检索结果-南通市图书馆

Intestinal microbiome changes in an infant with right atrial isomerism and recurrent necrotizing enterocolitis:A case report and review of literature

引用

World Journal of Clinical Cases 2022年第29期10卷 10583-10599页

作者： Aleksandra Kaplina Ekaterina Zaikova Artem Ivanov Yulia Volkova Tatiana Alkhova Vladimir Nikiforov Alexander Latypov Marina Khavkina Tatiana Fedoseeva Tatiana Pervunina Yulia skorobogatova svetlana Volkova Vladimir Ulyantsev Olga Kalinina stanislav sitkin Natalia Petrova Research Laboratory of Physiology and Diseases of Newborns Almazov National Medical Research CentreSt.Petersburg 197341Russia Research Laboratory of Autoimmune and Autoinflammatory Diseases Almazov National Medical Research CentreSt.Petersburg 197341Russia Vladimir Ulyantsev International Laboratory of Computer TechnologiesITMO UniversitySt.Petersburg 197101Russia Department of Cardiovascular surgery for Children Almazov National Medical Research CentreSt.Petersburg 197341Russia Department of Neonatal Physiology with an ICU Ward Almazov National Medical Research CentreSt.Petersburg 197341Russia Pediatric Cardiac Intensive Care Unit Almazov National Medical Research CentreSt.Petersburg 197341Russia Neonatal and Preterm special Care Unit(2nd stage Care) Almazov National Medical Research CentreSt.Petersburg 197341Russia Institute of Perinatology and Pediatrics Almazov National Medical Research CentreSt.Petersburg 197341Russia Express Laboratory of Perinatal Centre Almazov National Medical Research CentreSt.Petersburg 197341Russia Clinical Diagnostic Laboratory Almazov National Medical Research CentreSt.Petersburg 197341Russia Epigenetics and Metagenomics Group Institute of Perinatology and PediatricsAlmazov National Medical Research CentreSt.Petersburg 197341Russia Department of Internal Diseases Gastroenterology and DieteticsNorth-Western State Medical University named after I.I.MechnikovSt.Petersburg 191015Russia

BACKGROUND Necrotizing enterocolitis(NEC)is a multifactorial disease that predominantly affects premature *** dysbiosis plays a critical role in NEC pathogenesis in premature *** main risk factor for NEC in term infants is mesenteric hypoperfusion associated with ductaldependent congenital heart disease(CHD)that eventually leads to intestinal *** incidence of NEC in neonates with critical CHD is 6.8%-13%.However,the role of the intestinal microbiome in NEC pathogenesis in infants with ductal-dependent CHD remains *** sUMMARY A male term neonate with right atrial isomerism underwent modified Blalock-Taussig shunt placement on the 14^(th)day of life and had persistent mesenteric hypoperfusion after *** patient had episodes of NEC stageⅡA on the 1^(st)and 28^(th)days after cardiac *** microbial composition was analyzed before and after cardiac surgery by sequencing region V4 of the 16s rRNA *** surgery,species belonging to genera Veillonella and Clostridia and class Gammaproteobacteria were detected,Bifidobacteriaceae showed a low *** first NEC episode was associated with postoperative hemodynamic instability,intestinal ischemiareperfusion injury during cardiopulmonary bypass,and a high abundance of Clostridium paraputrificum(Clostridium sensu stricto I)(56.1%).Antibacterial therapy after the first NEC episode resulted in increased abundance of Gammaproteobacteria,decreased abundance of Firmicutes,and low alpha *** changes in the microbial composition promoted the growth of Clostridium sensu strictoⅠ(72.0%)before the second NEC *** A high abundance of Clostridium sensu strictoⅠand mesenteric hypoperfusion may have contributed to NEC in the present case.

