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Infiltrative xanthogranulomatous cholecystitis mimicking aggressive gallbladder carcinoma: A diagnostic and therapeutic dilemma

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World Journal of gastroenterology 2017年第48期23卷 8671-8678页

作者： Lucas souto Nacif Amelia Judith Hessheimer sonia Rodríguez gómez Carla Montironi Constantino Fondevila Department of surgery Institut de Malalties Digestives I Metabòliques(IMDM)Hospital Clínic CIBERehd IDIBAPSUniversity of Barcelona Department of Radiology Hospital Clínic Department of Pathology Hospital Clínic

Xanthogranulomatous cholecystitis(XgC) is an uncommon variant of chronic cholecystitis. The perioperative findings in aggressive cases may be indistinguishable from those of gallbladder or biliary tract carcinomas. Three patients presented mass lesions that infiltrated the hepatic hilum,provoked biliary dilatation and jaundice,and were indicative of malignancy. surgical excision was performed following oncological principles and included extirpation of the gallbladder,extrahepatic bile duct,and hilar lymph nodes,as well as partial hepatectomy. Postoperative morbidity was minimal. surgical pathology demonstrated XgC and absence of malignancy in all three cases. All three patients are alive and well after years of follow-up. XgC may have such an aggressive presentation that carcinoma may only be ruled out on surgical pathology. In such cases,the best option may be radical resection following oncological principles performed by expert surgeons,in order that postoperative complications may be minimized if not avoided altogether.

关键词： Hepaticojejuostomy Xanthogranulomatous cholecystitis gallbladder carcinoma Hepatectomy Hilar cholangiocarcinoma

Isolated colonic neurofibroma, a rare tumor: A case report and review of literature

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World Journal of Clinical Cases 2020年第10期8卷 1932-1938页

作者： sara ghoneim sonia sandhu Dalbir sandhu Department of Internal Medicine Case Western Reserve University at MetroHealth Medical CenterClevelandOH 44109United States Department of Hematology and Oncology Cleveland Clinic Akron GeneralClevelandOH 44307United States Division of gastroenterology Case Western Reserve University at MetroHealth Medical CenterClevelandOH 44109United States

BACKgROUND Neurofibromas are tumors comprised of peripheral nerve sheath and connective tissue *** can occur sporadically or as part of familial syndromes such as neurofibromatosis type *** colonic neurofibroma without systemic manifestations is a rarely reported clinical *** we present a case of a 51 years old male with an isolated colonic neurofibroma seen on a screening *** sUMMARY Fifty-one years old male who was otherwise healthy without a significant family history of cancer underwent a screening colonoscopy and was found have a 2.3 cm×1.4 cm lesion in the *** biopsy revealed a spindle cell *** resonance imaging of the pelvis was negative for *** underwent an endoscopic ultrasound that showed an ill-defined avascular lesion of mixed echogenicity measuring 2.8 cm×15.2 cm in the submucosa with no communication with muscularis mucosa or *** staining of the tumor was strongly positive for s100,with rare penetrating axons deep within the *** cells were negative for c-kit and desmin and had low Ki-67 *** findings were consistent with a solitary colonic submucosal neurofibroma.A detailed history and physical examination did not reveal any evidence of extraintestinal *** underwent transanal surgical resection of the *** patient tolerated the procedure well without any *** While neurofibromas have been well described in literature,an isolated colonic neurofibroma is a rare pathological *** transformation of neurofibromas has been reported in patients with neurofibromatosis *** report a case of isolated colonic neurofibroma and highlight the importance of resection due to the increased risk of tumorigenesis.

关键词： Neurofibroma Colonoscopy Neurofibromatosis type 1 Neurofibromatosis type 2 spindle cell tumor Endoscopic ultrasound Case report

An alternative perspective of an underutilized fruit tree Choerospondias axillaris in health promotion and disease prevention:A review

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Food Bioscience 2022年第3期47卷 32-45页

作者： sonia Mann Debolina Chakraborty sagarika Biswas Department of Integrative and Functional Biology CSIR- Institute of Genomics & Integrative BiologyMall RoadDelhi110007India Academy of scientific and Innovative Research (AcsIR) Ghaziabad201002India

Many underutilized fruit plants are still obscure,in spite of possessing high medicinal and nutritional ***,we reviewed one of the underutilized fruits tree(Choerospondias axillaris)and explored its occurrence,distribution,nutritional properties,phytochemicals,and medicinal value,along with associated challenges and *** mining using scientific and common name of this plant species,yielded 77 articles,indicating limited availability of *** parts of the species including fruits,seeds and bark have the potential to be used in different daily needs and therapeutic *** core problem to underutilized fruit tree sustainability includes indiscrimination,lesser accessibility and acceptability,insufficient information on their growth and *** challenges for the production and marketing of *** fruits along with the opportunities of having a high source of income and health benefits from these plants have been discussed.A scheme for the enhancement of utility of this underutilized fruit plants has been suggested in this review.A collective effort of botanists,food scientists,government and international shareholders are needed for promoting its domestication and *** fruits have been found to be a very promising resource in the areas of food and health industries,and possess great opportunity to flourish in the international market.

