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Risk prediction models for biochemical recurrence after radical prostatectomy using prostate-specific antigen and Gleason score

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Asian Journal of Andrology 2014年第6期16卷 897-901页

作者： Xin-Hai Hu Henning Cammann Hellmuth-A Meyer Klaus Jung Hong-Biao Lu Natalia Levas Ahmed Magheli Carsten stephan Jonas Busch Department of Urology Charite - Universitatsmedizin Berlin Berlin Germany Institute of Medical Informatics Charite - Universitatsmedizin Berlin Berlin Germany Berlin Institute for Urologic Research Berlin Germany Department of Urology Changzhou No. 2 People's Hospital Changzhou China Stanford University School of Medicine Stanford CA USA.

Many computer models for predicting the risk of prostate cancer have been developed including for prediction of biochemical recurrence （BCR）. However, models for individual BCR free probability at individual time-points after a BCR free period are rare. Follow-up data from 1656 patients who underwent laparoscopic radical prostatectomy （LRP） were used to develop an artificial neural network （ann） to predict BCR and to compare it with a logistic regression （LR） model using clinical and pathologic parameters, prostate-specific antigen （PSA）, margin status （RO/1）, pathological stage （pT）, and Gleason Score （GS）. For individual BCR prediction at any given time after operation, additional ann, and LR models were calculated every 6 months for up to 7.5 years of follow-up. The areas under the receiver operating characteristic （ROC） curve （AUC） for the ann （0.754） and LR models （0.755） calculated immediately following LRP, were larger than that for GS （AUC： 0.715; P= 0.0015 and 0.001）, pT or PSA （AUC： 0.619; Palways 〈0.0001） alone. The GS predicted the BCR better than PSA （P = 0.0001）, but there was no difference between the ann and LR models （P = 0.39）. Our ann and LR models predicted individual BCR risk from radical prostatectomy for up to 10 years postoperative. ann and LR models equally and significantly improved the prediction of BCR compared with PSA and GS alone. When the GS and ann output values are combined, a more accurate BCR prediction is possible, especially in high-risk patients with GS ≥7.

关键词： artificial neural network prostate cancer recurrence

Chiral Plasmonic Pinwheels Exhibit Orientation-Independent Linear Differential Scattering under Asymmetric Illumination

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Chemical & Biomedical Imaging 2023年第1期1卷 30-39页

作者： Lauren A.McCarthy Ojasvi Verma Gopal Narmada Naidu Luca Bursi Alessandro Alabastri Peter Nordlander stephan Link Department of Chemistry Rice UniversityHoustonTexas 77005United States Department of Chemistry University of Michigan930 N.University Ave.Ann ArborMI 48109 Department of Physics and Astronomy Rice UniversityHoustonTexas 77005United States Dipartimento di Fisica Informatica e Matematica-FIMUniversitàdi Modena e Reggio Emiliaand Istituto NanoscienzeConsiglio Nazionale delle Ricerche CNR-NANO-S3I-41125 ModenaItaly Department of Electrical and Computer Engineering Rice UniversityHoustonTexas 77005United States Department of Physics and Astronomy and Department of Electrical and Computer Engineering Rice UniversityHoustonTexas 77005United States

Plasmonic nanoantennas have considerably stronger polarization-dependent optical properties than their molecular counterparts,inspiring photonic platforms for enhancing molecular dichroism and providing fundamental insight into light-matter *** such insight is that even achiral nanoparticles can yield strong optical activity when they are asymmetrically illuminated from a single oblique angle instead of evenly *** effect,called extrinsic chirality,results from the overall chirality of the experimental geometry and strongly depends on the orientation of the incident *** extrinsic chirality has been well-characterized,an analogous effect involving linear polarization sensitivity has not yet been *** this study,we investigate the differential scattering of rotationally symmetric chiral plasmonic pinwheels when asymmetrically irradiated with linearly polarized *** their high rotational symmetry,we observe substantial linear differential scattering that is maintained over all pinwheel *** demonstrate that this orientation-independent linear differential scattering arises from the broken mirror and rotational symmetries of our overall experimental *** results underscore the necessity of considering both the rotational symmetry of the nanoantenna and the experimental setup,including illumination direction and angle,when performing plasmonenhanced chiroptical *** results demonstrate spectroscopic signatures of an effect analogous to extrinsic chirality for linear polarizations.

