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Clinicopathologic and molecular features associated with patient age in gastric cancer

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World Journal of Gastroenterology 2015年第22期21卷 6905-6913页

作者： Ji Yeon Seo Eun Hyo jin Hyun jin Jo Hyuk Yoon Cheol Min Shin Young soo Park Nayoung Kim Hyun Chae Jung Dong Ho Lee Department of Internal Medicine and Healthcare Research Institute Healthcare System Gangnam Center Seoul National University Hospital Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Department of Internal Medicine Seoul National University Bundang Hospital Seongnam-si

AIM: To compare characteristics and prognosis of gastric cancer based on ***: A retrospective study was conducted on clinical and molecular data from patients(n =1658) with confirmed cases of gastric cancer in Seoul National University Bundang Hospital(Seoul, South Korea) from 2003 to 2010 after exclusion of patients diagnosed with lymphoma, gastrointestinal stromal tumor, and metastatic cancer in the stomach. DNA was isolated from tumor and adjacent normal tissue,and a set of five markers was amplified by polymerase chain reaction to assess microsatellite instability(MSI). MSI was categorized as high, low, or stable if ≥ 2, 1, or 0 markers, respectively, had *** was performed on tissue sections to detect levels of expression of p53, human epidermal growth factor receptor(HER)-2, and epidermal growth factor receptor. Statistical analysis of clinical and molecular data was performed to assess prognosis based on the stratification of patients by age(≤ 45 and> 45 years).RESULTS: Among the 1658 gastric cancer patients, the number of patients with an age ≤ 45 years was 202(12.2%; 38.9 ± 0.4 years) and the number of patients> 45 years was 1456(87.8%; 64.1 ± 0.3 years).Analyses revealed that females were predominant inthe younger group(P < 0.001). Gastric cancers in the younger patients exhibited more aggressive features and were at a more advanced stage than those in older patients. Precancerous lesions, such as atrophic gastritis and intestinal metaplasia, were observed less frequently in the older than in the younger group(P < 0.001). Molecular characteristics, including overexpression of p53(P < 0.001), overexpression of HER-2(P = 0.006), and MSI(P = 0.006), were less frequent in gastric cancer of younger patients. Cancer related mortality was higher in younger patients(P= 0.048), but this difference was not significant after adjusting for the stage of ***: Gastric cancer is distinguishable between younger and older patien

关键词： Age Gastric cancer Microsatellite instability Molecular pathology Prognosis Stage

Primary intestinal lymphangiectasia with generalized warts

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World Journal of Gastroenterology 2015年第27期21卷 8467-8472页

作者： soon Jae Lee Hyun Joo Song Sun-jin Boo soo-Young Na Heung Up Kim Chang Lim Hyun Department of Internal Medicine Jeju National University School of Medicine Department of Pathology Jeju National University School of Medicine

Primary intestinal lymphangiectasia(PIL) is a rare protein-losing enteropathy with lymphatic leakage into the small intestine. Dilated lymphatics in the small intestinal wall and mesentery are observed in this disease. Laboratory tests of PIL patients revealed hypoalbuminemia, lymphocytopenia, hypogammaglobulinemia and increased stool α-1 antitrypsin clearance. Cell-mediated immunodeficiency is also present in PIL patients because of loss of lymphocytes. As a result, the patients are vulnerable to chronic viral infection and lymphoma. However, cases of PIL with chronic viral infection, such as human papilloma virus-induced warts, are rarely reported. We report a rare case of PIL with generalized warts in a 36-year-old male patient. PIL was diagnosed by capsule endoscopy and colonoscopic biopsy with histological tissue confirmation. Generalized warts were observed on the head, chest, abdomen, back, anus, and upper and lower extremities, including the hands and feet of the patient.

关键词： Protein-losing enteropathy Lymphocytopenia Cell-mediated immunodeficiency Primary intestinallymphangiectasia Warts

HETEROEPITAXIAL GROWTH OF PB(MG1/3TA2/3)O3THIN FILMS ON SRTIO3 SUBSTRATES USING CHEMICAL SOLUTION DEPOSITION;MICROSTRUCTURAL EVOLUTION

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HETEROEPITAXIAL GROWTH OF PB(MG1/3TA2/3)O3THIN FILMS ON SRTI...

