Inflammation in Mental Disorders:Is the Microbiota the Missing Link?

作     者：Sophie Ouabbou Ying He Keith Butler Ming Tsuang Sophie Ouabbou;Ying He;Keith Butler;Ming Tsuang

作者机构：Department of Psychiatryand National Clinical Research Center for Mental Disordersand Hunan Key Laboratory of Psychiatry and Mental HealthThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Human Microbiome Research ProgramFaculty of MedicineUniversity of Helsinki00290 HelsinkiFinland Cellular and Molecular Biology Research CentreUniversity of Costa RicaSan Jose´11501Costa Rica Center for Behavioral GenomicsDepartment of PsychiatryInstitute for Genomic MedicineUniversity of California San DiegoLa JollaCA 92093USA Harvard Institute of Psychiatric Epidemiology and GeneticsHarvard School of Public HealthBostonMA 02115USA 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2020年第36卷第9期

页      面：1071-1084页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (81871056) 

主　　题：Mental disorder Microbiota Immunology Neurodevelopment 

摘      要：Research suggests that inflammation is important in the pathophysiology of mental *** addition,a growing body of evidence has led to the concept of the microbiota-gut-brain *** understand the potential interactions,we begin by exploring the liaison between the immune system and mental disorders,then we describe the evidence that the microbiota impact the immune response in the developing ***,we review the literature that has documented microbiome alterations in major mental *** end with a summary of therapeutic applications,ranging from psycho-biotics to immunomodulatory drugs that could affect the microbiotagut-brain axis,and potential treatments to alleviate the adverse effects of antipsycho *** conclude that there is promising evidence to support the position that the microbiota plays an important role in the immunological pathophysiology of mental disorders with an emphasis on psychotic disorders and mood ***,more research is needed to elucidate the mechanisms.