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An architecture of knowledge management system based on agent and ontology

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The Journal of China Universities of Posts and Telecommunications 2008年第4期15卷 126-130页

作者： FU Rui-xue YUE xin song ming xin Zhan-hong School of Economics and Management Beijing University of Posts and Telecommunications Beijing 100876 China

To solve the problems in knowledge management system （KMS）, such as information sharing, the ability to extend and re-engineer, and the reusable ability of legacy systems in distributed and heterogeneous environments. This article presents a method based on agent and ontology of designing KMS. This method consists of two agencies. One is knowledge agency with three agents supporting knowledge management process. The other is application agency with three agents supporting knowledge application. In this method, ontology is used to represent the knowledge in knowledge base and the content in the message exchanged among agents. To demonstrate the advantages of this method, experiments have been carried out and the results imply that this method is efficient and effective for small and medium-size enterprises to design KMS.

关键词： KMS multi-agent system (MAS) ontology

Extended resection for locally advanced colorectal cancer

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Chinese Medical Journal 2006年第20期119卷 1675-1676页

作者： WANG Jian-ping song xin-ming Department of Gastrointestinopancreatic Surgery First Affiliated Hospital Sun Yat-sen University Guangzhou 510080 China

Colorectal cancer is a common cause of cancer-related mortality. In China, it is one of eight cancers in the cancer control blueprint, which are suggested to have comprehensive treatment. Some patients with colorectal cancer presented no symptoms when they were diagnosed, yet the tumor had already penetrated the intestinal wall and involved adjacent organs. If the tumor is localized at time of diagnosis without distant metastases, it is termed locally advanced colorectal cancer （LACC） regardless of whether there is lymph node metastasis. LACC commonly encountered in clinical practice accounts for 5%-10% of all colorectal cancers.

关键词： MULTIVISCERAL RESECTION CARCINOMA RECTUM COLON

角果木内生真菌Penicillium herquei JX4中2个新的pinophol类化合物

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中国中药杂志 2024年第13期49卷 3548-3551页

作者：劳先磊吴美珠郑婷陈光英郑彩娟陈雅林周金琪冯硕周学明宋鑫明海南师范大学热带药用资源化学教育部重点实验室、海南省热带药用植物化学重点实验室海南海口571158

应用OSMAC策略,对来源于红树角果木的内生真菌Penicillium herquei JX4进行次级代谢产物及其抗炎活性研究。综合运用硅胶柱色谱、凝胶柱色谱、ODS柱色谱以及半制备高效液相色谱技术对真菌*** JX4的PDB发酵物进行分离纯化以及鉴定,共分... 详细信息

应用OSMAC策略,对来源于红树角果木的内生真菌Penicillium herquei JX4进行次级代谢产物及其抗炎活性研究。综合运用硅胶柱色谱、凝胶柱色谱、ODS柱色谱以及半制备高效液相色谱技术对真菌*** JX4的PDB发酵物进行分离纯化以及鉴定,共分离鉴定了2个pinophol类新化合物:pinophol H(1)和pinophol I(2)。对这2个化合物进行了脂多糖(LPS)诱导RAW264.7细胞NO生成抑制活性测试,结果表明化合物1具有显著的NO生产抑制活性,其IC_(50)为8.12μmol·L^(-1)。

关键词：角果木内生真菌 Penicillium herquei JX4 pinophol 抗炎

Impact of Periconceptional Multi-micronutrient Supplementation on Gestation:A Population-based Study

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Biomedical and Environmental Sciences 2013年第1期26卷 23-31页

作者： WANG Ya Fei PEI Li Jun song xin ming CHEN Gong ZHENG Xiao Ying Institute of Population Research/WHO Collaborating Center on Reproductive Health and Population Science Peking University

Objective To examine the effect of periconceptional multi‐micronutrient supplementation on gestation and birth *** A population‐based community intervention program was conducted in 18 counties in *** were divided into an intervention group,who received multi‐micronutrient supplementation from at least 3 months before pregnancy throughout the first trimester,and a control *** women were followed up to record information about birth *** socio‐economic characteristics and main birth outcomes were *** age was further analyzed using survival analysis,to determine the time distribution of *** Periconceptional multi‐micronutrient supplementation was associated with higher birth weight,birth length and occipitofrontal head circumference,and with lower incidence rates for stillbirth,low birth weight,and preterm ***,periconceptional multi‐micronutrient supplementation changed the time distribution of delivery,making the deliveries more clustered in the period between day 275 and day 295 of *** Our study shows that periconceptional multi‐micronutrient supplementation is beneficial for fetal development and optimizes all measured aspects of health in neonates in socioeconomically disadvantaged areas in *** change in time distribution of deliveries caused by multi‐micronutrient supplementation needs further clarification.