关键词： Necrotizing enterocolitis Congenital heart disease Ivemark syndrome Heterotaxy Right atrial isomerism Intestinal microbiome Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

引用

Acta Pharmaceutica sinica B 2023年第5期13卷 2152-2175页

作者： Damijan Knez Daniel Diez-Iriepa Mourad Chioua Andrea Gottinger Milica Denic Fabien Chantegreil Florian Nachon Xavier Brazzolotto Anna skrzypczak-Wiercioch Ane Meden Anja Pilar Janko Kos simon akelj Jure stojan Kinga saat Julia serrano Ana Patricia Fernández Aitana sánchez-García Ricardo Martínez-Murillo Claudia Binda Francisco López-Muoz stanislav Gobec JoséMarco-Contelles University of Ljubljana Faculty of PharmacyLjubljana 1000Slovenia Laboratory of Medicinal Chemistry(Institute of Organic Chemistry CSIC)Madrid 28006Spain Departamento de Química Orgánicay Química Inorgánica Alcaláde HenaresMadrid 28871Spain Department of Biology and Biotechnology University of PaviaPavia 27100Italy Département de Toxicologie et Risques Chimiques Institut de Recherche Biomédicale des ArméesParis 91220France Department of Animal Anatomy and Preclinical sciences University Centre of Veterinary Medicine JU-UAUniversity of Agriculture in KrakowKrakow 30-059Poland Institute of Biochemistry Faculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia Department of Pharmacodynamics Chair of PharmacodynamicsFaculty of PharmacyJagiellonian University Medical CollegeKrakow 30-688Poland Department of Translational Neurobiology Neurovascular Research GroupCajal Institute(CSIC)Madrid 28002Spain Biotechnology and Vegetal Biology Department Escuela Técnica Superior de Ingeniería AgronómicaAlimentaria y de BiosistemasUniversidad Politécnica de MadridMadrid 28040Spain Faculty of Health Camilo JoséCela University of Madrid(UCJC)Neuropsychopharmacology Unit“Hospital 12 de Octubre”Research InstituteMadrid 28692Spain

We describe the development of quinolylnitrones(QNs)as multifunctional ligands inhibiting cholinesterases(ChEs:acetylcholinesterase and butyrylcholinesterase—h BChE)and monoamine oxidases(hMAO-A/B)for the therapy of neurodegenerative *** identified QN 19,a simple,low molecular weight nitrone,that is readily synthesized from commercially available *** 19 has no typical pharmacophoric element to suggest ChE or MAO inhibition,yet unexpectedly showed potent inhibition of h BChE(IC50=1.06±0.31 nmol/L)and h MAO-B(IC_(50)=4.46±0.18μmol/L).The crystal structures of 19 with hBChE and hMAO-B provided the structural basis for potent binding,which was further studied by enzyme *** 19 acted as a free radical scavenger and biometal chelator,crossed the blood—brain barrier,was not cytotoxic,and showed neuroprotective properties in a 6-hydroxydopamine cell model of Parkinson's *** addition,in vivo studies showed the anti-amnesic effect of 19 in the scopolamine-induced mouse model of AD without adverse effects on motoric function and ***,chronic treatment of double transgenic APPswe-Ps1δE9 mice with 19 reduced amyloid plaque load in the hippocampus and cortex of female mice,underscoring the disease-modifying effect of QN 19.

关键词： Quinolylnitrone Butyrylcholinesterase Monoamine oxidase B Alzheimer's disease Multifunctional ligands 6-Hydroxydopamine model Passive avoidance task Novel object recognition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Textural changes in metallurgical coke prepared with polyethylene

引用

International Journal of Minerals,Metallurgy and Materials 2014年第10期21卷 969-973页

作者： stanislav s.Gornostayev Jyrki J.Heino Tommi M.T.Kokkonen Hannu T.Makkonen satu M.M.Huttunen Timo M.J.Fabritius Laboratory of Process Metallurgy University of Oulu

The effect of high-density polyethylene （HDPE） on the textural features of experimental coke was investigated using polar- ized-light optical microscopy and wavelet-based image analysis. Metallurgical coke samples were prepared in a laboratory-scale furnace with 2.5%, 5.0%, 7.5%, 10.0%, and 12.5% HDPE by mass, and one sample was prepared by 100% coal. The amounts and distribution of textures （isotropic, mosaic and banded） and por^s were obtained. The calculations reveal that the addition of HDPE results in a decrease of mosaic texture and an increase of isotropic texture. Ethylene formed from the decomposition of HDPE is considered as a probable reason for the texture modifications. The approach used in this study can be applied to indirect evaluation for the reactivity and strength of coke.

