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Heterogeneous crystallization of Chlorzoxazone for modulating the physicochemical properties of crystals Author links open overlay panel

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Particuology 2024年第8期91卷 249-259页

作者： Dhayananth Natarajan Kalaichelvi Ponnusamy Radhakrishnan thota Karunakaran Department of Chemical Engineering National Institute of TechnologyTiruchirappalli620015TamilnaduIndia

The polymer on modulating the crystal's habit is an evolving research in pharmaceutical *** study demonstrates the crystal habit modification of chlorzoxazone(CHZ)by heterogeneous crystallization(HC)in the binary solvent acetonitrile-ethanol(A-E(1:1))in the presence of polyvinylpyrrolidine(PVP)at concentrations of 0.50,0.75,and 1.00 wt%.The A-E(1:1)and PVP in HC experiments influenced to change the shape of crystals from needle to plate shape and reduced the crystal size producing a lower aspect ratio(in the range of 1.5-2.3).In the presence of PVP,the CHZ size distribution is 65-78μm which tends to enhance the powder flow-ability of CHZ crystals and as the PVP concentration increases,the nucleation rate *** solubility of size-reduced CHZ crystals at different pH is found to be improved by 1.2-1.4 ***,HC is deemed effective in modifying the physicochemical attributes of CHZ.

关键词： Chlorzoxazone Polyvinylpyrrolidine Heterogeneous crystallization Crystal habit modification Aspect ratio

Synthesis,spectroscopic characterization and in vitro antitumor activities of some novel mononuclear Ru(Ⅱ) complexes

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Chinese Chemical Letters 2012年第4期23卷 466-469页

作者： sreekanth thota Mohammad Imran Manasa Udugula Rajeshwar Yerra Subhas S.Karki Jan Balzarini Erik De Clercq Department of Pharmaceutical Chemistry&Toxicology S.R.College of Pharmacy.Ananthasagar Warangal 506371Andhra Pradesh.India Department of Pharmaceutical Chemistry KLES College of PharmacyRajajinagarBangalore 560010India Rega Institute for Medical Research Katholieke Universiteit Leuven.Minderbroedersstraat 10.B-3000 Leuven.Belgium

The synthesis and spectroscopic characterization of ruthenium complexes（R-l to R-8） of the type[Ru（A）2（B）],（where A = 1,10-phenanthroline/2,2′-bipyridine and B = 3.4.5-tri-OCH_3DPC,4-CH3-DPC,4-N-（CH3）2-DPC,4-NO2-DPC arc described. These ligands form bidentate octahedral ruthenium *** title complexes were subjected to in vitro cytotoxic activity measurements against the human cancer T-lymphocyte cell lines MTT *** vitro evaluation of these ruthenium complexes revealed cytotoxic activity from 0.24 to 1.4μg/mL against CEM,0.44 to 1.9μg/mL against Molt4/C8.0.28 to 1.5μg/mL against L1210,0.24 to 0.98μg/mL against HL60,and 0.25 to 1.2μg/mL against BEL7402,depending the nature of the compound.

关键词： Ruthenium complexes Leukemia cells MTT assay

Two-dimensional materials for tunable and nonlinear metaoptics

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Advanced Photonics 2024年第3期6卷 16-34页

作者： Zeng Wang Kandammathe Valiyaveedu sreekanth Meng Zhao Jinpeng Nong Yincheng Liu Jinghua Teng Agency for Science Technology and Research (A*STAR) Institute of Materials Research and Engineering (IMRE)

Metaoptics formed by ultrathin and planar building blocks enable compact and efficient optical devices that manipulate light at the nanoscale. The development of tunable metaoptics holds the promise of miniaturized and efficient optical systems that can dynamically adapt to changing conditions or requirements,propelling innovations in fields ranging from telecommunication and imaging to quantum computing and sensing. Two-dimensional(2D) materials show strong promise in enabling tunable metaoptics due to their exceptional electronic and optical properties from the quantum confinement within the atomically thin layers. In this review, we discuss the recent advancements and challenges of 2D material-based tunable metaoptics in both linear and nonlinear regimes and provide an outlook for prospects in this rapidly advancing area.

