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Earthquake Engineering and Engineering Vibration 2012年第2期11卷 291-292页

作者： Gian Paolo Cimellaro Andrei M. Reinhorn Alessandro De stefano Department of Structural Geotechnical & Building Engineering (DISEG) Politecnico di Torino Corso Duca degli Abruzzi 24 10129 Turin Italy Department of Civil Structural & Environmental Engineering University at Buffalo the State University of New York 135 Ketter Hall Buffalo NY USA

The authors thank the discusser for the additional information,which is provided related to the historical interventions of the church through the centuries. This information was known to the authors,however they deci... 详细信息

关键词： Reply to A.M Reinhorn and A.De stefano Introspection on improper seismic retrofit of Basilica Santa Maria di Collemaggio after 2009 Italian earthquake by G.P Discussion 2 on De

A flexible multi-body model of a surface miner for analyzing the interaction between rock-cutting forces and chassis vibrations

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International Journal of Mining Science and Technology 2021年第3期31卷 365-375页

作者： Alessandro Medolago stefano Melzi Tesmec S.p.A. Grassobbio 24050Italy Department of Mechanics Politecnico di MilanoMilano 20156Italy

The discontinuous nature of rock cutting can easily cause unwanted vibrations in the structure of a surface *** these vibrations are not properly addressed,the related stress cycles can gradually damage the chassis resulting in fatigue *** events can seriously undermine the safety of operators and digging operations may be stopped for days,with an obvious economic *** work presents an analysis of the dynamics of a surface miner,focusing on the interaction between cutting machine dynamics and cutting forces,which is a new approach for this type of *** this purpose,the authors developed a numerical model of the cutting process made up of(1)a multi-body model of the cutting machine,which takes into account the chassis's flexibility;(2)a model of the rotating cutting head;and(3)a model of the interaction between the cutting head and rock,based on Shao's *** model was compared with experimental results and then used to investigate the effects of cutting speed and cutting depth on the machine dynamics.

关键词： Surface miner Flexible multi-body model Validation Cutting forces Chassis vibrations

SBV REGULARITY OF GENUINELY NONLINEAR HYPERBOLIC SYSTEMS OF CONSERVATION LAWS IN ONE SPACE DIMENSION

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Acta Mathematica Scientia 2012年第1期32卷 380-388页

作者： stefano Bianchini SISSA via Bonomea 265IT-34136 Trieste

The problem of the presence of Cantor part in the derivative of a solution to a hyperbolic system of conservation laws is considered. An overview of the techniques involved in the proof is given, and a collection of r... 详细信息

关键词： hyperbolic systems conservation laws SBV regularity

The implementation of international geospatial standards for earth and space sciences

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International Journal of Digital Earth 2010年第S1期3卷 2-13页

作者： stefano Nativi CNR-IMAA University of Florence at PratoPiazza Ciardi 2559100 PratoItaly

The Earth and Space Sciences Informatics division of European Geosciences Union(EGU)and the Open Geospatial Consortium jointly organised a special event entitled:‘Implementation of international geospatial standards for earth and space sciences event’at the EGU General Assembly meeting held in Vienna,April *** event objectives included:(a)to discuss the integration of information systems from different geosciences disciplines;(b)to promote and discuss the present process to scale from specific and monolithic systems towards independent and modular enabling infrastructuresforming an earth system science(ESS)infrastructure;and(c)to show some of the latest advances in implementing open *** manuscript introduces the event motivations and describes the abstract and holistic framework,which can be used to situate the topics and the developments presented by the event *** manuscript introduces important,and relatively new technologies to build a multi-disciplinary geosciences information system:the System of Systems approach and the Model Driven *** achieve that,three important information infrastructure categories are recognised:(a)ESS information infrastructure;(b)geospatial information infrastructure;and(c)distributed information *** Earth should support the discussed framework to accelerate information transfer from theoretical discussions to applications,in all fields related to global climate change,natural disaster prevention and response,new energy-source development,agricultural and food security,and urban planning and management.