关键词： linear dichroism phase retardation single-particle scattering spectroscopy chiral nanoantennas extrinsic chirality

Genome-wide association study detects novel risk locus psoriasis

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Genome-wide association study detects novel risk locus psori...

Abstracts from the 15th International Myopia Conference

中华医学会第16次全国皮肤性病学术年会

作者： stephan Weidinger Eva Buchert David Ellinghaus Philip E.Stuart Rajan P.Nair Sophie Debrus John V.Raelson Manfred Kunz Proton Rahman Dafna Gladman Christian Gieger H.erich Wichmann Tom H.Karlsen Dieter Kabelitz Goncalo R.Abecasis James T.Elder Stefan Schreiber michael Weichenthal Andre Franke Institute of Clinical Molecular Biology Christian-Albrechts-University24105 KielGermany Department of Dermatology and Allergy Technische Universitt Mnchen80802 MunichGermany Department of Dermatology University of MichiganAnn ArborMI 48109USA Christian-Albrechts-University 24105 KielGermany

Psoriasis is a complex polygenic disease characterized by epidermal proliferation,altered keratinocyte differentiation and chronic *** recently new insights into the genetic architecture of psoriasis were obtained,many susceptibility loci remain to be *** here present a genome-wide association analysis of 2,339,118 single nucleotide polymorphisms in 472 psoriasis patients and 1146

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez ann Nour Tobin Ansel Kathleen Abarr Luying Yan Keisha Roden David Troilo Chanyi Lu Miaozhen Pan Min Zheng Jia Qu Xiangtian Zhou Christine F. Wildsoet Fan Lu Jie Chen Jinhua Bao Liang Hu Qinmei Wang Zibing Jin Frances Rucker stephanie Britton stephan Hanowsky Molly Spatcher Hui-Ying Kuo Ching-Hsiu Ke I-Hsin Kuo Chien-Chun Peng Han-Yin Sun Ian G. Morgan Jeremy A. Guggenheim Rupal L. Shah Cathy Williams Jinglei Yang Peter S. Reinach Sen Zhang Wenfeng Sun Bo Liu Fen Li Xiaoqing Li Aihua Zhao Tianlu Chen Wei Jia Jun Jiang Haoran Wu Kazuo Tsubota Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel Rathbun Frank Schaeffel Ladan Ghodsi William K. Stell Machelle T. Pardue Ranjay Chakraborty Han na Park Curran S. Sidhu P. michael Iuvone michael J Collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline Cho SW Cheung Pei-Chang Wu Quan V. Hoang Duk C. Lee erica G. Landis michael A. Bergen Curran Sidhu Samer Hattar Richard A. Stone Ravi Metlapally Ruiqin Li Qinglin Xu Hong Zhong Chenglin Pan Weizhong Lan Xiaoning Li Ling Chen Zhikuan Yang Scott A. Read Seang-Mei Saw Shi-Jun Weng Xiao-Hua Wu Kang-Wei Qian Yun-Yun Li Guo-Zhong Xu Furong Huang Xiong-Li Yang Yong-Mei Zhong Earl L Smith, III Baskar Arumugam Li-Fang Hung Lisa A. Ostrin Klaus Trier Monica Jong Brien A. Holden Thomas Chuen Lam Samantha Shan Bing Zuo Dennis Yan-yin Tse Jingfang Bian King-Kit Li Quan Liu Chi-ho To Timothy J. Gawne John T. Siegwart, Jr. Alexander H. Ward Thomas T. Norton Yan Zhang Yue Liu Carol Ho Eileen Phan Abraham Hang Emily Eng Christine Wildsoet Department of Biological Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State Key Laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Social and Community Medicine University of Bristol Bristol UK School of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key Laboratory Cultivation Base and Key Laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic Research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eight had both contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated

Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,pere was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid