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Prediction of pathological complete response and prognosis in locally advanced rectal cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2520-2530页

作者： Yi-Jun Xu Dan Tao song-Bing Qin Xiao-Yan Xu kai-Wen Yang Zhong-Xu Xing Ju-Ying Zhou Yang Jiao Li-Li Wang Department of Radiation Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Radiation Oncology The Fourth Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina School of Radiation Medicine and Protection Medical College of Soochow UniversitySuzhou 215123Jiangsu ProvinceChina

BACKGROUND Colorectal cancer is currently the third most common malignant tumor and the second leading cause of cancer-related death *** chemoradiotherapy(nCRT)is standard for locally advanced rectal cancer(LARC).Except for pathological examination after resection,it is not known exactly whether LARC patients have achieved pathological complete response(pCR)before *** date,there are no clear clinical indicators that can predict the efficacy of nCRT and patient *** To investigate the indicators that can predict pCR and long-term outcomes following nCRT in patients with *** Clinical data of 128 LARC patients admitted to our hospital between September 2013 and November 2022 were retrospectively *** were categorized into pCR and non-pCR *** analysis(using the χ^(2) test or Fisher’s exact test)and logistic multivariate regression analysis were used to study clinical predictors affecting *** 5-year disease-free survival(DFS)and overall survival(OS)rates were calculated using Kaplan-Meier analysis,and differences in survival curves were assessed with the log-rank *** Univariate analysis showed that pretreatment carcinoembryonic antigen(CEA)level,lymphocyte-monocyte ratio(LMR),time interval between neoadjuvant therapy completion and total mesorectal excision,and tumor size were correlated with *** results showed that CEA≤5 ng/mL(P=0.039),LMR>2.73(P=0.023),and time interval>10 wk(P=0.039)were independent predictors for *** analysis demonstrated that patients in the pCR group had significantly higher 5-year DFS rates(94.7%vs 59.7%,P=0.002)and 5-year OS rates(95.8%vs 80.1%,P=0.019)compared to the non-pCR *** deposits(TDs)were significantly correlated with shorter DFS(P=0.002)and OS(P<0.001).CONCLUSION Pretreatment CEA,LMR,and time interval contribute to predicting nCRT efficacy in LARC *** pCR demonstrates longer DFS and *** correlate with poor pr

关键词： Locally advanced rectal cancer Neoadjuvant chemoradiotherapy Pathological complete response Carcinoembryonic antigen Inflammation-related markers Tumor deposit Prognosis

Modeling and characterization on electroplastic effect during dynamic deformation of 5182-O aluminum alloy

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2455-2475页

作者： Hong-chun shanG song-chen WANG Yan-shan LOU School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China

The coupling effects of electrical pulse,temperature,strain rate,and strain on the flow behavior and plasticity of 5182-O aluminum alloy were investigated and *** isothermal tensile test and electrically-assisted isothermal tensile test were performed at the same temperature,and three typical models were further embedded in ABAQUS/Explicit for numerical simulation to illustrate the electroplastic *** results show that electric pulse reduces the deformation resistance but enhances the elongation *** calibration accuracy of the proposed modified Lim−Huh model for highly nonlinear and coupled dynamic hardening behavior is not much improved compared to the modified Kocks−Mecking ***,the artificial neural network model is very suitable to describe the macromechenical response of materials under the coupling effect of different variables.

关键词： machine learning aluminium alloy electroplastic effect coupling effect finite element analysis

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基于小波分析的大豆叶面积高光谱反演

生态学杂志 2007年第10期26卷 1690-1696页

作者：宋开山张柏王宗明刘殿伟刘焕军杨飞中国科学院东北地理与农业生态研究所长春130012

实测了不同水肥耦合、经营制度及有效营养面积条件下的大豆(Glycinemax)冠层高光谱反射率与叶面积指数(LAI),并对光谱反射率、微分光谱与LAI的关系进行了分析;采用比值植被指数(RVI)与归一化植被指数(NDVI)建立了大豆LAI反演模型;采用... 详细信息