关键词： Multi‐micronutrient Supplementation Gestation Birth weight Gestational age

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基于类电磁诱导透明效应的极化转换滤波器

物理学报 2024年第18期73卷 261-267页

作者：王哲飞吴杰万发雨曾庆生侯建强傅佳辉吴群宋明歆 Tayeb A.Denidni 南京信息工程大学电子与信息工程学院南京210044 南京航空航天大学航天学院南京210016 西安电子科技大学电子工程学院西安710071 哈尔滨工业大学电子与信息工程学院哈尔滨150001 海南大学应用技术学院儋州571737 魁北克大学国立科学研究院加拿大蒙特利尔H5A1K6

在太赫兹频段基于类电磁诱导透明效应(electromagnetically induced transparency,EIT)提出了一种高效率极化转化滤波器,通过非对称结构激励了多能级明模路径,在传统EIT干涉效应的基础上,获得了正交的圆极化转换窗口.通过两组具有相似... 详细信息

在太赫兹频段基于类电磁诱导透明效应(electromagnetically induced transparency,EIT)提出了一种高效率极化转化滤波器,通过非对称结构激励了多能级明模路径,在传统EIT干涉效应的基础上,获得了正交的圆极化转换窗口.通过两组具有相似共振频率的明模相互干涉产生透射窗口,然后构造非对称结构来实现TE和TM极化下的透射窗口偏移,从而实现双频点极化转换.该超材料的单元结构由4个开口T型金属谐振组成.通过分析表面电流分布、频率响应特性以及入射角特性,探究了其工作机理.研究结果显示,该设计在不同极化下实现了电磁诱导透明现象.随后,基于两个入射极化的EIT共振,在0.692 THz处实现了线极化到右旋圆极化转换和0.782 THz处实现了线极化到左旋圆极化转换,透射系数分别为0.7和0.68.这种基于EIT的极化转化具有低损耗和超薄的特点,在紧凑型天线、衍生雷达相控阵和军事工业探测器领域有潜在应用价值.

关键词：超材料电磁诱导透明效应极化转换滤波器

F-01A,an antibiotic,inhibits lung cancer cells proliferation

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Chinese Journal of Natural Medicines 2014年第4期12卷 284-289页

作者： WANG Jing WU Xiao-Peng song xin-ming HAN Chang-Ri CHEN Zhong CHEN Guang-Ying Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education Hainan Normal University College of Life Sciences Hainan Normal University Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences

AIM: In an effort to identify novel, small molecules which can affect the proliferation of lung cancer cells, F-01A, a polyether antibiotic isolated from the fermentation broth of Streptomyces was tested. METHOD: F-01A was tested for its antitumor properties on the lung cancer cell line SPC-A-1, at six doses(0.1, 0.5, 1, 2.5, and 5 μmol·L-1), using various cellular assays. Cell viability was measured by the MTT assay, Hochest 33258 was used to study nuclear morphology; DNA ladder and the loss of mitochondrial membrane potential were also evaluated. RESULTS: F-01A induces apoptosis against SPC-A-1 cells in a dose-dependent manner. The IC50 is 0.65 μmol·L-1, and the inhibition at 5 μmol·L-1 is 87.89%. Further, JC-1 staining indicates F-01A could induce the loss of mitochondrial membrane potential, and the DNA fragment is evident. CONCLUSION: Mechanistic analysis showed that F-01A induced apoptosis of cancer cells probably in the mitochondrial pathway. The antitumor actions of F-01A involve activation of the apoptotic pathway against SPC-A-1 cells, and it may be valuable for further drug development.

关键词： Apoptosis Membrane potential SPC-A-1 cells Polyether antibiotic

Interfacial friction effects on sealing performances of elastomer packer

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Petroleum Science 2024年第3期21卷 2037-2047页

作者： Peng-Cheng Wang ming-Hui Chen Jim Jenkinson Yong-xin song Li Sun Department of Mechanical Engineering University of HoustonHoustonTX77024USA Guren Nanomaterials Suzhou215127JiangsuChina Department of Marine Engineering Dalian Maritime UniversityDalian116026LiaoningChina

