检索结果-南通市图书馆

Biobased polyurethanes for biomedical applications

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2021年第4期6卷 1083-1106页

作者： sophie Wendels Luc Av´erous BioTeam/ICPEES-ECPM UMR CNRS 7515Universit´e de Strasbourg25 Rue Becquerel67087Strasbourg Cedex 2France

Polyurethanes(PUs)are a major family of polymers displaying a wide spectrum of physico-chemical,mechanical and structural properties for a large range of *** have shown suitable for biomedical applications and are used in this domain since *** current variety of biomass available has extended the diversity of starting materials for the elaboration of new biobased macromolecular architectures,allowing the development of biobased PUs with advanced properties such as controlled biotic and abiotic *** this frame,new tunable biomedical devices have been successfully *** structures with precise tissue biomimicking can be obtained and are adequate for adhesion,proliferation and differentiation of many cell’s ***,new smart shape-memory PUs with adjustable shape-recovery properties have demonstrated promising results for biomedical applications such as wound *** fossil-based starting materials substitution for biomedical implants is slowly improving,nonetheless better renewable contents need to be achieved for most PUs to obtain biobased *** a presentation of some PU generalities and an understanding of a biomaterial structure-biocompatibility relationship,recent developments of biobased PUs for non-implantable devices as well as short-and long-term implants are described in detail in this review and compared to more conventional PU structures.

关键词： Polyurethanes Biobased Biomedical Bioactive Tissue engineering Biocompatibility Scaffold

Choroid plexus tumor necrosis factor receptor 1:a new neuroinflammatory piece of the complex Alzheimer's disease puzzle

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第7期14卷 1144-1147页

作者： sophie Steeland Roosmarijn E.Vandenbroucke VIB Center for Inflammation Research Department of Biomedical Molecular Biology Ghent University

Due to the aging of the population and despite the enormous scientific effort,Alzheimer's disease remains one of the biggest medical and pharmaceutical challenges in current *** insights highlight the importance of neuroinflammation as an undeniable player in the onset and progression of Alzheimer's *** necrosis factor is a master inflammatory cytokine that signals via tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2,but that also regulates several brain functions in health and ***,clinical trials investigating drugs that interfere with the tumor necrosis factor pathway in Alzheimer's disease led to inconclusive results,partially because not only the pro-inflammatory tumor necrosis factor/tumor necrosis factor receptor 1,but also the beneficial tumor necrosis factor/tumor necrosis factor receptor 2 signaling was antagonized in these *** recently found that tumor necrosis factor is the main upregulated cytokine in the choroid plexus of Alzheimer's disease patients,signaling via tumor necrosis factor receptor *** agreement with this,choroidal tumor necrosis factor/tumor necrosis factor receptor 1 signaling was also upregulated in different Alzheimer's disease mouse ***,both genetic and nanobody-based pharmacological blockage of tumor necrosis factor receptor 1 signaling was accompanied by favorable effects on Alzheimer's disease-associated inflammation,choroidal morphology and cognitive ***,we briefly summarize the detrimental effects that can be mediated by tumor necrosis factor/tumor necrosis factor receptor 1 signaling in(early) Alzheimer's disease,and the consequences this might have on the disease *** the main hypothesis in Alzheimer's disease clinical trials is still based on the amyloid beta-cascade,the importance of Alzheimer's disease-associated neuroinflammation urge the development of novel therapeutic strategies that might be effective in the early stages

关键词： tumor necrosis factor neuroinflammation blood-cerebrospinal fluid barrier preclinical research drug development neurodegeneration cognitive decline mouse models TNFR

Privacy-preserving analytics for the securitization market: a zero-knowledge distributed ledger technology application

在线全文

学校读者我要写书评

暂无评论

Financial Innovation 2020年第1期6卷 129-148页

作者： sophie Meralli Massachusetts Institute of Technology(MIT)Digital Currency Initiative 285 Third StreetUnit 71502142 CambridgeMassachusettsUSA

A zero-knowledge proof or protocol is a cryptographic technique for verifying private data without revealing it in its clear *** this paper,we evaluate the potential for zero-knowledge distributed ledger technology to alleviate asymmetry of information in the asset-backed securitization *** frame this inquiry,we conducted market data analyses,a review of prior literature,stakeholder interviews with investors,originators and security issuers and collaboration with blockchain engineers and *** introduce a new system which could enable all market participants in the securitization lifecycle(***,rating agencies,regulators and security issuers)to interact on a unique decentralized platform while maintaining the privacy of loan-level data,therefore providing the industry with timely analytics and performance *** platform is powered by zkLedger(Narula et al.2018),a zero-knowledge protocol developed by the MIT Media Lab and the first system that enables participants of a distributed ledger to run publicly verifiable analytics on masked data.