实测了不同水肥耦合、经营制度及有效营养面积条件下的大豆(Glycinemax)冠层高光谱反射率与叶面积指数(LAI),并对光谱反射率、微分光谱与LAI的关系进行了分析;采用比值植被指数(RVI)与归一化植被指数(NDVI)建立了大豆LAI反演模型;采用小波分析对采集的光谱反射率数据进行了能量系数提取,并以小波能量系数作为自变量进行了单变量与多变量回归分析,对大豆LAI进行估算。结果表明:大豆LAI与光谱反射率在可见光波段呈负相关;在近红外波段呈正相关;微分光谱在红边处与大豆LAI密切相关(R2=0.92);RVI与NDVI可以提高大豆LAI的估算精度(R2分别达0.79、0.84);各植被指数各有优缺点,应根据需要进行选择;小波能量系数回归模型可以进一步提高大豆叶面积的估算水平,以一个特定小波能量系数作为自变量的回归模型,大豆LAI回归确定系数R2高达0.884;以4个和6个小波能量系数建立LAI回归分析模型(R2分别达0.92、0.93),2个模型LAI预测值与大豆LAI实测值线性回归确定性系数R2分别为0.90、0.92。比较可知,小波分析可以对高光谱进行特征变量提取,进而反演大豆生理参数,并且反演的LAI精度较光谱反射率、微分光谱及植被指数都有明显提高,小波分析在植被生理参数的高光谱提取方面有着广阔的应用前景。

关键词：高光谱大豆叶面积指数光谱指数小波能量系数

Vaspin alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence

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Emergency and Critical Care Medicine 2024年第1期4卷 4-15页

作者： Haiying Rui Huaxiang Yu Dan Zou kai Chi Ping Xu Xiaoshuai song Lulu Liu Xuting Wu Jinxin Wang Li Xue Department of Emergency Medicine and Chest Pain Center Qilu Hospital of Shandong UniversityJinanShandongChina shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine Institute of Emergency and Critical Care Medicine of Shandong UniversityQilu Hospital of Shandong UniversityJinanShandongChina Key Laboratory of Emergency and Critical Care Medicine of shandong Province Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong ProvinceShandong Provincial Engineering Laboratory for Emergency and Critical Care MedicineQilu Hospital of Shandong UniversityJinanShandongChina The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of EducationChinese Ministry of Health and Chinese Academy of Medical SciencesThe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineQilu Hospital of Shandong UniversityJinanShandongChina.

Background:Visceral adipose tissue-derived serine protease inhibitor(vaspin),a secretory adipokine,protects against insulin *** studies have demonstrated that serum vaspin levels are decreased in patients with coronary artery disease and that vaspin protects against myocardial ischemia-reperfusion injury and ***,it remains unclear whether vaspin exerts specific effects on pathological cardiac ***:An in vivo study was conducted using a cardiac hypertrophy model established by subcutaneous injection of isoproterenol(ISO)in C57BL/6 and vaspin-ko *** was administered intraperitoneally to mice,for further study.H9c2 cells and neonatal rat ventricular myocytes(NRVMs)were treated with ISO to induce *** vaspin fusion protein,the proteasome inhibitor MG132,and chloroquine diphosphate were used for further mechanistic ***:Here,we provide the first evidence that vaspin knockdown results in markedly exaggerated cardiac hypertrophy,fibrosis,and cardiomyocyte senescence in mice treated with ***,the administration of exogenous recombinant human vaspin protected NRVMs in vitro against ISO-induced hypertrophy and ***,vaspin significantly potentiated the ISO-induced decrease in *** rapamycin and chloroquine diphosphate regulated autophagy in vivo and in vitro,respectively,and participated in vaspin-mediated ***,the PI3K-AKT-mTOR pathway plays a critical role in vaspin-mediated autophagy in cardiac tissues and *** data showed that vaspin downregulated the p85 and p110 subunits of PI3K by linking p85 and p110 to NEDD4L-mediated ubiquitination ***:Our results show,for the first time,that vaspin functions as a critical regulator that alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence,providing potential preventive and therapeutic targets for pathological cardiac hyper

关键词： Autophagic flux Myocardial senescence Pathological cardiac hypertrophy Ubiquitination Vaspin

Oxidation Mechanism and Toxicity Evolution of Linalool,a Typical Indoor Volatile Chemical Product

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Environment & Health 2024年第7期2卷 486-498页

