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突触结合蛋白Ⅰ的胞质片段与磷脂膜的相互作用

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生物化学与生物物理进展 2003年第1期30卷 84-88页

作者：贺雨虹隋森芳清华大学生物科学与技术系

突触结合蛋白Ⅰ是神经细胞突触囊泡上的一个膜整合蛋白 ,C2AB是其具有重要功能的胞质片段 .近年的研究表明 ,突触结合蛋白Ⅰ在钙引发的神经递质快速释放过程中起到钙感受器的作用 ,它与神经细胞突触前膜的相互作用与其生理功能有关 ,但... 详细信息

突触结合蛋白Ⅰ是神经细胞突触囊泡上的一个膜整合蛋白 ,C2AB是其具有重要功能的胞质片段 .近年的研究表明 ,突触结合蛋白Ⅰ在钙引发的神经递质快速释放过程中起到钙感受器的作用 ,它与神经细胞突触前膜的相互作用与其生理功能有关 ,但是其作用机制还不清楚 .利用气 /液单层膜技术结合荧光发射光谱和圆二色光谱技术 ,发现C2AB倾向于插入带负电荷的磷脂膜中 (如磷脂酰丝氨酸 ) ,而且插膜是钙依赖性的 ;对于不带电荷的磷脂不插膜 .C2AB与膜之间的作用力主要为静电力 .荧光发射光谱和圆二色光谱结果显示 ,它与膜相互作用时二级结构不发生显著变化 .结果表明 ,突触结合蛋白Ⅰ钙依赖的插入负电荷膜特点 ,可以帮助解释其钙感受器的作用机制 .

关键词：突触结合蛋白I 胞质片段磷脂膜相互作用临界插膜压神经细胞

Fstl1 Is a BMP4 Signaling Antagonist in Controlling Mouse Lung Development

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Fstl1 Is a BMP4 Signaling Antagonist in Controlling Mouse Lu...

The developmental trend of labrum and median eyes of Orsten-type preserved Phosphatocopina (Crustacea)

“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： Yan Geng~(*+),Yingying Dong~(*+),Ye-Guang Chen~(*),and Wen Ning~(*‖**) +Model Animal Research Center,Nanjing university,Nanjing 210061,china state key laboratory of biomembrane and membrane biotechnology,school of life sciences,Tsinghua university,beijing 100084,china ‖College of life sciences,Nankai university,Tianjin 300071,china.

Lung morphogenesis is a well-orchestrated,tightly regulated process through several molecular pathways including TGF/BMP *** of these signaling pathways leads to lung malformation. We herein investigated the role of Follistatin-like 1(Fstl1),a secreted follistatin-module containing glycoprotein,in lung *** of Fstl1 in mice led to postnatal lethality due to respiratory *** of the mutant phenotype showed that Fstl1 is essential for tracheal cartilage formation and alveolar *** of the Fstl1 gene resulted in malformed tracheal rings manifested as discontinued rings and reduced ring ***1 deficient mice displayed septal hypercellularity and end-expiratory atelectasis,which were associated with impaired differentiation of distal alveolar epithelial cells and insufficient production of mature surfactant ***,Fstl1 interacted directly with BMP4,negatively regulated BMP4/Smad 1/5/8 signaling,and inhibited BMP4-induced surfactant gene *** BMP signaling activity by Noggin rescued pulmonary atelectasis of Fstl1 deficient ***,we provide in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation,in part,through BMP4 signaling.

关键词： Fstll respiratory failure tracheal cartilage differentiation of alveolar epithelial cell BMP4

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Science china Earth sciences 2010年第1期53卷 18-26页

作者： LIU Zheng 1,2 & DONG XiPing 1,2 1 school of Earth and Space sciences,Peking university,beijing 100871,china 2 state key laboratory of Palaeobiology and Stratigraphy,Nanjing Institute of Geology and Palaeontology,Chinese Academy of sciences,Nanjing 210008,china 1. school of Earth and Space sciences Peking University Beijing 100871 China2. State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences Nanjing 210008 China

The Phosphatocopina (Crustacea,Arthropoda) is an important group of 'Orsten-type' preserved *** is resolved as the sister-group of *** we study the labrum,the median eyes,and the inner lamella of Phosphatocopina based on the selected specimens respectively from western Hunan,South china,and *** labrum characters of different species exhibit interspecific *** ratio of labrum length/shield length is significant to the reconstruction of the ontogeny of *** labrum characters should be introduced to the diagnosis of *** the earliest growth stage,the median eyes were inconspicuous,almost as flat as the other area of the ***,with the growth of the individuals they became *** were two obviously concave structures on the ventral side of the hypostome in later stages,which were the positions where the median eyes should have been *** addition,the two modes of preservation of the inner lamella,i.e.,that of shrinking and that of bulging up,are interpreted as the preservational artifact herein.

