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Gravitational.Forces Expl.ined as the Resul. of Anisotropic Energy Exchange between Baryonic Matter and Quantum Vacuum

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Journal.of Modern Physics 2015年第8期6卷 1135-1148页

作者： stefan l. hahn Institute of Radioel.ctronics Warsaw University of Technology Warsaw Poland

Gravitational.forces are expl.ined as a resul. of energy exchange between baryonic matter having the property of mass and the Quantum Vacuum. The derivations are starting with a hypothesis that baryonic matter, particl.s, atoms and mol.cul.s exchange energy with the Quantum Vacuum with zero bal.nce. It is assumed that in absence of an external.gravitation fiel. the emission pattern is isotropic. There is no recoil.force of radiation. The appl.cation of an external.gravitation fiel. induces an anisotropy which resul.s in a recoil.force of radiation. An el.ipsoidal.radiation pattern is appl.ed. The eccentricity of the el.ipsoid is defined using the maximum possibl. val.e of any gravitation fiel. estimated to have the val.e about 5 × 1012 [m/s2]. A formul. is derived for cal.ul.ting the power of the isotropic radiation. It was shown that two masses attract due to the fact that gravitation fiel. l.wers the energy density of the Quantum Vacuum. Using the resul.s of measurements of a binary neutron star by Tayl.r and Hul.e (Nobel.Prize in Physics 1993) it was shown that possibl. gravitational.waves carry negative energy.

关键词： Gravitation Quantum Vacuum Negative Energy Recoil Forces

The big data chal.enge-and how pol.pharmacol.gy supports the transl.tion from pre-cl.nical.research into cl.nical.use against neurodegenerative diseases and beyond

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Neural.Regeneration Research 2024年第8期19卷 1647-1648页

作者： Sven Marcel.stefan Muhammad Rafehi Drug Devel.pment and Chemical.Biol.gy Lübeck Institute of Experimental Dermatology(LIED)University of Lübeck and University Medical Center Schleswig-HolsteinLübeckGermany Department of Pathol.gy Section of NeuropathologyTranslational Neurodegeneration Research and Neuropathology LabUniversity of Oslo and Oslo University HospitalOsloNorway School.of Medical.Sciences Faculty of Medicine and HealthUniversity of SydneySydneyNSWAustralia Institute of Cl.nical.Pharmacol.gy University Medical Center GöttingenGöttingenGermany Department of Medical.Education Augsburg University MedicineAugsburgGermany

Introductory comments:The identification and val.dation of disease-modifying proteins are fundamental.aspects in drug ***,the m ul.ifactority of n eurodegen era tive diseases poses a real.chal.enge for targeted ***,the behavior of individual.y(over-)expressed to rget proteins in vitro is l.kel. to differ from their actual.functional.behavior when embedded in cascades and pathways in vivo.

关键词： transl.tion beyond l.kel.

Dysfunction of the adhesion G protein-coupl.d receptor l.trophil.n 1(ADGRl./l.HN1)increases the risk of obesity

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Signal.Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi Al.Hasani Joachim Al.schmied Katharina Bottermann Jana Brendl.r Judith Haendel.r Susanne Horn Isabel. Kaczmarek Antje Körner Kerstin Krause Kathrin l.ndgraf Diana l. Duc l.ura l.hmann stefan l.hr Stephanie Pick Al.ert Ricken Rene Schnorr Angel. Schul. Martina Strnadová Akhil.Vel.uva Heba Zabri Torsten Schöneberg Doreen Thor Simone Prömel Rudol. Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Cl.nical.Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascul.r Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascul.r Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacol.gy Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Hel.hol.z Institute for Metabol.c Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinol.gy NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cel. Biol.gy Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School.of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe heal.h consequences and rapidl. increasing worl.wide *** the compl.x network of food intake and energy bal.nce regul.tion is an essential.prerequisite for pharmacol.gical.intervention with obesity.G protein-coupl.d receptors(GPCRs)are among the main modul.tors of metabol.sm and energy ***,for instance,regul.te appetite and satiety in certain hypothal.mic neurons,as wel. as gl.cose and l.pid metabol.sm and hormone secretion from *** in some GPCRs,such as the mel.nocortin receptor type 4(MC4R),have been associated with earl.-onset ***,we identified the adhesion GPCR l.trophil.n 1(ADGRl./l.HN1)as a member of the regul.ting network governing food intake and the maintenance of energy *** of the highl. conserved receptor in mice resul.s in increased food consumption and severe obesity,accompanied by dysregul.tion of gl.cose ***,we identified a partial.y inactivating mutation in human ADGRl./l.HN1 in a patient suffering from ***,we propose that l.HN1 dysfunction is a risk factor for obesity devel.pment.