关键词： metallurgical coke texture image analysis polyethylene

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The 3’-untranslated region contributes to the pregnane X receptor(PXR) expression downregulation by PXR ligands and up-regulation by glucocorticoids

引用

Acta Pharmaceutica sinica B 2020年第1期10卷 136-152页

作者： Tomas smutny Jan Dusek Lucie Hyrsova Jana Nekvindova Alzbeta Horvatova stanislav Micuda sabine Gerbal-Chaloin Petr Pavek Department of Pharmacology and Toxicology Faculty of Pharmacy in Hradec KraloveCharles UniversityHradec Kralove CZ-50005Czech Republic Institute of Clinical Biochemistry and Diagnostics University Hospital Hradec KraloveHradec Kralove CZ-50005Czech Republic Department of Pharmacology Faculty of Medicine in Hradec KraloveCharles UniversityHradec Kralove CZ-50003Czech Republic IRMB INSERMUniversity MontpellierMontpellierFrance

Pregnane X receptor(PXR)is the major regulator of xenobiotic *** itself is controlled by various signaling molecules including ***,negative feed-back regulation has been proposed at the transcriptional *** examined the involvement of the 3’-untranslated region(3’-UTR)of NR1I2 mRNA and microRNAs in PXR-and glucocorticoid receptor(GR)-mediated regulation of NR1I2 gene *** ligands were found to significantly downregulate NR1I2 mRNA expression in a set of 14 human hepatocyte ***,PXR was downregulated by PCN in the C57/BL6 mice *** mechanistic studies with the full-length 3’-UTR cloned into luciferase reporter or expression vectors,we showed that the 3’-UTR reduces PXR *** the miRNAs tested,miR-18a-5p inhibited both NR 112 expression and CYP3A4 gene ***,we observed significant upregulation of miR-18a-5p expression 6 h after treatment with the PXR ligand rifampicin,which indicates a putative mechanism underlying NR1I2 negative feed-back regulation in hepatic ***,glucocorticoids upregulated NR1I2 expression not only through the promoter region but also via 3’-UTR regulation,which likely involves downregulation of *** conclude that miR-18a-5p is involved in the down-regulation of NR1I2expression by its ligands and in the upregulation of NR1I2 mRNA expression by glucocorticoids in hepatic cells.

关键词： Gene expression MicroRNA Glucocorticoid Regulation Pregnane X receptor Cytochrome P4503A4

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Robust reduction of graphene fluoride using an electrostatically biased scanning probe

引用

Nano Research 2013年第11期6卷 767-774页

作者： Woo-Kyung Lee stanislav Tsoi Keith E. Whitener Rory stine Jeremy T. Robinson Jonathon s. Tobin Asanka Weerasinghe Paul E. sheehan sergei F. Lyuksyutov Division of Chemistry US Naval Research Laboratory Washington DC20375 USA NOVA Research Alexandria Virginia 22308 USA Division of Electronic science and Technology US Naval Research Laboratory Washington DC 20375 USA The University of Akron Department of Physics Akron OH 44325 USA

我们报导一篇小说和容易可存取的方法化学上减少有用高静电的领域的 nanoscopic 精确的氟化物(GF ) 表在一台原子力量显微镜(AFM ) 之间产生了的 graphene 尖端和 GF 底层。由电场的氟的符号的减小急速地与表抵抗力与 105-1,800 nm 的... 详细信息

我们报导一篇小说和容易可存取的方法化学上减少有用高静电的领域的 nanoscopic 精确的氟化物(GF ) 表在一台原子力量显微镜(AFM ) 之间产生了的 graphene 尖端和 GF 底层。由电场的氟的符号的减小急速地与表抵抗力与 105-1,800 nm 的宽度生产 graphene nanoribbons (GNR ) 减少了从 > 1 T ????????  ?  ?

