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肺泡复张策略复合高水平呼气末正压通气不影响血容量充足的病态肥胖患者的血流动力学

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麻醉与镇痛 2011年第3期7卷 66-69页

作者： stephan H. Bohm, md Oliver C. Thamm, md Alexandra von Sandersleben, md Katrin Bangert, md Thomas E. Langwieler, md Gerardo Tusman, md Tim G. Strate, md, PhD Thomas G. Standl, md, PhD 邓希锦(译) Clinics of Anesthesiology Hospital Privado de Comunidad Mar del Plata Argentina General Visceral and Thoracic Surgery University Hospital Hamburg-Eppendorf Germany Hospital Privado de Comunidad Mar del Plata Argentina Department of Anesthesiology Hospital Privado de Comunidad Mar del Plata Argentina 不详

我们观察了20例血容量充足，准备行腹腔镜手术的病态肥胖（体重指数为50±9kg/m^2）患者，评估肺泡复张策略复合高水平呼气末正压通气（posidveend-expiratorypressure，PEEP）对其血流动力学的影响。肺泡复张策略是在有气腹和无气腹的... 详细信息

我们观察了20例血容量充足，准备行腹腔镜手术的病态肥胖（体重指数为50±9kg/m^2）患者，评估肺泡复张策略复合高水平呼气末正压通气（posidveend-expiratorypressure，PEEP）对其血流动力学的影响。肺泡复张策略是在有气腹和无气腹的情况下序贯进行，将PEEP水平逐渐升高，使平台压达到50—60cmH2O，呼吸10次／分，然后将PEEP水平逐渐降低。通过体循环和肺动脉导管的监测，没有发现肺泡复张及高水平PEEP对血流动力学产生显著的影响。经食管超声心动图显示左室舒张末期面积未发生变化，也无局部室壁运动异常的迹象。

关键词：呼气末正压通气血流动力学肥胖患者病态肥胖 P水平血容量肺泡复合

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麻醉与镇痛 2011年第4期7卷 46-55页

作者： Matthias Haenggi, md Heidi Ypparila-Wolters, PhD Sarah Buerki, cand. med Rebekka Schlauri, cand. med Ilkka Korhonen, PhD Jukka Takala, md, PhD stephan M. Jakob, md, PhD 马競(译) 王焱林(校) Department of Intensive Care Medicine Bern University Hospital and University of Bern Bern Switzerland VTF Technical Research Centre of Finland Tampere Finland 不详

背景包括镇静评分和常规镇静暂停在内的镇静方案，有助干减少机械通气时间和重症监护病房（ICU）入住时间。因临床上对于镇静深度的评估工作量大、仅能间断进行且干扰镇静和睡眠，所以通过脑电生理信号评估镇静深度的替代方法已经开始... 详细信息

背景包括镇静评分和常规镇静暂停在内的镇静方案，有助干减少机械通气时间和重症监护病房（ICU）入住时间。因临床上对于镇静深度的评估工作量大、仅能间断进行且干扰镇静和睡眠，所以通过脑电生理信号评估镇静深度的替代方法已经开始倍受青睐：我们想明确听觉诱发相关电位（ERPs）、脑电双频指数（BIS）和墒（Entropy）是否也能够评估临床镇静深度。方法选择10例择期全麻下行胸部或腹部手术的患者。手术后进入ICU，逐渐减少丙泊酚和瑞芬太尼靶控镇静程度[采用Rickmond Agitation镇静评分（RASS），-5分极深镇静，-4分深度镇静，-3～-1分中度镇静，0分清醒]期间，记录脑电图、BIS、状态熵（SE）、反应墒（RE）和ERPs。手术前或手术后数天测量指标的相关基础水平。结果基线、PASS-5分、RASS-4分、RASS-3至-1分和PASS-0分，对应的BIS值分别是94[4]（中位数，四分位数间距）、47[15]、68[9]、75[10]和88[6]；对应的SE值分别是87[3]、46[10]、60[22]、74[21]和87[5]；对应的RE值分别是97[4]、48[9]、71[25]、81[8]和96[3]（P〈0．05，Friedman检验）。BIS和墒都有高变异度。当单独考虑ERP振幅100时，各个镇静水平的ERPs值差异无显著性：但是、复括双参数主要变量分析的ERP辨别分析显示区别深度镇静、中度镇静和清醒状态的推算概率PK大约是0．89。与PK对应的RE，SE和BIS值分别是0．88、0．89和0．85。结论ERPs、BIS和熵均不能替代基于标准评分系统的临床镇静评估。全麻后对于极深镇静、深度到中度镇静和清醒的辨别，ERPs和脑电图仅能提供相似的PK值。BIS和熵存在较高的个体间和个体自身变异度，使其难以确定预测镇静水平的目标值范围，因而在危重患者中的使用受到限制。ERPs的变异度还不清楚。

