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Numerical investigation of the effects of soil-structure and granular material-structure interaction on the seismic response of a flat-bottom reinforced concrete silo

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 609-623页

作者： sonia Benkhellat Mohammed Kadri Abdelghani seghir Laboratory of solid Mechanics and systems University of M’Hamed BougaraBoumerdes 35000Algeria Laboratory of Geomaterials Environment and DevelopmentUniversity of M’Hamed BougaraBoumerdes 35000Algeria Research Laboratory of Applied Hydraulics and Environment Faculty of TechnologyUniversity of BejaiaBejaia 06000Algeria

In this work,a numerical study of the effects of soil-structure interaction(ssI)and granular material-structure interaction(GsI)on the nonlinear response and seismic capacity of flat-bottomed storage silos is c.nducted.A series of incremental dynamic analyses(IDA)are performed on a case of large reinforced concrete silo using 10 seismic *** IDA results are given by two average IDA capacity curves,which are represented,as well as the seismic capacity of the studied structure,with and without a consideration of the ssI while accounting for the effect of *** curves are used to quantify and evaluate the damage of the studied silo by utilizing two damage indices,one based on dissipated energy and the other on displacement and dissipated *** cumulative energy dissipation curves obtained by the average IDA capacity curves with and without ssI are presented as a function of the base shear,and these curves allow one to obtain the two critical points and the different limit states of the *** is observed that the ssI and GsI significantly influence the seismic response and capacity of the studied structure,particularly at higher levels of ***,the effect of the ssI reduces the damage index of the studied structure by 4%.

关键词： reinforced concrete silo perfectly matched layers soil-structure interaction granular material-structure interaction effective seismic input method damage index

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Nε-carboxymethyl-lysine and inflammatory cytokines,markers and mediators of coronary artery disease progression in diabetes

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World Journal of Diabetes 2024年第4期15卷 575-578页

作者： sonia Eiras Translational cardiology Health Research InstituteUniversity Hospital of Santiago de CompostelaSantiago de Compostela 15706Spain

This editorial refers to the article“comparative analysis of Nε-carboxymethyllysine and inflammatory markers in diabetic and non-diabetic coronary artery disease patients”,published in the recent issue of the World Journal of Diabetes 2023 is based on glucose metabolism,advanced glycation end products(AGEs),inflammation and adiposity on diabetes and coronary artery disease(cAD).This study has included cAD patients who were stratified according to glycosylated hemoglobin higher than 6.5 and sex-matched.A higher prevalence of hypertension,dyslipidemia,and non-vegetarian diet were found in the diabetic *** risk factors might influence body weight and adiposity and explain the increment of the left *** this data was not supported by the *** diet can also explain the non-enzymatic reactions on lipids,proteins,or nucleic acids and consequently an increment of *** molecules can emit ***,one of the non-fluorescent and most abundant AGEs is Nε-carboxymethyl-lysine(cML).Its association with coronary artery stenosis and severity in the diabetic group might suggest its role as a player in cAD ***,cML,after binding with its receptor(RAGE),can induce calcification cascade through reactive oxygen species and mitogen-activated protein ***,this interaction AGE-RAGE can cause activation of the transcription nuclear factor-kb and induce inflammatory *** might explain the relationship between cML and pro-inflammatory cytokines in diabetic and cAD *** this is a population from one center,the determination of cML and inflammatory cytokines might improve the diagnosis of severe and progressive *** and comparative studies among glycosylated hemoglobin,cML,and other AGE levels according to diagnosis and prognosis value might modify the clinical *** these molecules are irreversible,they can act through a specific receptor inducing a signal transduction that might be modulate

关键词： Nε-carboxymethyl-lysine Inflammatory cytokines Adiposity Diabetes coronary artery disease

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study of a Hydraulic Jump in an Asymmetric Trapezoidal channel with Different sluice Gates

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Fluid Dynamics & Materials Processing 2024年第7期20卷 1499-1516页

作者： Bouthaina Debabeche sonia cherhabil Research Laboratory in civil Engineering HydraulicsSustainable Development and Environment(LARGHYDE)University of BiskraBiskra7000Algeria Faculty of sciences Applied sciences Liege UniversityLiege4000Belgium Underground and surface Hydraulics Research Laboratory(LARHYss) Biskra7000Algeria

In this study,the main properties of the hydraulic jump in an asymmetric trapezoidal flume are analyzed experimentally,including the so-called sequent depths,characteristic lengths,and *** particular,an asymmetric trapezoidal flume with a length of 7 m and a width of 0.304 m is considered,with the bottom of the flume transversely inclined at an angle of m=0.296 and vertical lateral *** corresponding inflow Froude number is allowed to range in the interval(1.40s of this jump are compared to those of hydraulic jumps in channels with other types of cross-sections.A relationship for calculating hydraulic jump efficiency is proposed for the considered *** F1>5,the hydraulic jump is found to be more effective than that occurring in triangular and symmetric trapezoidal ***,when■mes>8 and■>5,the hydraulic jump in the asymmetrical trapezoidal channel downstream of a parallelogram sluice gate is completely formed as opposed to the situation where a triangular sluice is considered.