关键词：氟化石墨扫描探针静电场原子力显微镜健壮化学还原还原过程偏置电压

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Challenges in developing polymer flocculants to improve bitumen quality in *** extraction processes:an experimental study

引用

Petroleum science 2020年第3期17卷 811-821页

作者： Daniel V.Dixon stanislav R.stoyanov Yuming Xu Hongbo Zeng Joao B.P.soares Department of Chemical and Materials Engineering University of Alberta9211-116 Street NW.EdmontonAB T6G 1H9Canada CanmetENERGY Devon.Natural Resources Canada 1 Oil Patch DriveDevonAB T9G 1A8Canada

Western Canada’s oil sands hold the third-largest hydrocarbon deposits in the ***,a very heavy petroleum,is currently recovered by surface mining with warm water or in *** processes that use organic solvents are being developed to reduce water usage and tailings *** solvent-based methods can effectively extract bitumen,removal of residual fine solids from diluted bitumen product(DBP)to meet the pipeline transport requirement ofsolids and water in DBP remains a major *** propose a novel area of application of polymer flocculants for fine solids removal from *** principle,polymer flocculants can be applied to help remove these residual solids in conjunction with physical separation processes to increase process effectiveness and energy *** polymers are selected and screened for flocculation behavior using kaolinite suspended in DBP and toluene,as a model *** beam reflectance measurements and force tensiometer techniques are used to determine flocculation and sedimentation in *** observed flocculation and sedimentation rate enhancements indicate that the polymers tested have only minor effects,providing opportunities for advanced polymer *** findings exemplify the challenges in identifying polymers that may be effective as flocculants in heavy petroleum media.

关键词： Non-aqueous extraction Diluted bitumen Oil-soluble polymer flocculants sedimentation in dark and opaque media Focused beam reflectance measurements

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

small intestinal bacterial overgrowth syndrome

引用

World Journal of Gastroenterology 2010年第24期16卷 2978-2990页

作者： Jan Bures Jiri Cyrany Darina Kohoutova Miroslav Frstl stanislav Rejchrt Jaroslav Kvetina Viktor Vorisek Marcela Kopacova 2nd Department of Medicine Charles University in Praha Faculty of Medicine at Hradec Kralove University Teaching Hospital Institute of Clinical Microbiology Charles University in Praha Faculty of Medicine at Hradec Kralove University Teaching Hospital Institute of Experimental Biopharmaceutics Joint Research Centre of Czech Academy of Sciences and PRO.MED.CS Praha a.s. Institute of Clinical Biochemistry and Diagnostics Charles University in Praha Faculty of Medicine at Hradec Kralove University Teaching Hospital

Human intestinal microbiota create a complex polymi-crobial ecology. This is characterised by its high population density, wide diversity and complexity of interaction. Any dysbalance of this complex intestinal microbiome, both qualitative and quantitative, might have serious health consequence for a macro-organism, including small intestinal bacterial overgrowth syndrome (sIBO).sIBO is defined as an increase in the number and/or alteration in the type of bacteria in the upper gastro-intestinal tract. There are several endogenous defence mechanisms for preventing bacterial overgrowth: gastric acid secretion, intestinal motility, intact ileo-caecal valve, immunoglobulins within intestinal secretion and bacte-riostatic properties of pancreatic and biliary secretion. Aetiology of sIBO is usually complex, associated with disorders of protective antibacterial mechanisms (e.g. achlorhydria, pancreatic exocrine insuff iciency, immuno-deficiency syndromes), anatomical abnormalities (e.g. small intestinal obstruction, diverticula, f istulae, surgical blind loop, previous ileo-caecal resections) and/or motility disorders (e.g. scleroderma, autonomic neuropathy in diabetes mellitus, post-radiation enteropathy, small intestinal pseudo-obstruction). In some patients more than one factor may be involved. symptoms related to sIBO are bloating, diarrhoea, malabsorption, weight loss and malnutrition. The gold standard for diagnosing sIBO is still microbial investigation of jejunal aspirates. Noninvasive hydrogen and methane breath tests are most commonly used for the diagnosis of sIBO using glucose or lactulose. Therapy for sIBO must be com-plex, addressing all causes, symptoms and complica-tions, and fully individualised. It should include treatment of the underlying disease, nutritional support and cyclical gastro-intestinal selective antibiotics. Prognosis is usually serious, determined mostly by the underlying disease that led to sIBO.