第8届国际材联电子材料国际研讨会

作者： Dae-soo Jeong Yeon-Ah Shim Jong-Ha Moon Byung-Teak Lee jin Hyeok Kim Photonic and Electronic Thin Film Laboratory Department of Materials Science and Engineering Chonnam National University 300 Yongbong-Dong Puk-Gu Kwangju 500-757 South Korea

Lead-based perovskite relaxor ferroelectric materials have been subject of extensive research in recent decades because of their excellent dielectric, electromechanical and electro-optic properties. In the Pb(BB) O fa...

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Increase of Tissue Transglutaminase Confers Resistance to Apoptosisin Senescent Human Diploid Fibroblasts

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Increase of Tissue Transglutaminase Confers Resistance to Ap...

The 8th Asia/Oceania Regional Congress of Gerontology and Geriatrics

作者： Jeong-soo Park Hyung-Su Choi Hee-Young Kim Sung jin Ryu Sang Chul Park Department of Biochemistry College of Medicine Dankook University Department of Biochemistry College of Medicine Dankook University Department of Biochemistry College of Medicine Dankook University Department of Biochemistry and Molecular Biology The Aging and Apoptosis Research Center Seoul National University Medical SchoolKorea Department of Biochemistry and Molecular Biology The Aging and Apoptosis Research Center Seoul National University Medical SchoolKorea

＜正＞Reduced apoptotic response to various stimuli is a well-known characteristic of the aging *** there is much evidences that Tissue transglutaminase（tTG）plays a regulatory role in the process of apoptosis,we exa... 详细信息

关键词： cellular senescence apoptosis tissue transglutaminase

Transverse Flux Induction Coil for Uniform Bar Heating Excluding Edge

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Transverse Flux Induction Coil for Uniform Bar Heating Exclu...

第七届冶金与材料电磁过程国际会议（EPM2012）

作者： PARK Jong-soo BAE jin-Su CHO Un-Kwan HA Tae-Jong KIM Goo-Hwa Process Engineering Design Research Group Engineering Research CenterPOSCO

This work particularly focuses on compensating Joule heat in under-heated areas occurred when thin steel bar is(< 20 mm) heated by transverse flux induction heater(TFIH).The under-heated areas take place in range of 50 150 mm from the both edges,so Transverse Flux Induction Coil(TFIC) including a magnetic core is proposed and optimized to supplement this *** solutions on the electromagnetic field are obtained numerically by commercial code MAXWELL 3D software from ANSYS *** then,verified experimentally by pilot-scale tests,in which the TFIH was manufactured with a nominal power of 100 kW at a fundamental frequency of 1 ***,TFIC having geometrically the optimized magnetic core made the heating pattern U-shaped,so could supply a desirable temperature profile for the rolling process.

关键词： Transverse Flux Induction heating(TFIH) induction coil magnetic core uniform heating

New challenge for sclerotial development from mycelia culture of Polyporus umbellatus

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New challenge for sclerotial development from mycelia cultur...

2015第二届全国猪苓会议

作者： Ga-Heon jin Tae soo Lee Yong Mei Xing Shun Xing Guo Min Woong Lee Department of Ophthalmic Optics Shinhan University Division of Life Sciences Incheon National University Institute of Medicinal Plant Development Chinese Academy of Medical Sciences ＆ Peking Union Medical College Department of Life Science Dongguk University