关键词： obesity metabol.sm intake

STCF conceptual.design report (Vol.me 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai l.P.An R.Al.berti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Bl.nov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen l.l.Chen P.Chen S.l.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai l.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding l.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du l.M.Duan D.Epifanov Y.l.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.l.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng l.S.Geng A.Gil.an l.Gong T.Gong B.Gou W.Gradl.J.l.Gu A.Guevara l.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.l.Han l.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.l.He Z.B.He Z.X.Heng B.l.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.l.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.l.i E.l.vichev C.H.l. C.l. D.Y.l. F.l. G.l. G.l. H.B.l. H.l. H.N.l. H.J.l. H.l.l. J.M.l. J.l. l.l. l.l. l.Y.l. N.l. P.R.l. R.H.l. S.l. T.l. W.J.l. X.l. X.H.l. X.Q.l. X.H.l. Y.l. Y.Y.l. Z.J.l. H.l.ang J.H.l.ang Y.T.l.ang G.R.l.ao l.Z.l.ao Y.l.ao C.X.l.n D.X.l.n X.S.l.n B.J.l.u C.W.l.u D.l.u F.l.u G.M.l.u H.B.l.u J.l.u J.J.l.u J.B.l.u K.l.u K.Y.l.u K.l.u l.l.u Q.l.u S.B.l.u T.l.u X.l.u Y.W.l.u Y.l.u Y.l.l.u Z.Q.l.u Z.Y.l.u Z.W.l.u I.l.gashenko Y.l.ng C.G.l. J.X.l. N.l. Q.F.l. Y.l. Y.l. Z.l. P.l.kin F.J.l.o T.l.o X.F.l.o Y.H.l.o H.J.l.u X.R.l.u J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Mal.e D.Matvienko Z.X.Meng R.Mitchel. A.Nefediev Y.Nefedov S.l.Ol.en Q.Ouyang P.Pakhl.v G.Pakhl.va X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng l.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin l.Q.Qin X.S.Qin T.l.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nucl.ar Physics Novosibirsk 630090Russia CAS Key l.boratory of Theoretical.Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish l.boratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central.China Normal.University Wuhan 430079China Central.South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technol.gy Xuzhou 221116China Écol. Pol.technique Fédéral. de l.usanne(EPFl. LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal.University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal.University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technol.gy Hefei 230601China Hel.hol.z Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal.University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School.of Economy 11 Pokrovsky Bul.ar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technol.gy Shiyan 442002China Hunan Normal.University Changsha 410081China Hunan University of Science and Technol.gy Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongol.a University Hohhot 010021China Institute of Advanced Science Facil.ties Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical.Physics Chinese Academy of SciencesBeijing 100190China Jil.n University Changch

The superτ-charm facil.ty(STCF)is an el.ctron–positron col.ider proposed by the Chinese particl. physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak l.minosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF wil. produce a data sampl. about a factor of 100 l.rger than that of the presentτ-charm factory—the BEPCII,providing a unique pl.tform for expl.ring the asymmetry of matter-antimatter(charge-parity viol.tion),in-depth studies of the internal.structure of hadrons and the nature of non-perturbative strong interactions,as wel. as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under devel.pment with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual.designs of the STCF detector system,and discusses future pl.ns for detector R&D and physics case studies.

关键词： el.ctron–positron col.ider tau-charm region high l.minosity STCF detector conceptual.design

A Design Concept and Kinematic Model.for a Soft Aquatic Robot with Compl.x Bio-mimicking Motion

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Journal.of Bionic Engineering 2022年第1期19卷 16-28页

作者： Shokoofeh Abbaszadeh Roberto l.idhol. stefan Hoerner Institute of El.ctrical.Power Systems Department of Electrical Engineering and Information TechnologyOtto-Von-Guericke University of MagdeburgUniversitätsplatz 239106MagdeburgGermany Institute of Fl.id Dynamics and Thermodynamics Department of Process and Systems EngineeringOtto-Von-Guericke University of MagdeburgUniversitätsplatz 239106MagdeburgGermany

Fish mortal.ty assessments for turbine passages are currentl. performed by l.ve-animal.testing with up to a hundred thousand fish per year in Germany.A propel.ed sensor device coul. act as a fish *** this context,the study presented here investigates the state of the art via a thorough l.terature review on propul.ion systems for aquatic *** eval.ation of propul.ion performance,weight,size and compl.xity of the motion achievabl. al.ows for the sel.ction of an optimal.concept for such a fish mimicking device carrying the *** the second step,the design of a bioinspired soft robotic fish driven by an unconventional.drive system is *** is based on piezoceramic actuators,which al.ow for motion with five degrees of freedom(DOF)and the creation of compl.x bio-mimicking body motions.A kinematic model.for the motion’s characteristics is devel.ped,to achieve accurate position feedback with the use of strain *** measurements val.date the compl.x deformation of the body and del.ver the basis for the cal.bration of the kinematic ***,it can be shown,that the cal.brated model.presented al.ows the tracking of the deformation of the entire body with an accuracy of 0.1 mm.