关键词： Structured finance Securitization Blockchain Zero-knowledge proofs Distributed ledger technology Privacy Data analytics

Anti-fibrotic effect of adipose-derived stem cells on fibrotic scars

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2022年第2期14卷 200-213页

作者： sophie Vanderstichele Jan Jeroen Vranckx Master in Medicine KUL Leuven UniversityLeuven 3000Belgium Department of Plastic Reconstructive SurgeryKU-Leuven University HospitalsLeuven 3000Belgium

BACKGROUND Sustained injury,through radiotherapy,burns or surgical trauma,can result in fibrosis,displaying an excessive deposition of extracellular matrix(ECM),persisting inflammatory reaction,and reduced *** increasing recognition of fibrosis as a cause for disease and mortality,and increasing use of radiotherapy causing fibrosis,stresses the importance of a decent anti-fibrotic *** To obtain an in-depth understanding of the complex mechanisms underlying fibrosis,and more specifically,the potential mechanisms-of-action of adiposederived stomal cells(ADSCs)in realizing their anti-fibrotic *** A systematic review of the literature using PubMed,Embase and Web of Science was performed by two independent *** The injection of fat grafts into fibrotic tissue,releases ADSC into the ***’capacity to directly differentiate into key cell types(e.g.,ECs,fibroblasts),as well as to secrete multiple paracrine factors(e.g.,hepatocyte growth factor,basis fibroblast growth factor,IL-10),allows them to alter different mechanisms underlying fibrosis in a combined *** favor ECM degradation by impacting the fibroblast-to-myofibroblast differentiation,favoring matrix metalloproteinases over tissue inhibitors of metalloproteinases,positively influencing collagen organization,and inhibiting the pro-fibrotic effects of transforming growth factor-β***,they impact elements of both the innate and adaptive immune response system,and stimulate angiogenesis on the site of injury(through secretion of pro-angiogenic cytokines like stromal cell-derived factor-1 and vascular endothelial growth factor).CONCLUSION This review shows that understanding the complex interactions of ECM accumulation,immune response and vascularization,is vital to fibrosis treatments’effectiveness like fat *** details how ADSCs intelligently steer this complex system in an anti-fibrotic or pro-angiogenic direction,without falling in

关键词： Fibrosis Fat grafting Adipose-derived stem cells Angiogenesis Anti-fibrotic effect Immunomodulation

Response of nephelometric turbidity to hydrodynamic particle size of fine suspended sediment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Sediment Research 2020年第5期35卷 444-454页

作者： Christina Bright Sarah Mager sophie Horton School of Geography University of Otago

Turbidity is used as a surrogate for suspended sediment concentration(SSC),and as a regulatory tool for indicating land use disturbance and environmental *** relates linearly to suspended material,however,can show non-linear responses to particulate organic matter(POM),concomitant with changes in particle size distribution(PSD).In the paper the influence of ultra-fine particulate matter(UFPM) on specific turbidity and its association with POM in suspended sediment are shown for alpine rivers in the Southern Alps of New *** approach was two-fold:a field-based investigation of the relations between SSC,POM,and turbidity sampled during event flow;and experimental work on hydrodynamic particle size effects on SSC POM,PSD,and *** turbidity changes over event flow and are sensitive to increasing proportional amounts of sand,UFPM,and POM in ***,the UFPM is the size fraction(<6 μm) where POM *** implications of the current study are that the slopes of turbidity-SSC relations are undesirable in locations that may be dominated by cyclic release of POM or distinct pulses of fine-grained *** locations where the turbidity-SSC slopes approximate 2,the POM proportion is usually <10% of the total suspended ***,when turbidity-SSC slopes are <1 this is likely caused by high amounts of side-scatter from UFPM concomitant with higher proportions of ***,the use of turbidity as a proxy for determining SSC may have serious consequences for the measurement of representative suspended sediment data,particularly in locations where POM may be a significant contributor to overall suspended load.

关键词： Turbidity Nephelometry Suspended sediment concentration Particle size distribution Particulate organic matter

Inflammation in Mental Disorders:Is the Microbiota the Missing Link?