关键词： Asymmetric trapezoidal channel characteristic lengths efficiency Froude hydraulic jump sequent depths sluice gate

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Assessment of four different dietary amino acid profiles recommended for IsA Brown layer hens: A validation study

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Animal Nutrition 2024年第2期17卷 438-446页

作者： Mehdi Toghyani shemil Macelline Juliano c.de Paula Dorigam Peter V.chrystal Peter H.selle sonia Y.Liu school of Life and Environmental sciences Faculty of Science The University of Sydney Poultry Research Foundation The University of Sydney Evonik Operations GmbH

The current feeding study was designed to validate the two dietary essential amino acid profiles(EAAP)established based on linear broken-line(LBL) and quadratic broken-line(QBL) models, in a previous study, against Evonik(AMINOHen) and breeder recommendations for IsA Brown layers for peak production(PP, 20 to 44 weeks of age), and post peak production(post PP, 44 to 75 weeks of age). The EAAP based on LBL models on average had 19.5% and 26.0% lower digestible AA(Lys, Met + cys, Thr, Trp, Ile and Val), than the EAAP based on QBL models for PP and post PP, respectively. The EAAP based on AMINOHen and breeder recommendation had lower digestible AA than QBL, and higher EAAP than LBL models for both production phases. At 20 weeks of age, 224 IsA Brown layer hens were weighed and randomly allocated to individual battery cages. Each of the four diets was replicated 8 times with 7 birds per replicate. Egg production was recorded daily, and egg weights were measured at the end of each week. Feed consumption was measured at the end of each period. The egg production rate was not significantly affected by the diets and remained at around 98.0%(PP) and 95.0%(post PP)(P > 0.05). Birds fed diets based on LBL recommendation consistently laid smaller eggs, resulting in a lower egg mass(59.8 vs. 62.0 g egg/hen per day during PP, and 60.3 vs. 63.0 g egg/hen per day during post PP; P s had no significant effect on feed intake and body weight(P > 0.05). The highest feed conversion ratio(FcR) during PP(P = 0.067) and post PP(P s recorded for the birds offered diets based on LBL recommendation. In conclusion, all four EAAP tested in this study support an above average egg production rate. However, the EAAP based on LBL models may potentially decrease the input feed cost per kilogram of eggs but are not set to optimise FcR and maximise egg mass.

关键词： Ideal amino acid profile Regression model Egg production Egg mass

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Advanced brain organoids for neuroinflammation disease modeling

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Neural Regeneration Research 2024年第1期19卷 154-155页

作者： sonia sabate-soler Henry Kurniawan Jens christian schwamborn Luxembourg centre for systems Biomedicine University of LuxembourgEsch-sur-AlzetteLuxembourg

Brain organoids mimic closely the embryonic human brain:Over the last decade,the development of human organoid systems has evolved *** tissues have been modeled with organoids,such as the gut,lung,liver,kidney retina and *** systems have a high cellular heterogeneity,with many cell types integrated into the same ***'cellular populations interact between and amongst each other in a cellular and molecular level,which represents an advantage with respects to monolayer 2D cell culture systems.

关键词： inflammation lung kidney

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Exploring the effects of taurolidine on tumor weight and microvessel density in a murine model of osteosarcoma

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Oncology Research 2024年第7期32卷 1163-1172页

作者： LIsANNE K.A.NEIJENHUIs LEUTA L.NAUMANN sonia A.M.FERKEL sAMUEL J.s.RUBIN sTEPHAN ROGALLA Division of Gastroenterology and Hepatology Department of MedicineSchool of MedicineStanford UniversityStanford94305USA Department of surgery Leiden University Medical CenterLeiden2333 ZAThe Netherlands centre for Human Drug Research Leiden2333 CLThe Netherlands Department of General VisceralVascular and Thoracic SurgeryCharite University Medicine BerlinBerlin10117Germany

