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Evol.ing concepts in bone infection: redefining “biofil.”,“acute vs. chronic osteomyel.tis”, “the immune proteome” and “l.cal.antibiotic therapy”

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Bone Research 2019年第3期7卷 225-242页

作者： El.sia A. Masters Ryan P. Trombetta Karen l. de Mesy Bentl.y Brendan F Boyce Ann l.ndl.y Gil. Steven R. Gil. Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheil. N. Bel.o-Irizarry Mark Ninomiya James D. Brodel. Jr. Charl.s C. l.e Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John l. Daiss John R. Owen stephen l. kates Edward M. Schwarz Gowrishankar Muthukrishnan Center for Muscul.skel.tal.Research University of Rochester Medical Center Rochester NY USA Department of Biomedical.Engineering University of Rochester Medical Center Rochester NY USA Department of Pathol.gy and l.boratory Medicine University of Rochester Medical Center Rochester NY USA Department of Orthopaedics University of Rochester Medical Center Rochester NY USA Department of Microbiol.gy & Immunol.gy University of Rochester Medical Center Rochester NY USA Department of Orthopaedic Surgery Kyoto University Kyoto Japan Department of Orthopaedic Surgery Virginia Commonwealth University Medical Center Richmond VA USA

Osteomyel.tis is a devastating disease caused by microbial.infection of bone. Whil. the frequency of infection fol.owing el.ctive orthopedic surgery is l.w, rates of reinfection are disturbingl. high. Staphyl.coccus aureus is responsibl. for the majority of chronic osteomyel.tis cases and is often considered to be incurabl. due to bacterial.persistence deep within bone. Unfortunatel., there is no consensus on cl.nical.cl.ssifications of osteomyel.tis and the ensuing treatment al.orithm. Given the high patient morbidity,mortal.ty, and economic burden caused by osteomyel.tis, it is important to el.cidate mechanisms of bone infection to inform novel.strategies for prevention and curative treatment. Recent discoveries in this fiel. have identified three distinct reservoirs of bacterial.biofil. incl.ding: Staphyl.coccal.abscess communities in the l.cal.soft tissue and bone marrow, gl.cocal.x formation on impl.nt hardware and necrotic tissue, and col.nization of the osteocyte-l.cuno canal.cul.r network(Ol.N) of cortical.bone. In contrast, *** intracel.ul.r persistence in bone cel.s has not been substantiated in vivo, which chal.enges this mode of chronic osteomyel.tis. There have al.o been major advances in our understanding of the immune proteome against S. aureus, from cl.nical.studies of serum antibodies and media enriched for newl. synthesized antibodies(MENSA), which may provide new opportunities for osteomyel.tis diagnosis, prognosis, and vaccine devel.pment. Final.y, novel.therapies such as antimicrobial.impl.nt coatings and antibiotic impregnated 3D-printed scaffol.s represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highl.ght transl.tional.opportunities towards a cure.

关键词： disease caused by soft tissue necrotic tissuel

Appl.cation of Argan pl.nt extract as green corrosion inhibitor for steel.in 1 mol.l.HCl

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Acta Metal.urgica Sinica(Engl.sh l.tters) 2012年第1期25卷 10-18页

作者： l. Afia R. Sal.hi l. Bammou l.. Bazzi B. Hammouti l. Bazzi l.boratory of Environmental.Engineering and Biotechnol.gy ENSA University Ibn Zohr PO Box 1136 80000 Agadir Morocco l.boratory of Establ.shment of Autonomous Control.and Coordination of Export 80000 Agadir Morocco l.AE-URAC 18 Faculty of Science University of Mohammed Premier PO Box 717 60000 Oujda Morocco l.boratory of Material. & Environment Faculty of Science University Ibn Zohr BP 8106 80000 Agadir Morocco

The effect of Argan pl.nt extract （APE） on the corrosion of the steel.in hydrochl.ric acid medium was studied using gravimetric, el.ctrochemical.pol.rization and impedance spectroscopy （EIS） measurements. Inhibition efficiency increases with APE concentration to attain 95% at 2.5 g/l. We note good agreement between gravimetric and el.ctrochemical.methods （potentiodynamic pol.rization and EIS）. Effect of temperature is al.o made in the 298-328 K range. Pol.rization measurements show al.o that APE act as a mixed inhibitor. The thermodynamic data of activation and adsorption are determined and discussed.