作者： Zihao Fu song Guo Ying Yu Hong-Bin Xie Shiyu Li Daqi Lv Putian Zhou kai song Zheng Chen Rui Tan Kun Hu Ruizhe Shen Maosheng Yao Min Hu State Key Joint Laboratory of Environmental Simulation and Pollution Control International Joint Laboratory for Regional Pollution ControlMinistry of Education(IJRC)College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Nanjing University of Information Science&TechnologyNanjing 210044China Key Laboratory of Industrial Ecology and Environmental Engineering(Ministry of Education) School of Environmental Science and TechnologyDalian University of TechnologyDalian 116024China Institute for Atmospheric and Earth System Research/Physics Faculty of ScienceUniversity of HelsinkiP.O.Box 64FIN-00014 HelsinkiFinland

Linalool,a high-reactivity volatile chemical product(VCP)commonly found in cleaning products and disinfectants,is increasingly recognized as an emerging contaminant,especially in indoor *** the gas-phase oxidation mechanism of linalool is crucial for assessing its impact on atmospheric chemistry and human *** quantum chemical calculations and computational toxicology simulations,we investigated the atmospheric transformation and toxicity evolution of linalool under low and high NO/HO_(2·)levels,representing indoor and outdoor *** findings reveal that linalool can undergo the novel mechanisms involving concerted peroxy(RO_(2·))and alkoxy radical(RO·)modulated autoxidation,particularly emphasizing the importance of cyclization reactions *** expands the widely known RO_(2·)-dominated H-shift-driven autoxidation and proposes a generalized autoxidation mechanism that leads to the formation of low-volatility secondary organic aerosol(SOA)*** analysis shows that over half of transformation products(TPs)exhibited higher carcinogenicity and respiratory toxicity compared to *** also propose time-dependent toxic effects of TPs to assess their long-term *** results indicate that the strong indoor emission coupled with slow consumption rates lead to significant health risks under an indoor *** results highlight complex indoor air chemistry and health concerns regarding persistent toxic products during indoor cleaning,which involves the use of linalool or other VCPs.

关键词： volatile chemical products(VCPs) peroxy radicals(RO_(2·)) atmospheric autoxidation secondary organic aerosol(SOA) computational toxicology

Trade-offs between the accumulation of cuticular wax and jasmonic acid-mediated herbivory resistance in maize

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Journal of Integrative Plant Biology 2024年第1期66卷 143-159页

作者： Jiong Liu Lu Li Zhilong Xiong Christelle AMRobert Baozhu Li shan He Wenjie Chen Jiasheng Bi Guanqing Zhai Siyi Guo Hui Zhang Jieping Li Shutang Zhou Xi Zhang Chun‐Peng song School of Life Sciences Henan UniversityKaifeng 475004China State Key Laboratory of Crop Stress Adaptation and Improvement Henan UniversityKaifeng 475004China State Key Laboratory of Cotton Bio‐Breeding and Integrated Utilization Henan UniversityKaifeng 475004China Sanya Institute of Henan University Sanya 572025China Institute of Plant Sciences University of BernBern 3013Switzerland

Plants have evolved complex physical and chemical defense systems that allow them to withstand herbivory *** of a complex mixture of very-long-chain fatty acids(VLCFAs)and their derivatives,cuticular wax constitutes the first physical line of defense against ***,we report the function of Glossy 8(ZmGL8),which encodes a 3-ketoacyl reductase belonging to the fatty acid elongase complex,in orchestrating wax production and jasmonic acid(JA)-mediated defenses against herbivores in maize(Zea mays).The mutation of GL8 enhanced chemical defenses by activating the JA-dependent *** observed a trade-off between wax accumulation and JA levels across maize glossy mutants and 24 globally collected maize inbred *** addition,we demonstrated that mutants defective in cuticular wax biosynthesis in Arabidopsis thaliana and maize exhibit enhanced chemical *** transcriptomic and lipidomic analyses indicated that the gl8 mutant confers chemical resistance to herbivores by remodeling VLCFA-related lipid metabolism and subsequent JA biosynthesis and *** results suggest that VLCFA-related lipid metabolism has a critical role in regulating the trade-offs between cuticular wax and JA-mediated chemical defenses.

关键词： cuticular wax fall armyworm herbivore resistance jasmonic acid maize plant-herbivore interactions

Combined Effect of Outdoor Time and Other Modifiable Factors on Myopia Incidence Among Children and Adolescents—9 PLADs,China,2020

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China CDC weekly 2024年第9期6卷 151-156,I0001,I0002页

作者： Panliang Zhong Yunfei Liu Ning Ma Jiajia Dang Di Shi shan Cai Ziyue Chen Yanhui Dong Peijin Hu Jun Ma Patrick W.C Lau Randall S.Stafford Yi song Institute of Child and Adolescent Health School of Public HealthPeking UniversityNational Health Commission Key Laboratory of Reproductive HealthBeijingChina Department of Sport Physical Education&HealthHong Kong Baptist UniversityKowloon TongHong Kong Special Administrative RegionChina Department of Medicine Stanford Prevention Research CenterStanford University School of MedicineStanfordCAUnited States

Summary What is already known about this topic?Myopia has been identified as a significant emerging challenge and policy priority among children and adolescents in China by the Ministry of Education and seven other *** research has been conducted to investigate the collective impact of outdoor time and other modifiable factors on the incidence of myopia.

关键词： Incidence collective policy

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基于反射光谱特性的土壤分类研究

光谱学与光谱分析 2008年第3期28卷 624-628页

作者：刘焕军张柏张渊智宋开山王宗明李方胡茂桂中国科学院东北地理与农业生态研究所吉林长春130012 中国科学院研究生院北京100039 香港中文大学太空与地球信息科学研究所中国香港新界沙田

选取中国松嫩平原吉林省农安县主要土壤(黑土、黑钙土、草甸土、风砂土、冲积土)室内光谱反射率作为研究对象,利用去包络线方法提取反射光谱特征指标,作为输入变量建立BP神经网络模型,进行土壤分类研究,探索利用表层土壤反射光谱特性进... 详细信息

选取中国松嫩平原吉林省农安县主要土壤(黑土、黑钙土、草甸土、风砂土、冲积土)室内光谱反射率作为研究对象,利用去包络线方法提取反射光谱特征指标,作为输入变量建立BP神经网络模型,进行土壤分类研究,探索利用表层土壤反射光谱特性进行土壤分类的可行性。结果表明:(1)包络线去除后的曲线使土壤可见光近红外波段的吸收特征显著增强;农安县不同土壤在400～2500nm范围内主要有5个光谱吸收谷,前2个吸收谷主要是由于土壤有机质、铁及土壤机械组成引起的,后3个是土壤水分吸收光谱能量引起的;不同土壤类型反射光谱的差异主要表现在前2个吸收谷。(2)由于输入变量的选取客观准确,基于前2个吸收谷形状特征的BP神经网络模型的土壤分类精度显著优于以反射率或5个吸收谷形状特征为输入变量的模型,可以用于土壤分类。

关键词：反射光谱土壤分类去包络线高光谱

利用SEBAL模型与P-M公式估算乌裕尔河下游地表蒸散

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干旱地区农业研究 2009年第5期27卷 216-224,234页

作者：曾丽红宋开山张柏王宗明杜嘉中国科学院东北地理与农业生态研究所吉林长春130012 中国科学院研究生院北京100049

先通过SEBAL模型估算了乌裕尔河下游沼泽旱地交错区1992年7月9日、1994年7月15日、1995年7月18日、1999年7月13日4个时相的日蒸散量,并通过P-M公式与作物系数进行时间尺度扩展得到了这4个时相所处月份的蒸散量,最后对日蒸散量、作物系... 详细信息

先通过SEBAL模型估算了乌裕尔河下游沼泽旱地交错区1992年7月9日、1994年7月15日、1995年7月18日、1999年7月13日4个时相的日蒸散量,并通过P-M公式与作物系数进行时间尺度扩展得到了这4个时相所处月份的蒸散量,最后对日蒸散量、作物系数、月蒸散量的特征及其影响因素进行分析。结果表明:日蒸散量的频率分布图呈双峰结构,分别体现了旱地的蒸散特征、湿地与水体的蒸散特征;平均日蒸散量依照1994-07-15、1999-07-13、1995-07-18、1992-07-09的顺序依次降低;时相1994-07-15的平均日蒸散量与平均作物系数最高;通过逐步回归分析发现日平均风速、日照时数、日最低气温对参考作物日蒸散量的影响较为明显。

关键词：遥感蒸散 SEBAL P—M公式作物系数