Polyporus umbellatus（*** umbellata）is a sclerotium forming mushroom belongs to family Polyporaceae of Polyphorales,*** sclerotia of *** have long been used for traditional medicines in China,Korea and *** study was initiated to obtain the basic data for artificial sclerotial production of *** for a preliminary experiment,we found the favorable conditions for mycelial growth of *** and its symbiotic fungus Armillaria *** optimal conditions for mycelial growth of *** were 20℃and pH 4,while the conditions for mycelial growth of *** were 25℃and pH *** carbon sources for optimal mycelial growth of *** were fructose and glucose,while carbon sources for favorable mycelial growth of *** were also fructose and *** nitrogen sources for favorable mycelial growth *** were peptone and yeast extract,while optimal mycelial growth of *** were obtained in peptone and yeast *** the observation of symbiotic relation between *** and Armillaria *** tested five species and sixteen strains of *** the species of Armillaria,*** 741 and *** 134 were vigorous in their mycelia growth,whereas *** 4939 and *** 4857 were least affect on mycelia *** culture of both fungi on complete medium showed a good growth of mycelia and forming thicker mycelia layer at contact surface of both *** good growth species were ***186,***4585,*** 741,*** 2620,*** 42574 and *** 43894 *** those species Armillaria mellea 4585 was selected and test on woodchip *** was colonized well over the mycelia of *** to form symbiotic *** were some sign of pseudosclerotia formation in bottle culture type as time *** can finally concluded and expect to have small shape of pseudo type sclerotia in vitro condition.

关键词： Armillaria mellea Polyporus umbellatus Sclerotium Symbiosis dual culture woodchip pseudosclerotia

Optimal initiation of Helicobacter pylori eradication in patients with peptic ulcer bleeding

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World Journal of Gastroenterology 2015年第8期21卷 2497-2503页

作者： Hyuk Yoon Dong Ho Lee Eun Sun Jang Jaihwan Kim Cheol Min Shin Young soo Park jin-Hyeok Hwang jin-Wook Kim sook-Hayng Jeong Nayoung Kim Departments of Internal Medicine Seoul National University Bundang Hospital

AIM:To evaluate when Helicobacter pylori(***)eradication therapy(ET)should be started in patients with peptic ulcer bleeding(PUB).METHODS:Clinical data concerning adults hospitalizedwith PUB were retrospectively collected and ***,sex,type and stage of peptic ulcer,whether endoscopic therapy was performed or not,methods of *** detection,duration of hospitalization,and specialty of the attending physician were *** influencing the confirmation of *** infection prior to discharge were determined using multiple logistic regression *** *** eradication rates of patients who received ET during hospitalization and those who commenced ET as outpatients were ***:A total of 232 patients with PUB were evaluated for *** infection by histology and/or rapid urease *** these patients,53.7%(127/232)had confirmed results of *** infection prior to *** multivariate analysis,duration of hospitalization and ulcer stage were factors independently influencing whether *** infection was confirmed before or after *** the patients discharged before confirmation of *** infection,13.3%(14/105)were lost to *** the patients found to be ***-positive after discharge,41.4%(12/29)did not receive *** was no significant difference in the *** eradication rate between patients who received ET during hospitalization a n d t h o s e w h o c o m m e n c e d E T a s o u t p a t i e n t s[intention-to-treat:68.8%(53/77)vs 60%(12/20),P=0.594;per-protocol:82.8%(53/64)vs 80%(12/15),P=0.723].CONCLUSION:Because many patients with PUB who were discharged before *** infection status was confirmed lost an opportunity to receive ET,we should confirm *** infection and start ET prior to discharge.

关键词： Helicobacter pylori Peptic ulcer hemorrhage Diseas

Efficacy of moxifloxacin-based sequential therapy for first-line eradication of Helicobacter pylori infection in gastrointestinal disease

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World Journal of Gastroenterology 2015年第16期21卷 5032-5038页

作者： Jae jin Hwang Dong Ho Lee Ae-Ra Lee Hyuk Yoon Cheol Min Shin Young soo Park Nayoung Kim Department of Internal Medicine Seoul National University Bundang Hospital