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2020年第9期36卷 1071-1084页

作者： sophie Ouabbou Ying He Keith Butler Ming Tsuang Department of Psychiatry and National Clinical Research Center for Mental Disordersand Hunan Key Laboratory of Psychiatry and Mental HealthThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Human Microbiome Research Program Faculty of MedicineUniversity of Helsinki00290 HelsinkiFinland Cellular and Molecular Biology Research Centre University of Costa RicaSan Jose´11501Costa Rica Center for Behavioral Genomics Department of PsychiatryInstitute for Genomic MedicineUniversity of California San DiegoLa JollaCA 92093USA Harvard Institute of Psychiatric Epidemiology and Genetics Harvard School of Public HealthBostonMA 02115USA

Research suggests that inflammation is important in the pathophysiology of mental *** addition,a growing body of evidence has led to the concept of the microbiota-gut-brain *** understand the potential interactions,we begin by exploring the liaison between the immune system and mental disorders,then we describe the evidence that the microbiota impact the immune response in the developing ***,we review the literature that has documented microbiome alterations in major mental *** end with a summary of therapeutic applications,ranging from psycho-biotics to immunomodulatory drugs that could affect the microbiotagut-brain axis,and potential treatments to alleviate the adverse effects of antipsycho *** conclude that there is promising evidence to support the position that the microbiota plays an important role in the immunological pathophysiology of mental disorders with an emphasis on psychotic disorders and mood ***,more research is needed to elucidate the mechanisms.

关键词： Mental disorder Microbiota Immunology Neurodevelopment

Emerging analytical methods to characterize zeolite-based materials

在线全文

学校读者我要写书评

暂无评论

National Science Review 2022年第9期9卷 47-66页

作者： sophie H.van Vreeswijk Bert M.Weckhuysen Inorganic Chemistry and Catalysis Debye Institute for NanomaterialsUtrecht University

Zeolites and zeolitic materials are,through their use in numerous conventional and sustainable applications,very important to our daily lives,including to foster the necessary transition to a more circular *** characterization of zeolite-based materials has a tremendous history and a great number of applications and properties of these materials have been discovered in the past *** review focuses on recently developed novel as well as more conventional techniques applied with the aim of better understanding zeolite-based *** explored analytical methods,*** probe tomography,scanning transmission X-ray microscopy,confocal fluorescence microscopy and photo-induced force microscopy,are discussed on their important contributions to the better understanding of zeolites as they mainly focus on the micro-to nanoscale chemical imaging and the revelation of structure-composition-performance *** other techniques have a long and established history,*** magnetic resonance,infrared,neutron scattering,electron microscopy and X-ray diffraction techniques,and have gone through increasing developments allowing the techniques to discover new and important features in zeolite-based *** to the increasing application of these methods,multiple techniques are nowadays used to study zeolites under working conditions(*** in situ/operando mode of analysis) providing new insights in reaction and deactivation mechanisms.

关键词： catalysis zeolites spectroscopy microscopy structure–composition–performance relationships

Large-scale industrial manufacturing of carbon nanotubes in a continuous inclined mobile-bed rotating reactor via the catalytic chemical vapor deposition process

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2017年第2期11卷 280-289页

作者： sophie L. Pirard Sigrid Douven Jean-Paul Pirard Laboratory of Chemical Engineering Department of Chemical Engineering University of Liege B-4000 Liege Belgium

This article reports the different steps of the design, development and validation of a process for continuous production of carbon nanotubes （CNTs） via catalytic chemical vapor deposition from the laboratory scale to the industrial production. This process is based on a continuous inclined mobile-bed rotating reactor and very active catalysts using methane or ethylene as carbon source. The importance of modeling taking into account the hydrodynamic, physicochemical and physical phenomena that occur during CNT production in the process analysis is emphasized. The impact of this invention on the environment and human health is taken into consideration too.

关键词： carbon nanotubes catalytic chemical vapor deposition inclined rotating reactor industrial process scaling-up

Investigation of unique hue setting changes with ageing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Optics Letters 2011年第5期9卷 89-93页

作者： Chenyang Fu Kaida Xiao Dimosthenis Karatzas sophie Wuerger University of Liverpool Liverpool UK Computer Vision Centre Barcelona Spain

Clromatic sensitivity along the protan, deutan, and tritan lines and the loci of the unique hues （red, green, yellow, blue） for a very large sample （n = 185） of colour-normal observers ranging from 18 to 75 years of age are assessed. Visual judgments are obtained under normal viewing conditions using colour patches on self-luminous display under controlled adaptation conditions. Trivector discrimination thresholds show an increase as a function of age along the protan, deutan, and tritan axes, with the largest increase present along the tritan line, less pronounced shifts in unique hue settings are also observed. Based on the chromatic （protan, deutan, tritan） thresholds and using scaled cone signals, we predict the unique hue changes with ageing. A dependency on age for unique red and unique yellow for predicted hue angle is found. We conclude that the chromatic sensitivity deteriorates significantly with age, whereas the appearance of unique hues is much less affected, remaining almost constant despite the known changes in the ocular media.

关键词： Cathode ray tubes Color Color vision Photometry Range finding Retina