Genome-wide association study detects novel risk locus psoriasis

作     者：Stephan Weidinger Eva Buchert David Ellinghaus Philip E.Stuart Rajan P.Nair Sophie Debrus John V.Raelson Manfred Kunz Proton Rahman Dafna Gladman Christian Gieger H.Erich Wichmann Tom H.Karlsen Dieter Kabelitz Goncalo R.Abecasis James T.Elder Stefan Schreiber Michael Weichenthal Andre Franke 

作者单位：Institute of Clinical Molecular BiologyChristian-Albrechts-University24105 KielGermany Department of Dermatology and AllergyTechnische Universitt Mnchen80802 MunichGermany Department of DermatologyUniversity of MichiganAnn ArborMI 48109USA Christian-Albrechts-University24105 KielGermany 

会议名称：《中华医学会第16次全国皮肤性病学术年会》

会议日期：2010年

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

摘      要：Psoriasis is a complex polygenic disease characterized by epidermal proliferation,altered keratinocyte differentiation and chronic *** recently new insights into the genetic architecture of psoriasis were obtained,many susceptibility loci remain to be *** here present a genome-wide association analysis of 2,339,118 single nucleotide polymorphisms in 472 psoriasis patients and 1146