*** link between cognitive impairment and drusen quantity in age-related macular degeneration
作者机构：Department of PsychologyConcordia UniversityMontréalQCCanada CRIR/Centre de réadaptation MAB-Mackay du CIUSSS du CentreOuest-de-l’Île-de-MontréalMontrealQCCanada
出 版 物：《Annals of Eye Science》 (眼科学年鉴（英文）)
年 卷 期：2019年第1期
页 面：210-210页
主 题：Age-related macular degeneration(AMD) drusen cognitive impairment aging
摘 要：Background:Age-related macular degeneration(AMD)is a common cause of severe vision impairment in populations over 50 years *** is characterized by drusen;the accumulation of waste between the retinal pigment epithelium and Bruch’s *** have been identified in the eyes of Alzheimer’s patients,***,beta-amyloid,best known as a pathological component of the senile plaques in Alzheimer’s disease,has been identified as a component of drusen in *** have also demonstrated an increased prevalence of cognitive impairment in individuals with *** current study uses optical coherence tomography(OCT)and a cognitive assessment to investigate the potential use of drusen as a biomarker of cognitive *** overall number of drusen detectable on the OCT scans of individuals who exhibit mild cognitive impairment is compared to the number of drusen detectable on the OCT scans of individuals who do not exhibit mild cognitive ***:To date,10 participants(nine women)aged 74 to 95 years with a diagnosis of AMD and/or drusen have been *** Optos®OCT/SLO imaging system was used to take cross-sectional images of the *** images were then manually graded by two trained graders to determine the number of drusen present along the *** Montreal Cognitive Assessment(MoCA)was used to assess overall cognitive ***:Of the 10 participants,three passed the full MoCA(*** at or above 26 out of 30 possible points)and seven did not pass,scoring positive for mild cognitive impairment(Mpass=27.33,SDpass=0.58;Mfail=21.86,SDfail=2.55).Preliminary analyses have demonstrated that individuals who pass the MoCA seem to have fewer drusen present overall(Mdn=35)compared to those who score positive for cognitive impairment(Mdn=63).However,a Mann-Whitney U test revealed that these findings are not significant;U=5,P=***:The results agree with previous literature demonstrating an increased prevalence of
维普期刊数据库