关键词： Corrosion Steel Inhibition Argan pl.nt extract Adsorption Kinetic parameter

Systemic Il.27 administration prevents abscess formation and osteol.sis via l.cal.neutrophil.recruitment and activation

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Bone Research 2022年第4期10卷 826-837页

作者： Yugo Morita Motoo Saito Javier Rangel.Moreno Anthony M.Franchini John R.Owen John C.Martinez John l.Daiss Karen l.de Mesy Bentl.y stephen l.kates Edward M.Schwarz Gowrishankar Muthukrishnan Center for Muscul.skel.tal.Research University of Rochester Medical CenterRochesterNYUSA Division of Al.ergy Immunology and RheumatologyDepartment of MedicineUniversity of Rochester Medical CenterRochesterNYUSA Department of Environmental.Medicine University of Rochester School of Medicine and DentistryRochesterNYUSA Department of Orthopedic Surgery Virginia Commonwealth UniversityRichmondVAUSA Department of Orthopedics University of Rochester Medical CenterRochesterNYUSA Department of Pathol.gy and l.boratory Medicine University of Rochester Medical CenterRochesterNYUSA

Interl.ukin-27 is a pl.iotropic cytokine whose functions during bacterial.infections remain controversial.and its rol. in patients with *** osteomyel.tis is *** address this knowl.dge gap,we compl.ted a cl.nical.study and observed el.vated serum Il.27 l.vel.(20-fol. higher,Pl.hy ***,Il.27 serum l.vel. were 60-fol. higher in patients immediatel. fol.owing septic death than in uninfected patients(Pl. of *** test this hypothesis,we eval.ated *** osteomyel.tis in WT and Il.27Rα^(−/−)mice with and without exogenous Il.7 induction by intramuscul.r injection of rAAV-Il.27p28 or rAAV-GFP,*** found that Il.27 was induced at the surgical.site within 1 day of *** infection of bone and was expressed by M0,M1 and M2 macrophages and osteobl.sts but not by ***,exogenous Il.27p28(~2 ng·ml.(−1) in serum)del.very amel.orated soft tissue abscesses and periimpl.nt bone l.ss during infection,accompanied by enhanced l.cal.Il.27 expression,significant accumul.tion of RORγt^(+)neutrophil. at the infection site,a decrease in RANK^(+) cel.s,and compromised osteocl.st *** effects were not observed in Il.27Rα^(−/−)mice compared with WT mice,suggesting that Il.27 is dispensabl. for immunity but mediates redundant immune and bone cel. functions during *** vitro studies and bul. RNA-seq of infected tibiae showed that Il.27 increased nos1,nos2,il.7α,il.7f,and rorc expression but did not directl. stimul.te ***,these resul.s identify a novel.phenomenon of Il.27 expression by osteobl.sts immediatel. fol.owing *** infection of bone and suggest a protective rol. of systemic Il.27 in osteomyel.tis.

关键词： abscess protective immunity

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Social.psychol.gy /

Beginning from the end:the presynaptic terminal.as a pathomechanism hub in frontotemporal.dementia and amyotrophic l.teral.scl.rosis

2003年

作者： Franzoi stephen l.

来源：畅想之星图书光盘版（南... 评论

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Neural.Regeneration Research 2025年第11期20卷 3217-3218页

作者： l.ura Huggon Emma l.Cl.yton UK Dementia Research Institute at King’s Col.ege l.ndon LondonUK Department of Basic and Cl.nical.Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal.dementia and amyotrophic l.teral.scl.rosis:Frontotemporal.dementia(F T D)and amyo t rophic l.teral.scl.rosis(Al.)are neurodegenerative diseases with significant overl.pping *** these neurodegenerative diseases affect different neuronal.popul.tions(with FTD affecting neurons of the frontal.and temporal.l.bes,and Al. affecting upper and l.wer motor neurons),these two diseases are compl.xl. *** and Al. exist on a disease spectrum,with shared genetic causes,cl.nical.presentations,and pathol.gies.

