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Endoscopic lysis of bladder scar associated with Hunner’s lesions:A new technique

Asian Journal of Urology 2015年第1期2卷 59-62页

作者： sonia Bahlani Robert Moldwin The Smith Institute for Urology North Shore-Long Island Jewish Health SystemNew Hyde ParkNYUSA

Objective:Five to ten percent of interstitial cystitis/bladder pain syndrome(IC/BPS)patients have Hunner’s lesions(HL),areas of non-specific inflammation and *** poor quality of life of patients with HL is entwined in associated pain and loss of bladder *** the decrease in bladder capacity is usually dependent on pain,it may also be dependent upon scarring and associated compliance changes produced by the inflammatory *** report reviews the potential role of endoscopic scar lysis using the holmium laser in the management of these patients whose only other therapeutic option is urinary ***:Two patients with HL and“end stage”bladders who underwent holmium laser division of bladder wall scar/tethering were *** data were reviewed with emphasis on safety and ***:Both patients selected for this procedure underwent holmium laser lysis of known scar tissue in an effort to increase bladder capacity and improve symptoms of urinary frequency and pain with bladder *** median age of patients who underwent the procedure was 63(59-67)*** were made with the holmium laser at frequencies of 3e10 Hz of 300e700 J along the region of *** procedures were performed by the same *** was an increase in bladder capacity by 58.3%(50.0%-66.7%).During a mean follow-up of 4.2 years,there appeared to be a significant improvement with an increase in interval time between voids and a decrease in pain with bladder ***:Patients with IC/BPS may be severely debilitated by a clinically significant decrease in their bladder capacity,especially in the face of *** use of the holmium laser to incise regions of scar and bladder wall tethering may produce a clinically significant and durable increase in bladder *** use of this technique as a means of treating bladder scarring poses an excellent adjunct to existing treatment strategies.

关键词： Hunner’s lesions Bladder scar Endoscopic lysis

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Mastering stakeholders’engagement to reach national scale,sustainability and wide adoption of digital health initiatives:lessons learnt from Burkina Faso

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Family Medicine and Community Health 2021年第3期9卷 41-46页

作者： Riccardo Lampariello sonia Ancellin-Panzani Programmes HealthTerre des Hommes FoundationLausanneSwitzerland Scaling Up Nutrition Movement Secretariat Country Liaison TeamUnited Nations Office for Project ServicesGenevaSwitzerland

Although low-income countries have recently seen an exponential flourishing of digital health initiatives,the landscape is characterised by a myriad of small pilots that rarely reach scaling,sustainability and wide *** case of Burkina Faso represents an exception where a digital health initiative initially conceived to improve the diagnosis of sick children under 5 has supported millions of *** aspects such as interoperability,standardisation,and adaptation to the existing infrastructure were considered as they are prerequisites for scaling;so was the demonstration of the health impact and affordability of the *** those factors which are largely documented in the literature,the experience in Burkina Faso showed that the positive outcome was also determined by the support of numerous stakeholders.A vast network of stakeholders from the Ministry of Health to child caregivers is involved and each of them could have either blocked or promoted the digital health *** to an extensive,time-consuming and tailored stakeholder strategy,it was possible to avoid potential blockages from multiple actors and gain their engagement.

关键词： income scaling landscape

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Exact Boundary Conditions for PeriodicWaveguides Containing a Local Perturbation

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Communications in Computational Physics 2006年第6期1卷 945-973页

作者： Patrick Joly Jing-Rebecca Li sonia Fliss Domaine de Voluceau-Rocquencourt-B.P.105 78153 Le Chesnay CedexFrance

We consider the solution of the Helmholtz equation−u(x)−n(x)2ω2u(x)=f(x),x=(x,y),in a domain which is infinite in x and bounded in *** assume that f(x)is supported in 0:={x∈|a− 详细信息

We consider the solution of the Helmholtz equation−u(x)−n(x)2ω2u(x)=f(x),x=(x,y),in a domain which is infinite in x and bounded in *** assume that f(x)is supported in 0:={x∈|a−

关键词： Exact boundary conditions periodic media Dirichlet to Neumann maps

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Lipid reserves and immune defense in healthy and diseased migrating monarchs Danaus plexippus

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Current Zoology 2013年第3期59卷 393-402页

作者： Dara A. SATTERFIELD Amy E. WRIGHT sonia ALTIZER Odum School of Ecology University of Georgia Athens GA 30602 USA

