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数学译林 2014年第4期33卷 292-292页

作者： Jean-Francois le gall 丁璐张伟王世坤法国巴黎第十一大学不详

此报告介绍和研究一个普适的二维随机几何模型．为此，我们开始于在球面上画一个离散的、从某类图形中以一个给定尺寸n随机和均匀地选择图形，例如，从球面上所有三角剖分类选择有n个面的图形．

关键词：几何模型随机和球面图形三角

The HINT ProjectmExploring the Use of New Technologies in Heritage Interpretation

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Journal of Earth Science and Engineering 2014年第3期4卷 156-174页

作者： Robina R. Barton David Cooper Anne Guyomard sophie. C. Justice Peter Samsom Elizabeth Picket Cathrien. L. Posthumus Nathalie Cayla Geopark Shetland Shetland Amenity Trust Garthspool Lerwick ZEl ONY UK . Geopark Chablais Syndicatlntercommunald Amenagement du Chablais Thonon-Les-Bains 74200 France North Pennines AONB Partnership The Old Co-op Building Stanhope DL13 2UY UK Geopark de Hondsrug Bronnegerstraat 129531 TG Borger The Netherlands ED YTEM (Laboratory of Environment Dynamics and Territories) UMR CNRS-University of Savoy Technolac 73 376 Le Bourgetdu Lac Cedex France

The HINT project is a four-country collective of Global heritage interpretation. HINT is a two-year project part funded Geoparks researching the uses and benefits of new technologies in by the European leader Programme. The partners are Geopark Shetland （Scotland）, Chablais Geopark （France）, North Pennines Area of Outstanding Natural Beauty （England） and Geopark de Hondsrug （The Netherlands）. Each partner has developed a pilot project to investigate the practicalities of interpreting and communicating heritage, especially geological heritage, using a particular technology. An overview of each of the four pilot projects is given. The overall aim of the pilot projects is to develop best practice in using new technologies for heritage interpretation and to share information and ideas within the project partnership and with geoparks and heritage organizations around the world. This paper, developed by the HINT partners, aims to give an insight into the practical process of developing interpretive tools using new technologies. Some common problems are highlighted and some ways in which these can be addressed are shown.

关键词： Technology interpretation education tourism heritage.

Nanoscale Stiffness Distribution in Bone Metastasis

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World Journal of Nano Science and Engineering 2015年第4期5卷 219-228页

作者： Ludovic Richert Laetitia Keller Quentin Wagner Fabien Bornert Catherine Gros sophie Bahi Francois Clauss William Bacon Philippe Clézardin Nadia Benkirane-Jessel Florence Fioretti Centre National de la Recherche Scientifique(CNRS) UMRFacultéde Pharmacie de l’Universitéde Strasbourg(UdS)IllkirchFrance Institut National de la Santéet de la Recherche Médicale(INSERM) Osteoarticular and Dental Regenerative NanomedicineUMRFacultéde Médecine de l’Universitéde Strasbourg and FMTSStrasbourgFrance Facultéde Chirurgie Dentaire de l’Universitéde Strasbourg(UdS) StrasbourgFrance Hopitaux Universitaires de Strasbourg StrasbourgFrance Institut National de la Santéet de la Recherche Médicale(INSERM) UMRFacultéde Médecine Laennec de l’UniversitéClaude Bernard Lyon 1LyonFrance

Nanomechanical heterogeneity is expected to have an effect on elasticity, injury and bone remodelling. In normal bone, we have two types of cells (osteoclasts and osteoblasts) working together to maintain existing bone. Bone cancers can produce factors that make the osteoclasts work harder. This means that more bone is destroyed than rebuilt, and leads to weakening of the affected bone. We report here the first demonstration of the nanoscale stiffness distribution in bone metastases before and after treatment of animals with the bisphosphonate Risedronate, a drug which is currently used for the treatment of bone metastases in patients with advanced cancers. The strategy used here is applicable to a wide class of biological tissues and may serve as a new reflection for biologically inspired scaffolds technologies.

