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Expression of the Arabidopsis thaliana Histone Gene AtHTA1 Enhances Rice Transformation Efficiency

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Molecular Plant 2009年第4期2卷 832-837页

作者： Ye Zheng Xiao-Wei He Ying-Hui Ying Jiang-Feng Lu stanton b. Gelvin Hui-Xia Shou State Key Laboratory of Plant Physiology and biochemistry College of Life Sciences Zhejiang University Yuhangtanghe Road 368 Hangzhou 310058 China Department of biological Sciences Purdue University West Lafayette IN 47907-1392 USA

We expressed the Arabidopsis thaliana histone AtHTA1 in rice under the control of the maize ubiquitin promoter. Transformation efficiencies of rice plants that constitutively expressed AtHTA 1 were 28-44% higher than calli containing an empty vector control. Furthermore, co-infection of rice calli with a vector containing AtHTA 1 and another vector with the target gene increased transformation by 27-50%. Thus, expression of AtHTA 1 either transiently or in stably transformed cells improved rice transformation efficiency.

关键词： Arabidopsis histone H2A Agrobacterium rice transformation.

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孟加拉国卫生保健的自付费用研究

中国社会医学杂志 1990年第3期7卷 138-141页

作者： stanton b Clemens J 王光祖

应用经济学家提出的分析框架,本文对居住在孟加拉国(潜在的执行自付费用的国家)的个人,研究自付费用对其健康的可能影响。结果表明,现存的政府卫生保健系统看来已对穷人和妇女这两组医疗上最易感人群提供了保健措施,而征收自付费用可严... 详细信息

应用经济学家提出的分析框架,本文对居住在孟加拉国(潜在的执行自付费用的国家)的个人,研究自付费用对其健康的可能影响。结果表明,现存的政府卫生保健系统看来已对穷人和妇女这两组医疗上最易感人群提供了保健措施,而征收自付费用可严重地干扰到这种保健状况。通过对个人、家庭及社区治疗性保健的公共卫生的重要作用的讨论,我们建议政府在组织制定自付费用政策前,卫生保健人员、人类学家、经济学家应多提几个问题,这些措施应先以实验方式进行,并开展严格而广泛的影响评价。

关键词：卫生保健公共卫生保健状况社区治疗对抗疗法性保健卫生系统卫生服务用可应用经济学

双亲干预的随机试验:父母对青少年危险行为、理解力和知识水平有显著长期的影响

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世界核心医学期刊文摘（儿科学分册） 2005年第3期1卷 21-22页

作者： stanton b. Cole M. Galbraith J. 刘莉 Department of Pediatrics Children's Hospital of Michigan Wayne State University 3901 Beaubien St Detroit MI 48201 United States

背景:尽管大量的干预措施被证明在短期内能够减少青少年的危险行为,但其作用随着持续的行为改变包括若干危险行为的出现而变得模糊起来。目的:确定有无后继措施的父母其同时告知父母和孩子(ImPACT)的监视干预是否能进一步减少青少年逃... 详细信息

背景:尽管大量的干预措施被证明在短期内能够减少青少年的危险行为,但其作用随着持续的行为改变包括若干危险行为的出现而变得模糊起来。目的:确定有无后继措施的父母其同时告知父母和孩子(ImPACT)的监视干预是否能进一步减少青少年逃避、物质滥用、性等危险行为,分析接受危险减少干预措施——儿童重点干预措施(FOK)2年后青少年的理解能力是否改变。

关键词：物质滥用随机试验基线年龄性伙伴多重比较城市社区组内相关系数一般线性模型干预性差异法

选择性表浅毛细血管治疗前后银屑病斑块中的血流改变

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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 6-7页

作者： Hern S. stanton A.W.b. Mellor R.H. 刘燕 Dermatology Unit Cardiac and Vascular Sciences St. George' s Hospital Medical School Cranmer Terrace London SW17 0RE United Kingdom

background: blood flow is substantially raised in psoriatic plaques. In addition, mechanisms of vasoconstriction and vasodilatation (locally and neurally mediated), although intact, are altered in magnitude. The elevated blood flow is considered to be a result of abnormalities (increase in vessel number, width and length) in the superficial capillary loops rather than changes in the deeper feeding vessels (arterioles). Objectives: To determine if selective thermolysis of psoriatic capillaries with a pulsed dye laser (PDL) leads to normalization of blood flow and also if the vasoconstrictor and vasodilator responses are returned to normal magnitude. Methods: Laser Doppler red cell flux was recorded from plaques on the forearm or elbow (untreated plaque site) and from clinically uninvolved skin at an equivalent site on the opposite limb. Plaques were treated on three occasions, at 2- weekly intervals, with a PDL. Laser Doppler red cell flux measurements were then repeated, 2 weeks after the final laser treatment was performed (treated plaque site). Results: There was significant clinical improvement in plaques after treatment (P=0.02), but complete clearance of lesions did not occur. blood flow in plaques under basal conditions remained significantly elevated above blood flow in clinically uninvolved skin, despite laser treatment (P bility of psoriatic resistance vessels to constrict and dilate. However, there was only partial resolution of the percentage responses to the provocation tests towards the values recorded in clinically uninvolved skin. Conclusions: The results: indicate that it is unlikely that the reduced resistance of the expanded superficial capillary bed is solely responsible for the massively elevated blood flow in plaque skin. It is more likely that the vascular abnormalities in psoriasis also extend to involve the deeper, larger resistance vesse

