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Gastric mucosal precancerous lesions in Helicobacter pyloriinfected pediatric patients in central China:A single-center,retrospective investigation

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World Journal of Gastroenterology 2022年第28期28卷 3682-3694页

作者： Miao Yu Jing Ma xiao-xia song Qiao-Qiao Shao Xue-Chun Yu Muhammad Noman Khan Ya-Bin Qi Ruo-Bing Hu Pei-Ru Wei Wei xiao Bai-Ling Jia Yan-Bo Cheng Ling-Fei Kong Chuan-Liang Chen song-Ze Ding Department of Gastroenterology and Hepatology People’s Hospital of Zhengzhou UniversityHenan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Pathology People’s Hospital of Zhengzhou UniversityHenan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Pediatrics People’s Hospital of Zhengzhou UniversityHenan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Medical Imaging People’s Hospital of Zhengzhou UniversityHenan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina

BACKGROUND Helicobacter pylori(***)infects about 50%of the world population and is the major cause of chronic gastritis,peptic ulcers,and gastric *** *** infection induces gastric mucosal precancerous lesions mostly in adulthood,and it is debatable whether these pathological conditions can occur in childhood and adolescents as *** this is a critical issue to determine if intervention should be offered for this population group,we investigated the gastric mucosal precancerous lesions in pediatric patients in an area in central China with a high prevalence of *** and gastric *** To investigate the relationship of *** infection and gastric mucosal precancerous lesions in children and adolescents in central *** We screened 4258 ward-admitted children and adolescent patients with upper gastrointestinal symptoms,and finally enrolled 1015 pediatric patients with *** infection and endoscopic and histological *** infection status was determined by rapid urease test and histopathological *** clinical and pathological data were collected and analyzed *** of gastric mucosal precancerous lesions,inflammatory activity and degree of inflammatory cell infiltration between ***-positive and-negative groups were *** Among the 1015 eligible children and adolescents,the overall *** infection rate was 84.14%(854/1015).The infection rate increased with *** incidence of gastric mucosal precancerous lesions in ***-infected children was 4.33%(37/854),which included atrophic gastritis(17 cases),intestinal metaplasia(11 cases)and dysplasia(9 cases).In ***-negative patients,only 1 atrophic gastritis case[0.62%,(1/161)]was found(P<0.05).Active inflammation in *** patients was significantly higher than that in non-infected patients,and the *** group showed more severe lymphocyte and neutrophil granulocyte infiltration(P<0.001).In

关键词： Helicobacter pylori Gastric cancer Precancerous lesions Inflammation Children and adolescents

SLC6A14 promotes ulcerative colitis progression by facilitating NLRP3 inflammasome-mediated pyroptosis

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World Journal of Gastroenterology 2024年第3期30卷 252-267页

作者： Qing Gu Huan xia Yue-Qiong song Jun Duan Yun Chen You Zhang He-Ping Chen Li Zhang Department of Elderly Digestive Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalUniversity of Electronic Science and TechnologyChengdu 610072Sichuan ProvinceChina Geriatrics Research Institute Sichuan Provincial People’s HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Ulcerative colitis(UC)is an inflammatory condition with frequent relapse and *** suggests the involvement of SLC6A14 in UC pathogenesis,but the central regulator remains *** To explore the role of SLC6A14 in UC-associated *** Quantitative real-time polymerase chain reaction(qRT-PCR),immunoblotting,and immunohistochemical were used to assess SLC6A14 in human UC ***(LPS)was used to induce inflammation in FHC and NCM460 cells and model enteritis,and SLC6A14 levels were *** markers were quantified using enzyme-linked immunosorbent assay,Western blotting,and qRT-PCR,and EdU incubation,CCK-8 assays and flow cytometry were used to examine proliferation and *** models of UC were used for *** SLC6A14 was increased and correlated with NLRP3 in UC ***-induced FHC and NCM460 cells showed increased SLC6A14 *** SLC6A14 increased cell proliferation and suppressed *** SLC6A14 decreased pyroptosis-associated proteins(ASC,IL-1β,IL-18,NLRP3).NLRP3 overexpression counteracted the effects of sh-SLC6A14 on LPS-induced FHC and NCM460 cell ***6A14 improved the mucosa in mice with dextran sulfate sodium-induced *** SLC6A14 promotes UC pyroptosis by regulating NLRP3,suggesting the therapeutic potential of modulating the SLC6A14/NLRP3 axis.