关键词： Phosphatocopina Crustacea Orsten-type preservation morphology ontogeny Cambrian South china Sweden

Environmental archaeology of the Dachang region in the Daning Valley,the Three Gorges reservoir region of the Yangtze River,china

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Chinese Science Bulletin 2008年第S1期53卷 140-152页

作者： ZHANG Yun 1 &ZHU Cheng 2 1 state key laboratory of Vegetation and Environmental Change,Institute of Botany,Chinese Academy of sciences,beijing 100093, china 2 school of Geographic and Oceanographic sciences,Nanjing university,Nanjing 210093,china 1. state key laboratory of Vegetation and Environmental Change Institute of Botany Chinese Academy of Sciences Beijing 100093 China 2. school of Geographic and Oceanographic sciences Nanjing University Nanjing 210093 China

Environmental archaeology of archaeological sites on both sides of the Dachang section in the Daning River,the Three Gorges of the Yangtze River,shows that riverbed evolution has a great influence on the distribution of archaeological sites during the prehistorical and historical period,and it restricts human activity and the development of ancient *** investigation,dating data,paleocurrent analysis of 100 gravels on the riverbed and archaeological excavation reveal that the riverbed of the Dachang section developed in the Shuangyantang region during the early stage,after about 30 kaBP it shifted westward gradually and reached the present *** with the westward shift,the focus of ancient culture changed for several *** the Western Zhou Dynasty's period,the east riverbank of the Daning River was the main residential *** the Han Dynasty,along with the westward shift,the living space of ancient people was no longer confined to the east riverbank and the focus of culture moved *** the Zhangjiawan site became the main dwelling *** the late Han Dynasty, the villages were flooded and the ancients had to immigrate to a high *** of the Han and the Jin Dynasties outcropped on the flood plain of the east bank because their surface sediments were eroded by several flood events and the westward shift of the riverbed.

关键词： the Daning River environmental archaeology the Shuangyantang site the Zhangjiawan site tombs of the Han and the Jin Dynasties

Weight hierarchies of linear codes satisfying the Near-Chain condition

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Progress in Natural Science:Materials International 2005年第9期15卷 784-792页

作者： LIU Zihui1** and CHEN Wende2(1. school of Mathematical sciences, Peking university, beijing 100871, china 2. laboratory of Systems and Control and key state laboratory of Information Security, Institute of Systems Science, Academy of Mathematics and Systems Science, Chinese Academy of sciences, beijing 100080, china) school of Mathematical sciences Peking University Beijing 100871 China. laboratory of Systems and Control and key state laboratory of Information Security Institute of Systems Science Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 China

The weight hierarchies of a linear [n,k;q] code C satisfying the Near-Chain condition are studied, almost all the weight hierarchies of such code are determined.

关键词： weight hierarchy Near-Chain condition difference sequence linear code.

Optimization model and algorithm for mixed traffic of urban road network with flow interference

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Science china(Technological sciences) 2008年第12期51卷 2213-2222页

作者： SI BingFeng,LONG JianCeng & GAO ZiYou state key laboratory of Rail Traffic Control and Safety,beijing Jiaotong university,beijing 100044,china state key laboratory of Rail Traffic Control and Safety Beijing Jiaotong University Beijing 100044 China

In this paper,the problem of interferences between motors and non-motors in urban road mixed traffic network is considered and the corresponding link impedance function is presented based on travel *** the base of this,the main factors that influence travelers' traffic choices are all considered and a combined model including flow-split and assignment problem is *** a bilevel model with its algorithm for system optimization of urban road mixed traffic network is *** the application of the model and its algorithm is illus-trated with a numerical example.