关键词： Bone Metastasis Stiffness Risedronate

海恩堡马丁路德教堂奥地利(2008-2011)

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世界建筑导报 2016年第2期31卷 82-83页

作者：沃尔夫.狄.普瑞克斯 sophie-charlotte grell duccio malagamba 无不详蓝天组建筑设计事务所

这所新教教堂由四个主要建筑单元构成：圣殿、社区会堂、圣器收藏室和雕塑钟塔。建筑的形状像一张巨大的＂桌子＂,整个屋顶被四条＂桌子腿＂（四根钢柱）支撑着。屋顶及其三个醒目的天窗是本建筑的重要构件。外皮由焊接在框架结构上的8... 详细信息

这所新教教堂由四个主要建筑单元构成：圣殿、社区会堂、圣器收藏室和雕塑钟塔。建筑的形状像一张巨大的＂桌子＂,整个屋顶被四条＂桌子腿＂（四根钢柱）支撑着。屋顶及其三个醒目的天窗是本建筑的重要构件。外皮由焊接在框架结构上的8毫米厚立体弧形钢板构成。屋顶构件的建造采用了造船技术。勒·柯布西耶（le Corbusier）在将造船技术运用到建筑方面起了重要的示范作用,这同样还包括他建造的拉图雷特修道院。前院的雕塑钟塔高20米,是一个垂直框架的自承重钢结构。

关键词：勒·柯布西耶马丁路德造船技术框架结构自承塔高技术运用 shipbuilding 单元构成 longitudinal

消瘿清热汤联合穴位注射治疗甲亢伴胫前黏液性水肿临床观察

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中国中医药现代远程教育 2022年第9期20卷 109-111页

作者：于乐抚顺市中医院内分泌科辽宁抚顺113000

目的系统性评估消瘿清热汤联合穴位注射治疗对甲状腺功能亢进症(简称甲亢)伴胫前黏液性水肿患者的临床效果。方法选取自2019年5月—2020年5月于抚顺市中医院内分泌科病房住院并接受治疗的甲亢伴胫前黏液性水肿患者60例,入组病例均采用... 详细信息

目的系统性评估消瘿清热汤联合穴位注射治疗对甲状腺功能亢进症(简称甲亢)伴胫前黏液性水肿患者的临床效果。方法选取自2019年5月—2020年5月于抚顺市中医院内分泌科病房住院并接受治疗的甲亢伴胫前黏液性水肿患者60例,入组病例均采用信封法随机分为对照组和试验组。对照组30例,应用甲巯咪唑内服联合穴位注射治疗方案,试验组30例,在对照组基础上联合消瘿清热汤内服治疗方案,观察2组患者治疗前后中医证候积分、甲状腺激素水平及胫前黏液性水肿皮损面积变化情况。结果经临床治疗,试验组中医证候评分、T3激素、T4激素、皮损面积均优于对照组,差异有统计学意义(P<0.05)。结论消瘿清热汤联合穴位注射可显著稳定患者甲状腺素水平,滋阴清热、散结解郁、养血消瘿,临床效果显著,值得临床推广。

关键词：瘿病甲状腺功能亢进症胫前黏液性水肿消瘿清热汤甲状腺素

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“玩”心未泯的海报设计

艺术与设计 2021年第10期10卷 78-83页

作者：赵乐无(图) 不详玩设计

能将“玩”(Play)字纳入工作室命名中,想必“我们玩设计”(WePlayDesign)是一家童心未泯的设计工作室。工作室的创办人苏菲·鲁宾(sophie Rubin)和塞德里克·罗塞尔(Cedric Rossel)解释道,他们眼中的“玩”并非大众化的“可爱”或“讨喜... 详细信息

能将“玩”(Play)字纳入工作室命名中,想必“我们玩设计”(WePlayDesign)是一家童心未泯的设计工作室。工作室的创办人苏菲·鲁宾(sophie Rubin)和塞德里克·罗塞尔(Cedric Rossel)解释道,他们眼中的“玩”并非大众化的“可爱”或“讨喜”,更多的是游戏感和实验性,也强调动感、时间和叙述及互动概念。他们在采访中提到的第一个案例是2018年的标志之作:日内瓦音乐节(Festival Archipel)。

关键词：创办人设计工作室德里克海报设计童心未泯罗塞尔游戏感

*** link between cognitive impairment and drusen quantity in age-related macular degeneration

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Annals of Eye Science 2019年第1期 210-210页

作者： Stephanie Pietrangelo Caitlin Murphy sophie Hallot Aaron Johnson Department of Psychology Concordia UniversityMontréalQCCanada CRIR/Centre de réadaptation MAB-Mackay du CIUSSS du CentreOuest-de-l’Île-de-Montréal MontrealQCCanada

