-38,40,42页

作者： Vikas Dhurka steven chen Cypress半导体公司

随着所有移动设备中丰富的多媒体内容的增加,用户可以充分利用USB 3.0的超高速,传送大量的商用和用户生成的内容。

关键词：移动设备连接速度传输速率 USB3.0 Cypress

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