Recent studies suggest that the energetic demands of long-distance migration might lower the pool of resources available for costly immune defenses. Moreover, migration could amplify the costs of parasitism if animals suffering from para- site-induced damage or depleted energy reserves are less able to migrate long distances. We investigated relationships between long-distance migration, infection, and immunity in wild fall-migrating monarch butterflies Danaus plexippus. Monarchs migrate annually from eastern North America to central Mexico, accumulating lipids essential for migration and winter survival as they travel southward. Monarchs are commonly infected by the debilitating protozoan parasite Ophryocystis elektroscirrha （OE）. We collected data on lipid reserves, parasite loads, and two immune measures （hemocyte concentration and phenoloxidase activity） from wild monarchs migrating through north GA （USA） to ask whether （1） parasite infection negatively affects lipid reserves, and （2） greater investment in lipid reserves is associated with lower immune measures. Results showed that monarchs sampled later in the fall migration had lower but not significantly different immune measures and significantly higher lipid reserves than those sampled earlier. Lipid measures correlated negatively but only nearly significantly with one measure of immune defense （phenoloxidase activity） in both healthy and infected monarchs, but did not depend on monarch infection status or parasite load. These results provide weak support for a trade-off between energy reserves and immune defense in migrants, and suggest that previously-demonstrated costs of OE infection for monarch migration are not caused by depleted lipid reserves .

关键词： Butterfly Hemocytes Migration Neogregarine Infection Energy reserves

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Sorption of 2,4-dinitroanisole (DNAN) on lignin

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Journal of Environmental Sciences 2012年第5期24卷 808-813页

作者： Rabih Saad Zorana Radovic-Hrapovic Behzad Ahvazi sonia Thiboutot Guy Ampleman Jalal Hawari Biotechnology Research Institute National Research Council of Canada6100 Royalmount AvenueMontréalQuebecCanada Defense Research Development Canada Department of National DefenseValcartierQuebecCanada

The present study describes the use of two commercially available lignins,namely,alkali and organosolv lignin,for the removal of2,4-dinitroanisole（DNAN）,a chemical widely used by the military and the dye industry,from *** of DNAN on bothlignins reached equilibrium within 10 hr and followed pseudo second-order kinetics with sorption being faster with alkali than withorganosolv lignin,i.e.k2 10.3 and 0.3 g/（mg·hr）,*** a separate study we investigated sorption of DNAN between 10 and40 C and found that the removal of DNAN by organosolv lignin increased from 0.8 to 7.5 mg/g but reduced slightly from 8.5 to 7.6mg/g in the case of alkali *** isotherms for either alkali or organosolv lignin best fitted Freundlich equation with enthalpyof formation,H0 equaled to 14 or 80 kJ/*** help understand DNAN sorption mechanisms we characterized the two lignins byelemental analysis,BET nitrogen adsorption-desorption and 31P *** in elemental compositions between the two ligninsindicated that alkali lignin should have more sites（O-and S-containing functionalities） for *** BET surface area andcalculated total pore volume of alkali lignin were almost 10 times greater than that of organosolv lignin suggesting that alkali ligninshould provide more sites for sorption.31P NMR showed that organosolv lignin contains more phenolic-OH groups than alkali lignin,i.e.,70% and 45%,*** variations in the type of OH groups between the two lignins might have affected the strength ofH-bonding between DNAN and the type of lignin used.

关键词： sorption DNAN lignin kinetics isotherms.

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A New Hybrid SARFIMA-ANN Model for Tourism Forecasting

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Computers, Materials & Continua 2022年第6期71卷 4785-4801页

作者： Tanzila Saba Mirza Naveed Shahzad sonia Iqbal Amjad Rehman Ibrahim Abunadi Artificial Intelligence&Data Analytics Research Lab(AIDA) CCIS Prince Sultan UniversityRiyadh11586Saudi Arabia Department of Statistics University of GujratGujrat50700Pakistan Department of Statistics University of SialkotSialkot51310Pakistan

Many countries developed and increased greenery in their country sights to attract international *** planning is now significantly contributing to their *** next task is to facilitate the tourists by sufficient arrangements and providing a green and clean environment;it is only possible if an upcoming number of tourists’arrivals are accurately *** accurate prediction is not easy as empirical evidence shows that the tourists’arrival data often contains linear,nonlinear,and seasonal *** traditional model,like the seasonal autoregressive fractional integrated moving average(SARFIMA),handles seasonal trends with *** contrast,the artificial neural network(ANN)model deals better with nonlinear time *** get a better forecasting result,this study combines the merits of the SARFIMA and the ANN models and the purpose of the hybrid SARFIMA-ANN ***,we have used the proposed model to predict the tourists’arrival inNew Zealand,Australia,and *** results showed that the proposed hybrid model outperforms in predicting tourists’arrival compared to the traditional SARFIMA and ANN ***,these results can be generalized to predict tourists’arrival in any country or region with a complicated data pattern.