Background:Osteosarcoma is the most common malignant primary bone *** prognosis for patients with disseminated disease remains very poor despite recent advancements in ***,current treatment regimens bear a signiﬁcant risk of serious side ***,there is an unmet clinical need for effective therapies with improved safety proﬁ*** is an antibacterial agent that has been shown to induce cell death in different types of cancer cell ***:In this study,we examined both the antineoplastic and antiangiogenic effects of taurolidine in animal models of osteosarcoma.K7M2 murine osteosarcoma cells were injected,both intramuscular and intraperitoneal,into 60 BALB/c mice on day *** were then randomized to receive treatment with taurolidine 2%(800 mg/kg),taurolidine 1%(400 mg/kg),or Nacl 0.9%control for seven days by intravenous or intraperitoneal ***:After 35 days,mice were euthanized,and the tumors were harvested for *** mice were excluded from the analysis due to *** weight was signiﬁcantly lower in the 2%taurolidine intraperitoneal treatment group from day 9 to 21,consistent with elevated mortality in this *** tumor weight was signiﬁcantly lower in the 1%(p=0.003)and 2%(p=0.006)intraperitoneal taurolidine treatment groups compared to the *** antineoplastic effects were observed on intramuscular tumors or for intravenous administration of *** were no signiﬁcant differences in microvessel density or mitotic rate between treatment *** body weight and elevated mortality in the 2%taurolidine intraperitoneal group suggest that the lower 1%dose is ***:In conclusion,there is no evidence of antiangiogenic activity,and the antitumor effects of taurolidine on osteosarcoma observed in this study are ***,its toxic proﬁle grants further *** these observations,further research is necessary to

关键词： Osteosarcoma Taurolidine cancer treatment chemotherapy Murine models

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Primary repair of esophageal atresia Gross type c via thoracoscopic magnetic compression anastomosis:Is it the best option?

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World Journal of Gastrointestinal surgery 2024年第5期16卷 1474-1481页

作者： sonia Pérez-Bertólez Jorge Godoy-Lenz Department of Pediatric surgery Sant Joan de Deu HospitalUniversity of BarcelonaBarcelona 08950Spain Department of Pediatric surgery Clínica Alemana of SantiagoSantiago 7650568Chile

Magnetic compression anastomosis is a promising treatment option for patients with complex esophageal atresia;but,at the present time,should not be the first therapeutic option in those cases where the surgeon can per... 详细信息

关键词： Esophageal atresia Tracheoesophageal fistula Thoracoscopy Magnamosis Magnetic anastomosis

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Organizational ambidexterity, open innovation and innovation outputs: How do followers and low-flyer EU countries innovate?

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International Journal of Innovation studies 2024年第2期8卷 186-235页

作者： Joao Leitao sonia de Brito Dina Pereira Faculty of social and Human sciences NECE-Research Unit in Business SciencesUniversity of Beira Interior6200-001CovilhaPortugal Research Unit in Business sciences(NEcE) University of Beira InteriorCovilhaPortugal centre for Management studies of Instituto superior Tecnico(cEG-IsT) University of Lisbon1649-004LisboaPortugal Instituto de ciencias sociais ICsUniversity of Lisbon1649-004LisboaPortugal

This study analyses the role played by organizational ambidexterity and open innovation in innovation outputs,considering business units with different levels of technological intensity(medium-high and high tech,and medium-low and low tech)for countries with different inno-vation *** countries considered in this paper are i)Estonia and slovenia as innovation followers;i)slovakia,Hungary,spain,czech Republic,Italy,Portugal,Norway,and croatia as moderate innovators;and ii)Bulgaria,Lithuania and Romania as modest *** the empirical approach,the research hypotheses arise from the literature review and are tested using sec.ndary data collected from the community Innovation survey(cIs)*** conceptual model is tested using the logistic regression method,which indicates suitable accuracy and reliability for empirical testing *** evidence reveals that for innovation followers,ambidexterity has a greater influence on the practice of eco-innovation,marketing innovation,and product *** moderate innovators,ambidexterity has a greater influence on the practice of product innovation,process innovation,and *** modest in-novators,ambidexterity has a greater influence on the practice of product innovation,process innovation,and *** regard to open innovation,for innovation followers,this has a negative influence on product innovation in medium-high and high-tech *** moderate innovators,open innovation has a greater influence in process,organizational,and *** the case of modest innovators,open innovation is more significant for innovation outputs in product,organizational,and marketing *** is not always positively related to innovation outputs.