关键词：脑电双频指数重症监护病房镇静评分危重患者相关电位听觉诱发状态熵 Friedman

新型神经肌肉阻滞评价系统改善肌肉松弛效果的随机对照临床研究

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麻醉与镇痛 2010年第2期6卷 75-82页

作者： Terence J. Gilhuly, MASc Bernard A. MacLeod, md, FRCPC Guy A. Dumont, PhD Alex M. Bouzane, MSc, md stephan K. W. Schwarz 宋宗斌(译) 郭曲练(校) Department of Anesthesiology Pharmacology & Therapeutics Hugill Anesthesia Research Centre Department of Electrical and Computer Engineering Department of Anesthesia St. Paul's Hospital The University of British Columbia Vancouver B.C. Canada 不详

背景传统的单次推注肌肉松弛药的给药方式存在着手术中可控性有限、潜在的苏醒延迟和麻醉恢复期残余阻滞等问题。为此，我们开发了一种新的自适应电脑程序，即神经肌肉阻滞评价系^（NMBAS）。该程序以六阶拉盖尔模型及患者的肌电反应记... 详细信息

背景传统的单次推注肌肉松弛药的给药方式存在着手术中可控性有限、潜在的苏醒延迟和麻醉恢复期残余阻滞等问题。为此，我们开发了一种新的自适应电脑程序，即神经肌肉阻滞评价系^（NMBAS）。该程序以六阶拉盖尔模型及患者的肌电反应记录为基础，向麻醉医师提供肌肉松弛药的时效及剂量的建议。本研究中，我们对使用NMBAS后的神经肌肉阻滞是否优于常规治疗方法进行了探讨。方法这是一项随机、双盲、平行对照的前瞻性临床研究。73例接受腹部手术的患者（ASAI～Ⅲ级），使用罗库溴铵为肌肉松弛剂，全身麻醉时间≥1．5小时。患者分别按常规方式或NMBAS指导下给予罗库溴铵。主要结果变量为反映肌肉松弛不完善的围手术期事件发生率。次级变量包括手术后拮抗前4个成串刺激（TOF）比值，罗库溴铵总量，拮抗剂、麻醉药物及其他药物的用量，手术后不良事件的发生率以及麻醉医师不依从NMBAS建议的发生率。结果73例患者中，每组有30例符合统计分析的要求。两组问患者一般资料具有可比性。与常规组相比，NMBAS组患者围手术期肌肉松弛不完善相关事件的发生率明显降低（19／30VS8／30；P=0．004），NMBAS组平均TOF比值明显增高（0.59[95％CI：0．48～0．69]vs0．14[95％CI：0．04～0．24]；P〈0．0001）。罗库澳铵总量、拮抗剂、其他药物应用及手术后不良事件的发生率无差异。结论与常规方法相比，NMBAS指导的肌肉松弛方案可改善肌肉松弛质量，提高手术后TOF比值，减少肌肉松弛残余的危险性，提高患者围手术期的安全。

关键词：随机对照临床研究神经肌肉阻滞肌肉松弛药评价系统前瞻性临床研究罗库溴铵围手术期麻醉药物

Lyocell短切纤维在湿法成网水刺非织造布中的应用

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国际纺织导报 2021年第2期49卷 24-26,28页