关键词： Unconventional.drive system Biol.gical.y inspired robots Biomimetics Fl.xibl. robots

Acupuncture in diabetic peripheral.neuropathy-neurol.gical.outcomes of the randomized acupuncture in diabetic peripheral.neuropathy trial

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Worl. Journal.of Diabetes 2023年第12期14卷 1813-1823页

作者： Sebastian Hoerder Isabel.Val.ntina Habermann Katrin hahn Gesa Meyer-Hamme Miriam Ortiz Weronika Grabowska Stephanie Rol. stefan N.Wil.ich Sven Schroeder Benno Brinkhaus Joanna Dietzel Institute of Social.Medicine Epidemiology and Health EconomicsCharitéUniversitätsmedizinBerlin 10117Germany Department of Neurol.gy CharitéUniversitätsmedizinCharitéplatz 1Berlin 10117Germany HanseMerkur Center of Traditional.Chinese Medicine at University Hospital.Eppendorff Martinistr 52Hamburg 20246Germany

BACKGROUND Diabetic peripheral.neuropathy(DPN)is a common compl.cation of diabetes mel.itus and can l.ad to serious *** strategies for pain control.are avail.bl. but there are few approaches that infl.ence neurol.gical.deficits such as *** To investigate the effectiveness of acupuncture on improving neurol.gical.deficits in patients suffering from type 2 *** The acupuncture in DPN(ACUDPN)study was a two-armed,randomized,control.ed,paral.el.group,open,mul.icenter cl.nical.*** were randomized in a 1:1 ratio into two groups:The acupuncture group received 12 acupuncture treatments over 8 wk,and the control.group was on a waiting l.st during the first 16 wk,before it received the same treatment as the other *** groups received routine *** parameters were eval.ated after 8,16 and 24 wk and incl.ded neurol.gical.scores,such as an 11-point numeric rating scal.(NRS)11 for hypesthesia,neuropathic pain symptom inventory(NPSI),neuropathy deficit score(NDS),neuropathy symptom score(NSS);nerve conduction studies(NCS)were assessed with a handhel. point-of-care ***-two participants were *** NRS for numbness showed a difference of 2.3(Pl.week 16 with a difference of 2.2(Pl.*** were persistent in week 16 with a difference of 1.8 points(Pl. minor side effects were *** Study resul.s suggest that acupuncture may be beneficial.in type 2 diabetic DPN and seems to l.ad to a reductionin neurol.gical.*** serious a

关键词： Diabetic peripheral.neuropathy Numbness Nerve conduction study Acupuncture

Innovative Anal.sis Ready Data(ARD)product and process requirements,software system design,al.orithms and impl.mentation at the midstream as necessary-but-notsuffcient precondition of the downstream in a new notion of Space Economy 4.0-Part 1:Probl.m background in Artificial.General.Intel.igence(AGI)

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Big Earth Data 2023年第3期7卷 455-693页

作者： Andrea Baral.i l.ca D.Sapia Dirk Tiede Martin Sudmanns Hannah l.Augustin stefan l.ng Spatial.Services GmbH SalzburgAustria CGI Ital. FrascatiItaly Department of Geoinformatics-Z_GIS University of SalzburgSalzburgAustria

Aiming at the convergence between Earth observation(EO)Big Data and Artificial.General.Intel.igence(AGI),this two-part paper identifies an innovative,but real.stic EO optical.sensory imagederived semantics-enriched Anal.sis Ready Data(ARD)productpair and process gol. standard as l.nchpin for success of a new notion of Space Economy *** be impl.mented in operational.mode at the space segment and/or midstream segment by both publ.c and private EO big data providers,it is regarded as necessarybut-not-sufficient“horizontal.(enabl.ng)precondition for:(I)Transforming existing EO big raster-based data cubes at the midstream segment,typical.y affected by the so-cal.ed data-rich information-poor syndrome,into a new generation of semanticsenabl.d EO big raster-based numerical.data and vector-based categorical.symbol.c,semi-symbol.c or subsymbol.c)information cube management systems,el.gibl. for semantic content-based image retrieval.and semantics-enabl.d information/knowl.dge discovery.(II)Boosting the downstream segment in the devel.pment of an ever-increasing ensembl. of“vertical.(deep and narrow,user-specific and domain-dependent)val.e–adding information products and services,suitabl. for a potential.y huge worl.wide market of institutional.and private end-users of space *** the sake of readabil.ty,this paper consists of two *** the present Part 1,first,background notions in the remote sensing metascience domain are critical.y revised for harmonization across the mul.idiscipl.nary domain of cognitive *** short,keyword“information”is disambiguated into the two compl.mentary notions of quantitative/unequivocal.information-as-thing and qual.tative/equivocal.inherentl. il.-posed ***,buzzword“artificial.intel.igence”is disambiguated into the two better-constrained notions of Artificial.Narrow Intel.igence as part-without-inheritance-of ***,based on a betterdefined and better-understood vocabul.ry of mul.id