关键词： Alternative food Choerospondias axillaris Ethnomedicine Phytoconstituents Underutilized

CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation

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signal Transduction and Targeted Therapy 2024年第8期9卷 3519-3532页

作者： Alvaro Quintanal-Villalonga Kenta Kawasaki Esther Redin Fathema Uddin swanand Rakhade Vidushi Durani Amin sabet Moniquetta shafer Wouter R.Karthaus samir Zaidi Yingqian A.Zhan Parvathy Manoj Harsha sridhar Dennis Kinyua Hong Zhong Barbara P.Mello Metamia Ciampricotti Umesh K.Bhanot Irina Linkov Juan Qiu Radhika A.Patel Colm Morrsey sanjoy Mehta Jesse Barnes Michael C.Haffner Nichlas D.socci Richard P.Koche Elisa de stanchina sonia Molina-Pinelo sohrab salehi Helena A.Yu Joseph M.Chan Charles M.Rudin Department of Medicine Thoracic Oncology ServiceMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Cancer Biology and genetics Program Sloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Vagelos College of Physicians and surgeons Columbia UniversityNew YorkNYUSA Weill Cornell graduate school of Medical sciences Weill Cornell MedicineNew YorkNYUA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Center for Epigenetics Research Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Pathology Core Facilty Department of Pathology and Laboratory MedicineMSKCCNew YorkNYUSA Antitumor Assessment Core Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Divisionsof Human Biology and Clinical Research Fred Hutchinon Cancer CenterSeattleWAUSA Deparmentof Urology University of WashingtonSeattleWAUSA gene Editing&screening Core Facility Memorial sloan Kettering Cancer Center New YorkNYUSA Department of Laboratory Medicine and Pathology University of WashingtonSeattleWAUSA Bioinfomatics CoreFacility Memorial Soan Kettering Cancer CenterNew YorkNYUSA Institute of Biomedicine of seille(Bis) HURCSCUniversidad de SevillaSevilleSpain Computational Oncology Department of Epidemiology and BiostatisticsMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Well Cornell Medical College New York NYUSA Present address:swiss Institute for Experimental Cancer Research(IsREC) School of Life SciencesEPFLLausanneSwitzerland

Neuroendocrine(NE)transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor *** to date,even if patients at high risk of transformation can be identified by the occurrence of Tumor Protein P53(TP53)and Retinoblastoma Transcriptional Corepressor 1(RB1)mutations in their tumors,no therapeutic strategies are available to prevent or delay histological *** of the cell cycle kinase Cell Division Cycle 7(CDC7)occurred in tumors during the initial steps of NE transformation,already after TP53/RB1 co-inactivation,leading to induced sensitivity to the CDC7 inhibitor ***7 inhibition suppressed NE transdifferentiation and extended response to targeted therapy in in vivo models of NE transformation by inducing the proteasome-mediated degradation of the MYC Proto-Oncogen(MYC),implicated in stemness and histological *** overexpression of a degradation-resistant MYC isoform reestablished the NE transformation phenotype observed on targeted therapy,even in the presence of ***7 inhibition also markedly extended response to standard cytotoxics(cisplatin,irinotecan)in lung and prostate small cell carcinoma *** results nominate CDC7 inhibition as a therapeutic strategy to constrain lineage plasticity,as well as to effectively treat NE tumors de novo or after *** simurosertib clinical efficacy trials are ongoing,this concept could be readily translated for patients at risk oftransformation.

关键词： tumors markedly transformation

Transmission Control under Multi-service Disciplines in Wireless sensor Networks

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Computers, Materials & Continua 2021年第8期68卷 2127-2143页

作者： Cheng gong Dingbang Xie Chao guo sonia Kherbachi school of Computer and Communication Engineering University of Science and Technology BeijingBeijing100083China Department of Electronics and Communication Engineering Beijing Electronics Science and Technology InstituteBeijing100070China Department of Management University of BejaiaBejaia06000Algeria

The wireless sensor network(WsN),as the terminal data acquisition system of the 5g network,has attracted attention due to advantages such as low cost and easy *** development is mainly restricted by *** traditional transmission control scheme is not suitable for WsNs due to the significant information interaction.A switchable transmission control scheme for WsNs based on a queuing game(sQgTC)is proposed to improve network *** that sensor nodes compete for the resources of sink nodes to realize data transmission,the competitive relationship between nodes is described from the perspective of a *** types of sensor node requests require a sink node to provide different service *** models of social welfare are established for a sink node under the service disciplines of first-come,first-served(FCFs),egalitarian processor sharing(EPs),and shortest service first(ssF).The optimal service strategies are obtained by maximizing social *** sensor nodes provide the expected benefits and satisfy the service requirements of the requests,and the sink node switches the transmission control strategy for the *** results show that the proposed scheme improves the data transmission efficiency of WsNs and achieves the optimal allocation of resources.

