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World Journal of Gastroenterology 2006年第24期12卷 3901-3905页

作者： Martin Bortlík Ivana Vítková Martina Pape(z|ˇ)ová Milada Kohoutová Ale(s|ˇ) Novotn(y|') stanislav Adamec Petra Chalupná Milan Luká(s|ˇ) Gastroenterology Center 4th Internal Department General Faculty Hospital1st School of MedicineCharles UniversityPragueCzech Republic Department of Pathology General Faculty Hospital 1st School of MedicineCharles UniversityPragueCzech Republic Institute for Biology and Medical Genetics General Faculty Hospital 1st School of MedicineCharles UniversityPragueCzech Republic

瞄准：评估腺瘤结肠息肉病(APC ) 蛋白质的损失的频率并且把 APC 地位与颜色的特征作比较表面的腺瘤。方法：APC 蛋白质的 Immunohistochemical 分析在 118 个腺瘤上被执行，结果与病人的恶意的潜力，腺瘤的地点，宏观的外观和年龄的参... 详细信息

瞄准：评估腺瘤结肠息肉病(APC ) 蛋白质的损失的频率并且把 APC 地位与颜色的特征作比较表面的腺瘤。方法：APC 蛋白质的 Immunohistochemical 分析在 118 个腺瘤上被执行，结果与病人的恶意的潜力，腺瘤的地点，宏观的外观和年龄的参数相比。结果：APC 蛋白质的完全的损失在 28 被发现的 A (24%) 腺瘤，当(76%) 90 是 APC 时积极。腺瘤的吝啬的尺寸是 13.5 +/- 14.2 公里(95% CI 10.5-16.5 ) 在 APC 积极，并且 13.8 +/- 在 APC 否定的腺瘤的 15.5 公里(95% CI 7.8-19.8 )(P = 0.364 ) 。统计分析没至于组织学的类型揭示 APC 积极、否定的腺瘤之间的差别(P = 0.327 ) 并且发育异常的等级(P = 0.494 ) 。我们发现甚至先进的腺瘤没与非先进的肿瘤在他们的 APC 地位不同(P = 0.414 ) 。最后，当时，没有差别被发现地点(P = 0.157 ) ，宏观的外观(P = 0.571 ) 并且病人的年龄(P = 0.438 ) 在两个 APC 积极、否定的腺瘤之间被分析并且比较。结论：大多数腺瘤表示了全身的 APC 蛋白质，建议那蛋白质表情不是为对 APC 基因变化的评价的一个可靠标记。APC 蛋白质的完全的损失没影响腺瘤的形态学，地点，或外观，它也不受病人的年龄影响。

关键词：腺瘤息肉大肠杆菌结肠癌直肠癌临床组织学

schrödinger’s Cat Paradox Resolution Using GRW Collapse Model: Von Neumann Measurement Postulate Revisited

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Journal of Applied Mathematics and Physics 2017年第2期5卷 494-521页

作者： Jaykov Foukzon Alex Potapov Elena Men’kova stanislav Podosenov Center for Mathematical sciences Israel Institute of Technology Haifa Israel IRE RAs Moscow Russia All-Russian Research Institute Moscow Russia

In his famous thought experiment, schr?dinger (1935) imagined a cat that measures the value of a quantum mechanical observable with its life. since schr?dinger’s time, no any interpretations or modifications of quantum mechanics have been proposed which give clear unambiguous answers to the questions posed by schr?dinger’s cat of how long superpositions last and when (or whether) they collapse? In this paper appropriate modification of quantum mechanics is proposed. We claim that canonical interpretation of the wave function is correct only when the supports of the wave functions and essentially overlap. When the wave functions and have separated supports (as in the case of the experiment that we are considering in this paper) we claim that canonical interpretation of the wave function is no longer valid for a such cat state. Possible solution of the schr?dinger’s cat paradox is considered. We pointed out that the collapsed state of the cat always shows definite and predictable outcomes even if cat also consists of a superposition: .

关键词： Probability Representation of Quantum states schrödinger’s Cat GRW Collapse Model Von Neumann Measurement Postulate

Electrodynamics in Noninertial Reference Frames

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Journal of Applied Mathematics and Physics 2016年第4期4卷 806-843页

作者： stanislav A. Podosenov Jaykov Foukzon Alexander Potapov Elena Men’kova All-Russian Research Institute for Optical and Physical Measurements Moscow Russia Center for Mathematical sciences Israel Institute of Technology Haifa Israel Kotel’nikov Institute of Radioengineering and Electronics Russian Academy of Sciences Moscow Russia

The electrodynamics both in RF with prescribed law of motion and in FR with prescribed structure is considered. Parallel comparison for solutions in “uniformly accelerated” NRF M?ller system and in uniformly accelerated rigid NFR in the space of the constant curvature is carried out. The stationary criterion is formulated. On the basis of this criterion, one of the “eternal physical problems” concerning the field at uniformly accelerated charge motion is considered. The problems of electromagnetic wave spreading, Doppler’s effect and field transformations are discussed.