关键词：银屑病血管舒张对侧肢体血管数量脉冲染料激光阻力血管营养血管血管收缩最后一次

Infant feces-derived bifidobacterium breve CCFM1078 inhibits the occurrence of rheumatoid cachexia by IRS1/PI3K/Akt signaling pathway

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Food Science and Human Wellness 2024年

作者： bowen Li Mengfan Ding Chen Chi Guoxun Shi Xiaoming Liu Jianxin Zhao Paul Ross Catherine stanton Wei Chen bo Yang State Key Laboratory of Food Science and Resources， Jiangnan University School of Food Science and Technology， Jiangnan University Department of Rheumatology， Jiangnan University Medical Center International Joint Research Center for Probiotics & Gut Health， Jiangnan University APC Microbiome Ireland， University College Cork Teagasc Food Research Centre National Engineering Research Center for Functional Food， Jiangnan University

This study aimed to investigate the effects of infant feces-derived bifidobacterium breve CCFM1078 on rheumatoid cachexia （RC）. Twenty-four female Wistar rats were assigned to three groups: CON group （normal saline by gavage）， CIA group （collagen-induced arthritis， normal saline by gavage）， and CCFM1078 group (collagen-induced arthritis， 3×109CFU/rat/day b breve CCFM1078 gavage). The results demonstrated that b. breve CCFM1078 not only improved skeletal muscle function in CIA rats， but also modulated the gut microbiota， skeletal muscle metabolism and hormone levels， reduced inflammation in the knee joint and skeletal muscles， decreased activity of the NF-κb inflammatory signaling pathway， enhanced the IRS1/PI3K/Akt signaling pathway， promoted skeletal muscle differentiation， and maintained skeletal muscle fiber diameter， consequently slowing down the progression of RC. These findings suggested that b. breve CCFM1078 may have a beneficial role as part of a dietary intervention for RC， enhancing overall therapeutic effects.

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bifidobacterium breve CCFM1078 regulates bone development in growing bALb/c mice via gut microbiota and metabolites to balance bone formation and resorption

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Food Science and Human Wellness 2024年

作者： bowen Li Mengfan Ding Xiaoming Liu Haiqin Chen Jianxin Zhao R.Paul Ross Catherine stanton Shilong Jiang Wei Chen bo Yang Nutrition and Metabolism Research Division， Innovation Center， Heilongjiang Feihe Dairy Co.， Ltd. National Engineering Research Center for Functional Food， Jiangnan University State Key Laboratory of Food Science and Technology， Jiangnan University PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development APC Microbiome Ireland， University College Cork School of Food Science and Technology， Jiangnan University International Joint Research Center for Probiotics & Gut Health， Jiangnan University Teagasc Food Research Centre

This study endeavors to investigate the effects of bifidobacterium breve CCFM1078 on bone formation and resorption balance in growing bALb/c mice. Newborn bALb/c mice were assigned to the control group (administration saline) and the CCFM1078 group (administration b. breve CCFM1078， 3 × 109CFU/day) in 3-， 4-， and 5-week tests. All the groups have male and female distinctions. Our findings demonstrate that b. breve CCFM1078 exerts on the dynamic equilibrium between bone formation and resorption during the critical period of growth in mice by modulating the composition of gut microbiota and metabolites (hexadecanamide， linoleoyl ethanolamide， and palmitoyl ethanolamide)， the genes and proteins expression related to the GH/IGF-1 axis and Gs/PKA/CREb signaling pathways， as well as downstream osteogenic and osteoclastic differentiation factors. The effects of b. breve CCFM1078 were different with age and gender dependent. This finding suggests b. breve CCFM1078 may have potential applications in regulating bone metabolism in the growth period population.