关键词： digital earth infrastructures System of Systems multi-disciplinary interoperability interoperability standards information modelling approach

Hubbard U through polaronic defect states

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npj Computational Materials 2022年第1期8卷 2504-2511页

作者： stefano Falletta Alfredo Pasquarello Chaire de Simulationàl’Echelle Atomique(CSEA) Ecole Polytechnique Fédérale de Lausanne(EPFL)CH-1015LausanneSwitzerland

Since the preliminary work of Anisimov and co-workers,the Hubbard corrected DFT+U functional has been used for predicting properties of correlated materials by applying on-site effective Coulomb interactions to specific ***,the determination of the Hubbard U parameter has remained under intense discussion despite the multitude of approaches ***,we define a selection criterion based on the use of polaronic defect states for the enforcement of the piecewise linearity of the total energy upon electron occupation.A good agreement with results from piecewise linear hybrid functionals is found for the electronic and structural properties of polarons,including the formation *** values of U determined in this way are found to give a robust description of the polaron energetics upon variation of the considered *** particular,we also address a polaron hopping pathway,finding that the determined value of U leads to accurate energetics without requiring a configurational-dependent *** is emphasized that the selection of U should be based on physical properties directly associated with the orbitals to which U is applied,rather than on more global properties such as band gaps and band *** comparison,we also determine U through a well-established linear-response scheme finding noticeably different values of U and consequently different formation *** origins of these discrepancies are *** case studies,we consider the self-trapped electron in BiVO_(4),the self-trapped hole in MgO,the Li-trapped hole in MgO,and the Al-trapped hole inα-SiO_(2).

关键词： Hubbard polaron piecewise

CFD simulation of fluidization quality in the three-dimensional fluidized bed

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Progress in Natural Science:Materials International 2008年第6期18卷 729-733页

作者： stefano Brandani Edinburgh EH9 3JL IMP-SEE University of Edinburgh The King’s Buildings UK

Multiphase computational fluid dynamics(CFD)has become an alternative method to experimental investigation for predicting the fluid dynamics in gas-solid fluidized *** model of Brandani and Zhang,which contains additional terms in both the gas-and solid-phase momentum equations,is employed to explore homogeneous fluidization of Geldart type A particles and bubbling fluidization of Geldart type B particles in three-dimensional gas-fluidized *** this model,only a correlation for drag force is necessary to close the governing *** kinds of solids,i.e.,fine alumina powder(dp=60 lm and qp=1500 kg/m3)and sand(dp=610 lm and qp=2500 kg/m3),are numerically simulated in a rectangular duct of 0.2 m(long)0.2 m(wide)0.5 m(high)*** results show good agreement with the classic theory of Geldart.

关键词： Three-dimensional gas-solid fluidized bed Fluidization quality CFD simulation

Colorectal cancer screening behavior and willingness

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World Journal of Gastroenterology 2012年第22期18卷 2885-2886页

作者： stefano Pontone Department of Surgical Sciences "Sapienza" University of Rome V.le Regina Elena 324 00161 Rome Italy

The outpatient-based study by Deng et al [World J Gastroenterol 2011 July 14; 17(26): 3133-3139] on the factors that may influence the colorectal cancer (CRC) screening feasibility, encouraged our curiosity. Establishing a simple method for quickly assessing the educational level of patients and modulating a questionnaire for each type of patient, may be an effective protocol to increase the people participation, mainly in countries where sufficient medical resources and financial support are lacking. In fact, the knowledge directly affects the feasibility when screening is offered. Patient educational level influences the understanding of the knowledge and the screening method. This factor may affect patient's priority level on the study participation, the understanding of questions, and the motivation to complete the questionnaire and, consequently, the screening success. Recent studies have found a relationship between high educational level and CRC screening participation, and emphasized the question-naire ineffectiveness in the illiterate people. Although the questionnaire is an excellent method for this kind of evaluation, physician's contribution could be the most important factor associated with the screening method. Thus, further studies should be conducted to explore the compliance of patients with low educational level and to look for the best solutions for their enrollment.

