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Recycled oceanic crust as a source for tonalite intrusions in the mantle section of the Khor Fakkan block, Semail ophiolite(UAE)

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Geoscience Frontiers 2019年第3期10卷 1187-1210页

作者： Hosung Joun sotirios kokkalas Stylianos Tombros Department of Earth Sciences Khalifa University Department of Geology University of Patras

Several types of felsic granitoid rocks have been recognized, intrusive in both the mantle and the crustal sequence of the Semail ophiolite. Several models have been proposed for the source of this suite of tonalites, granodiorites, trondhjemites intrusions, however their genesis is still not clearly *** sampled Dadnah tonalites that intruded in the mantle section of the Semail ophiolite display arctype geochemical characteristics, are high siliceous, low-potassic, metaluminous to weakly peraluminous, enriched in LILE, show positive peaks for Ba, Pb, Eu, negative troughs for U, Ti and occur with low δ^(18)O_(H_2 O), moderate ε_(Sr) and negative eNd values. They have crystallized at temperatures that range from～550 ℃ to ～720 ℃ and pressure ranging from 4.4 kbar to 6.5 kbar. The isotopic ages from our tonalite samples range between 98.6 Ma and 94.9 Ma, slightly older and overlapping with the age of the metamorphic sole. Our field observations, mineralogical, petrological, geochemical, isotopic and melt inclusion data suggest that the Dadnah tonalites formed by partial melting(～10%-15% continuous or ～12% batch partial melting), accumulation of plagioclase, fractional crystallization(～55%-57%), and interaction with their host harzburgites. These tonalites were the end result of partial melting and subsequent contamination and mixing of ～4% oceanic sediments with ～96% oceanic lithosphere from the subducted slab. This MORB-type slab melt composed from ～97% recycled oceanic crust and ～3% of the overlying *** suggest that a possible protolith for these tonalites was the basaltic lavas from the subducted oceanic slab that melted during the initial stages of the supra-subduction zone(SSZ), which was forming synchronously to the spreading ridge axis. The tonalite melts mildly modified due to low degree of mixing and interaction with the overlying lithospheric mantle. Subsequently, the Dadnah tonalites emplaced at the upper part of the mantle sequence of the Se

关键词： Tonalites Felsic granitoids Recycled oceanic crust Source contribution Partial melting Melt inclusions

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Overview of the Association Between Non-Alcoholic Fatty Liver Disease and Hypertension

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Cardiology Discovery 2024年第1期4卷 30-37页

作者： Niki S.Kakouril Costas G.Thomopoulos Eirini P.Siafi Angeliki E.Valatsoul Kyriakos S.Dimitriadis Iliana P.Mani sotirios P.Patsilinakos Dimitrios M.Tousoulis Konstantinos P.Tsioufis First Department of Cardiology Medical SchoolNational and Kapodistrian University of AthensHippokration HospitalAthens 11527Greece Department of Cardiology Elena Venizelou HospitalAthens 11521Greece Department of Cardiology General Hospital Agia OlgaAthens 14233Greece

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and its prevalence is rising. NAFLD is closely associated with metabolic syndrome, with both conditions sharing common clinical characteristics such as obesity, insulin resistance, type 2 diabetes mellitus, hypertension, and hypertriglyceridemia. Several observational studies have evaluated the relationship between NAFLD and hypertension, with the overall evidence suggesting a bidirectional relationship. It is hypothesized that activation of the sympathetic nervous and renin-angiotensin systems, observed in NAFLD with or without insulin resistance promotes the development of hypertension. In patients with hypertension, activation of these systems can lead to hepatic fibrosis and progressive inflammation through increased oxidative stress and activation of hepatic stellate cells and Kupffer cells. The present review examines the pathophysiologic and clinical evidence supporting the bidirectional association between NAFLD and hypertension.

关键词： Hypertension Non-alcoholic fatty liver disease Insulin resistance Sympathetic nervous system Metabolic syndrome

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Enhancing the robustness of object detection via 6G vehicular edge computing

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Digital Communications and Networks 2022年第6期8卷 923-931页

作者： Chen Chen Guorun Yao Chenyu Wang sotirios Goudos Shaohua Wan School of Telecommunication Engineering Xidian UniversityXi'an710071China Department of Physics ELEDIA@AUTHAristotle University of Thessaloniki54124ThessalonikiGreece Shenzhen Institute for Advanced Study University of Electronic Science and Technology of ChinaShenzhen518110China

Academic and industrial communities have been paying significant attention to the 6th Generation (6G) wireless communication systems after the commercial deployment of 5G cellular communications. Among the emerging technologies, Vehicular Edge Computing (VEC) can provide essential assurance for the robustness of Artificial Intelligence (AI) algorithms to be used in the 6G systems. Therefore, in this paper, a strategy for enhancing the robustness of AI model deployment using 6G-VEC is proposed, taking the object detection task as an example. This strategy includes two stages: model stabilization and model adaptation. In the former, the state-of-the-art methods are appended to the model to improve its robustness. In the latter, two targeted compression methods are implemented, namely model parameter pruning and knowledge distillation, which result in a trade-off between model performance and runtime resources. Numerical results indicate that the proposed strategy can be smoothly deployed in the onboard edge terminals, where the introduced trade-off outperforms the other strategies available.

