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Enhancing maize's nitrogen-fixing potential through ZmSBT3, a gene suppressing mucilage secretion∞

Journal of Integrative Plant Biology 2023年第12期65卷 2645-2659页

作者： jingyang Gao Peijiang Feng jingli Zhang Chaopei Dong zhao wang Mingxiang Chen Zhongliang Yu Bowen zhao Xin Hou Huijuan wang zhaokun Wu Razia Sultana Jemim Haidong Yu Doudou Sun Pei jing Jiafa Chen Weibin song Xuecai Zhang Zijian zhou Jianyu Wu College of Agronomy State Key Laboratory of Wheat and Maize Crop ScienceHenan Agricultural UniversityZhengzhou 450002China College of life Sciences Henan Agricultural UniversityZhengzhou 450002China State Key Laboratory of Plant Physiology and Biochemistry National Maize Improvement CenterCollege of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100193China International Maize and Wheat Improvement Center(CIMMYT) El BatanTexcoco 56237Mexico

Maize(Zea mays)requires substantial amounts of nitrogen,posing a challenge for its *** work discovered that some ancient Mexican maize landraces harbored diazotrophic bacteria in mucilage secreted by their aerial *** see if this trait is retained in modern maize,we conducted a field study of aerial root mucilage(ARM)in 258 inbred *** observed that ARM secretion is common in modern maize,but the amount significantly varies,and only a few lines have retained the nitrogen‐fixing traits found in ancient *** mucilage of the high‐ARM inbred line HN5‐724 had high nitrogen‐fixing enzyme activity and abundant diazotrophic *** genome‐wide association study identified 17 candidate genes associated with ARM across three *** of one candidate gene,the subtilase family gene ZmSBT3,confirmed that it negatively regulates ARM ***,the ZmSBT3 knockout lines had increased biomass and total nitrogen accumulation under nitrogen‐free culture *** ARM was associated with three ZmSBT3 haplotypes that were gradually lost during maize domestication,being retained in only a few modern inbred lines such as HN5‐*** summary,our results identify ZmSBT3 as a potential tool for enhancing ARM,and thus nitrogen fixation,in maize.

关键词： maize aerial root mucilage nitrogen‐fixing ZmSBT3 GWAS gene cloning Diazotroph

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Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

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Signal Transduction and Targeted Therapy 2022年第2期7卷 502-518页

作者： Zhen wang Fan-lian Zeng Ya-wen Hu Xiao-yan wang Fu-lei zhao Pei zhou jing Hu Yuan-yuan Xiao Zhong-lan Hu Ming-feng Guo Xiao-qiong Wei Xiao liu Nong-yu Huang Jun Zhang Shu-wen Chen Juan Cheng Hua-ping Zheng Hong zhou Qi-xiang zhao Chen Zhang Yan Hao song Zou Yi-yue Gui Jia-dong Yu lin-na Gu Cheng-cheng Yue Hao-zhou Zhang Wen-ling Wu Yi-fan zhou Xi-kun zhou Guo-bo Shen xiu Teng Jiong li State Key Laboratory of Biotherapy and Cancer Center West China HospitalWest China Medical SchoolSichuan University and Collaborative Innovation Center for BiotherapyChengduSichuan 610041China Department of liver Surgery&liver Transplantation West China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengduSichuan 610041China Laboratory of liver Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of EducationSichuan UniversityChengdu 610041China Department of Cardiovascular Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Laboratory of Human Disease and Immunotherapies West China HospitalSichuan UniversityChengduSichuan 610041China