关键词： mixed traffic impedance function user equilibrium optimization

Zircon LA-ICPMS study and petrogenesis simulation of Dahuabei pluton in the Wulashan area,Inner Mongolia

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Progress in Natural Science:Materials International 2009年第12期19卷 1727-1737页

作者： Dapeng Li~(a,b),Yuelong Chen~(a,*),Liemeng Chen~c,Zhong Wang~d,Jinbao Liu~d a school of Earth sciences and Resources,china university of Geosciences(beijing),beijing 100083,china b state key laboratory of Geological Process and Mineral Resources,china university of Geosciences,Wuhan 430074,china c state key laboratory of Ore Deposit Geochemistry,Institute of Geochemistry,Chinese Academy of sciences,Guiyang 550002,china d Geological Survey Institute of Inner Mongolia,Hohhot 010010,china [a]school of Earth sciences and Resources China University of Geosciences (Beijing) Beijing 100083 China [b]state key laboratory of Geological Process and Mineral Resources China University of Geosciences Wuhan 430074 China [c]state key laboratory of Ore Deposit Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang 550002 China [d]Geological Survey Institute of Inner Mongolia Hohhot 010010 China

Dahuabei pluton in the Wulashan area,Inner Mongolia,is an alkaline and peraluminous granitic ***-ICPMS U-Pb dating of zircons indicates that this pluton crystallized at 330±10 *** pluton did not experience apparent zircon *** consistent temperatures between Zr saturation(765℃) and the average zircon-rutile Ti equilibrium(780℃),together with zircon ages and their CL images,indicated that there were no inherited zircons in this *** the simulation of the dry-system crystallization process of magma cooling at 200 MPa and 1100-709℃,the phase diagram and composition evolution tendency of different phases were *** magma reached its liquidus at 1069℃.Sanidine was the first crystallized phase;at 709℃the residual magma was less than 4%,and the range of 1069-719℃should be the most suitable approach to the real *** is shown that at least some part of the pluton underwent such isobaric equilibrium crystallization processes during its crystallization.

关键词： Dahuabei pluton Petrogenesis simulation Geochemistry Zircon LA-ICPMS

Terrestrial transect study on driving mechanism of vegetation changes

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Science china Earth sciences 2008年第7期51卷 984-991页

作者： ZHANG YuJin1,2 & ZHOU GuangSheng1 1 state key laboratory of Vegetation and Environmental Change, Institute of Botany, Chinese Academy of sciences, beijing 100093, china 2 Graduate university of Chinese Academy of sciences, beijing 100049, china 1. state key laboratory of Vegetation and Environmental Change Institute of Botany Chinese Academy of Sciences Beijing 100093 China 2. Graduate university of Chinese Academy of sciences Beijing 100049 China

In terms of Chinese climate-vegetation model based on the classification of plant functional types, to- gether with climatic data from 1951 to 1980 and two future climatic scenarios (SRES-A2 and SRES-B2) in china from the highest and the lowest emission scenarios of greenhouse gases, the distribution patterns of vegetation types and their changes along the Northeast china Transect (NECT) and the North-South Transect of Eastern china (NSTEC) were simulated in order to understand the driving mechanisms of vegetation changes under climatic change. The results indicated that the vegetation distribution patterns would change significantly under future climate, and the major factors driving the vegetation changes were water and heat. However, the responses of various vegetation types to the changes in water and heat factors were obviously different. The vegetation changes were more sensi- tive to heat factors than to water factors. Thus, in the future climate warming will significantly affect vegetation distribution patterns.

关键词： driving mechanism vegetation terrestrial transect climatic change plant functional types

Heterogeneous reactions of gaseous methanesulfonic acid with calcium carbonate and kaolinite particles

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Science china Chemistry 2010年第12期53卷 2657-2662页

作者： TANG MingJin,LI MengQiu & ZHU Tong state key Joint laboratory of Environmental Simulation and Pollution Control College of Environmental sciences and Engineering,Peking university,beijing 100871,china 1. state key Joint laboratory of Environmental Simulation and Pollution Control College of Environmental sciences and Engineering Peking University Beijing 100871 China

Heterogeneous reactions of gaseous methanesulfonic acid (MSA) with calcium carbonate (CaCO3) and kaolinite particles at room temperature were investigated using diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) and ion chromatography (IC).Methanesulfonate (MS-) was identified as the product in the condensed phase,in accordance with the product of the reaction of gaseous MSA with NaCl and sea salt *** the concentration of gaseous MSA was 1.34 × 10-13 molecules cm-3,the uptake coefficient was (1.21 ± 0.06) × 10-8 (1) for the reaction of gaseous MSA with CaCO3 and (4.10 ± 0.65) × 10 10 (1) for the reaction with *** uptake coefficients were significantly smaller than those of the reactions of gaseous MSA with NaCl and sea salt particles.

关键词： gaseous MSA heterogeneous reaction calcium carbonate kaolinite