作者： S.Schlager T.maier S.Jary S.Rahbaran S.Kulka 王宏球(译) 于俊荣(校) 兰精集团(奥地利) 不详

研究展示了含有Lenzing Lyocell短切纤维的湿法成网水刺湿巾的性能,该短切纤维既能满足高性能非织造布的要求,又能实现湿巾的快速分解或分散。

关键词： Lyocell短切纤维非织造布湿强分解性能

Panda X-III： Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers

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Science China(Physics,Mechanics & Astronomy) 2017年第6期60卷 8-47页

作者： Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan NPAC and Department of Physics and Astronomy Shanghai Jiao Tong University Shanghai Laboratory for Particle Physics and Cosmology Shanghai 200240 China College of Physical Science and Technology Central China Normal University Wuhan 430079 China China Institute of Atomic Energy Beijing 102413 China School of Physics Peking University Beijing 100871 China School of Physics and Key Laboratory of Particle Physics and Particle Irradiation (MOE) Shandong University Jinan 250100 China School of Physics and Engineering Sun Yat-Sen University Guangzhou 510275 China Department of Modern Physics University of Science and Technology of China Hefei 230026 China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of China Hefei 230026 China University ofZaragoza C/P Cerbuna 12 50009 Zaragoza Spain IRFU CEA Universite Paris-Saclay F-91191 Gif-sur-Yvette France Department of Physics University of Maryland College Park MD 20742 USA Nuclear Science Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Center for Excellence in High Energy Physics and Astrophysics Suranaree University of Technology Nakhon Ratchasima 30000 Thailand

Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation *** X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 *** pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the *** signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial *** detector will be immersed in a large water tank to ensure～5 m of water shielding in all *** second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds.

关键词： neutrinoless double beta decay lepton number violation underground experiment TPC Micromegas

Abstracts from the 15th International Myopia Conference

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel Kathleen Abarr Luying Yan Keisha Roden David Troilo Chanyi Lu Miaozhen Pan Min Zheng Jia Qu Xiangtian Zhou Christine F. Wildsoet Fan Lu Jie Chen Jinhua Bao Liang Hu Qinmei Wang Zibing Jin Frances Rucker stephanie Britton stephan Hanowsky Molly Spatcher Hui-Ying Kuo Ching-Hsiu Ke I-Hsin Kuo Chien-Chun Peng Han-Yin Sun Ian G. Morgan Jeremy A. Guggenheim Rupal L. Shah Cathy Williams Jinglei Yang Peter S. Reinach Sen Zhang Wenfeng Sun Bo Liu Fen Li Xiaoqing Li Aihua Zhao Tianlu Chen Wei Jia Jun Jiang Haoran Wu Kazuo Tsubota Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel Rathbun Frank Schaeffel Ladan Ghodsi William K. Stell Machelle T. Pardue Ranjay Chakraborty Han na Park Curran S. Sidhu P. Michael Iuvone Michael J Collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline Cho SW Cheung Pei-Chang Wu Quan V. Hoang Duk C. Lee Erica G. Landis Michael A. Bergen Curran Sidhu Samer Hattar Richard A. Stone Ravi Metlapally Ruiqin Li Qinglin Xu Hong Zhong Chenglin Pan Weizhong Lan Xiaoning Li Ling Chen Zhikuan Yang Scott A. Read Seang-Mei Saw Shi-Jun Weng Xiao-Hua Wu Kang-Wei Qian Yun-Yun Li Guo-Zhong Xu Furong Huang Xiong-Li Yang Yong-Mei Zhong Earl L Smith, III Baskar Arumugam Li-Fang Hung Lisa A. Ostrin Klaus Trier Monica Jong Brien A. Holden Thomas Chuen Lam Samantha Shan Bing Zuo Dennis Yan-yin Tse Jingfang Bian King-Kit Li Quan Liu Chi-ho To Timothy J. Gawne John T. Siegwart, Jr. Alexander H. Ward Thomas T. Norton Yan Zhang Yue Liu Carol Ho Eileen Phan Abraham Hang Emily Eng Christine Wildsoet Department of Biological Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State Key Laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Social and Community Medicine University of Bristol Bristol UK School of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key Laboratory Cultivation Base and Key Laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic Research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eight had both contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated