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Exosomal PD-L1: an effective liquid biopsy target to predict immunotherapy response

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National Science Review 2019年第6期6卷 1103-1104页

作者： yanling song Lingling Wu Chaoyong Yang Institute of Molecular Medicine Renji HospitalSchool of Medicine Shanghai Jiao Tong University MOE Key Laboratory of Spectrochemical Analysis & Instrumentation Key Laboratory for Chemical Biology of Fujian Province State Key Laboratory of Physical Chemical of Solid Surfaces College of Chemistry and Chemical Engineering Xiamen University

Up-regulation of programmed deathligand 1(PD-L1) may allow cancer cells to evade the host immune system by recognizing the immune checkpoint programmed death-1(PD-1) on T cells to promote self-tolerance by suppressing T-cell inflammatory activity [1]. Blocking the interaction between PD-L1 and PD-1 has positive anti-tumor effects [2].

关键词： Exosomal PD-L1 an effective liquid biopsy target to predict immunotherapy response

Life history pattern and fitness of an endangered Hainan Eld’s deer population

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Integrative Zoology 2011年第1期6卷 63-70页

作者： Haiyan NIE yanling song Zhigao ZENG Qiong ZHANG Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijingChina College of Life Science and Technology Central South University of Forestry and TechnologyChangshaChina

Understanding life history patterns,individual fitness and population fitness can assist with conservation of endangered *** data on life history traits(*** specific fecundity,age specific mortality,age at first reproduction,litter size and adult life expectancy)were collected from 121 Hainan Eld’s deer(Cervus eldi hainanus Thomas,1918),an in situ herd of an endemic,rare and endangered cervid inhabiting Bangxi Natural Reserve of Hainan Island,from 1990 to ***,we constructed a dynamic life table to analyze the life history pattern of the population,which showed that the difference between the average lifespan of males and females was not significant(P>0.05),and that the difference between the average lifespan of the whole Hainan Eld’s deer population and that of other Eld’s deer populations living in South Asia(P>0.05),North America(P>0.05)and Europe(P>0.05)was not ***,we used individual reproductive success or number of offspring of a male over its lifetime to estimate male individual *** analysis showed that male individual fitness was not significantly correlated with total antler velvet ***,we used the population intrinsic rate of increase to measure population fitness,and population fitness of Hainan Eld’s deer was compared with similar indexes of 5 other cervid *** Eld’s deer population fitness index was 0.012,the second lowest value relative to other *** indicated that this rare species is still endangered and is in need of additional protection.

关键词： Cervus eldi hainanus conservation fitness Hainan Eld’s deer life history pattern

Important population viability analysis parameters for giant pandas(Aliuropoda melanoleuca)

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Zoological Research 2012年第3期33卷 18-24页

作者： Minghao GONG yanling song Zhisong YANG Chen LIN Wildlife Monitoring Centre Academy of Forest Inventory and PlanningState Forestry AdministrationBeijing 100714China Institute of Zoology the Chinese Academy of SciencesBeijing 100101China Institute of Rare Animals and Plants China West Normal UniversityNanchong 637002China

Population viability analysis(PVA)is a tool to evaluate the risk of extinction for endangered species and aid conservation *** quality of PVA output is dependent on parameters related to population dynamics and life-history;however,it has been difficult to collect this information for the giant panda(Aliuropoda melanoleuca),a rare and endangered mammal native to China,confined to some 30 fragmented habitat *** giant pandas are long-lived,mature late,have lower reproductive rates,and show little sexual dimorphism,obtaining data to perform adequate PVA has been ***,we develop a parameter sensitivity index by modeling the dynamics of six giant panda populations in the Minshan Mountains,in order to determine the parameters most influential to giant panda *** data shows that the giant panda populations are most sensitive to changes in four female parameters:initial breeding age,reproductive rate,mortality rate between age 0 and 1,and mortality rate of *** parameter sensitivity index strongly correlated with initial population size,as smaller populations were more sensitive to changes in these four *** model suggests that demographic parameters of females have more influence on the results of PVA,indicating that females may play a more important role in giant panda population dynamics than ***,reintroduction of female individuals to a small giant panda population should be a high priority for conservation *** findings form a technical basis for the coming program of giant panda reintroduction,and inform which parameters are crucial to successfully and feasibly monitoring wild giant panda populations.

关键词： Giant panda PVA Population parameter Parameter sensitivity index

Rut-induced changes in the activity budgets of male tropical ungulates： Eld＇s deer on Hainan Island

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Current Zoology 2012年第4期58卷 536-540页

作者： Jianhua DING Zhitao LIU yanling song Zhigao ZENG Qiong ZHANG Benjamin D.BRAVERY Anhui Key Laboratory of Resource and Plant Biology School of Life SciencesHuaibei Normal UniversityHuaibei 235000ER.China Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China School of Life Sciences Harbin Normal UniversityHarbin 150025China

Aspects of time budgets, activity patterns and rut-related changes in behavior are well documented in temperate un-gulates; however, the application of this understanding to tropical and sub-tropical ungulate species has attracted less attention and remains an area that may re-shape our knowledge of ungulate behavior. Eld＇s deer Cervus eldi hainanus has a tropical and sub-tropical distribution on Hainan Island, China, and males have an extended rut exceeding five months during which they do not maintain harems or defend resources. We studied males from the only remaining population on Hainan Island, and describe rut-related changes in behavior by collecting data on time budgets and activity patterns. We show that male Eld＇s deer do not fol- low a strict crepuscular activity pattern, do not spend the majority of their time foraging and do not increase foraging nor display rut-induced hypophagia during rut, in obvious contrast to temperate ungulates. These results are discussed in light of current hy- potheses explaining the proximate mechanisms governing feeding time in ungulates, while appreciating the need for further re-search .

关键词： Activity Cervus eldi hainanus Eld's deer Rut Time budget Tropical ungulate

Nano transdermal system combining mitochondria-targeting cerium oxide nanoparticles with all-trans retinoic acid for psoriasis

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Asian Journal of Pharmaceutical Sciences 2023年第5期18卷 112-124页

作者： Wei Wang Xinyi Xu yanling song Lan Lan Jun Wang Xinchang Xu Yongzhong Du Department of Pharmacy Hangzhou Third People’s HospitalAffiliated Hangzhou Dermatology HospitalZhejiang University School of MedicineHangzhou 310009China College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China Department of Dermatology Affiliated Hangzhou Dermatology HospitalZhejiang University School of MedicineHangzhou 310009China Innovation Center of Translational Pharmacy Jinhua Institute of Zhejiang UniversityJinhua 321299China

Psoriasis is an inflammatory skin disease that is intricately linked to oxidative *** and inhibition of abnormal proliferation of keratinocytes are pivotal strategies for *** drugs with these effects to the site of skin lesions is a challenge that needs to be ***,we reported a nanotransdermal delivery system composed of all-trans retinoic acid(TRA),triphenylphosphine(TPP)-modified cerium oxide(CeO2)nanoparticles,flexible nanoliposomes and gels(TCeO_(2)-TRA-FNL-Gel).The results revealed that TCeO_(2)synthesized by the anti-micelle method,with a size of approximately 5 nm,possessed excellent mitochondrial targeting ability and valence conversion capability related to scavenging reactive oxygen species(ROS).TCeO_(2)-TRA-FNL prepared by the film dispersion method,with a size of approximately 70 nm,showed high drug encapsulation efficiency(>96%).TCeO_(2)-TRA-FNL-Gel further showed sustained drug release behaviors,great transdermal permeation ability,and greater skin retention than the free *** results of in vitro EGF-induced and H2O2-induced models suggested that TCeO_(2)-TRA-FNL effectively reduced the level of inflammation and alleviated oxidative stress in HaCat *** results of in vivo imiquimod(IMQ)-induced model indicated that TCeO_(2)-TRA-FNL-Gel could greatly alleviate the psoriasis *** summary,the transdermal drug delivery system designed in this study has shown excellent therapeutic effects on psoriasis and is prospective for the safe and accurate therapy of psoriasis.

关键词： Psoriasis Cerium oxide nanoparticles All-trans retinoic acid Flexible nanoliposomes Transdermal delivery

Habitat Utilization of the Golden Takin During Later Autumn and Winter in Foping National Nature Reserve

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生物多样性 1995年第B6期3卷 73-78页

作者： song yanling YU YUQUN GONG HUISHENG ZHANG SHANNING Institute of Zoology Academia Sinica. Beijing 100080 Zoological Institute of Shaanxi. Xian 710032 Foping National Nature Reserve Foping shaanxi 723400

Integrated microfluidic devices for in vitro diagnostics at point of care

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Aggregate 2022年第5期3卷 130-143页

作者： Dan Liu YingWang Xingrui Li Mengmeng Li Qiaoyi Wu yanling song Zhi Zhu Chaoyong Yang Engineering Research Centre of Molecular Medicine of Ministry of Education Key Laboratory of Fujian Molecular MedicineKey Laboratory of Precision Medicine and Molecular Diagnosis of Fujian UniversitiesKey Laboratory of Xiamen Marine and Gene DrugsSchool of Biomedical SciencesHuaqiao UniversityFujianChina Xinjiang Key Laboratory of Biological Resources and Genetic Engineering College of Life Science and TechnologyXinjiang UniversityUrumqiChina The Department of Emergency Surgery The First Affiliated Hospital of Fujian Medical UniversityFujianChina The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation The Key Laboratory of Chemical Biology of Fujian ProvinceState Key Laboratory of Physical Chemistry of Solid SurfacesCollaborative Innovation Center of Chemistry for Energy MaterialsDepartment of Chemical BiologyCollege of Chemistry and Chemical EngineeringXiamen UniversityFujianChina