关键词： Colorectal cancer Screening Educationallevel Survey Socioeconomic factors

TICA: Transcriptional Interaction and Coregulation Analyzer

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Genomics, Proteomics & Bioinformatics 2018年第5期16卷 342-353页

作者： stefano Perna Pietro Pinoli stefano Ceri Limsoon Wong Dipartimento di Elettronica Informazione e Bioingegneria Politecnico di Milano School of Computing National University of Singapore

Transcriptional regulation is critical to cellular processes of all organisms. Regulatory mechanisms often involve more than one transcription factor(TF) from different families, binding together and attaching to the DNA as a single complex. However, only a fraction of the regulatory partners of each TF is currently known. In this paper, we present the Transcriptional Interaction and Coregulation Analyzer(TICA), a novel methodology for predicting heterotypic physical interaction of TFs. TICA employs a data-driven approach to infer interaction phenomena from chromatin immunoprecipitation and sequencing(ChIP-seq) data. Its prediction rules are based on the distribution of minimal distance couples of paired binding sites belonging to different TFs which are located closest to each other in promoter regions. Notably, TICA uses only binding site information from input ChIP-seq experiments, bypassing the need to do motif calling on sequencing data. We present our method and test it on ENCODE ChIP-seq datasets, using three cell lines as reference including HepG2, GM12878, and K562. TICA positive predictions on ENCODE ChIP-seq data are strongly enriched when compared to protein complex(CORUM) and functional interaction(BioGRID) databases. We also compare TICA against both motif/ChIP-seq based methods for physical TF–TF interaction prediction and published literature. Based on our results, TICA offers significant specificity(average 0.902) while maintaining a good recall(average 0.284) with respect to CORUM, providing a novel technique for fast analysis of regulatory effect in cell lines. Furthermore, predictions by TICA are complementary to other methods for TF–TF interaction prediction(in particular, TACO and CENTDIST). Thus, combined application of these prediction tools results in much improved sensitivity in detecting TF–TF interactions compared to TICA alone(sensitivity of 0.526 when combining TICA with TACO and 0.585 when combining with CENTDIST)with little compromise

关键词： Transcription factors Coregulation Protein–protein interactions Machine learning Data-driven analysis

Endocannabinoid immune and vascular signaling

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Acta Pharmacologica Sinica 2000年第12期21卷 16-26页

作者： George B stefano Beth Israel Deaconess Medical Center Boston MA 02215 NY 11568 and Mind Body Medical Institute Neuroscience Research Institute P O Box 210 State University of New York at Old Westbury USA

HISTORY Hemp has been cultivated for 7000 to 8000 yearsc. The Sumerian/Babylonian term for cannabis hemp is K (a)N(a)B(a), and it is one of the longest surviving root words in Indo-Semitic-European language. In 2700 BC, Shen Nung, a contributor to early Chinese medicine, mentions cannabis in the pharmacopoeia. Around 500 BC Zoroaster, a Persian prophet, in the Zend-Avesta, listing 10 000 medicinal plants, includes hemp. In the first century AD the Chinese begin making paper from hemp as an inexpensive means of preserving information. In 800 AD the Islamic prophet Mohammed allows cannabis use. In 1100, Moslems use cannabis to start

关键词： anandamide nitric oxide 2-arachi-donyl-glyceral cannabinoid receptors vascular endothe-lium hemp immune cells

Theory,simulations and the design of functionalized nanoparticles for biomedical applications:A Soft Matter Perspective

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npj Computational Materials 2017年第1期3卷 52-66页

作者： stefano Angioletti-Uberti Department of Materials Imperial College LondonLondon SW72AZUK Beijing Advanced Innovation Centre for Soft Matter Science and Engineering Beijing University of Chemical Technology100099 BeijingPR China

Functionalised nanoparticles for biomedical applications represents an incredibly exciting and rapidly growing field of *** the complexity of the nano-bio interface,an important question is to what extent can theory and simulations be used to study these systems in a realistic,meaningful *** this review,we will argue for a positive answer to this *** the issue from a“Soft Matter”perspective,we will consider those properties of functionalised nanoparticles that can be captured within a classical *** will thus not concentrate on optical and electronic properties,but rather on the way nanoparticles’interactions with the biological environment can be tuned by functionalising their surface and exploited in different contexts relevant to *** particular,we wish to provide a critical overview of theoretical and computational coarsegrained models,developed to describe these interactions and present to the readers some of the latest results in this fascinating area of research.

关键词： functional meaningful biomedical