关键词： Noninertial Reference Frame (NFR) Möller system space-Time Curvature Anholonomic Transformations Doppler’s Effect Electromagnetic Wave

Efficacy of the new therapeutic approach in curing malignant neoplasms on the model of human glioblastoma

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Cancer Biology & Medicine 2021年第3期18卷 910-930页

作者： Evgeniya V.Dolgova Oleg M.Andrushkevich Polina E.Kisaretova Anastasia s.Proskurina Genrikh s.Ritter Tatyana D.Dubatolova Margarita V.Romanenko Oleg s.Taranov Yaroslav R.Efremov Evgeniy L.Zavyalov Alexandr V.Romaschenko sergey V.Mishinov svetlana s.Kirikovich Evgeniy V.Levites Ekaterina A.Potter Alexandr A.Ostanin Elena R.Chernykh stanislav Yu.Roshchin Anatoliy V.Bervitskiy Galina I.Moysak Jamil A.Rzaev sergey s.Bogachev Institute of Cytology and Genetics sB RAs Novosibirsk 630090Russia A.I.Evdokimov Moscow state University of Medicine and Dentistry Moscow 127473Russia Institute of Molecular and Cellular Biology Novosibirsk 630090Russia Novosibirsk state University Novosibirsk 630090Russia The state Research Center of Virology and Biotechnology"Vector" KoltsovoNovosibirsk 630559Russia First Department of Neurosurgery Ya.L.Tsivian Novosibirsk Research Institute of Traumatology and OrthopaedicsNovosibirsk 630091Russia Institute of Fundamental and Clinical immunology Novosibirsk 630099Russia sklifosovsky Research Institute of Emergency Medicine Moscow 129010Russia Federal Center of Neurosurgery Novosibirsk 630048Russia

Objective:Glioma is a highly invasive tumor,frequently disposed in essential areas of the brain,which makes its surgical excision extremely difficult;meanwhile adjuvant therapy remains quite ***:In the current report,a new therapeutic approach in curing malignant neoplasms has been performed on the U87 human glioblastoma *** approach,termed"Karanahan",is aimed at the eradication of cancer stem cells(CsCs),which were recently shown to be capable of internalizing fragments of extracellular double-stranded *** being internalized,these fragments interfere in the process of repairing interstrand cross-links caused by exposure to appropriate cytostatics,and such an interference results either in elimination of CsCs or in the loss of their tumorigenic *** of the approach requires a scheduled administration of cytostatic and complex composite double-stranded DNA ***:U87 cells treated in vitro in accordance with the Karanahan approach completely lost their tumorigenicity and produced no grafts upon intracerebral transplantation into immunodeficient *** sCID mice with developed subcutaneous grafts,the treatment resulted in reliable slowing down of tumor growth rate(Psplantation of U87 cells followed by surgical excision of the developed graft and subsequent therapeutic treatment,the Karanahan approach was shown to reliably slow down the tumor growth rate and increase the median survival of the mice twofold relative to the ***:The effectiveness of the Karanahan approach has been demonstrated both in vitro and in vivo in treating developed subcutaneous grafts as well as orthotopic grafts after surgical excision of the tumor.

关键词： Glioblastoma U87 cell line mytomycin C cancer stem cells TAMRA

Determination of the Lunar Ground Characteristics Using Bistatic Radar

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International Journal of Geosciences 2015年第12期6卷 1267-1276页

作者： Oleg I. Yakovlev Olga V. Yushkova stanislav s. Matyugov Alexander G. Pavelyev Vladimir M. smirnov Kotel’nikov Institute of Radio Engineering and Electronics of the Russian Academy of sciences Fryazino Russia

At present, an investigation of the lunar ground at great depths is of paramount importance. This investigation can be carried out using decameter and meter waves. This article aims to analyze the variations of the reflectioncoefficient?at?decametric,?meter and decimeteric bands.?A?possibility of determination?of lunar ground characteristics by bistatic radar using powerful ground-based transmitters?at VHF and UHF bands and a receiver aboard a?Moon’s satellite?is analysed. Appropriate algorithms are considered for determinationof the regolith layer thickness,?dielectric permittivity, loss tangent, and density of the regolith and bedrocks. Expected results of measurements have been presented for a two-layer model of lunar ground, consisting of an upper layer with the loose porous rocks (regolith), and the rocks situated more deeply. Revealed regularities are a basis for determining the distribution of the permittivity in subsurface layer.