Given the continuous and growing demand for point of care(POC)diagnostic tests,attention has been shifted toward integration and miniaturization of laboratory protocols into“sample-in-answer-out”*** technologies have been considered an ideal solution to address the requirements of POC diagnostics since many laboratory functions can be miniaturized and incorporated onto a single integrated *** this review,we summarize the advances of integrated microfluidic devices for POC diagnostics in the last 3 ***,we summarize current materials used for microfluidic chip fabrication,discuss the innovation of versatile integrated microfluidic devices,especially the strategies for simplifying sample preparation in manual or self-driven systems,and new detection methods of microfluidic *** addition,we describe new integrated microfluidic devices for POC diagnostics of protein-targeted immunodiagnostics,nucleic acid molecular tests,and small molecule metabolites *** also provide future perspectives and current challenges for clinical translation and commercialization of these microfluidic technologies.

关键词： in vitro diagnostics microﬂuidic devices point of care

Crosstalk-free colloidosomes for high throughput single-molecule protein analysis

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Science China Chemistry 2020年第10期63卷 1507-1514页

作者： Kun Yin Xi Zeng Xuan Liang Haopai Wei Huimin Zeng Wei Qi Weidong Ruan yanling song Chaoyong Yang Zhi Zhu The Key Laboratory of Chemical Biology of Fujian Province the MOE Key L aboratory of Spectrochemical Analysis&InstrumentationState Key Laboratory of Physical Chemistry of Solid SurfacesCollaborative Innovation Center of Chemistry for Energy MaterialsDepartment of Chemical EngineeringDepartment of Chemical BiologyCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China

Droplet microfluidics is a powerful platform for high-throughput single-molecule protein ***,the issues of coalescence and crosstalk of droplets compromise the accuracy of detection and hinder its wide *** address these limitations,a novel colloidosome-based method was presented by combining a Pickering emulsion with droplet microfluidics for single-molecule protein *** the self-assembly of easily synthesized colloidal surfactant F-SiO2 NPs at the water/oil interface,the colloidosomes are rigidly stabilized and can effectively avoid the leakage of fluorescent *** crosstalk-free colloidosomes enable high-throughput single-molecule protein analysis,including heterogenous dynamic studies and digital *** a robust and accurate method,colloidosome-based microfluidics is promising as a powerful tool for a wide variety of applications,such as directed enzyme evolution,digital enzyme-linked immunosorbent assay(ELISA),and screening of antibiotics.

关键词： colloidosomes droplet microfluidics crosstalk-free single-molecule analysis protein detection

Effects of Drought on Winter Wheat Yield in North China During 2012-2100

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Acta meteorologica Sinica 2012年第4期26卷 516-528页

作者：宋艳玲赵艳霞 National Climate Center China Meteorological Administration Chinese Academy of Meteorological Sciences China Meteorological Administration

Winter wheat is one of China＇s most important staple food crops, and its production is strongly influenced by weather, especially droughts. As a result, the impact of drought on the production of winter wheat is associated with the food security of China. Simulations of future climate for scenarios A2 and AIB provided by GFDL-CM2, MPI_ECHAM5, MRI_CGCM2, NCAR_CCSM3, and UKMO_HADCM3 during 2001- 2100 are used to project the influence of drought on winter wheat yields in North China. Winter wheat yields are simulated using the crop model WOFOST （WOrld FOod STudies）. Future changes in temperature and precipitation are analyzed. Temperature is projected to increase by 3.9-5.5 ℃ for scenario A2 and by 2.9-5.1 ℃ for scenario A1B, with fairly large interannual variability. Mean precipitation during the growing season is projected to increase by 16.7 and 8.6 mm （10 yr）-1, with spring precipitation increasing by 9.3 and 4.8 mm （10 yr）-1 from 2012 2100 for scenarios A2 and AIB, respectively. For the next 10-30 years （2012- 2040）, neither the growing season precipitation nor the spring precipitation over North China is projected to increase by either scenario. Assuming constant winter wheat varieties and agricultural practices, the influence of drought induced by short rain on winter wheat yields in North China is simulated using the WOFOST crop model. The drought index is projected to decrease by 9.7% according to scenario A2 and by 10.3% according to scenario A1B during 2012 2100. This indicates that the drought influence on winter wheat yields may be relieved over that period by projected increases in rain and temperature as well as changes in the growth stage of winter wheat. However, drought may be more severe in the near future, as indicated by the results for the next 10 30 years.

关键词： drought climate change winter wheat North China