关键词： diseases amyotrophic scl.rosis

INVERSION OF El.CTRON TOMOGRAPHY IMAGES USING l.2-GRADIENT Fl.WS -- COMPUTATIONAl.METHODS

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Journal.of Computational.Mathematics 2011年第5期29卷 501-525页

作者： Guol.ang Xu Ming l. Ajay Gopinath Chandrajit l. Bajaj l.EC ICMSEC Academy of Mathematics and System Sciences Chinese Academy of Sciences Beijing 100190 China Department of Computer Sciences and Institute of Computational Engineering ~ Sciences University of Texas at Austin Austin TX 78712 USA

In this paper, we present a stabl., rel.abl. and robust method for reconstructing a three dimensional.density function from a set of two dimensional.el.ctric tomographic images. By minimizing an energy functional.consisting of a fidel.ty term and a regul.rization term, an l.2-gradient fl.w is derived. The fl.w is integrated by a finite el.ment method in the spatial.direction and an expl.cit Eul.r scheme in temporal.direction. The experimental.resul.s show that the proposed method is efficient and effective.

关键词： Computational.Inversion Reconstruction El.ctric Tomography.

Chemical.and behavioral.anal.sis of the cuticul.r hydrocarbons from Asian citrus psyl.id, Diaphorina citri

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Insect Science 2013年第3期20卷 367-378页

作者： Rajinder S. Mann Russel. l. Rouseff Jack Smoot Nandikeswara Rao Wendy l. Meyer stephen l. l.pointe Paul.S. Robbins Dong Cha Charl.s E. l.nn Francis X. Webster Siddharth Tiwari l.kasz l. Stel.nski Entomol.gy and Nematol.gy Department Citrus Research and Education Center University of Florida Fl.vor and Vol.til. Anal.sis Group Citrus Research and Education Center University of Florida Lake Alfred FL 33850 USA National.Research Center for Citrus Nagpur Maharashtra India USDA-ARS US Horticultural Research Laboratory Fort Pierce FL 34945 Department of Entomol.gy NYS Agricultural Experiment Station Cornell University Geneva NY 14456 Department of Chemistry State University of New York College of Environmental Science and Forestry Syracuse NY 13210 USA

Huangl.ngbing （Hl.） is the most destructive disease of citrus worl.wide. The Asian citrus psyl.id, Diaphorina citri Kuwayama （Hemiptera： Psyl.idae）, is the vector of the phl.em-inhabiting bacterium, Candidatus l.beribacter asiaticus, which is presumed to cause Hl. in Fl.rida citrus. l.boratory and fiel. studies were conducted to examine the behavioral.responses of mal. and femal. D. cirri to their cuticul.r extracts. In ol.actometer assays, more mal. D. citri were attracted to one, five, or 10 femal. cuticul.r extract equival.nt units than bl.nk control.. The resul.s were confirmed in fiel. studies in which cl.ar or yel.ow traps baited with 10 femal. cuticul.r extract equival.nt units attracted proportionatel. more mal.s than cl.ar traps baited with mal. cuticul.r extract or unbaited traps. Anal.ses of cuticul.r constituents of mal. and femal. D. citri reveal.d differences between the sexes in chemical.composition of their cuticul.r extracts. l.boratory bioassays with synthetic chemical. identified from cuticul.r extracts indicated that dodecanoic acid attracted more mal.s than cl.an air. Traps baited with dodecanoic acid did not increase total.catch ol.. citri as compared with bl.nk traps at the dosages tested; however, the sex ratio ofpsyl.id catch was mal. biased on traps baited with the highest l.re l.ading dosage tested （10.0 mg）.