关键词： Bistatic Radar Lunar Ground Regolith Reflection Coefficient Permittivity

雅库茨克热电厂建筑物周边及地下的地温动态(英文)

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黑龙江大学工程学报 2014年第3期5卷 67-77页

作者： stanislav I.Zabolotnik Pavel s.Zabolotnik 俄罗斯科学院西伯利亚分院麦尔尼科夫冻土研究所

对在冻土条件下的雅库茨克热电厂的长期(2008~2011年)研究进行分析。对沿着建筑物和墙壁邻近地区的36个水井地下4~16 m温度进行测量。目前融化区域下所有的建筑,利用循环泵站和东北的水墙附近的锅炉设备可以观测到最高年平均气温(12~13... 详细信息

对在冻土条件下的雅库茨克热电厂的长期(2008~2011年)研究进行分析。对沿着建筑物和墙壁邻近地区的36个水井地下4~16 m温度进行测量。目前融化区域下所有的建筑,利用循环泵站和东北的水墙附近的锅炉设备可以观测到最高年平均气温(12~13℃)和不冻层厚度(23~25 m)。根据化学水处理东部解冻较早的土壤冻结从顶部到8.0~9.5m。解冻层保留较深,其中在2011年10~11 m深度年平均气温下降到0.3~0.6℃。在雅库茨克热电厂的大部分地区仍然是永久冻结地区。在主楼下方4~10 m的深度的年平均气温为0^-4.1℃。近年来,筑物地温逐步恢复的基础依据已经发生变化。

关键词：年平均地温冻土融化层

Crystallography of low Z material at ultrahigh pressure:Case study on solid hydrogen

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Matter and Radiation at Extremes 2020年第3期5卷 40-54页

作者： Cheng Ji Bing Li Wenjun Liu Jesse s.smith Alexander Bjoorling Arnab Majumdar Wei Luo Rajeev Ahuja Jinfu shu Junyue Wang stanislav sinogeikin Yue Meng Vitali B.Prakapenka Eran Greenberg Ruqing Xu Xianrong Huang Yang Ding Alexander soldatov Wenge Yang Guoyin shen Wendy L.Mao Ho-Kwang Mao Center for High Pressure science and Technology Advanced Research Beijing 100094China High Pressure Collaborative AccessTeam Geophysical LaboratoryCarnegie Institution of WashingtonArgonneIllinois 60439USA Center for the study of Matter at Extreme Conditions and Department of Mechanical and Materials Engineering Florida International UniversityMiamiFlorida 33199USA Advanced Photon source Argonne National LaboratoryLemontIllinois 60439USA HPCAT X-Ray Science DivisionArgonne National LaboratoryLemontIllinois 60439USA MAX IV Laboratory Lund University22100 LundSweden Condensed Matter Theory Group Materials Theory DivisionDepartment of Physics and AstronomyUppsala UniversityUppsala S-75120Sweden Center for Advanced Radiation sources University of ChicagoChicagoIllinois 60637USA Department of Engineering sciences and Mathematics Lule°a University of Technology97187 Lule°aSweden Department of Geological sciences Stanford UniversityStanfordCalifornia 94305USA stanford Institute for Materials and Energy sciences SLAC National Accelerator LaboratoryMenlo ParkCalifornia 94025USA

Diamond anvil cell techniques have been improved to allow access to the multimegabar ultrahigh-pressure region for exploring novel phenomena in ***,the onlyway to determine crystal structures of materials above 100 GPa,namely,X-ray diffraction(XRD),especially for lowZ materials,remains nontrivial in the ultrahigh-pressure region,even with the availability of brilliant synchrotron X-ray *** thiswork,we performa systematic study,choosing hydrogen(the lowest X-ray scatterer)as the subject,to understand how to better perform XRD measurements of low Z materials at multimegabar *** techniques that we have developed have been proved to be effective in measuring the crystal structure of solid hydrogen up to 254GPa at room temperature[*** et al.,Nature 573,558–562(2019)].Wepresent our discoveries and experienceswith regard to several aspects of thiswork,namely,diamond anvil selection,sample configuration for ultrahigh-pressure XRDstudies,XRDdiagnostics for low Z materials,and related issues in data interpretation and pressure *** that these methods can be readily extended to other low Z materials and can pave the way for studying the crystal structure of hydrogen at higher pressures,eventually testing structural models of metallic hydrogen.