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bifidobacterium longum subsp. infantis CCFM1269 promotes intestinal barrier and release of IFN-β through TLR4-TRIF dependent way in growing mice

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Food Science and Human Wellness 2024年

作者： Mengfan Ding bo Yang bowen Li Haiqin Chen Renqiang Yu R.Paul Ross Catherine stanton Shilong Jiang Jianxin Zhao Wei Chen State Key Laboratory of Food Science and Resources， Jiangnan University Teagasc Food Research Centre Nutrition and Metabolism Research Division， Innovation Center， Heilongjiang Feihe Dairy Co.， Ltd. Department of Neonatology， Wuxi Maternity and Child Health Care Hospital， Affiliated Women's Hospital of Jiangnan University National Engineering Research Center for Functional Food， Jiangnan University School of Food Science and Technology， Jiangnan University PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development International Joint Research Center for Probiotics & Gut Health， Jiangnan University APC Microbiome Ireland， University College Cork

bifidobacterium longum subsp. infantis is a commensal bacterium that predominates in the infant gut， playing a critical role in both preventing foreign infections and facilitating immune development. This study aimed to explore the effects of b. longum subsp. infantis supplementation on interferon-beta (IFN-β) secretion and intestinal barrier improvement in growing mice. Female and male mice were orally administered either saline or b. longum subsp. infantis CCFM1269 or I5TI (1 × 109CFU/mice per day， n = 8) from 1-week-age until 3-， 4-， and 5-week-age. RNA sequencing analysis revealed that CCFM1269 exhibited potential antiviral capacity through increasing 2’-5’ oligoadenylate synthetase (OAS). Additionally， CCFM1269 supplementation significantly increased colonic IFN-β levels which combined with OAS in 3-week-old female and male mice by activating the TLR4-TRIF-dependent signaling pathway. However， this effect was not observed in 4- and 5-week-old mice. Furthermore， both CCFM1269 were found to modulate the gut microbiota composition and enhance the intestinal barrier function in 3-， 4-， and 5-week-old mice. In summary， the results of this study suggested that b. longum subsp. infantis CCFM1269 promoting intestinal barrier and releasing IFN-β in growing mice was in a strain-specific and time-dependent manner.

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大洋环流和海-气交换

气象科技 1992年第1期20卷 64-71页

作者： b.R.stanton 智勇新西兰海洋学研究所

海洋通过海-气交换过程对气候产生重要的影响.然而,我们现有对这些过程认识的局限性是不能够精确模拟气候变化的重要因素.本文评述海洋结构和环流的现有知识,特别重点放在南半球海洋,而且讨论了主要的海-气交换,还讨论了全球变暖情况下... 详细信息

海洋通过海-气交换过程对气候产生重要的影响.然而,我们现有对这些过程认识的局限性是不能够精确模拟气候变化的重要因素.本文评述海洋结构和环流的现有知识,特别重点放在南半球海洋,而且讨论了主要的海-气交换,还讨论了全球变暖情况下的南北半球非对称性的影响.在九十年代,通过实施计划中的一些国际海洋研究试验,将改进对海洋的认识,进而得到更完善的气候模式.

关键词：大洋环流海-气交换

Protective Effects of bifidobacterium breve on IMQ-Induced Psoriasis in Mice through Secondary bile Acid Production and FXR-TLR4/NF-κb Pathway

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Food Science and Human Wellness 2023年

作者： Xinqi Chen Yang Chen Catherine stanton R.Paul Ross Jianxin Zhao bo Yang Wei Chen National Engineering Research Center for Functional Food， Jiangnan University School of Food Science and Technology， Jiangnan University State Key Laboratory of Food Science and Technology， Jiangnan University APC Microbiome Ireland， University College Cork Teagasc Food Research Centre International Joint Research Center for Probiotics & Gut Health， Jiangnan University

This study aimed to evaluate the effects of bifidobacterium breve CCFM683 on psoriasis and to investigate the underlying mechanisms. bifidobacterium breve CCFM683 significantly ameliorated psoriasis in mice as well as elevated the deoxycholic acid (DCA) and lithocholic acid (LCA) in the colon compared with those of the imiquimod-treated mice. Meanwhile， b. breve CCFM683 increased the relative abundance of DCA-producing Lachnoclostridium and diminished the harmful Desulfovibrio and Prevotellaceae UCG001. Additionally， the farnesoid X receptor (FXR) in the skin was activated and the expression of the TLR4/NF-κb pathway was inhibited， and the downstream IL-17 and TNF-α were downregulated whereas IL-10 was up-regulated . Moreover， the subsequent hyperproliferation of keratinocytes and the dysfunction of the epidermal barrier were improved. In conclusion， CCFM683 administration ameliorated IMQ-induced psoriasis via modulating gut microbiota， promoting the DCA production， regulating the FXR-TLR4/NF-κb pathway， diminishing proinflammatory cytokines， and regulating keratinocytes and epidermal barrier. These findings may be conducive to elucidating the mechanism for probiotics to ameliorate psoriasis and to promote its clinical trials in skin disease.

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