Overview of the Association Between Non-Alcoholic Fatty Liver Disease and Hypertension
Overview of the Association Between Non-Alcoholic Fatty Liver Disease and Hypertension作者机构：First Department of CardiologyMedical SchoolNational and Kapodistrian University of AthensHippokration HospitalAthens 11527Greece Department of CardiologyElena Venizelou HospitalAthens 11521Greece Department of CardiologyGeneral Hospital Agia OlgaAthens 14233Greece
出 版 物：《Cardiology Discovery》 (心血管病探索（英文）)
年 卷 期：2024年第4卷第1期
页 面：30-37页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Hypertension Non-alcoholic fatty liver disease Insulin resistance Sympathetic nervous system Metabolic syndrome
摘 要：Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and its prevalence is rising. NAFLD is closely associated with metabolic syndrome, with both conditions sharing common clinical characteristics such as obesity, insulin resistance, type 2 diabetes mellitus, hypertension, and hypertriglyceridemia. Several observational studies have evaluated the relationship between NAFLD and hypertension, with the overall evidence suggesting a bidirectional relationship. It is hypothesized that activation of the sympathetic nervous and renin-angiotensin systems, observed in NAFLD with or without insulin resistance promotes the development of hypertension. In patients with hypertension, activation of these systems can lead to hepatic fibrosis and progressive inflammation through increased oxidative stress and activation of hepatic stellate cells and Kupffer cells. The present review examines the pathophysiologic and clinical evidence supporting the bidirectional association between NAFLD and hypertension.
维普期刊数据库