Background:Age-related macular degeneration(AMD)is a common cause of severe vision impairment in populations over 50 years *** is characterized by drusen;the accumulation of waste between the retinal pigment epithelium and Bruch’s *** have been identified in the eyes of Alzheimer’s patients,***,beta-amyloid,best known as a pathological component of the senile plaques in Alzheimer’s disease,has been identified as a component of drusen in *** have also demonstrated an increased prevalence of cognitive impairment in individuals with *** current study uses optical coherence tomography(OCT)and a cognitive assessment to investigate the potential use of drusen as a biomarker of cognitive *** overall number of drusen detectable on the OCT scans of individuals who exhibit mild cognitive impairment is compared to the number of drusen detectable on the OCT scans of individuals who do not exhibit mild cognitive ***:To date,10 participants(nine women)aged 74 to 95 years with a diagnosis of AMD and/or drusen have been *** Optos®OCT/SLO imaging system was used to take cross-sectional images of the *** images were then manually graded by two trained graders to determine the number of drusen present along the *** Montreal Cognitive Assessment(MoCA)was used to assess overall cognitive ***:Of the 10 participants,three passed the full MoCA(*** at or above 26 out of 30 possible points)and seven did not pass,scoring positive for mild cognitive impairment(Mpass=27.33,SDpass=0.58;Mfail=21.86,SDfail=2.55).Preliminary analyses have demonstrated that individuals who pass the MoCA seem to have fewer drusen present overall(Mdn=35)compared to those who score positive for cognitive impairment(Mdn=63).However,a Mann-Whitney U test revealed that these findings are not significant;U=5,P=***:The results agree with previous literature demonstrating an increased prevalence of

关键词： Age-related macular degeneration(AMD) drusen cognitive impairment aging

AB034. Knowledge and understanding of eye disease among older adults with vision impairment

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Annals of Eye Science 2019年第1期 209-209页

作者： Caitlin Murphy Stephanie Pietrangelo sophie Hallot Jonah Toulch Aaron Johnson Department of Psychology Concordia UniversityMontrealQCCanada School of Optometry Universitéde MontréalMontrealQCCanada CRIR/Centre de réadaptation MAB-Mackay du CIUSSS du Centre-Ouest-de-l’Île-de-Montréal MontrealQCCanada

Background:By 2026,projections indicate that 1/5 Canadians will be over the age of *** shift in demographics will be accompanied by an increase in age-related eye *** studies have reported vision loss as a major medical concern among older adults,but there is little information on older adults’awareness and knowledge of age-related eye diseases.A lack of knowledge can lead to missed or delayed treatment and/or lifestyle *** study aims to assess the knowledge and understanding older adults have of their own eye disease and its ***:Participants over the age of 50 with a visual impairment were recruited from the MAB-Mackay Rehabilitation Centre,the Low Vision Self-Help Association(LVSHA)of the West Island and through word of *** acuity and contrast sensitivity were measured using the ETDRS charts and Mars Charts,*** coherence tomography(OCT)/scanning laser ophthalmoscopy was used to take cross-sectional images of participant *** were asked to name their visual diagnoses and describe them in their own *** diagnoses were compared to diagnoses determined by an optometrist or ***:To date,this study has recruited 26 participants(7M,19F)over the age of 50 years(range,51-95 years).Many participants(73%)were able to name their visual diagnoses,articulate their symptoms,and discuss their treatment and *** majority of these individuals(67%)were clients of the MAB-Mackay or participants in the *** the 27%(4M,4F)who were unclear or had misunderstood their diagnoses,half were participants in a low vision support group,but they had multiple visual diagnoses and it was the congenital or trauma-related visual impairments acquired before joining the MAB-Mackay or LVSHA that remained *** other 4 individuals who misunderstood their diagnoses were not involved with any low vision or rehabilitation ***:Visual impairment is some

关键词： Low vision low vision rehabilitation aging awareness

胆囊肿瘤组织CA72.4和CA242表达临床意义的研究

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中华肿瘤防治杂志 2009年第8期16卷 607-609页