Interleukin-37b(hereafter called IL-37)was identified as fundamental inhibitor of natural and acquired *** molecular mechanism and function of IL-37 in colorectal cancer(CRC)has been ***,we found that IL-37 transgenic(IL-37tg)mice were highly susceptible to colitis-associated colorectal cancer(CAC)and suffered from dramatically increased tumor burdens in ***,IL-37 is dispensable for intestinal mutagenesis,and CRC cell proliferation,apoptosis,and ***,IL-37 dampened protective cytotoxic T cell-mediated immunity in CAC and B16-OVA ***8^(+)T cell dysfunction is defined by reduced retention and activation as well as failure to proliferate and produce cytotoxic cytokines in IL-37tg mice,enabling tumor evasion of immune *** dysfunction led by IL-37 antagonizes IL-18–induced proliferation and effector function of CD8+T cells,which was dependent on SIGIRR(single immunoglobulin interleukin-1 receptor-related protein).Finally,we observed that IL-37 levels were significantly increased in CRC patients,and positively correlated with serum CRC biomarker CEA levels,but negatively correlated with the CD8+T cell infiltration in CRC *** findings highlight the role of IL-37 in harnessing antitumor immunity by inactivation of cytotoxic T cells and establish a new defined inhibitory factor IL-37/SIGIRR in cancerimmunity cycle as therapeutic targets in CRC.

关键词： immunity cytotoxic Interleukin

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Solar X-ray and EUV imager on board the FY-3E satellite

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light(Science & Applications) 2022年第12期11卷 2939-2951页

作者： Bo Chen Xiao-Xin Zhang ling-Ping He Ke-Fei song Shi-Jie liu Guang-Xing Ding Jin-Ping Dun Jia-Wei li zhao-Hui li Quan-Feng Guo Hai-Feng wang Xiao-Dong wang Yun-Qi wang Hong-Ji Zhang Guang Zhang Zhen-Wei Han Shuang Dai Pei-Jie Zhang liang Sun Yang liu software engineer Peng wang Kun Wu Chen Tao Shi-Lei Mao Gui Mei liang Yang li-Heng Chen Chun-Yang Han Bin Huang Yang liu mechanical engineer Shuai Ren Peng zhou Ze-XiWei Xiao-Xue Zhang Yue Zhang Xin Zheng Yang wang Ya Chen jing-Jiang Xie Fei He Qiao song Wei-Guo Zong xiu-Qing Hu Peng Zhang jing-song wang Zhong-Dong Yang Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina State Key Laboratory of Applied Optics Chinese Academy of SciencesChangchunChina National Satellite Meteorological Center China Meteorological AdministrationBeijingChina Key Laboratory of Space Weather National Center for Space WeatherChina Meteorological AdministrationBeijingChina Innovation Center for Fengyun Meteorological Satellite(FYSIC) BeijingChina Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijingChina

The solar X-ray and Extreme Ultraviolet Imager(X-EUVI),developed by the Changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences(CIOMP),is the first space-based solar X-ray and Extreme ultraviolet(EUV)imager of China loaded on the Fengyun-3E(FY-3E)satellite supported by the China Meteorological Administration(CMA)for solar *** started work on July 11,2021,X-EUVI has obtained many solar *** instrument employs an innovative dual-band design to monitor a much larger temperature range on the Sun,which covers 0.6-8.0 nm in the X-ray region with six channels and 19.5 nm in the EUV region.X-EUVI has a field of view of 42′,an angular resolution of 2.5″per pixel in the EUV band and an angular resolution of 4.1″per pixel in the X-ray *** instrument also includes an X-ray and EUV irradiance sensor(X-EUVS)with the same bands as its imaging optics,which measures the solar irradiance and regularly calibrates the solar *** radiometric calibration of X-EUVS on the ground has been completed,with a calibration accuracy of 12%.X-EUVI is loaded on the FY-3E satellite and rotates relative to the Sun at a uniform ***-field calibration is conducted by utilizing successive rotation solar *** agreement between preliminarily processed X-EUVI images and SDO/AIA and Hinode/XRT images indicates that X-EUVI and the data processing algorithm operate properly and that the data from X-EUVI can be applied to the space weather forecast system of CMA and scientific investigations on solar activity.