Elastomer sealing performance is of critical importance for downhole tools application including the use of fracturing(Frac)plugs during multi-stage hydraulic *** practice sealing performances of such plugs are normally evaluated through pressure tests,and in numerical simulation studies,maximum contact stress,average contact stress and contact length data are used to determine sealing quality between a packer and *** previous studies,the impact of friction forces on sealing performance is often *** work aims to fill this knowledge gap in determining the influence of friction forces on elastomer packer sealing *** first determined the most appropriate constitutive hyperelastic model for the elastomers used in frac *** we compared analytical calculation results with Finite Element Analysis simulation using a simplified tubular geometry and showed the significant influences on interfacial friction on elastomer packer stress distribution,deformation,and contact stress after *** the demonstration of validity of FEA method,we conducted systematic numerical simulation studies to show how the interfacial friction coefficients can affect the maximum contact stress,average contact stress,contact stress distribution,and maximum mises stress for an actual packer used in plug *** addition,we also demonstrated how the groove in a packer can affect packer deformation and evolvement during setting with the consideration of interfacial *** study underscores the critical role that friction forces play in Frac plug performance and provides a new dimension for optimizing packer design by controlling interfacial interactions at the packer contact surfaces.

关键词： Elastomer seal Friction Sealing performance Contact stress

Utilization of human excrement in pre-modern China,its theoretical interpretations and ecological significance

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Soil Ecology Letters 2024年第1期6卷 1-5页

作者： xin-Hao Du Yuan-ming song Ji-An Cai Yong-Guan Zhu Institute for the History of Natural Sciences Chinese Academy of SciencesBeijing 100190China Institute for Cultural Heritage and History of Science&Technology University of Science and Technology BeijingBeijing 100083China Faculty of History Nankai UniversityTianjin 300350China Research Center for Eco Environmental Sciences Chinese Academy of SciencesBeijing 100085China

The use of human excrement as fertilizer is a characteristic of traditional Chinese agriculture..The application of excrement from urban residents in agriculture since the song Dynasty has ensured the cleanliness and hygiene of *** early as the ming Dynasty,the Chinese people defined the principle of fertilizing fields with human excrement from the perspective of *** concept Peri-URban ecosystems(PURE)provides inspiration forurban-rural symbiosis regarding *** use of human excrement in fertilization is a major attribute differentiating the Chinese traditional agriculture from the agriculture in other regions around the *** the fact that the exact record showing that human excrement was used as fertilizer in China emerged in the Western Han Dynasty(B.C.202-A.D.8),such records did not become prevalent until the Southern song Dynasty(A.D.1127-1279).In the ming and Qing eras(A.D.1368-1912),human excrement was even considered"top-class fertilizerand servedas themost essential fertilizerin farmland *** importance of human excrement in the ming and Qing was mainly reflected by farmers'purchase of human excrement from urban *** fertilization practices became increasingly popular during the period,men of letters built a localized theoretical system centering on human *** the use of human excrement had both positive and negative impacts on public health and the ecological environment,the positive overshadowed the negativeas a ***,it is worth pondering on how the utilization of human excrement as an agricultural resource can be improved so that a material cycle system can be rebuilt to re-connect the urban and rural areas.

关键词： excrement fertilizer theorization urban and rural ecology public health

Bearing mechanism of roof and rib support structure in automatically formed roadway and its support design method

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Journal of Central South University 2024年第7期31卷 2467-2487页

作者： JIANG Bei WANG ming-zi WANG Qi xin Zhong-xin xinG Xue-yang DENG Yu-song YAO Liang-di State Key Laboratory for Tunnel Engineering China University of Mining and Technology-BeijingBeijing 100083China Research Center of Geotechnical and Structural Engineering Shandong UniversityJi􀆳nan 250061China College of Civil Engineering and Architecture Shandong University of AeronauticsBinzhou 256600China

Non-pillar mining technology with automatically formed roadway is a new mining method without coal pillar reservation and roadway *** stability control of automatically formed roadway is the key to the successful application of the new *** order to realize the stability control of the roadway surrounding rock,the mechanical model of the roof and rib support structure is established,and the influence mechanism of the automatically formed roadway parameters on the compound force is *** this basis,the roof and rib support structure technology of confined lightweight concrete is proposed,and its mechanical tests under different eccentricity are carried *** results show that the bearing capacity of confined lightweight concrete specimens is basically the same as that of ordinary confined concrete *** bearing capacity of confined lightweight concrete specimens under different eccentricities is 1.95 times higher than those of U-shaped steel *** comparing the test results with the theoretical calculated results of the confined concrete,the calculation method of the bearing capacity for the confined lightweight concrete structure is *** design method of confined lightweight concrete support structure is established,and is successfully applied in the extra-large mine,Ningtiaota Coal Mine,China.

关键词： automatically roadway with non-pillar confined lightweight concrete roof and rib support mechanical model bearing behaviour