关键词： ultrahigh solid eventually

Immunological aspects of COVID-19:What do we know?

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World Journal of Biological Chemistry 2020年第2期11卷 14-29页

作者： Tsvetelina Veselinova Velikova stanislav Vasilev Kotsev Daniel stefanov Georgiev Hristiana Momchilova Batselova Department of Clinical Immunology University Hospital LozenetzSofia 1407Bulgaria Department of Infectious Diseases Pazardzhik Multiprofile Hospital for Active TreatmentPazardzhik 4400Bulgaria Dental Faculty Medical University of PlovdivPlovdiv 4002Bulgaria Department of Epidemiology and Disaster Medicine Medical UniversityPlovdivUniversity Hospital“St George”Plovdiv 4002Bulgaria

The newly emerged coronavirus(severe acute respiratory syndrome coronavirus 2 sARs-CoV-2)and the disease that it causes coronavirus disease 2019(COVID-19)have changed the world we ***,the origin and evolution of sARs-CoV-2 remain mostly *** virulence factors and immune mechanisms contribute to the deteriorating effects on the organism during sARs-CoV-2 *** humoral and cellular immune responses are involved in the pathophysiology of the disease,where the principal and effective immune response towards viral infection is the cell-mediated *** clinical picture of COVID-19,which includes immune memory and reinfection,remains unclear and ***,many hopes are put in developing an effective vaccine against the virus,and different therapeutic options have been implemented to find effective,even though not specific,treatment to the *** can assume that the interaction between the sARs-CoV-2 virus and the individual's immune system determines the onset and development of the disease significantly.

关键词： sARs-CoV-2 COVID-19 Immune memory Anti-sARs-CoV-2 antibodies COVID-19 treatment Plasma therapy

Epigenetics and chromatin plasticity in embryonic stem cells

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World Journal of stem Cells 2013年第3期5卷 73-85页

作者： Terézia Pikrylová Jií Pacherník stanislav Kozubek Eva Bártová Institute of Biophysics Academy of Sciences of the Czech Republic Department of Animal Physiology Faculty of Sciences Masaryk University

The study of embryonic stem cells is in the spotlight in many laboratories that study the structure and function of chromatin and epigenetic processes. The key properties of embryonic stem cells are their capacity for selfrenewal and their pluripotency. Pluripotent stem cells are able to differentiate into the cells of all three germ layers, and because of this property they represent a promising therapeutic tool in the treatment of diseases such as Parkinson's disease and diabetes, or in the healing of lesions after heart attack. As the basic nuclear unit, chromatin is responsible for the regulation of the functional status of cells, including pluripotency and differentiation. Therefore, in this review we discuss the functional changes in chromatin during differentiation and the correlation between epigenetics events and the differentiation potential of embryonic stem cells. In particular we focus on post-translational histone modification, DNA methylation and the heterochromatin protein HP1 and its unique function in mouse and human embryonic stem cells.

关键词： Chromatin Epigenetics Embryonic stem cells Nucleus Pluripotency Differentiation

Glass-Reinforced Plastic Filled by Multiwall Carbon Nanotubes and Their Modified Forms

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Journal of Materials science and Chemical Engineering 2019年第7期7卷 26-35页

作者： Yurii sementsov Oksana Cherniuk Galyna Dovbeshko serhii Zhuravskyi stanislav Makhno Bo Wang Mykola Kartel Transportation and Logistics College Ningbo University of Technology Ningbo China Department of Nanoporous and Nanosized Carbon Materials Chuiko Institute of Surface Chemistry NAS of Ukraine Kyiv Ukraine Department of Physics of Biological systems Institute of Physics NAS of Ukraine Kyiv Ukraine

The effect of modifying the surface of multiwall carbon nanotubes (CNT’s) by oxygen and nitrogen on the strength characteristics of the fiberglass filled with them was investigated by testing for tension and bending. The method of obtaining nitrogen-containing nanostructures is developed. It was shown that in the epoxide system LR285-LH286 hydrophobic CNT’s (outgoing) at introducing into the catalyst polymerization of LH286, increase the strength with respect to unreinforced CNT’s by 48% - 54%. Oxidized CNT’s (200 A?h/kg) introduced into the resin LR285 increase the strength by 59%. The distribution of the filler particles in size, both in the epoxy resin and in the catalyst, depends on their concentration nonlinear, and correlates with the strength characteristics of the composite.

关键词： Fiberglass Multiwall Carbon Nanotubes Polymer Composite Materials