关键词： Ulcerative colitis SLC6A1 NLRP3 Pyroptosis Inflammasome

METTL1 promotes colorectal cancer cell proliferation by attenuating CHEK2-induced G1/S phase arrest

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Genes & Diseases 2024年第2期11卷 579-581页

作者： Houxiang Jiang Ying Liu Huibin song Jinquan xia Ying Tian Luolin Wang Mingwei Li Zhenyu Xu Zhenglei Xu Chang Zou Department of Gastrointestinal Surgery The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)WuhuAnhui 241001China Anhui Province Clinical Research Center for Critical Respiratory Medicine WuhuAnhui 241001China Department of Clinical Medical Research Center The Second Clinical Medical College (Shenzhen People's Hospital) of Jinan UniversityThe First Affiliated Hospital of Southern University of Science and TechnologyShenzhenGuangdong 518020China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhouGuangdong 510632China School of Pharmacy Southwest Medical UniversityLuzhouSichuan 646000China Department of Gastroenterology Shenzhen People's Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdong 518020China Precision Medicine Center The First Affiliated Hospital of Wannan Medical College(Yijishan Hospital of Wannan Medical College)WuhuAnhui 241001China School of Medicine Life and Health SciencesThe Chinese University of Hong KongShenzhenGuangdong 518172China

Colorectal carcinoma(CRC),the third most commonly diagnosed cancer,accounts for 9.7%of all newly diagnosed cancer cases and 9.4%of cancer-related deaths globally.1 Recent studies have demonstrated that post-transcriptional RNA modifications,such as N^(6)-methyladenosine,N^(5)-methylcytosine,and N^(7)-methylguanosine,play critical roles in the regulation of mRNA stability and translation,primary microRNA processing,and lncRNA-protein complex that contributes to the progression of human cancer.

关键词： cancer colorectal globally

鄱阳湖流域南昌湖区农业面源污染现状及控制策略

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能源研究与管理 2024年第1期16卷 49-55,75页

作者：刘勇夏嵩闫冰詹聪聂含冰桂双林李荣富魏源送张洪吴勇明江西省科学院能源研究所南昌330096 江西省碳中和研究中心南昌330096 江西省科学院微生物研究所南昌330029 中国科学院生态环境研究中心水污染控制实验室北京100085 南昌市生态环境局南昌330199

农业面源污染治理是我国“十四五”重点流域水环境综合治理中的重要组成部分,为了解析鄱阳湖流域农业面源污染特征与时空分布情况,推进区域内农业面源污染治理工作的落实开展,以鄱阳湖流域南昌湖区为研究对象,通过资料收集、实地考察以... 详细信息

农业面源污染治理是我国“十四五”重点流域水环境综合治理中的重要组成部分,为了解析鄱阳湖流域农业面源污染特征与时空分布情况,推进区域内农业面源污染治理工作的落实开展,以鄱阳湖流域南昌湖区为研究对象,通过资料收集、实地考察以及数据分析等方法,系统地统计了2020年度鄱阳湖流域南昌湖区五大国控断面汇水区域内的农村生活污水、农业种植、畜禽养殖、水产养殖四大农业面源污染产生的入湖污染负荷,分析了南昌湖区不同农业面源类型污染特征以及入湖污染物的空间分布情况。结果表明:农村生活污水污染主要集中在青岚湖、金溪咀刘家和伍湖分场3个国控断面汇水区域,农业种植面源污染主要集中于青岚湖国控断面汇水区域,畜禽养殖污染绝大部分集中在青岚湖、金溪咀刘家国控断面汇水区域,水产养殖污染主要集中在金溪咀刘家、南矶山国控断面汇水区域;其中青岚湖和金溪咀刘家区域内的农业面源污染是南昌湖区亟需治理的重点,COD、NH_(4)^(+)-N、TN、TP产生量分别占据5个国控断面农业面源污染总量的78.6%、66.7%、70.9%和69.0%。