关键词： 6G Vehicular edge computing Object detection Feature fusion Model compression Model deployment

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Treatment of Helicobacter pylori infection:Meeting the challenge of antimicrobial resistance

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World Journal of Gastroenterology 2014年第29期20卷 9898-9911页

作者： Vasilios Papastergiou sotirios D Georgopoulos Stylianos Karatapanis Department of Internal Medicine General Hospital of Rhodes Department of Gastroenterology Athens MedicalP Faliron Hospital

Treatment of Helicobacter pylori (H. pylori) infection is paramount for the management of prevalent gastrointestinal disorders including peptic ulcer disease and gastric cancer. Due to the wide increase in prevalence of H. pylori resistance to antibiotics, clarithromycin-based triple therapies are not any more suitable for unconditional empiric use, and should not be recommended, unless local resistance to this antibiotic is low (< 20%). Alternative strategies have been proposed to overcome the issue of increasing clarithromycin resistance, and some of them are already implemented in clinical practice. These comprise: (1) adoption of novel, more effective, empirical treatments: bismuth quadruple, sequential, non-bismuth quadruple (concomitant), dual-concomitant (hybrid), and levofloxacin-based regimens, the latter mainly designated as second-line/rescue options; (2) perspectives for a susceptibility-guided (tailored) therapeutic approach based on culture-free molecular testing methods; and (3) adjunct use of probiotics to improve eradication rates. The present article is aimed to provide a comprehensive overview of current and emerging strategies in the treatment of H. pylori infection, focusing on the challenge of antimicrobial resistance.

关键词： Helicobacter pylori Antibiotic resistance Bismuth-quadruple Concomitant Sequential

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Investigation of proper modeling of very dense granular flows in the recirculation system of CFBs

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Particuology 2012年第6期10卷 699-709页

作者： Aristeidis Nikolopoulos Nikos Nikolopoulos Nikos Varveris sotirios Karellas Panagiotis Grammelis Emmanuel Kakaras Laboratory of Steam Boilers and Thermal Plants Thermal Engineering SectorSchool of Mechanical EngineeringNTUAAthensGreece Centre for Research and Technology Hellas Institute for Solid Fuels Technology and ApplicationsAthens Gr-15310Greece

The aim of this paper is the development of new models and] or the improvement of existing numerical models, used for simulating granular flow in CFB （circulating fluidized bed） recirculation systems. Most recent models follow the TFM （two-fluid model） methodology, but they cannot effectively simulate the inter-particle friction forces in the recirculation system, because the respective stress tensor does not incorporate compressibility of flow due to change of effective particle density. As a consequence, the induced normal and shear stresses are not modeled appropriately during the flow of the granular phase in the CFB recirculation system. The failure of conventional models, such as that of yon MisesJCoulomb, is mainly caused by false approximation of the yield criterion which is not applicable to the CFB recirculation system. The present work adopts an alternative yield function, used for the first time in TFM Eulerian modeling. The proposed model is based on the Pitman-Schaeffer-Gray-Stiles yield criterion. Both the temporal deformation of the solid granular phase and the repose angle that the granular phase forms are more accurately simulated by this model. The numerical results of the proposed model agree well with experimental data, implying that frictional forces are efficiently simulated by the new model.

关键词： Euler-EulerCFBRepose angleFull-loop simulationGranular viscosityYield criterion

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Fragility assessment of tunnels in soft soils using artificial neural networks

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Underground Space 2022年第2期7卷 242-253页

作者： Zhongkai Huang sotirios A.Argyroudis Kyriazis Pitilakis Dongmei Zhang Grigorios Tsinidis Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Department of Geotechnical EngineeringTongji UniversityShanghaiChina Department of Civil and Environmental Engineering Brunel University LondonUxbridge UB83PHUnited Kingdom Department of Civil Engineering Aristotle UniversityThessalonikiGreece

Recent earthquakes have shown that tunnels are prone to damage,posing a major threat to safety and having major cascading and socioeconomic ***,reliable models are needed for the seismic fragility assessment of underground structures and the quantitative evaluation of expected *** on previous researches,this paper presented a probabilistic framework based on an artificial neural network(ANN),aiming at the development of fragility curves for circular tunnels in soft ***,a two-dimensional incremental dynamic analysis of the nonlinear soil-tunnel system was performed to estimate the response of the tunnel under ground *** effects of soil-structure-interaction and the ground motion characteristics on the seismic response and the fragility of tunnels were adequately considered within the proposed *** ANN was employed to develop a probabilistic seismic demand model,and its results were compared with the traditional linear regression *** curves were generated for various damage states,accounting for the associated *** results indicate that the proposed ANN-based probabilistic framework can results in reliable fragility models,having similar capabilities as the traditional approaches,and a lower computational cost is *** proposed fragility models can be adopted for the risk analysis of typical circular tunnel in soft soils subjected to seismic loading,and they are expected to facilitate decision-making and risk management toward more resilient transport infrastructure.