关键词： image instrument Solar

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Catheter ablation versus medical therapy for atrial fibrillation with prior stroke history:a prospective propensity score-matched cohort study

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Journal of Geriatric Cardiology 2023年第10期20卷 707-715,I0006页

作者： Wen-li DAI Zi-Xu zhao Chao JIANG liu HE Ke-Xin YAO Yu-Feng wang Ming-Yang GAO Yi-Wei lai jing-Rui ZHANG Ming-Xiao li song ZUO Xue-Yuan GUO Ri-Bo TANG song-Nan li Chen-Xi JIANG Nian liU De-Yong LONG Xin DU Cai-Hua SANG Jian-Zeng DONG Chang-Sheng MA Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityNational Clinical Research Center for Cardiovascular DiseasesBeijingChina Heart Health Research Center BeijingChina Department of Cardiovascular Medicine the First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

BACKGROUND Patients with atrial fibrillation(AF)and prior stroke history have a high risk of cardiovascular events despite anticoagulation *** is unclear whether catheter ablation(CA)has further benefits in these *** AF patients with a previous history of stroke or systemic embolism(SE)from the prospective Chinese Atrial Fibrillation Registry study between August 2011 and December 2020 were included in the *** were matched in a 1:1 ratio to CA or medical treatment(MT)based on propensity *** primary outcome was a composite of all-cause death or ischemic stroke(IS)/*** During a total of 4.1±2.3 years of follow-up,the primary outcome occurred in 111 patients in the CA group(3.3 per 100 person-years)and in 229 patients in the MT group(5.7 per 100 person-years).The CA group had a lower risk of the primary outcome compared to the MT group[hazard ratio(HR)=0.59,95%CI:0.47–0.74,Plity(HR=0.43,95%CI:0.31–0.61,Plity(HR=0.32,95%CI:0.19–0.54,Plinical trials are warranted to confirm the benefits of CA in these patients.

关键词： prospective fibrillation matched

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Mobility in China, 2020: a tale of four phases

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National Science Review 2021年第11期8卷 110-120页

作者： Suoyi Tan Shengjie lai Fan Fang Ziqiang Cao Bin Sai Bing song Bitao Dai Shuhui Guo Chuchu liu Mengsi Cai Tong wang Mengning wang Jiaxu li Saran Chen Shuo Qin Jessica R.Floyd Zhidong Cao jing Tan Xin Sun Tao zhou Wei Zhang Andrew J.Tatem Petter Holme Xiaohong Chen Xin Lu College of Systems Engineering National University of Defense Technology WorldPop School of Geography and Environmental ScienceUniversity of Southampton School of Mathematics and Big Data Foshan University State Key Laboratory on Blind Signal Processing State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of Sciences Chinese Evidence-Based Medicine Center National Clinical Research Center for Geriatrics West China Hospital Sichuan University Big Data Research Center University of Electronic Science and Technology of China West China Biomedical Big Data Center West China Hospital Sichuan University Tokyo Tech World Hub Research Initiative Institute of Innovative Research Tokyo Institute of Technology School of Business Central South University Institute of Big Data and Internet Innovations Hunan University of Technology and Business

2020 was an unprecedented year,with rapid and drastic changes in human mobility due to the COVID-19 *** understand the variation in commuting patterns among the Chinese population across stable and unstable periods,we used nationwide mobility data from 318 million mobile phone users in China to examine the extreme fluctuations of population movements in 2020,ranging from the Lunar New Year travel season(chunyun), to the exceptional calm of COVID-19 lockdown,and then to the recovery *** observed that cross-city movements,which increased substantially in chunyun and then dropped sharply during the lockdown,are primarily dependent on travel distance and the socio-economic development of *** the Lunar New Year holiday,national mobility remained low until mid-February,and COVID-19 interventions delayed more than 72.89 million people returning to large *** network analysis revealed clusters of highly connected cities,conforming to the social-economic division of urban agglomerations in *** the mass migration back to large cities was delayed,smaller cities connected more densely to form new *** the recovery period after travel restrictions were lifted,the netflows of over 55% city pairs reversed in direction compared to before the *** findings offer the most comprehensive picture of Chinese mobility at fine resolution across various scenarios in China and are of critical importance for decision making regarding future public-health-emergency response,transportation planning and regional economic development,among others.