关键词： SARFIMA hybrid model tourists’arrival forecasting ANN

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A pan-cancer fingerprint:common molecular denominators of the human tumor microenvironment

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3371-3372页

作者： Susanna S.Ng sonia Leonardelli Michael Hölzel Institute of Experimental Oncology University Hospital BonnUniversity of Bonn53127 BonnGermany

In a recent study published in Cancer Cell,Bagaev et *** a pan-cancer tumor microenvironment(TME)classification that can be predictive of response to immune checkpoint inhibitor(ICI)therapy.1 The authors presented a detailed visualization that can be generated for each tumor,which combines the 29 functional gene expression signatures(Fges)used to subtype the TME with targetable genomic *** the compartments and pathways within the TME could aid decision-making in patient-specific treatment of cancer,especially in the context of immunotherapies.2 The increasing use of ICIs have shown promising clinical outcomes in several cancer ***,response to treatment is heterogenous and often results in immune-related adverse events.3 Therefore,efforts are focused on the development of prognostic tools to predict response to *** analysis of 468 melanoma patients resulted in grouping of the TME into four major subsets based on manually curated Fges.

关键词： cancer alterations

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New era of personalized medicine:Advanced therapy medicinal products in Europe

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World Journal of Immunology 2021年第1期11卷 1-10页

作者： Javier García-González sonia Marhuenda-castillo Sheila Romero-Carretero Jesús Beltrán-García Strategy and Market Access Pharmaceutical IndustryMadrid 28012Spain Clinical Research International CROMadrid 28003Spain Department of Physiology Faculty of Medicine and DentistryUniversity of ValenciaValencia 46010Spain Center for Biomedical Research in Rare Diseases Network(CIBERER) Carlos III Health InstituteValencia 46010Spain INCLIVA Institute of Sanitary Research Valencia 46010Spain

Advanced therapy medicinal products are human medical therapies based on genes,cells,or tissues,and due to their characteristics,they offer new innovative opportunities for the treatment of diseases and injuries,especially for diseases beyond the reach of traditional *** therapies are at the forefront of innovation and have historically been very controversial,although in the last decade they have gained prominence while the number of new advanced therapies has increased every *** this regard,despite the controversy they may generate,they are expected to dominate the market in the coming *** based on advanced therapies are the present and future of medicine and bring us closer to the long-awaited precision *** we review the field as it stands today,with a focus on the molecular mechanisms that guided the different advanced therapies approved by the European Medicines Agency,their current status,and their legal approval.

关键词： Advanced therapy Advanced therapy medicinal products Cell therapy Gene therapy Tissue therapy Chimeric antigen receptor T cell

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Primary pancreatic gastrointestinal stromal tumor

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Hepatobiliary & Pancreatic Diseases International 2021年第4期20卷 391-393页

作者： Whayoung Lee Xiaodong Li sonia Lee Vishal S Chandan Department of Pathology and Laboratory Medicine University of CaliforniaIrvineCA 92868USA Department of Radiological Sciences University of CaliforniaIrvineCA 92868USA

Gastrointestinal stromal tumor (GIST) arises from the interstitial cells of Cajal (ICC) and is the most common mesenchymal tumor of the gastrointestinal tract,accounting for approximately 1%-2%of all malignant gastroi... 详细信息

关键词： gastrointestinal stomach tumor

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Stand-level biomass models for predicting C stock for the main Spanish pine species

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Forest Ecosystems 2021年第2期8卷 387-402页

作者： Ana Aguirre Miren del Río Ricardo Ruiz-Peinado sonia Condés Department of Natural Systems and Resources School of Forest Engineering and Natural ResourcesUniversidad Politécnica de MadridMadridSpain INIA Forest Research CenterDepartment of Forest Dynamics and ManagementMadridSpain iuFOR Sustainable Forest Management Research InstituteUniversity of Valladolid and INIAValladolidSpain

Background:National and international institutions periodically demand information on forest indicators that are used for global *** other aspects,the carbon accumulated in the biomass of forest species must be *** this purpose,one of the main sources of data is the National Forest Inventory(NFI),which together with statistical empirical approaches and updating procedures can even allow annual estimates of the requested ***:Stand level biomass models,relating the dry weight of the biomass with the stand volume were developed for the five main pine species in the Iberian Peninsula(Pinus sylvestris,Pinus pinea,Pinus halepensis,Pinus nigra and Pinus pinaster).The dependence of the model on aridity and/or mean tree size was explored,as well as the importance of including the stand form factor to correct model ***,the capability of the models to estimate forest carbon stocks,updated for a given year,was also ***:The strong relationship between stand dry weight biomass and stand volume was modulated by the mean tree size,although the effect varied among the five pine *** humidity,measured using the Martonne aridity index,increased the biomass for a given volume in the cases of Pinus sylvestris,Pinus halepensis and Pinus *** that consider both mean tree size and stand form factor were more accurate and less biased than those that do *** models developed allow carbon stocks in the main Iberian Peninsula pine forests to be estimated at stand level with biases of less than 0.2 Mg·ha^(-1).Conclusions:The results of this study reveal the importance of considering variables related with environmental conditions and stand structure when developing stand dry weight biomass *** described methodology together with the models developed provide a precise tool that can be used for quantifying biomass and carbon stored in the Spanish pine forests in specific years when no field data are available.

关键词： Martonne aridity index Dry weight biomass Carbon stock National Forest Inventory Peninsular pine forest Biomass expansion factor

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