关键词： Circular tunnels Fragility curves Artificial neural network Numerical study Probabilistic seismic demand model

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The emerging epigenetics of PARK7 and its implication in neurodegenerative disease

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Neural Regeneration Research 2018年第9期13卷 1542-1543页

作者： George D.Vavougios sotirios G.Zarogiannis Department of Neurology Athens Naval Hospital Department of Physiology Faculty of MedicineUniversity of Thessaly

PARK7/DJ-1 is a multifunctional protein that acts as a regulator in stress responsive *** its original discovery as a novel oncogene,DJ-1 was further implicated in the correspondingly dubbed PARK7 autosomal recessive early onset Parkinson’s Disease variant,expanding the spectrum of its pathophysiologyto neurodegenerative disease.

关键词： The emerging epigenetics of PARK7 and its implication in neurodegenerative disease

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Multiple primary malignancies: a report of two cases

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Chinese Journal of Cancer Research 2014年第2期26卷 215-218页

作者： Minas Sakellakis Stavros Peroukides Gregoris Iconomou sotirios Boumpoucheropoulos Haralabos Kalofonos Division of Oncology Department of Medicine University Hospital of Patras

The diagnosis of multiple primary malignancies （MPMs） in a patient has been reported rather frequently during the past decade. Here we present two cases with three synchronous primary malignant tumors. The first patient is a 66-year-old male with synchronous colorectal cancer, renal cell carcinoma （RCC） and non-small cell lung cancer （NSCLC）. The second patient is a 64-year-old female with breast cancer, transitional cell carcinoma of the ureter and endometrial cancer. MPMs seem to be diagnosed in a higher incidence than that predicted only by the influence of hazard and, whenever found, they raise questions regarding not only possible common etiologic factors or same pathogenetic mechanisms but also they cause a lot of troubles to both clinicians and patients because the therapeutic options usually become limited.

关键词： Multiple primary malignancies synchronous metachronous

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Inferior mesenteric arteriovenous fistula: Case report and world-literature review

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World Journal of Gastroenterology 2014年第25期20卷 8298-8303页

作者： Antonios Athanasiou Adamantios Michalinos reas Alexrou sotirios Georgopoulos Evangelos Felekouras First Department of Surgery Laikon University HospitalAthens 11527Greece

Arteriovenous fistulas between the inferior mesenteric artery and vein are rare, with only 26 primary and secondary cases described in the literature. Secondary fistulas occur following operations of the left hemicolon and manifest as abdominal pain, abdominal mass, gastrointestinal bleeding, colonic ischemia and portal hypertension. Symptom intensities are flow-dependent, and can range from minimal symptoms to severe heart failure due to left to right shunt. Diagnosis is usually established by radiological or intraoperative examination. Treatment options include embolization and/or surgical resection. Therapeutic decisions should be adapted to the unique characteristics of the fistula on an individual basis. A new case of a primary arteriovenous fistula is described and discussed along with a complete review of the literature. The patient in this report presented with signs and symptoms of colonic ischemia without portal hypertension. The optimal treatment for this pa-tient required a combination of embolization and surgical operation. The characteristics of these rare inferior mesenteric arteriovenous fistulas are examined and some considerations concerning diagnostic and therapeutic strategies that should be followed are presented.

关键词： Inferior mesenteric artery Arteriovenous fistula Colectomy Embolization Portal hypertension

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The conflict on posttreatment Lyme disease syndrome: a clinical mini review

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Neuroimmunology and Neuroinflammation 2016年第1期3卷 10-13页

作者： Manos Bogdos sotirios Giannopoulos Maria Kosmidou Department of Neurology School of MedicineUniversity of Ioannina45110 IoanninaGreece Neurosurgical Research Institute School of MedicineUniversity of Ioannina45110 IoanninaGreece st Division of Internal Medicine School of MedicineUniversity of Ioannina45110 IoanninaGreece

Is Borrelia burgdorferi responsible for the persistence of symptoms after the standard successful course of antibiotics in Lyme disease patients?This highly controversial issue,concerning the underlying mechanism of posttreatment Lyme disease syndrome(PTLDS),still seems to be a matter of intense conflict of *** is the manifestation of nonspecific symptoms including fatigue,musculoskeletal pain,dysesthesias,and neurocognitive deterioration after the standard antimicrobial therapy administered to patients suffering from Lyme *** this article,we review the conflicting views and published highlights of recent human studies regarding PTLDS.

关键词： Antibiotic therapy duration of therapy Lyme disease nonspecific symptoms posttreatment Lyme disease syndrome

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