关键词：鄱阳湖农业面源污染国控断面水环境质量防治策略

Inorganic nitrogen removal of toilet wastewater with an airlift external circulation membrane bioreactor

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Journal of Environmental Sciences 2007年第1期19卷 12-17页

作者： LI Gang WU Lin-lin DONG Chun-song WU Guang-xia FAN Yao-bo Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Removal of inorganic nitrogen （inorganic-N） from toilet wastewater, using a pilot-scale airlift external circulation membrane bioreactor （AEC-MBR） was studied. The results showed that the use of AEC-MBR with limited addition of alkaline reagents and volumetric loading rates of inorganic-N of 0.19-0.40 kg inorganic-N/（m^3·d） helped achieve the desired nitrification and denitrification. Furthermore, the effects of pH and dissolved oxygen （DO） on inorganic-N removal were examined. Under the condition of MLSS at 1.56-2.35 g/L, BODs/ammonia nitrogen （NH4＋-N） at 1.0, pH at 7.0-7.5, and DO at 1.0-2.0 mg/L, the removal efficiencies of NH4^＋-N and inorganic-N were 91.5% and 70.0%, respectively, in the AEC-MBR. The cost of addition of alkaline reagent was approximately 0.5-1.5 RMB yuan/m^3, and the energy consumption was approximately 0.72 kWh/m^3 at the flux of 8 L/（m^2-h）.

关键词： inorganic nitrogen removal treatment of wastewater from toilet airlift external circulation membrane bioreaetor (AECMBR) membrane bioreactor (MBR)

An Elliptic Centerness for Object Instance Segmentation in Aerial Images

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Journal of Remote Sensing 2022年第1期2022卷 182-195页

作者： Yixin Luo Jiaming Han Zhou Liu Mi Wang Gui-song xia LIESMARS Wuhan UniversityWuhanChina School of Computer Science Wuhan UniversityWuhanChina

Instance segmentation in aerial images is an important and challenging *** of the existing methods have adapted instance segmentation algorithms developed for natural images to aerial ***,these methods easily suffer from performance degradation in aerial images,due to the scale variations,large aspect ratios,and arbitrary orientations of instances caused by the bird’s-eye view of aerial *** address this issue,we propose an elliptic centerness(EC)for instance segmentation in aerial images,which can assign the proper centerness values to the intricate aerial instances and thus mitigate the performance ***,we introduce ellipses to fit the various contours of aerial instances and measure these fitted ellipses by two-dimensional anisotropic Gaussian *** with EC,we develop a one-stage aerial instance segmentation *** experiments on a commonly used dataset,the instance segmentation in aerial images dataset(iSAID),demonstrate that our proposed method can achieve a remarkable performance of instance segmentation while introducing negligible computational cost.

关键词： instance negligible fitted

Field test of high-power microwave-assisted mechanical excavation for deep hard iron ore

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 1922-1935页

作者： Feng Lin xia-Ting Feng Shiping Li xiao Hai Jiuyu Zhang xiangxin Su Tianyang Tong Jianchun song Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang110819China Benxi Longxin Mining Corporation Limited Benxi117000China

Microwave-assisted mechanical excavation has great application prospects in mines and tunnels,but there are few field experiments on microwave-assisted rock *** paper takes the Sishanling iron mine as the research object and adopts the self-developed high-power microwave-induced fracturing test system for hard rock to conduct field experiments of microwave-induced fracturing of iron *** heating and reflection evolution characteristics of ore under different microwave parameters(antenna type,power,and working distance)were studied,and the optimal microwave parameters were ***,the ore was irradiated with the optimal microwave parameters,and the cracking effect of the ore under the action of the high-power open microwave was *** results show that the reflection coefficient(standing wave ratio)can be rapidly(<5 s)and automatically adjusted below the preset threshold value(1.6)as microwave irradiation is *** using a right-angle horn antenna with a working distance of 5 cm,the effect of automatic reflection adjustment reaches the best among other antenna types and working *** the working distance is the same,the average temperature of the irradiation surface and the area of the high-temperature area under the action of the two antennas(right-angled and equal-angled horn antenna)are basically the same and decrease with the increase of working *** optimal microwave parameters are:a right-angle horn antenna with a working distance of 5 ***,in further experiments,the optimal parameters were used to irradiate for 20 s and 40 s at a microwave power of 60 kW,*** surface damage extended 38 cm×30 cm and 53 cm×30 cm,respectively,and the damage extended to a depth of about 50 *** drilling speed was increased by 56.2%and 66.5%,respectively,compared to the case when microwaves were not used.