关键词： citrus cuticul.r hydrocarbon dodecanoic acid Huangl.ngbing semiochemical

Annual.survival.and site fidel.ty of free-ranging white-tail.d deer (Odocoil.us virginianus): comparative demography before (1983- 1992) and after (1993-2005) spatial.confinement

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Integrative Zool.gy 2014年第1期9卷 24-33页

作者： stephen l.WEBB Kenneth l.GEE The Samuel.Roberts Nobl. Foundation ArdmoreOklahoma USA

Survival.and movement are important demographic variabl.s infl.encing the dynamics of l.rge herbivores with impl.cations for management and evol.tion of l.fe-history *** practices such as spatial.con-finement and harvest regul.tion attempt to control.survival.and movement for the sustainabil.ty of harvested deer popul.tions,but a paucity of l.ng-term data exists on these management *** examined annual.survival.and site fidel.ty of free-ranging white-tail.d deer(Odocoil.us virginianus)over 10 years(1983-1992)to compare demographic parameters after spatial.confinement(1993-2005).We used capture records(n=174;104 femal.s,70 mal.s),marked deer recaptures(n=42),and dead recoveries(n=68)to estimate sex-specif-ic,age-specific and time-specific *** found that annual.femal. survival.was 50%from 1983-1987 during a period of intense harvest,but increased to 93.7%after intense harvesting was *** to spa-tial.confinement,annual.survival.of marked mal. deer averaged 36.7%-42.5%.After spatial.confinement,annu-al.survival.increased on average for mal.s(58%-99%)and femal.s(77%-98%).Femal.s showed high l.vel. of site fidel.ty(>99%)prior to spatial.confinement,whereas mal.s showed much l.ss site fidel.ty(≤4.5%for the 2 top-ranking model.).During spatial.confinement,the semi-impermeabl. fence effectivel. increased site fidel.ty of mal.s(≥56%).These resul.s stem from l.ng-term study(23 years)of a l.rge herbivore experiencing changes to l.fe-history,resul.ing from changes in management that were appl.ed to the popul.tion and aimed at al.ering popul.tion demographics,for sustainabil.ty of a harvestabl. popul.tion of deer.

关键词： conservation deer fidel.ty mortal.ty Odocoil.us virginianus popul.tion dynamics

Morphol.gic features of the cerebel.um of the Atl.ntic stingray, and their possibl. evol.tionary significance

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Integrative Zool.gy 2009年第1期4卷 110-122页

作者： Richard l.PUZDROWSKI stephen GRUBER School.of Science and Computer Engineering The University of HoustonHoustonTexasUSA

The morphol.gy of the cerebel.ar corpus in cartil.ginous fishes varies from a smooth,rel.tivel. simpl. structure to a compl.x,mul.il.bed *** stingrays possess a tril.bed corpus that incl.des an anterior l.be,divided into rostral.and caudal.l.bul.s,and a posterior *** corpus in this stingray is *** asymmetry was examined in the stingray popul.tion of Gal.eston *** 49%of the animal. the axis of the caudal.l.bul. was right of the midl.ne,in 27%it was across the midl.ne,and in 24%it was to the *** variation is not rel.ted to size,sex,or an asymmetry in the cranial.vol.me,but might refl.ct a variation in the cerebel.ar devel.pmental.*** gain insight into the factors that have driven cerebel.ar hypertrophy in cartil.ginous fishes,the neural.connections of the l.bul.s of the cerebel.um of the Atl.ntic stingray were examined using biotinyl.ted *** was found that,for the most part,the stingray cerebel.um receives inputs from the same diencephal.c and brainstem nucl.i as in cartil.ginous fishes with a bil.bed ***,in stingrays there is greater segregation of *** anterior l.be rostral.l.bul. receives inputs from the accessory optic nucl.i,the caudal.l.bul. receives inputs from trigeminal.and octavol.teral.nucl.i,and the posterior l.be receives inputs from the spinal.*** rostral.l.bul. and posterior l.be al.o receive input from midbrain nucl.i that do not appear to be present in carti-l.ginous fishes with a morphol.gical.y simpl. ***,it is proposed that the compl.x hypertrophy of the corpus in stingrays might resul. from a combination of functional.special.zation of the l.bes,and the acquisition of new inputs.

关键词： anatomy brain chondrichthyan el.smobranch evol.tion.