关键词： metaoptics tunable metaoptics two-dimensional optoelectronics nonlinear optics excitons polaritons

3D reservoir characterization of the Mangahewa Formation,Mangahewa Field,Taranaki Basin,New Zealand

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Energy Geoscience 2024年第2期5卷 152-170页

作者： Dk Nurulnazihah Pg Norsahminan Md Aminul Islam Surya Tejasvi thota Mohamed Ragab Shalaby Department of Geosciences Faculty of ScienceUniversiti Brunei DarussalamJalan Tungku LinkGadong BE1410Brunei Darussalam

The Mangahewa Formation is the primary reservoir target in the Mangahewa Field in the Taranaki Basin,New *** formation is distinguished by its marginal marine substantial tight-sand reservoir,having thickness exceeding 800 *** aim of this study is to assess the reservoir properties of the Mangahewa Formation through 3D reservoir modeling,employing 3D seismic data,core data,and well data from the Mangahewa *** variance attributes,the faults and horizons have been identified successfully within the *** majority of the interpreted faults exhibit dip angles exceeding 60,with a maximum displacement of 118 *** detect direct hydrocarbon indicators,root-mean-square amplitude seismic attribute,envelope,and generalized spectral decomposition techniques have been ***,four lithofacies,comprising 78.3%sandstone,9.2%siltstone,9.5%claystone,and 3.0%coal have been established by utilizing the Sequential Indicator Simulation(SIS)algorithm to create a lithofacies model.A property model has been generated using the Sequential Gaussian Simulation(SGS)*** evaluation indicates that the Mangahewa Formation exhibits reservoir qualities ranging from fair to good,with porosity levels between 8%and 11%,permeability averaging up to 10 mD,variable shale volumes,and hydrocarbon saturation in the range of 40%e50%.This study's methodologies and findings can serve as a valuable foundation for similar investigations in other tightsand gas fields located in different regions.

关键词： Marginal marine Tight-sand reservoir Mangahewa formation Mangahewa gas-condensate field Northern taranaki basin

Direct-Seeded Rice: Genetic Improvement of Game-Changing Traits for Better Adaption

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Rice science 2024年第4期31卷 417-433页

作者： Priyanka NEGI Jagadish RANE Rajendra Sadashiv WAGH Tukaram Jayaram BHOR Dipti Digambar GODSE Priyanka JADHAV C.ANILKUMAR Dasari sreekanth K.SAMMI REDDY Sharad Ramrao GADAKH K.M.BORAIH C.B.HARISHA P.S.BASAVARAJ Indian Council of Agricultural Research(ICAR)-National Institute of Abiotic Stress Management Baramati 413115India Mahatma Phule Krishi Vidyapeeth Rahuri 413722India ICAR-Central Institute for Arid Horticulture Bikaner 334006India ICAR-National Rice Research Institute Cuttack 753006India ICAR-Directorate of Weed Research Jabalpur 482004India Dr.Panjabrao Deshmukh Krishi Vidyapeeth Akola 444104India

The sustainability of rice production continues to be a subject of uncertainty and inquiry attributed to shifts in climatic conditions. In light of the impending climate change crisis and the high labor and water costs accompanying it, direct-seeded rice(DSR) is unquestionably one of the most practical solutions. Despite its resource and climate-friendly advantages, early maturing rice faces weed competitiveness and seedling establishment challenges. Resolving these issues is crucial for promoting its wider adoption among farmers, presenting it as a more effective sustainable rice cultivation method globally. Diverse traditional and contemporary breeding methods are employed to mitigate the limitations of the DSR approach, leveraging advanced techniques such as speed breeding and genome editing. Focusing on key traits like mesocotyl length elongation, early seedling vigor, root system architecture, and weed competitiveness holds promise for transformative improvements in DSR adaptation at a broader scale within farming communities. This review aims to summarize how these features contribute to increased crop production in DSR conditions and explore the research efforts focusing on enhancing DSR adaptation through these traits. Emphasizing the pivotal role of these game-changing traits in DSR adaptation, our analysis sheds light on their potential transformative impact and offers valuable insights for advancing DSR practices.