作者：苗雄鹰杨竹林杨乐平付汐中南大学湘雅二医院肝胆胰疾病研究室湖南长沙410011

目的:探讨胆囊腺癌、癌旁上皮和慢性胆囊炎组织中CA72.4和CA242表达水平及其临床意义。方法:108例胆囊腺癌、46例癌旁组织和35例慢性胆囊炎组织手术切除标本常规石蜡包埋切片,EnVi-sionTM免疫组化法对CA72.4和CA242染色。结果:胆囊腺癌... 详细信息

目的:探讨胆囊腺癌、癌旁上皮和慢性胆囊炎组织中CA72.4和CA242表达水平及其临床意义。方法:108例胆囊腺癌、46例癌旁组织和35例慢性胆囊炎组织手术切除标本常规石蜡包埋切片,EnVi-sionTM免疫组化法对CA72.4和CA242染色。结果:胆囊腺癌组织中,CA72.4和CA242阳性表达率明显高于癌旁组织和慢性胆囊炎组织的表达率,P<0.01。腺瘤癌变、肿块最大径<2cm、无淋巴结转移和未侵犯周围组织病例的CA72.4和CA242阳性表达率,明显低于低分化腺癌、肿块最大径≥2cm、淋巴结转移及侵犯周围组织病例的表达率,P<0.01;胆囊腺癌组织中两者表达呈高度一致性,χ2=56.24,P<0.01。结论:CA72.4和CA242可作为反映胆囊腺癌进展、生物学行为及预后的重要标志。

关键词：胆囊肿瘤慢性胆囊炎糖类抗原类免疫组织化学

Screening of Myocardial Cardiotoxicity Induced by Anticancer Chemotherapy and the Importance of Global Longitudinal Strain

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World Journal of Cardiovascular Diseases 2024年第6期14卷 381-391页

作者： Marguerite Téning Diouf Fatou Aw Hussein Khadra sophie Ba Doudou Diouf Michel Ngonar Sarr Joseph Salvador Mingou Malick Ndiaye Simon Antoine Sarr Momar Dioum Aliou Alassane Ngaide Serigne Mor Beye Simon Manga Alain Affangla Youssou Diouf Khadimu Rassoul Diop Malick Bodian Mohamed leye Mouhamadou Bamba Ndiaye Alassane Mbaye Adama Kane Maboury Diao Abdoul Kane Cardiology Department of the Dalal Jamm Hospital Dakar Senegal Cardiology Department Hospital Aristide Le Dantec Dakar Senegal Cardiology Department Hospital Fann Dakar Senegal UFR2S Saint Louis Saint Louis Senegal UFR Ziguinchor Ziguinchor Senegal Training and Research in Health Sciences Unit University of Thies Thies Senegal Cardiology Department Hospital General Idrissa Pouye Dakar Senegal

Introduction: The improvement of survival in patients with cancer and the expansion of therapeutic options have led to the emergence of a new profile of cardiotoxicity, specifically associated with antimitotic agents. Our study aimed to assess the incidence of chemotherapy-induced myocardial toxicity in patients with cancer. Patients and Methods: We conducted a looking-forward longitudinal cohort study including all patients admitted to the Cardiology departments of Aristide le Dantec Hospital and Dalal Jamm National Hospital Centre for apre-chemotherapy check-up. The included patients did not undergo any pre-existing cardiopathy. Results: Over a period of two years ranging from January 2019 to December 2021, a total of 37 patients were included in the study. Notably, there was a female predominance (92%) with an average age of 49.7 years ± 13.69. Breast cancer accounted for 70% of the neoplasms. Laboratory findings revealed moderate anemia in 19 patients (51%). At inclusion, the left ventricle (LV) was of normal size (LV diastole at 44.46 ± 4.97 mm). The systolic function of the left ventricle was normal in all patients, with an average ejection fraction (EF) of 63.1% ± 5.80 and a mean global longitudinal strain (GLS) of −20.4% ± 2.58. The most commonly used agents were anthracyclines. During follow-up, 3 patients (8.1%) developed clinical symptoms of left heart failure, and LV dysfunction on echocardiography was observed in 5 (13.5%) patients, with a significant decrease in EF Conclusion: The incidence of cardiac toxicity is not negligible, hence the importance of early screening. Strain imaging is an essential tool that should be performed as part of the assessment before chemotherapy and re-evaluated during treatment.

关键词： Cancer Chemotherapy Global Longitudinal Strain Cardiotoxicity