Isolated colonic neurofibroma, a rare tumor: A case report and review of literature

作     者：Sara Ghoneim Sonia Sandhu Dalbir Sandhu 

作者机构：Department of Internal MedicineCase Western Reserve University at MetroHealth Medical CenterClevelandOH 44109United States Department of Hematology and OncologyCleveland Clinic Akron GeneralClevelandOH 44307United States Division of GastroenterologyCase Western Reserve University at MetroHealth Medical CenterClevelandOH 44109United States 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2020年第8卷第10期

页      面：1932-1938页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Neurofibroma Colonoscopy Neurofibromatosis type 1 Neurofibromatosis type 2 Spindle cell tumor Endoscopic ultrasound Case report 

摘      要：BACKGROUND Neurofibromas are tumors comprised of peripheral nerve sheath and connective tissue *** can occur sporadically or as part of familial syndromes such as neurofibromatosis type *** colonic neurofibroma without systemic manifestations is a rarely reported clinical *** we present a case of a 51 years old male with an isolated colonic neurofibroma seen on a screening *** SUMMARY Fifty-one years old male who was otherwise healthy without a significant family history of cancer underwent a screening colonoscopy and was found have a 2.3 cm×1.4 cm lesion in the *** biopsy revealed a spindle cell *** resonance imaging of the pelvis was negative for *** underwent an endoscopic ultrasound that showed an ill-defined avascular lesion of mixed echogenicity measuring 2.8 cm×15.2 cm in the submucosa with no communication with muscularis mucosa or *** staining of the tumor was strongly positive for S100,with rare penetrating axons deep within the *** cells were negative for c-kit and desmin and had low Ki-67 *** findings were consistent with a solitary colonic submucosal neurofibroma.A detailed history and physical examination did not reveal any evidence of extraintestinal *** underwent transanal surgical resection of the *** patient tolerated the procedure well without any *** While neurofibromas have been well described in literature,an isolated colonic neurofibroma is a rare pathological *** transformation of neurofibromas has been reported in patients with neurofibromatosis *** report a case of isolated colonic neurofibroma and highlight the importance of resection due to the increased risk of tumorigenesis.