关键词： Bacterial overgrowth Breath test Hydrogen Methane small intestine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Method of Forming stable states of Dense High-Temperature Plasma

引用

Journal of Modern Physics 2013年第4期4卷 481-485页

作者： stanislav I. Fisenko Igor s. Fisenko Rusthermosynthesis Moscow Russia

The concept of gravitational radiation as a radiation of one level with the electromagnetic radiation is based on theoretically proved and experimentally confirmed fact of existence of electron’s stationary states in own gravitational field, characterized by gravitational constant K = 1042 G (G-Newtonian gravitational constant) and by irremovable space-time curvature. The received results strictly correspond to principles of the relativistic theory of gravitation and the quantum mechanics. The given work contributes into further elaboration of the findings considering their application to dense high-temperature plasma of multiple-charge ions. This is due to quantitative character of electron gravitational radiation spectrum such that amplification of gravitational radiation may take place only in multiple-charge ion high-temperature plasma. In elaboration of the authors’ works [1-4], an essential instantiation of the concept of fusion plasma’s steady states formation (as the last paragraph outlines) and boundary conditions refinement in the electron’s stationary-states-in-proper-gravitational-field problem are appended to this article.

关键词： Gravity Electron spectrum Discharge Fusion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Is Gravitational Radiation a Radiation of the same Level as Electromagnetic Radiation?

引用

Journal of Modern Physics 2014年第15期5卷 1397-1401页

作者： stanislav I. Fisenko I. s. Fisenko Rusthermosynthesis JsC Moscow Russia

The notion of gravitational radiation as a radiation of the same level as the electromagnetic radiation is based on the theoretically proven and experimentally confirmed facts of the existence of stationary states of an electron in its gravitational field, characterized by the gravitational constant K = 1042 G (G is Newtonian gravitational constant) and unrecoverable space-time curvature Λ. These experimental facts include, in particular, data on the broadening of the spectra of the characteristic radiation of multielectron atoms. This broadening of the spectra can be only due to the additional broadening mechanism, in particular the presence of excited states of electrons in their gravitational field. Another fact is the new line in the X-ray emission spectrum according to the results of observation with MOs-camera of the XMM-Newton observatory. This line unlike other identified lines of electromagnetic radiation cannot be assigned to any atomic transition.

关键词： Electron stationary state Characteristic Radiation The Broadening of the Emission spectra

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A New Fairness-Oriented Packet scheduling scheme with Reduced Channel Feedback for OFDMA Packet Radio systems

引用

International Journal of Communications, Network and system sciences 2009年第7期2卷 608-618页

作者： stanislav NONCHEV Mikko VALKAMA 不详

In this paper, we propose a flexible and fairness-oriented packet scheduling approach for 3GPP UTRAN long term evolution (LTE) type packet radio systems, building on the ordinary proportional fair (PF) scheduling principle and channel quality indicator (CQI) feedback. special emphasis is also put on practical feedback reporting mechanisms, including the effects of mobile measurement and estimation errors, reporting delays, and CQI quantization and compression. The performance of the overall scheduling and feedback re-porting process is investigated in details, in terms of cell throughput, coverage and resource allocation fairness, by using extensive quasistatic cellular system simulations in practical OFDMA system environment with frequency reuse of 1. The performance simulations show that by using the proposed modified PF ap-proach, significant coverage improvements in the order of 50% can be obtained at the expense of only 10-15% throughput loss, for all reduced feedback reporting schemes. This reflects highly improved fairness in the radio resource management (RRM) compared to other existing schedulers, without essentially com-promising the cell capacity. Furthermore, we demonstrate the improved functionality increase in radio re-source management for UE’s utilizing multi-antenna diversity receivers.

关键词： Radio Resource Management Packet scheduling Proportional-Fair Channel Quality Feedback Throughput Fairness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：