关键词： climate change direct-seeded rice aerobic rice early vigor trait

Bilateral pericapsular end nerve blocks for steroid-induced avascular necrosis following COVID-19 infection requiring bilateral total hip replacement

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World Journal of Anesthesiology 2024年第1期13卷 1-8页

作者： Somita Christopher Sweety Dutta thota Venkata Sanjeev Gopal Department of Anaesthesiology Care HospitalsHyderabad 500025India

BACKGROUND Osteonecrosis or avascular necrosis(AVN)of the hip was one of the dreaded complications of coronavirus disease 2019(COVID-19),which emerged in patients who received steroid *** have been a mainstay in the treatment protocol of COVID-19 *** corticosteroid drugs used in patients suffering from COVID-19 were intravenous(IV)or oral dexamethasone,methylprednisolone or *** use of such high doses of corticost-eroids has shown very positive results and has been lifesaving in many ***,long-term consequences were drug-induced diabetes,osteoporosis,Cushing syndrome,muscle wasting,peripheral fat mobilization,AVN,hirsutism,sleep disturbances and poor wound healing.A significant number of young patients were admitted for bilateral total hip replacements(THR)secondary to AVN following steroid use for COVID-19 *** To assess the efficacy of bilateral pericapsular end nerve group(PENG)blocks in patients posted for bilateral THR post-steroid therapy after COVID-19 infection and assess the time taken to first ambulate after *** This prospective observational study was conducted between January 2023 and August 2023 at Care Hospitals,Hyderabad,*** young patients 30-35 years of age who underwent bilateral THR were studied after due consent over 8 *** the patients received spinal anaesthesia for surgery and bilateral PENG blocks for postoperative *** The duration of surgery was 2.5 h on *** out of twenty patients(85%)had a Visual Analog Score(VAS)of less than 2 and did not require any *** patient was removed from the study,as he required *** remaining two patients had a VAS of more than 8 and received IV morphine post-operatively as a rescue analgesic *** out of seventeen patients(88.2%)could be mobilized 12 h after the *** Osteonecrosis or AVN of the hip was one of the dreaded complications of COVID-19

关键词： Avascular necrosis Pericapsular end nerve group block Analgesia Hip replacement COVID-19 Steroids

Reservoir quality evaluation using sedimentological and petrophysical characterization of deep-water turbidites:A case study of Tariki Sandstone Member,Taranaki Basin,New Zealand

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能源地球科学(英文) 2023年第1期4卷 13-32页

作者： Surya Tejasvi thota Md Aminul Islam Mohamed Ragab Shalaby Department of Geosciences Faculty of ScienceUniversiti Brunei DarussalamJalanTungku LinkGadong1410Brunei Darussalam

The current study aims to ascertain the reservoir characteristics of the Tariki Sandstone Member of the Otaraoa Formation,Taranaki Basin,New *** study was carried out by integrating the comprehensive petrophysical evaluation,sedimentological and petrographic studies,as well as well log analysis by using data from six *** porosity-permeability relationship is used to divide the samples of the Tariki Sandstone Member into reservoir and non-reservoir facies.A thorough petrophysical analysis shows that the maximum porosity values fluctuate between 16.6%and 22.1%,while permeability ranges from 102 mD to 574 mD,which indicates fair to good reservoir ***,the Tariki sandstone represents six hydraulic flow units with a high reservoir quality index and flow zone indicator representing good reservoir *** pore size varies between nano and megapores with dominant *** on the sedimentological and petrographic analysis,the Tariki Sandstone Member is classified as a combination of subarkose,arkose,and lithic arkose with fine to medium and moderately to moderately well-sorted *** main diagenetic factor affecting the reservoir quality is cementation,which occupied all the pores with *** the bright side,the secondary pores are developed due to the dissolution of calcite cement and few *** well log analysis demonstrates the presence of low clay volume ranging from 0.3%to 3.1%,fair to good effective porosity values between 13.6%and 15.9%,net pay thickness from 18.29 m to 91.44 m,and hydrocarbon saturation from 56%to 77.9%.The findings from this study revealed that the Tariki Sandstone Member possesses fair to good reservoir quality and hydrocarbon potential,which indicate submarine fans as appealing hydrocarbon *** study can be used in similar depositional environments elsewhere in the world.