关键词： WsNs transmission control queuing game service disciplines

β-Estradiol 17-acetate enhances the in vitro vitality of endothelial cells isolated from the brain of patients subjected to neurosurgery

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Neural Regeneration Research 2023年第2期18卷 389-395页

作者： sonia guzzo Pasquale De Bonis Barbara Pavan Luciano Fadiga Department of Neuroscience and Rehabilitation Section of PhysiologyUniversity of FerraraFerraraItaly Center for Translational Neurophysiology of speech and Communication(CTNsC) Italian Institute of Technology(IIT)FerraraItaly Department of Translational Medicine and for Romagna University of FerraraFerraraItaly

In the current landscape of endothelial cell isolation for building in vitro models of the blood-brain barrier,our work moves towards reproducing the features of the neurovascular unit to achieve glial compliance through an innovative biomimetic coating technology for brain chronic *** hypothesized that the autologous origin of human brain mic rovascular endothelial cells(hBMECs)is the first requirement for the suitable coating to prevent the glial inflammato ry response trigge red by foreign *** re,this study established a new procedure to preserve the in vitro viability of hBMECs isolated from gray and white matter specimens taken from neurosurge ry *** adult hBMECs is generally considered a challenging task due to the difficult survival ex vivo and progressive reduction in proliferation of these *** addition of 10 nMβ-estradiol 17-acetate to the hBMEC culture medium was found to be an essential and discriminating factor promoting adhesion and proliferation both after isolation and thawing,suppo rting the well-known protective role played by estrogens on *** particular,β-estradiol 17-acetate was critical for both freshly isolated and thawed female-derived hBMECs,while it was not necessary for freshly isolated male-derived hBMECs;however,it did countera ct the decay in the viability of the latter after *** tumo r-free hBMECs were thus cultured for up to 2 months and their growth efficiency was assessed befo re and after two periods of *** pite the thermal stress,the hBMECs remained viable and suitable for re-freezing and storage for several *** approach increasing in vitro viability of hBMECs opens new perspectives for the use of cryopreserved autologous hBMECs as biomimetic therapeutic tools,offering the potential to avoid additional surgical sampling for each patient.

关键词： β-estradiol 17-acetate 17β-estradiol cryopreservation gender-specific gray matter human brain microvascular endothelial cells surgical resections vascular protection white matter

Bill Morphology Does Not Influence Vocal Performance in Darwin’s small Tree Finch on Floreana Island

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Zoological Research 2009年第4期30卷 423-428页

作者： Rebekah Christensen sonia Kleindorfer school of Biological sciences Flinders University

Bird song is used for mate attraction and is important for establishing reproductive isolation. Current research highlights performance constraints on song production that may be influenced by variation in bill morphology. Darwin＇s finches are a model system for studying the relationship between morphology and song performance, with previous studies suggesting that lower vocal performance is correlated with larger bill size. Here, we tested for a relationship between bill morphology and vocal performance in Darwin＇s small Tree Finch （Camarhynchus parvulus） on Floreana Island. We found no evidence of a correlation between bill morphology and vocal performance. This finding is in agreement with prior study of the small Tree Finch, but contrasts a greater body of work addressing song in Darwin＇s Finches. We discussed our findings in the context of ecological divergence, and ecological variation across species.

关键词： Darwin's finches Bill morphology small Tree Finch song Vocal performance

Long term immunological perturbations post DAA therapy in chronic HCV/HIV co-infected patients

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BIOCELL 2022年第12期46卷 2695-2699页

作者： sonia MORETTI FLAVIA MANCINI ALEssANDRA BORsETTI National HIV/AIDs Research Center Istituto Superiore di SanitàRome00161Italy

Direct-acting antiviral(DAA)therapies are efficacious for the achievement of sustained virologic response(sVR)in almost all treated hepatitis C virus(HCV)-infected ***,the impacts of HCV eradication on immune function and chronic immune activation in the long-term remain controversial and limited,especially in patients co-infected with human immunodeficiency virus(HIV).Indeed,although restoration of many immune responses clearly can be observed,several features of immune perturbations persist over time after HCV *** the degree and reasons of the partial recovery of the immune system in chronic HCV/HIV coinfection after HCV elimination is pivotal to avoid disease progression and possible long-term clinical outcomes in cured patients,as well as contributing to the development of immunotherapy drug design.

关键词： HCV infection HCV/HIV co-infection DAA therapy Immune activation Inflammation Immune system

One-Pot green synthesis of 1,4-Dihydropyridine Derivatives Using Polyindole TiO2 Nanocatalyst by solvent Free Method

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