关键词： Microwave parameters High power Field experiment Mechanical mining

Analysis of choroidal morphology and comparison of imaging findings of subtypes of polypoidal choroidal vasculopathy:a new classification system

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 731-736页

作者： Zi-Yang Liu Bing Li song xia You-Xin Chen Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Ophthalmology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Key Laboratory of Ocular Fundus Diseases Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Ophthalmology Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina

AIM:To classify polypoidal choroidal vasculopathy(PCV)into 2 subtypes based on the subfoveal choroidal thickness(SFCT)and to further evaluate their multimodal image ***:A retrospective observational case series ***-four eyes of 64 patients with PCV were enrolled and classified into 2 groups based on SFCT(thick-choroid group/thin-choroid group).Then further analyze the spectrum domain optical coherence tomography(SD-OCT)and indocyanine green angiography(ICGA)differences of the two *** analysis included measurement of SFCT,maximum vascular diameter ratio(MVDR),choroidal vascularity index(CVI),central macular thickness(CMT),and the presence of pigment epithelial detachment(PED)on *** lesions(polyps)number,branching vascular network(BVN)area,greatest linear dimension(GLD),and the choroidal vascular hyperpermeability(CVH)were analyzed by ***:The distribution of SFCT was bimodal with two peaks at 195 and 285μm,and a trough at 225μ*** 225μm was taken as the cutoff point for the following classification of thick/thin choroid *** PCV eyes in the thick-choroid group presented with greater MVDR,CVI within 3 and 6 mm of the fovea,but lower CMT,less PED,small PED diameters on SD-OCT scans,and fewer polyps,smaller BVN and GLD,but more frequency of CVH on ***:The SFCT at 225μm can be used as a readily available indicator for the classification of PCV *** thick-choroid group presents much apparent enlargement of the choroidal layer and vasculature expansion,which indicates different pathogenesis of the two subtypes.

关键词： polypoidal choroidal vasculopathy spectral-domain optical coherence tomography indocyanine green angiography subfoveal choroidal thickness

Ten-year observation of corneal densitometry and associated factors following small incision lenticule extraction

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 485-490页

作者： xiao-song Han Fei xia Zhuo-Yi Chen Pei-Jun Yao Dong-Mei Yang Jing Zhao Xing-Tao Zhou Eye Institute and Department of Ophthalmology Eye&ENT HospitalFudan UniversityShanghai 200031China NHC Key Laboratory of Myopia(Fudan University) Key Laboratory of MyopiaChinese Academy of Medical SciencesShanghai 200031China Shanghai Research Center of Ophthalmology and Optometry Shanghai 200031China Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care(20DZ2255000) Shanghai 200031China

●AIM:To investigate the long-term changes of corneal densitometry(CD)and its contributing elements after small incision lenticule extraction(SMILE).●METHODS:Totally 31 eyes of 31 patients with mean spherical equivalent of-6.46±1.50 D and mean age 28.23±7.38y were ***-scale examinations were conducted on all patients preoperatively and during *** acuity,manifest refraction,axial length,corneal thickness,corneal higher-order aberrations,and CD were evaluated.●RESULTS:All surgeries were completed successfully without complications or adverse ***-year safety index was 1.17±0.20 and efficacy 1.04±*** value of 0–6 mm zones in central layer was statistically significantly lower 10y postoperatively,compared with preoperative values(0–2 mmΔ=-1.62,2–6 mmΔ=-1.24,P<0.01).There were no correlations between CD values and factors evaluated.●CONCLUSION:SMILE is a safe and efficient procedure for myopia on a long-term *** values get lower 10y postoperatively,whose mechanism is to be further discussed.

关键词： myopia small incision lenticule extraction corneal densitometry