关键词： Reservoir quality Tariki sandstone Petrophysical analysis Petrophysical parameter

NADPH oxidase family proteins:signaling dynamics to disease management

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Cellular & Molecular Immunology 2022年第6期19卷 660-686页

作者： Rizwana Begum Shilpa thota Abubakar Abdulkadir Gagandeep Kaur Prathyusha Bagam Sanjay Batra Present address:Department of Environmental Medicine University of RochesterSchool of Medicine and DentistryRochesterNY14642USA Laboratory of Pulmonary Immunotoxicology Department of Environmental ToxicologySouthern University and A&M CollegeBaton RougeLA70813USA Present address:Division of Systems Biology National Center for Toxicological ResearchJeffersonAR72079USA

Reactive oxygen species(ROS)are pervasive signaling molecules in biological *** humans,a lack of ROS causes chronic and extreme bacterial infections,while uncontrolled release of these factors causes pathologies due to excessive *** phagocytes such as neutrophils(PMNs),eosinophils,monocytes,and macrophages use superoxide-generating NADPH oxidase(NOX)as part of their arsenal of antimicrobial mechanisms to produce high levels of *** is a multisubunit enzyme complex composed of five essential subunits,two of which are localized in the membrane,while three are localized in the *** resting phagocytes,the oxidase complex is unassembled and inactive;however,it becomes activated after cytosolic components translocate to the membrane and are assembled into a functional *** NOX isoforms play a variety of roles in cellular differentiation,development,proliferation,apoptosis,cytoskeletal control,migration,and *** studies have identified NOX as a major contributor to disease pathologies,resulting in a shift in focus on inhibiting the formation of potentially harmful free ***,a better understanding of the molecular mechanisms and the transduction pathways involved in NOX-mediated signaling is essential for the development of new therapeutic agents that minimize the hyperproduction of *** current review provides a thorough overview of the various NOX enzymes and their roles in disease pathophysiology,highlights pharmacological strategies,and discusses the importance of computational modeling for future NOX-related studies.

关键词： NADPH oxidase Reactive oxygen species Inflammation Inhibitors In silico

A Resource-Efficient Communication Architecture for Chip Multiprocessors on FPGAs

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Journal of Computer Science & Technology 2011年第3期26卷 434-447页

作者： Maggie Swetha thota Department of Electrical and Computer Engineering Villanova University

Significant advances in field-programmable gate arrays （FPGAs） have made it viable to explore innovative multiprocessor solutions on a single FPGA chip. For multiprocessors, an efficient communication network that matches the needs of the target application is always critical to the overall performance. Wormhole packet-switching network-on-chip （NoC） solutions are replacing conventional shared buses to deal with scalability and complexity challenges coming along with the increasing number of processing elements （PEs）. However, the quest for high performance networks has led to very complex and resource-expensive NoC designs, leaving little room for the real computing force, i.e., PEs. Moreover, many techniques offer very small performance gains or none at all when network traffic is light while increasing the resource usage of routers. We argue that computation is still the primary task of multiprocessors and sufficient resources should be reserved for PEs. This paper presents our novel design and implementation of a resource-efficient communication network for multiprocessors on FPGAs. We reduce not only the required number of routers for a given number of PEs by introducing a new PE-router topology, but also the resource requirement of each router. Our communication network relies on the NEWS channels to transfer packets in a pipelined fashion following the path determined by the routing network, The implementation results on various Xilinx FPGAs show good performance in the typical range of network load for multiprocessor applications.

关键词： chip multiprocessors FPGA network on chip mesh topology resource efficient