AIM:To evaluate the efficacy of 14-d moxifloxacinbased sequential therapy as first-line eradication treatment of Helicobacter pylori(***) ***:From December 2013 to August 2014, 161 patients with confirmed *** infection randomly received 14 d of moxifloxacin-based sequential group(MOX-ST group, n = 80) or clarithromycin-based sequential group(CLA-ST group, n = 81) *** infection was defined on the basis of at least one of the following three tests:a positive 13C-urea breath test; histologic evidence of *** by modified Giemsa staining; or a positive rapid urease test(CLOtest; Delta West, Bentley, Australia) by gastric mucosal *** eradication therapy for *** infection was defined as a negative 13C-urea breath test four weeks after the end of eradication *** was defined as good when drug intake was at least 85%.*** eradication rates, patient compliance with drug treatment, adverse event rates, and factors influencing the efficacy of eradication therapy were ***:The eradication rates by intention-to-treat analysis were 91.3%(73/80;95%CI:86.2%-95.4%)in the MOX-ST group and 71.6%(58/81;95%CI:65.8%-77.4%)in the CLA-ST group(P=0.014).The eradication rates by per-protocol analysis were 93.6%(73/78;95%CI:89.1%-98.1%)in the MOX-ST group and 75.3%(58/77;95%CI:69.4%-81.8%)in the CLAST group(P=0.022).Compliance was 100%in both *** adverse event rates were 12.8%(10/78)and 24.6%(19/77)in the MOX-ST and CLA-ST group,respectively(P=0.038).Most of the adverse events were mild-to-moderate in intensity;there was none serious enough to cause discontinuation of treatmentin either *** multivariate analysis,advanced age(≥60 years)was a significant independent factor related to the eradication failure in the CLA-ST group(adjusted OR=2.13,95%CI:1.97-2.29,P=0.004),whereas there was no significance in the MOX-ST ***:The 14-d moxifloxacin-based sequential therapy is effective.M

关键词： Helicobacter pylori First-line eradicationtreatment Moxifloxacin Sequential therapy Eradicationrate

Fourteen- vs seven-day bismuth-based quadruple therapy for second-line Helicobacter pylori eradication

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World Journal of Gastroenterology 2015年第26期21卷 8132-8139页

作者： Jae jin Hwang Dong Ho Lee Ae-Ra Lee Hyuk Yoon Cheol Min Shin Young soo Park Nayoung Kim Department of Internal Medicine Seoul National University Bundang Hospital

AIM: To compare the efficacy of 14- and 7-d bismuthbased quadruple therapies as second-line eradication treatment for Helicobacter pylori(***) ***: Between 2004 and 2014,the medical records of 790 patients who had experienced failure of first-line proton pump inhibitor(PPI)-based eradication therapy and were then treated with bismuth-based quadruple therapy were retrospectively *** who received bismuth-based quadruple therapy [PPI,bismuth,metronidazole,and tetracycline(PBMT)] for either 7 d or 14 d were assigned to a PBMT-7 group(n = 543) or a PBMT-14 group(n = 247),*** eradication rates for both groups were determined by intention-to-treat(ITT) and per-protocol(PP) *** analysis compared the treatment groups as originally allocated while the PP analysis including only those patients who had completed the treatment as originally *** eradication therapy for *** infection was defined as a negative 13C-urea breath test 4 wk after the end of eradication ***: The overall ITT eradication rate was 69.1%(546/790).Final ITT eradication rates were 67.4%(366/543; 95%CI: 63.1%-71.7%) in the PBMT-7 group and 72.8%(180/247; 95%CI: 67.4%-78.2%) in the PBMT-14 group(P = 0.028).The overall PP eradication rate was 80.0%(546/682),and the final PP eradication rates were 78.2%(366/468; 95%CI: 72.1%-84.0%) in the PBMT-7 group and 84.1%(180/214; 95%CI: 76.8%-90.8%) in the PBMT-14 group(P = 0.009).The *** eradication rates in the PBMT-14 group weresignificantly higher than in the PBMT-7 group according to both ITT(P = 0.028) and PP analysis(P = 0.009).Compliance was similar in both groups(PBMT-7 group: 97.9%; PBMT-14 group: 96.4%).Adverse event rates were 10.7%(51/478) and 17.1%(38/222) in the PBMT-7 and PBMT-14 groups,respectively(P = 0.487).CONCLUSION: The 14-d bismuth-based quadruple therapy is a significantly more effective second-line eradication treatment for *** infection than the 7-d al

关键词： Helicobacter pylori Treatment failure Second-line treatment Bismuth Eradication rate