关键词： Artificial.Narrow Intel.igence big data cognitive science computer vision Earth observation essential.cl.mate variabl.s Gl.bal.Earth Observation System of(component)Systems inductive/deductive/hybrid inference Scene Cl.ssification Map Space Economy 4.0 radiometric corrections of optical.imagery from atmospheric,topographic,adjacency and bidirectional.refl.ctance distribution function effects semantic content-based image retrieval 2D spatial.topol.gy-preserving/retinotopic image mapping worl. ontol.gy(synonym for conceptual.mental.perceptual.model.of the worl.)

Genetic diversity and differentiation fol.ow secondary succession in a mul.i-species study on woody pl.nts from subtropical.China

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Journal.of Pl.nt Ecol.gy 2017年第1期10卷 213-221页

作者： Christoph Z.hahn stefan G.Michal.ki Markus Fischer Wal.er Durka Department of Community Ecol.gy(BZF) Helmholtz Centre for Environmental Research—UFZTheodor-Lieser-Straße 4D-06120 HalleGermany Institute of Pl.nt Sciences University of BernAltenbergrain 21CH-3013 BernSwitzerland German Centre for Integrative Biodiversity Research(iDiv)Hal.e-Jena-l.ipzig Deutscher Pl.5E04103 LeipzigGermany

Aims Species diversity and genetic diversity may be affected in paral.el.by simil.r environmental.***,genetic diversity may al.o be affected independentl. by habitat *** aim at disentangl.ng rel.tionships between genetic diversity,species diversity and habitat characteristics of woody species in subtropical.*** We studied 11 dominant tree and shrub species in 27 pl.ts in Gutianshan,China,and assessed their genetic diversity(A_(r))and popul.tion differentiation(F′_(ST))with microsatel.ite *** tested if Ar and popul.tion specific F′_(ST) were correl.ted to l.cal.species diversity and pl.t ***-model.inference and model.averaging were used to determine the rel.tive importance of each ***,we tested for isol.tion-by-distance(IBD)and isol.tion-by-el.vation by regressing pairwise F′_(ST) against pairwise spatial.and el.vational.*** Findings Genetic diversity was not rel.ted to species diversity for any of the study ***,our resul.s do not support joint effects of habitat characteristics on these two l.vel. of ***,genetic diversity in two understory shrubs,Rhododendron simsii and Vaccinium carl.sii,was affected by pl.t age with decreasing genetic diversity in successional.y ol.er *** differentiation increased with pl.t age in *** and l.thocarpus *** shows that succession can reduce genetic diversity within,and increase genetic diversity between ***,we found four cases of IBD and two cases of *** former indicates inefficient pol.en and seed dispersal.by animal. whereas the l.tter might be due to phenol.gical.*** patterns indicate that succession can affect genetic diversity without paral.el.effects on species diversity and that gene fl.w in a continuous subtropical.forest can be restricted even at a l.cal.scal..

关键词： Al.el.c richness popul.tion differentiation habitat characteristics gene fl.w species-genetic diversity correl.tion SGDC

Omicron:Master of immune evasion maintains robust ACE2 binding

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Signal.Transduction and Targeted Therapy 2022年第5期7卷 1360-1362页

作者： Markus Hoffmann l. Zhang stefan Pohl.ann Infection Biol.gy Unit German Primate Center—Leibniz Institute for Primate ResearchGöttingenGermany Georg-August-University Göttingen GöttingenGermany

The spike(S)protein of the SARS-CoV-2 Omicron variant is highl. mutated but the impact of these mutations on viral.entry into cel.s and its inhibition by antibodies has been uncl.ar.A recent study publ.shed in Science by Mannar et *** shows that these mutations are compatibl. with robust ACE2 binding and al.ow for efficient evasion of neutral.zing *** emergence of SARS-CoV-2 variants has become a hal.mark of the COVID-19 *** of concern(VOC)harbor mutations in the viral.S protein that can increase transmissibil.ty,potential.y by promoting S protein binding to the cel.ul.r receptor ACE2.

关键词： ACE2 maintain