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Isolated colonic neurofibroma, a rare tumor: A case report and review of literature

World Journal of Clinical Cases 2020年第10期8卷 1932-1938页

作者： Sara Ghoneim sonia sandhu Dalbir sandhu Department of Internal Medicine Case Western Reserve University at MetroHealth Medical CenterClevelandOH 44109United States Department of Hematology and Oncology Cleveland Clinic Akron GeneralClevelandOH 44307United States Division of Gastroenterology Case Western Reserve University at MetroHealth Medical CenterClevelandOH 44109United States

BACKGROUND Neurofibromas are tumors comprised of peripheral nerve sheath and connective tissue *** can occur sporadically or as part of familial syndromes such as neurofibromatosis type *** colonic neurofibroma without systemic manifestations is a rarely reported clinical *** we present a case of a 51 years old male with an isolated colonic neurofibroma seen on a screening *** SUMMARY Fifty-one years old male who was otherwise healthy without a significant family history of cancer underwent a screening colonoscopy and was found have a 2.3 cm×1.4 cm lesion in the *** biopsy revealed a spindle cell *** resonance imaging of the pelvis was negative for *** underwent an endoscopic ultrasound that showed an ill-defined avascular lesion of mixed echogenicity measuring 2.8 cm×15.2 cm in the submucosa with no communication with muscularis mucosa or *** staining of the tumor was strongly positive for S100,with rare penetrating axons deep within the *** cells were negative for c-kit and desmin and had low Ki-67 *** findings were consistent with a solitary colonic submucosal neurofibroma.A detailed history and physical examination did not reveal any evidence of extraintestinal *** underwent transanal surgical resection of the *** patient tolerated the procedure well without any *** While neurofibromas have been well described in literature,an isolated colonic neurofibroma is a rare pathological *** transformation of neurofibromas has been reported in patients with neurofibromatosis *** report a case of isolated colonic neurofibroma and highlight the importance of resection due to the increased risk of tumorigenesis.

关键词： Neurofibroma Colonoscopy Neurofibromatosis type 1 Neurofibromatosis type 2 Spindle cell tumor Endoscopic ultrasound Case report

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Hepatocellular carcinoma in non-cirrhotic liver: A comprehensive review

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World Journal of Hepatology 2019年第1期11卷 1-18页

作者： Aakash Desai sonia sandhu Jin-Ping Lai Dalbir Singh sandhu Department of Internal Medicine Case Western Reserve University/MetroHealth Medical Center Department of Hematology and Oncology Cleveland Clinic/Akron GeneralMedical Center Department of Pathology University of Florida Division of Gastroenterology and Hepatology Case Western Reserve University/MetroHealth Medical Center

Hepatocellular carcinoma(HCC) is the most common type of primary liver cancer, which in turns accounts for the sixth most common cancer *** being the 6 th most common cancer it is the second leading cause of cancer related deaths. HCC typically arises in the background of cirrhosis, however,about 20% of cases can develop in a non-cirrhotic liver. This particular subgroup of HCC generally presents at an advanced stage as surveillance is not performed in a non-cirrhotic liver. HCC in non-cirrhotic patients is clinically silent in its early stages because of lack of symptoms and surveillance imaging; and higher hepatic reserve in this population. Interestingly, F3 fibrosis in non-alcoholic fatty liver disease, hepatitis B virus and hepatitis C virus infections are associated with high risk of developing HCC. Even though considerable progress has been made in the management of this entity, there is a dire need for implementation of surveillance strategies in the patient population at risk, to decrease the disease burden at presentation and improve the prognosis of these patients. This comprehensive review details the epidemiology, risk factors, clinical features,diagnosis and management of HCC in non-cirrhotic patients and provides future directions for research.

关键词： Hepatocellular carcinoma Non-cirrhotic liver Hepatitis B Hepatitis C Risk factors Clinical features Diagnostic modalities Management strategies Future directions

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