关键词： human mobility travel restrictions COVID-19 mobile phone data behavioral response

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Updated overall survival and circulating tumor DNA analysis of ensartinib for crizotinib-refractory ALK-positive NSCLC from a phase II study

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Cancer Communications 2024年第4期44卷 455-468页

作者： jing Zheng Tao wang Yunpeng Yang Jie Huang Jifeng Feng Wu Zhuang Jianhua Chen Jun zhao Wei Zhong Yanqiu zhao Yiping Zhang Yong song Yi Hu Zhuang Yu Youling Gong Yuan Chen Feng Ye Shucai Zhang Lejie Cao Yun Fan Gang Wu Yubiao Guo Chengzhi zhou Kewei Ma Jian Fang Weineng Feng Yunpeng liu Zhendong Zheng Gaofeng li Huijie wang Shundong Cang Ning Wu Wei song Xiaoqing liu Shijun zhao lieming Ding Giovanni Selvaggi Yang wang Shanshan Xiao Qian wang Zhilin Shen Jianya zhou Jianying zhou li Zhang Department of Respiratory Disease Thoracic Disease CenterThe First Affiliated HospitalCollege of MedicineZhejiang UniversityZhejiang Provincial Clinical Research Center for Respiratory DiseaseHangzhouZhejiangP.R.China Hangzhou Repugene Technology Co. LtdHangzhouZhejiangP.R.China Department of Medical Oncology Sun Yat-sen University Cancer Cen-terState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology Jiangsu Cancer HospitalJiangsu Institute of Cancer ResearchThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsuP.R.China Department of Thoracic Oncology Fujian Provincial Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianP.R.China Department of Medical Oncology-Chest Hunan Cancer HospitalChangshaHunanP.R.China Department of Thoracic Oncology Beijing Cancer HospitalBeijingP.R.China Department of Pulmonary Medicine Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijingP.R.China Respiratory Department of Internal Medicine Henan Provincial Can-cer HospitalAffiliated Cancer Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Thoracic Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Division of Respiratory Medicine Jinling HospitalNanjing University School of MedicineNanjingJiangsuP.R.China Department of Oncology Chinese People’s Liberation Army(PLA)General HospitalBeijingP.R.China Department of Oncology The Affiliated Hospital of Qingdao UniversityQingdaoShandongP.R.China Department of Thoracic Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuanP.R.China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Medical Oncology Cancer HospitalThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityTeaching Hospital of

Background:The initial phase II stuty(NCT03215693)demonstrated that ensartinib has shown clinical activity in patients with advanced crizotinib-refractory,anaplastic lymphoma kinase(ALK)-positive non-small cell lung cancer(NSCLC).Herein,we reported the updated data on overall survival(OS)and molecular profiling from the initial phase Ⅱ ***:In this study,180 patients received 225 mg of ensartinib orally once daily until disease progression,death or *** was estimated by Kaplan‒Meier methods with two-sided 95%confidence intervals(CIs).Next-generation sequencing was employed to explore prognostic biomarkers based on plasma samples collected at baseline and after initiating *** tumor DNA(ctDNA)was detected to dynamically monitor the genomic alterna-tions during treatment and indicate the existence of molecular residual disease,facilitating improvement of clinical ***:At the data cut-off date(August 31,2022),with a median follow-up time of 53.2 months,97 of 180(53.9%)patients had *** median OS was 42.8 months(95%CI:29.3-53.2 months).A total of 333 plasma samples from 168 patients were included for ctDNA *** inferior OS correlated sig-nificantly with baseline ALK or tumor protein 53(TP53)*** addition,patients with concurrent TP53 mutations had shorter OS than those without con-current TP53 *** ctDNA levels evaluated by variant allele frequency(VAF)and haploid genome equivalents per milliliter of plasma(hGE/mL)at baseline were associated with poor ***,patients with ctDNA clear-ance at 6 weeks and slow ascent growth had dramatically longer OS than those with ctDNA residual and fast ascent growth,***,patients who had a lower tumor burden,as evaluated by the diameter of target lesions,had a longer *** Cox regression analysis further uncovered the independent prognostic values of bone metastases,higher hGE,and elevated ALK mutation abundance at 6 we

关键词： anaplastic lymphoma kinase ctDNA ensartinib non-small cell lung cancer overall survival

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Waveguide distribution system of the HEPS linac

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Radiation Detection Technology and Methods 2023年第4期7卷 502-513页