关键词： Organizational ambidexterity cIs cooperation Open innovation Public innovation policies

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The potential of glutamine supplementation in reduced-crude protein diets for chicken-meat production

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Animal Nutrition 2024年第3期18卷 49-56页

作者： Peter H.selle shemil P.Macelline Mehdi Toghyani sonia Yun Liu Poultry Research Foundation within the University of sydney CamdenNSW 2570Australia sydney school of Veterinary science The University of SydneyCamdenNSW 2570Australia school of Life and Environmental sciences Faculty of ScienceThe University of SydneyCamdenNSW 2570Australia

This review explores the potential of including glutamine,a so-called non-essential amino acid,in the formulation of reduced-crude protein(cP)diets for broiler *** is a precedent for benefits when including glycine and serine in reduced-cP *** this is due to decreases in non-essential amino acid concentrations in reduced-cP diets—an unavoidable consequence of reducing cP without amino acid *** situation for glutamine is complicated because analysed dietary concentrations are very rarely provided as standard assays do not differentiate between glutamine and glutamate and are reported on a combined basis as glutamic *** dietary requirement for glutamic acid is approximately 36.3 g/kg but it is increasingly unlikely that this requirement will be met as dietary cP levels are progressively *** is an abundant and versatile amino acid and constitutes 50.5 mg/g of whole-body chicken protein and is the dominant free amino acid in systemic plasma where it has been shown to provide 22.6%(139.9 of 620.3μg/mL)of the total in birds offered 215 g/kg cP,wheat-based *** addition to dietary intakes,glutamine biosynthesis is derived mainly from the c.ndensation of glutamate and ammonia(NH3)catalysed by glutamine synthetase,a reaction that is pivotal to NH3 *** and NH3 are converted to glutamine by phosphate-dependent glutaminase in the reciprocal reaction;thus,glutamine and glutamate are interchangeable amino ***,the rate of glutamine biosynthesis may not be adequate in rapidly growing broiler chickens and exogenous and endogenous glutamine levels are probably insufficient in birds offered reduced-cP *** many functional roles of glutamine,including NH3 detoxification and maintenance of acid-base homeostasis,then become *** feeding studies were identified where dietary glutamine supplementation,usually 10 g/kg,was evaluated in birds kept under thermoneutral ***

关键词： Broiler chicken Glutamate Glutamic acid Glutamine

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Facile synthesis of graphene anchored rare earth doped mixed metal ferrite nanorods:A potential c.ndidate for azo dye mineralization

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Journal of Rare Earths 2024年第5期42卷 907-916,I0004页

作者： Tehmina Kousar Muhammad Aadil sonia Zulfiqar sobhy MIbrahim sidra Mubeen Warda Hassan Kashuf shafiq Farzana Mahmood Institute of chemical sciences Bahauddin Zakariya UniversityMultan60800Pakistan Department of chemistry Rahim Yar Khan CampusThe Islarnia University of BahawalpurRahim Yar Khan64200Pakistan Department of chemistry Faculty of ScienceUniversity of Ostrava30.Dubna 22Ostrava70103Czech Republic Department of chemical and Biological Engineering Iowa State UniversitySweeney Hall618 Bissell RoadAmeslowa50011United States Department of Biochemistry College of ScienceKing Saud UniversityPO.Box 2455Riyadh11451Saudi Arabi Department of chemistry The Women University Multan66000Pakistan

Bandgap tuning using rare earth metals as dopants in ferrite-based photocatalytic materials has received a lot of interest because the Fermi 4f energy of these metals generates a sub-energy state in the bandgap generated by the overlapping of Fe-3d and O-2p ***,dysprosium-doped cobalt-nickel mixed ferrite(D-cNFO)and its graphene-reinforced composite(D-cNFO@G)were prepared and an ideal photocatalyst material for azo dye mineralization was proposed.A cost-effective combination of wetchemical and ultrasonication methods was used to prepare the doped and composite *** characterization methodologies were used to scrutinize the optical,compositional,structural,morphological,and photocatalytic characteristics of as-prepared *** X-ray diffraction analysis identified the spinel phase's(cubic)structure,while the electronic spectroscopy examination confirmed the prepared samples'rod-like *** UV/visible absorbance spectrum shows the higher light harvesting behavior of the D-cNFO@G in the visible *** mineralization performance of the DcNFO and D-cNFO@G composites was analyzed using congo-red(an anionic dye),a well-known azo *** D-cNFO@G sample removes congo-red dye at a rate almost 2.4%faster than the D-cNFO *** experiment involving trapping free radicals indicates that hydroxyl radical play s a crucial role in dye *** the D-cNFO@G catalyst is magnetic and can be isolated easily from the photocatalytic system,it shows an awkward cycle activity of more than 96%after five mineralization *** asprepared D-cNFO@G composite is proved as an excellent option for azo dye mineralization because of the combined impacts of rare earth doping,graphene reinforcement and nanotechnology.

关键词： azo-dye composite Graphene Dy-doped Nanotechnology Rare earths

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