作者： Xiang He jing-Ru Zhang Hua Shi Ou-Zheng Xiao jing-Dong liu Nan Gan Hao Zeng Xiao-Ping li Guan Shu Feng-li zhao Sheng-Chang wang Xin-Peng Ma Cai Meng Da-Yong He Fei li Dong Dong Zu-Sheng zhou jing-Yi li Jian-li wang Bing-lin Deng Pi-Long Tian Xu-Jian wang Hong song Qi Yang Xiang-Cheng Kong National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei230029China Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China Zhang Jiang Laboratory Shanghai200120China

Purpose The High-Energy Photon Source(HEPS)is a 6 GeV storage ring-based light source under construction in Beijing,*** accelerator consists of a 6 GeV storage ring,a full-energy booster,an S-band normal-conducting 500 MeV linac,and three transport *** the beginning of HEPS,a stable linac is quite important,which needs a qualified waveguide distribution system to transmit microwave power from klystrons to accelerating *** Installation and high-power conditioning of the HEPS linac were performed from February to September *** assembly and conditioning of the waveguide distribution system were completed in April and July,*** design of the waveguide distribution system began in 2018 and was finalized at the end of 2020 after multiple *** Owing to careful design,fabrication,and assembly preparation,the assembly and conditioning of the system proceeded smoothly and considerable time was *** The entire process from the design to the ultimate realization of the system is introduced in detail in this *** measurement results were obtained for some waveguide components.

关键词： HEPS linac Waveguide distribution system System design Assembly and commissioning High-power conditioning

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Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-Sheng zhao Dong li Shao-lin Xiong Yan-Qiu Zhang Yang Su Wei Chen Yi zhao Xiao-Bo li Jia-Cong liu Wen-Xi Peng Rui Qiao Xin-Qiao li Xiang-Yang Wen li-Ming song Shi-Jie Zheng Xin-Ying song Xiao-Yun zhao Yue Huang Shuang-Nan Zhang Shuo Xiao Ce Cai Zheng-Hua An Can Chen Gang Chen Wei Chen Yan-Qi Du Min Gao Ke Gong Dong-Ya Guo Zhi-Wei Guo Jian-Jian He Bin li Chao li Chao-Yang li Gang li Jian-Hui li Lu li Qing-Xin li Yan-Guo li jing liang Xiao-Hua liang Jin-Yuan liao Xiao-jing liu Ya-Qing liu Qi Luo Xiang Ma Bin Meng Ge Ou Dong-li Shi jing-Yan Shi Gong-Xing Sun Xi-Lei Sun You-li Tuo Chen-Wei wang Hui wang Jin wang Jin-zhou wang Ping wang Wen-Shuai wang Hong Wu Sheng-Lun Xie Yan-Bing Xu Yu-Peng Xu wang-Chen Xue Sheng Yang Min Yao Jian-Ying Ye Qi-Bin Yi Chao-Yue Zhang Da-li Zhang Fan Zhang Fei Zhang Hong-Mei Zhang Kai Zhang Peng Zhang Xiao-Lu Zhang Zhen Zhang Guo-Ying zhao Shi-Yi zhao Chao Zheng Xing zhou Yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics Sciences&Technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

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Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study

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Neural Regeneration Research 2024年第5期19卷 1126-1132页

作者： Hengxing zhou Yongfu Lou lingxiao Chen Yi Kang Lu liu Zhiwei Cai David BAnderson Wei wang Chi Zhang jinghua wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng wang Wei Mei Yueming song Yue zhou Maosheng Xia Huan wang Jie zhao Guoyong Yin Tao Zhang Feng jing Rusen Zhu Bin Meng li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai lin Huang Zhanhai Yin Kainan li Shibao Lu Shiqing Feng Department of Orthopedics The Second HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Shandong University Center for OrthopedicsQilu HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Tianjin Medical University General HospitalInternational Science and Technology Cooperation Base of Spinal Cord InjuryTianjin Key Laboratory of Spine and Spinal CordTianjinChina Faculty of Medicine and Health The Back Pain Research TeamSydney Musculoskeletal HealthThe Kolling InstituteUniversity of SydneySydneyNSWAustralia Department of Spine Surgery Honghui HospitalXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General HospitalBeijingChina Faculty of Medicine and Health School of Health SciencesUniversity of SydneyNSWAustralia Sydney Spine Institute BurwoodSydneyNSWAustralia Laboratory of Epidemiology Tianjin Neurological InstituteDepartment of NeurologyTianjin Medical University General Hospital&Tianjin Neurological InstituteKey Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina Department of Orthopedics Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Department of Spinal Surgery The Third Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Orthopedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Spine Surgery Zhengzhou Orthopedics HospitalZhengzhouHenan ProvinceChina Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqingChina Department of Orthopedics The First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Spinal Surgery Shengj

Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even *** has the largest population of patients with traumatic spinal cord *** studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been *** the best of our knowledge,no national-level study of treatment status and economic burden has been *** retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national *** included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of *** epidemiological and clinical features,treatment status,and total and daily costs were *** in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression *** percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent *** 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 *** total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 ho

关键词： China clinical features costs epidemiology methylprednisolone sodium succinate methylprednisolone retrospective study traumatic spinal cord injury treatment

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Scientific objectives of the Hot Universe Baryon Surveyor(HUBS) mission

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Science China(Physics,Mechanics & Astronomy) 2023年第9期66卷 134-178页

作者： Joel Bregman Renyue Cen Yang Chen Wei Cui Taotao Fang Fulai Guo Edmund Hodges-Kluck Rui Huang Luis C.Ho li Ji Suoqing Ji Xi Kang Xiaoyu lai Hui li Jiangtao li Miao li Xiangdong li Yuan li zhaosheng li Guiyun liang Helei liu Wenhao liu Fangjun Lu Junjie Mao Gabriele Ponti Zhijie Qu Chenxi Shan lijing Shao Fangzheng Shi Xinwen Shu Lei Sun Mouyuan Sun Hao Tong Junfeng wang Junxian wang Q.Daniel wang song wang Tinggui wang Weiyang wang Zhongxiang wang Dandan Xu Haiguang Xu Heng Xu Renxin Xu Xiaojie Xu Yongquan Xue Hang Yang Feng Yuan Shuinai Zhang Yuning Zhang Zhongli Zhang Yuanyuan zhao Enping zhou Ping zhou Department of Astronomy University of MichiganAnn Arbor MI 48109-1107USA Institute for Astronomy School of PhysicsZhejiang UniversityHangzhou 310027China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Key Laboratory of Modern Astronomy and Astrophysics Nanjing UniversityNanjing 210023China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Astronomy Xiamen UniversityXiamen 361005China Astrophysics Division Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China NASA Goddard Space Flight Center Greenbelt MD 20771USA Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China Department of Physics and Astronomy Hubei University of EducationWuhan 430205China Department of Physics University of North TexasDenton TX 76203USA Key Laboratory of Stars and Interstellar Medium Xiangtan UniversityXiangtan 411105China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Physical Science and Technology Xinjiang UniversityUrumuqi 830046China Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China INAF-Osservatorio Astronomico di Brera Merate(LC)I-23807Italy Department of Astronomy&Astrophysics the University of ChicagoChicago IL 60637USA School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics Anhui Normal UniversityWuhu 241002China School of Physics and Materials Science Guangzhou UniversityGuangzhou 510006China Department of Astronomy University of Science and Technology of ChinaHefei 230026China Depart

The Hot Universe Baryon Surveyor(HUBS) is a proposed space-based X-ray telescope for detecting X-ray emissions from the hot gas content in our universe. With its unprecedented spatially-resolved high-resolution spectroscopy and large field of view,the HUBS mission will be uniquely qualified to measure the physical and chemical properties of the hot gas in the interstellar medium, the circumgalactic medium, the intergalactic medium, and the intracluster medium. These measurements will be valuable for two key scientific goals of HUBS, namely to unravel the AGN and stellar feedback physics that governs the formation and evolution of galaxies, and to probe the baryon budget and multi-phase states from galactic to cosmological scales. In addition to these two goals, the HUBS mission will also help us solve some problems in the fields of galaxy clusters, AGNs, difuse X-ray backgrounds, supernova remnants, and compact objects. This paper discusses the perspective of advancing these fields using the HUBS telescope.

关键词： X-ray telescopes Galactic halo X-ray sources

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